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Article
Environmental Sciences
Zhou Sun et al.
Summary: This study reveals the association of histone modifiers with the development of prostate cancer and identifies YWHAH as a potential diagnostic and therapeutic biomarker for prostate cancer. A risk model based on four prognostic marker genes is established with high predictive potency. These findings provide novel insights and open up new avenues for customized treatment alternatives for prostate cancer.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Oncology
Yong Xia et al.
Summary: PKM2 plays an essential role in promoting tumor growth and maintenance by enhancing angiogenesis and metabolic addiction, although it is not required for tumor initiation. The PKM2-STAT3-HIF1 alpha/VEGF signaling axis may be critical in bladder cancer and could be a potential therapeutic target.
Article
Immunology
Xin Qing et al.
Summary: This study systematically assessed the association between angiogenesis and gastric cancer (GC). The authors identified two molecular subtypes and determined the correlation between angiogenesis-associated genes mutations, clinicopathological characteristics, prognosis, immune cell infiltration, and tumor microenvironment. They established an AAG_score for predicting overall survival (OS) and created a reliable nomogram for clinical viability. The study provides insights into the characteristics of TME and potential immunotherapy strategies in GC.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Xinyuan Li et al.
Summary: This study identifies five angiogenesis-related long non-coding RNAs (lncRNAs) and validates their clinical significance and prognostic values in bladder urothelial carcinoma (BUC). These findings provide new perspectives and promising antiangiogenic targets for clinical diagnosis and treatment strategies of BUC.
CANCER CELL INTERNATIONAL
(2022)
Article
Immunology
Songwei Feng et al.
Summary: This study aims to develop a non-invasive radiogenomics approach for identifying a hypoxia pattern in ovarian cancer and predicting patient prognostication. Hypoxia-related genes and subtypes were identified based on RNA-seq analysis of OC cell lines. Various bioinformatics algorithms were used to explore immune microenvironment, prognosis, pathway alteration, and drug sensitivity. A radiogenomics model was constructed for predicting patient risk status. The study demonstrates the potential of computed tomography-based radiogenomics biomarkers in predicting hypoxia pattern, prognosis, therapeutic effect, and immune microenvironment in OC patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Songwei Feng et al.
Summary: This study identified prognostic genes associated with cancer-associated fibroblasts (CAFs) in ovarian cancer patients. The researchers used bioinformatics analysis to identify CAF-associated hub genes and constructed a prognostic signature. The analysis indicated that high-risk patients have worse prognosis, weaker immune response, and lower tumor mutational burden (TMB) status but may be more sensitive to routine chemotherapeutic agents. The study suggests that the CAF-related signature may serve as a pretreatment guide for anti-CAFs and prognostic markers in CAFs could be potential therapeutic targets to inhibit ovarian cancer progression.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Lihua Chen et al.
Summary: Lactate plays a crucial role in connecting immune evasion and metabolic reprogramming in cancer. Lactate metabolism promotes key processes in tumor development, and protein lactylation is essential for lactate's function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Jiahao Gao et al.
Summary: A novel non-invasive radiogenomics biomarker was constructed to predict immune-related gene expression in ccRCC patients. Using non-negative matrix decomposition clustering, immune-related molecular subtypes were identified, and a risk model based on an immune-related gene subset was built to predict prognosis. Radiomic features were extracted from CT images to stratify immune-related gene expression levels, and a nomogram combining radiogenomics and clinicopathological information was constructed to enhance the model's predictive efficacy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Patrick J. Hensley et al.
Summary: Staging of bladder cancer is crucial for prognosis and treatment decisions, but traditional methods have limitations. Novel biomarkers and imaging modalities, particularly MRI, show promising potential to improve diagnostic accuracy in bladder cancer staging.
EUROPEAN UROLOGY ONCOLOGY
(2022)
Article
Ophthalmology
Prateek Prasanna et al.
Summary: This study evaluated the potential of radiomics-based UWFA-derived imaging biomarkers in predicting therapeutic durability of intravitreal aflibercept injection (IAI). Two new UWFA image-derived biomarkers were identified as potential predictors for treatment durability and tolerance of longer treatment intervals.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Oncology
Rebecca L. Siegel et al.
Summary: Every year, the American Cancer Society projects the numbers of new cancer cases and deaths in the United States, with the latest data showing a significant decline in lung cancer mortality, while prostate cancer mortality has plateaued and breast and colorectal cancer mortality have slowed. Improvements in treatment have accelerated progress against lung cancer, leading to a record drop in overall cancer mortality.
CA-A CANCER JOURNAL FOR CLINICIANS
(2021)
Article
Oncology
Chen Han et al.
Summary: This study constructed a prognostic signature of angiogenesis-related lncRNAs for accurately predicting the survival time of stomach adenocarcinoma (STAD) patients. The prognostic signature showed high efficacy and independence in predicting the prognosis of STAD patients. Additionally, the study also explored the coexpression of ARLncs with mRNAs, biological processes involved, and the correlation with angiogenesis markers, providing potential biomarkers and therapeutic strategies for STAD patients.
Review
Pharmacology & Pharmacy
Jinyi Liu et al.
Summary: Exosomes are cell-derived nanovesicles that play essential roles in intercellular communication, cancer progression, and drug delivery. They have potential applications in cancer diagnosis, treatment, and research.
ACTA PHARMACEUTICA SINICA B
(2021)
Review
Oncology
M. Rey-Cardenas et al.
Summary: Urothelial bladder cancer is the most common malignancy of the urinary system, and the use of immunotherapy and immune checkpoint inhibitors has transformed treatment strategies, showing improvements in metastatic disease but posing challenges for locally invasive disease.
CANCER TREATMENT REVIEWS
(2021)
Review
Biochemistry & Molecular Biology
Xiaoqi Mao et al.
Summary: CAFs, as a crucial component of TME, play significant roles in promoting tumor growth, invasion, and metastasis. The interaction between CAFs and tumor cells, as well as immune cells in TIME, is critical for tumor progression.
Article
Immunology
Fangdie Ye et al.
Summary: This study aimed to develop a noninvasive radiogenomics approach to predict survival outcomes and therapeutic responses in bladder cancer patients by combining factors such as m6A methylation status, immune infiltration, and biological pathway alterations. Through the analysis of m6A subtypes and radiogenomics models, effective performance in predicting survival outcomes and therapeutic responses was demonstrated. Interdisciplinary exploration in the combination of medicine and electronics is essential for further advancements in this field.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Yingjie Xv et al.
Summary: This study developed and validated a CT-based radiomics nomogram integrated with clinic-radiological factors for preoperative differentiation of high-grade from low-grade CCRCC. The nomogram showed better predictive performance than clinic-radiological and radiomics signature models, with potential clinical usefulness indicated by decision curve analysis.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Leire Bejarano et al.
Summary: This review provides a comprehensive analysis of the current therapies targeting the TME, combining a discussion of the underlying basic biology with clinical evaluation of different therapeutic approaches, and highlighting the challenges and future perspectives.
Article
Oncology
Jennifer Xiao et al.
Summary: The study evaluated the association of breast cancer features on dynamic contrast-enhanced MRI with MVD, a marker for angiogenesis. Lesions with high MVD levels showed higher peak SER and WF, and some radiomics texture features were promising in predicting increased MVD. DCE-MRI can non-invasively assess breast cancer angiogenesis, which could help optimize treatments based on tumor biology.
Article
Multidisciplinary Sciences
Kenneth H. Gouin et al.
Summary: The study identified an epithelial subpopulation in bladder cancer with therapeutic response prediction ability through single nuclei RNA sequencing and spatial analysis, indicating CDH12-enriched tumors have poor outcome following surgery but superior response to ICT. This study provides a potential framework for designing biomarker-guided clinical trials in bladder cancer therapeutics.
NATURE COMMUNICATIONS
(2021)
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Urology & Nephrology
Aurelie Kamoun et al.
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Peripheral Vascular Disease
Daniela Unterleuthner et al.
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Biochemistry & Molecular Biology
Nicole M. Anderson et al.
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Oncology
Haoyu Ren et al.
Article
Multidisciplinary Sciences
Weimin Wang et al.
Review
Oncology
Rosa Nadal et al.
CANCER TREATMENT REVIEWS
(2019)
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Peripheral Vascular Disease
Nicholas J. Protopsaltis et al.
Review
Oncology
Lingling Ge et al.
FRONTIERS IN ONCOLOGY
(2019)
Review
Oncology
Francesco Massari et al.
CANCER TREATMENT REVIEWS
(2018)
Article
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Shaoxu Wu et al.
CLINICAL CANCER RESEARCH
(2017)
Review
Peripheral Vascular Disease
Claire Viallard et al.
Review
Medicine, Research & Experimental
Chenxi Hu et al.
BIOMEDICINE & PHARMACOTHERAPY
(2017)
Article
Hematology
Christopher L. Plaisier et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2009)
