Synthesis of Indole-2-carboxylates via Condensation of Nitroacetic Esters and 2-Dimethylbenzaldehydes

A new operationally simple single step method for synthesis indole-2-carboxylates from 2-dimethylaminobenzaldehydes and nitroacetic acid esters in 22-59 % yields has been developed. A new simple single step method for synthesis indole-2-carboxylates from 2-dimethylaminobenzaldehydes and nitroacetic acid esters are presented.image

Automated summary

A new operationally simple single step method has been developed for the synthesis of indole-2-carboxylates from 2-dimethylaminobenzaldehydes and nitroacetic acid esters, with yields ranging from 22% to 59%.