Inhibition of USP21 leads to ovarian carcinoma cell death by suppressing MAPK signaling

Article Cell Biology

USP21 regulates Hippo signaling to promote radioresistance by deubiquitinating FOXM1 in cervical cancer

Zhengliang Li et al.

Summary: USP21 contributes to radio-resistance in cervical cancer cells through the FOXM1/Hippo signaling pathway, suggesting its potential as a target for radiosensitizers in radiotherapy.

HUMAN CELL (2022)

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Article Oncology

RAF-MEK-ERK pathway in cancer evolution and treatment

Rahim Ullah et al.

Summary: The RAF-MEK-ERK signaling cascade is a well-characterized MAPK pathway that plays a critical role in cell proliferation and survival. Genetic alterations in this pathway are highly prevalent in human cancers and can lead to uncontrolled cell growth and tumor formation. The crosstalk between the RAF-MEK-ERK axis and other signaling pathways further enhances its proliferative potential in human cancers.

SEMINARS IN CANCER BIOLOGY (2022)

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Review Neurosciences

The DUB Club: Deubiquitinating Enzymes and Neurodevelopmental Disorders

Lachlan A. Jolly et al.

Summary: This review discusses the roles and importance of deubiquitinating enzymes (DUBs) in neurodevelopmental disorders (NDDs). Current genetic evidence and functional studies show that DUBs are associated with various NDDs and their study provides insights into protein degradation during brain development. The regulation of protein networks by DUBs and their connection to NDD genes offer opportunities for developing new therapeutic approaches.

BIOLOGICAL PSYCHIATRY (2022)

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Article Cell Biology

RBM47/SNHG5/FOXO3 axis activates autophagy and inhibits cell proliferation in papillary thyroid carcinoma

Yuan Qin et al.

Summary: This study revealed the regulatory mechanism of the RBM47/SNHG5/FOXO3 axis on cell proliferation and autophagy in PTC, which may provide valuable insight for the treatment of PTC.

CELL DEATH & DISEASE (2022)

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Review Pharmacology & Pharmacy

Insights Into the Properties, Biological Functions, and Regulation of USP21

Tao An et al.

Summary: DUBs counteract ubiquitination by removing ubiquitin from their substrates. USP21, a member of the largest subfamily of DUBs, has been shown to play a significant role in controlling physiological and pathological processes. Recent research has highlighted the importance of USP21 in various biological processes, particularly in carcinogenesis. This comprehensive review provides an overview of USP21, including its properties, biological functions, pathophysiological roles, and cellular regulation. The limited pharmacological interventions for USP21 emphasize the need for novel and specific inhibitors.

FRONTIERS IN PHARMACOLOGY (2022)

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Review Oncology

Chemoresistance in Ovarian Cancer: Prospects for New Drugs

Shivani Tendulkar et al.

Summary: This review focuses on conventional treatments, signaling pathways, and reasons for drug resistance in ovarian cancer, as well as novel methods that may lead to more effective therapies. Patients with ovarian cancer typically respond initially to chemotherapy but may later develop drug resistance, with mechanisms including epithelial-mesenchymal transition, DNA repair activation, and autophagy.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY (2021)

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Article Biochemistry & Molecular Biology

PR-619, a General Inhibitor of Deubiquitylating Enzymes, Diminishes Cisplatin Resistance in Urothelial Carcinoma Cells through the Suppression of c-Myc: An In Vitro and In Vivo Study

Fu-Shun Hsu et al.

Summary: Cisplatin-based chemotherapy is the standard treatment for bladder urothelial carcinoma but chemoresistance often occurs, leading to treatment failure. The deubiquitylating enzyme inhibitor PR-619 has shown promise in enhancing the antitumor effects of cisplatin in cisplatin-resistant bladder UC by targeting the c-Myc pathway, providing potential therapeutic strategies to overcome chemoresistance.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Cell Biology

De-Ubiquitinating Enzymes USP21 Regulate MAPK1 Expression by Binding to Transcription Factor GATA3 to Regulate Tumor Growth and Cell Stemness of Gastric Cancer

Qingqu Guo et al.

Summary: This study identified a new USP21/GATA3/MAPK1 axis that plays a pivotal role in promoting the malignant progression of gastric cancer. The axis may provide a potential target for treatment.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Biochemistry & Molecular Biology