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Current Advances on Nanomaterials Interfering with Lactate Metabolism for Tumor Therapy

ADVANCED SCIENCE (2023)

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Article Chemistry, Multidisciplinary

A Biomimetic Metal-Organic Framework Nanosystem Modulates Immunosuppressive Tumor Microenvironment Metabolism to Amplify Immunotherapy

Huaiji Wang et al.

Summary: We constructed a biomimetic nanosystem to modulate tumor immunosuppressive microenvironment (iTME) and enhance immunogenic cell death (ICD)-induced immunotherapy. The nanosystem selectively accumulated in tumors and inhibited tumor growth, while also enhancing cytotoxic T cell infiltration, repolarizing tumor-associated macrophages, decreasing regulatory T cell levels, and increasing CD8+ T to CD4+ T cell ratios.

JOURNAL OF CONTROLLED RELEASE (2023)

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Article Chemistry, Physical

Mesothelin targeted nano -system enhanced chemodynamic therapy and tirapazamine chemotherapy via lactate depletion

Guodong Cao et al.

Summary: By constructing the MTM nanosystem, we overcame the EPR defects and achieved targeted delivery to the tumor site, lactate depletion, promoted reactive oxygen species (ROS) induction, and enhanced the effect of TPZ, demonstrating a potential synergistic combination of cancer therapy with better efficacy and biosafety.

NANO RESEARCH (2023)

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Article Biotechnology & Applied Microbiology

Lactate oxidase/catalase-displaying nanoparticles efficiently consume lactate in the tumor microenvironment to effectively suppress tumor growth

Hyukjun Choi et al.

Summary: The aggressive proliferation of tumor cells often requires increased glucose uptake and excessive anaerobic glycolysis, leading to the massive production and secretion of lactate to form a unique tumor microenvironment (TME).

JOURNAL OF NANOBIOTECHNOLOGY (2023)

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Article Chemistry, Multidisciplinary

Insights into the Effect of Catalytic Intratumoral Lactate Depletion on Metabolic Reprogramming and Immune Activation for Antitumoral Activity

Junlong Zhao et al.

Summary: This study illustrates the instructive relationships between intratumoral lactate regulation, metabolic reprogramming, and immune activation for catalytic immunotherapy of tumors. The catalysts efficiently oxidize intratumoral lactate, induce tumor cell apoptosis, reprogram metabolism, and activate antitumor immunity.

ADVANCED SCIENCE (2023)

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Review Engineering, Biomedical

Intelligent polymeric hydrogen sulfide delivery systems for therapeutic applications

Fan Rong et al.

Summary: This review focuses on the design, preparation, and therapeutic applications of intelligent polymeric H2S delivery systems in cardiovascular therapy, inflammatory therapy, tissue regenerative therapy, cancer therapy and bacteria-associated therapy. Precise H2S therapies, especially imaging-guided H2S theranostics, are highlighted.

BIOACTIVE MATERIALS (2023)

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Review Oncology

Advances in the Study of Hexokinase 2 (HK2) Inhibitors

Shaopei Wang et al.

Summary: This study systematically summarizes the characteristics of HK2 inhibitors reported in the literature and patents, analyses the active site of HK2, and evaluates the structure, function, activity, and mechanism of action of these inhibitors. The results show that current HK2 inhibitors have poor efficacy, low specificity, and many side effects, highlighting the urgent need for HK2 inhibitors with improved activity and high selectivity.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY (2023)

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Article Chemistry, Multidisciplinary

Heterostructural Nanoadjuvant CuSe/CoSe2 for Potentiating Ferroptosis and Photoimmunotherapy through Intratumoral Blocked Lactate Efflux

Chunzheng Yang et al.

Summary: An activatable immunomodulatory nanoadjuvant, CSC@Syro, is constructed to relieve the immunosuppressive tumor microenvironment and boost tumor immune response. The nanoadjuvant induces tumor cell ferroptosis and immunogenic cell death, while blocking lactate metabolism and neutralizing acidic tumor microenvironment. This synergistic therapy integrates tumor metabolic regulation and ferroptosis with immunotherapy, effectively suppressing tumor proliferation and metastasis.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2023)

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Article Chemistry, Multidisciplinary

Nitrogen-Centered Lactate Oxidase Nanozyme for Tumor Lactate Modulation and Microenvironment Remodeling

Senfeng Zhao et al.

Summary: A coordination strategy is proposed to mimic lactate oxidase by modulating the electronic properties at the N center in a Co-x-N nanocomposite. The optimized nanozyme Co4N/C shows superior oxidation of lactate and inhibits tumor growth and metastasis.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2023)

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Article Chemistry, Physical

Pd@Ir-LOD multienzyme utilizing endogenous lactate consumption cooperates with photothermal for tumor therapy

Zichen Ye et al.

Summary: In this study, a novel lactate oxidase (LOD) conjugated two-dimensional Pd@Ir nanoplatform was designed to combine cascade reaction with photothermal therapy for tumor treatment. The platform can convert lactic acid into highly toxic reactive oxygen species (ROS) through cascade reaction and has excellent photothermal conversion efficiency. This study is of great significance for tumor therapy.

NANO RESEARCH (2023)

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Review Chemistry, Multidisciplinary

Lactate-Oxidase-Instructed Cancer Diagnosis and Therapy

Shanshan Jiang et al.

Summary: Lactate oxidase (LOx) has been widely studied for its specific catalysis on l-lactate, which is highly correlated with tumor growth, metastasis, and recurrence. LOx-based biosensors and cancer therapy strategies have been developed, including H2O2-based, O-2-based, pH-sensitive, and electrochemical sensors for cancer diagnosis, as well as lactate-depletion-based metabolic cancer therapy/immunotherapy, hypoxia-activated chemotherapy, H2O2-based chemodynamic therapy, and multimodal synergistic cancer therapy. This review summarizes the recent advances and potential of LOx-based platforms in cancer diagnosis and therapy, and highlights the challenges and potential of LOx-based nanomedicines.

ADVANCED MATERIALS (2023)

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Article Chemistry, Multidisciplinary

Metal-Phenolic Nanomedicines Regulate T-Cell Antitumor Function for Sono-Metabolic Cancer Therapy

Jie Yan et al.

Summary: Cancer cells compete with tumor-infiltrating T lymphocytes (TILs) for glucose uptake, which alters the tumor microenvironment (TME) and impairs CD8(+) TIL effector function. Inhibiting aerobic glycolysis in cancer cells and inducing mitochondrial dysfunction can reprogram TME and enhance CD8(+) T cell activation. A sono-metabolic cancer therapy using Hyaluronic Acid (HA)-modified metal-phenolic nanomedicine (HPP-Ca@GSK) is proposed to achieve these goals. In vitro and in vivo studies show that HPP-Ca@GSK-based sono-metabolic treatment exhibits significant anticancer activity and can be further enhanced by destabilizing T-reg cells with anticytotoxic T lymphocyte-associated protein-4 antibodies. These findings provide a metabolic intervention strategy for cancer immunotherapy.

ACS NANO (2023)

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Article Plant Sciences

Anti-tumor effects of novel alkannin derivatives with potent selectivity on comprehensive analysis

Zi-qi Dai et al.

Summary: In this study, the toxicity of alkannin was improved through structural modification, and the mechanism of the superior derivative 23 in lung cancer therapy was elucidated. Derivative 23 showed high cytotoxicity selectivity against cancer cells compared to normal cells. It induced apoptosis and cell cycle arrest in A549 cells and inhibited glycolysis by targeting the PKM2/STAT3 phosphorylation signaling pathway. In vivo studies also demonstrated the significant inhibitory effect of derivative 23 on tumor growth. Overall, this study highlights the potential value of derivative 23 in treating lung cancer.

PHYTOMEDICINE (2023)

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Article Chemistry, Physical

Mesothelin targeted nano-system enhanced chemodynamic therapy and tirapazamine chemotherapy via lactate depletion

Guodong Cao et al.

Summary: In this study, we overcame the EPR defects via the MTM nanosystem, which can realize acute targeted delivery to the tumour site, lactate depletion, promoted reactive oxygen species (ROS) induction, and enhanced the effect of TPZ, demonstrating a potential synergistic combination of cancer therapy with better efficacy and biosafety.

NANO RESEARCH (2023)

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Review Oncology

Nanoparticles for cancer therapy: a review of influencing factors and evaluation methods for biosafety

Jinghua Li et al.

Summary: Nanoparticles are widely used in the biomedical field for their small size, high carrier capacity, and ease of modification. However, their unique physicochemical properties and interactions with biological components create a high potential for unpredictable adverse effects on human organs, tissues, and cells. It is essential to evaluate the safety of nanoparticles in living organisms by considering their properties and utilizing common methods for biosafety evaluation.

CLINICAL & TRANSLATIONAL ONCOLOGY (2023)

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Review Nanoscience & Nanotechnology

Nanoparticles: a promising vehicle for the delivery of therapeutic enzymes

Swati Tripathi et al.

Summary: Nanomedicine and nanodelivery involve the synthesis of nanoscale materials for targeted drug delivery. Despite some disadvantages such as toxicity, nanotechnology holds promising prospects for the prevention, diagnosis, management, and cure of various diseases. Therapeutic enzymes, when delivered using nanoparticles, can effectively treat cancer, AIDS, and other diseases.

INTERNATIONAL NANO LETTERS (2023)

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Review Oncology

Advances in the Study of Hexokinase 2 (HK2) Inhibitors

Shaopei Wang et al.

Summary: HK2 has been proven to be a key target for cancer treatment. This study systematically summarised the characteristics of HK2 inhibitors reported in the literature and patents, and analysed and illustrated the structure of small molecules with the catalytic domain of HK2 to develop highly selective and low-toxicity HK2 inhibitors.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY (2023)

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Article Chemistry, Multidisciplinary

Self-Delivery Ternary Bioregulators for Photodynamic Amplified Immunotherapy by Tumor Microenvironment Reprogramming

Lin-Ping Zhao et al.

Summary: In this study, self-delivery ternary bioregulators were constructed for photodynamic amplified immunotherapy against colorectal cancer by reprogramming tumor microenvironments. The ternary bioregulators exhibited improved tumor accumulation, penetration, and cellular uptake. The study found that the ternary bioregulators could not only inhibit tumor growth, but also induce immunogenic cell death and activate immune response, leading to significant suppression of distant and metastatic tumor growth. This research has the potential to advance the development of nanomedicine for malignant tumor growth and metastasis.

ACS NANO (2022)

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Article Chemistry, Multidisciplinary

Coordination Polymer-Coated CaCO3 Reinforces Radiotherapy by Reprogramming the Immunosuppressive Metabolic Microenvironment

Chunjie Wang et al.

Summary: The pH-responsive nanomedicine prepared in this study has shown promising results in enhancing the therapeutic efficacy of radiotherapy against tumors by neutralizing tumor acidity and inhibiting IDO1, resulting in robust antitumor immunity and suppression of tumor metastasis and recurrence.

ADVANCED MATERIALS (2022)

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Article Engineering, Biomedical

Multifunctional liquid metal-based nanoparticles with glycolysis and mitochondrial metabolism inhibition for tumor photothermal therapy

Xing-Lan Ding et al.

Summary: This study designed a tumor acidity-responsive nanoparticle that combines ATP generation inhibition and photothermal therapy to enhance tumor treatment. By inhibiting glycolysis and increasing oxidative stress, the nanoparticles degrade and cause mitochondrial dysfunction, leading to reduced ATP production and heat shock protein expression, ultimately improving the therapeutic effect of photothermal therapy.

BIOMATERIALS (2022)

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Article Chemistry, Physical

Synergetic lethal energy depletion initiated by cancer cell membrane camouflaged nano-inhibitor for cancer therapy

Fudan Dong et al.

Summary: Mitochondrial bioenergy plays a vital role in cancer occurrence and development. The study presents a cancer cell membrane camouflaged nano-inhibitor that can block two different energy pathways and exhibit precision tumor-targeting. Under laser irradiation, the nano-inhibitor inhibits oxidative phosphorylation and reduces tumor energy, significantly suppressing tumor growth.

NANO RESEARCH (2022)

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Article Chemistry, Multidisciplinary

Yeast@MOF bioreactor as a tumor metabolic symbiosis disruptor for the potent inhibition of metabolically heterogeneous tumors

Wenjie Wang et al.

Summary: A yeast@MOF bioreactor was designed to disrupt tumor metabolic symbiosis by depriving the energy supply of tumor cells and inhibiting the growth of metabolically heterogeneous tumors.

NANO TODAY (2022)

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Article Chemistry, Multidisciplinary

Microbiotic nanomedicine for tumor-specific chemotherapy-synergized innate/adaptive antitumor immunity

Wencheng Wu et al.

Summary: This study reports a novel microbiotic nanomedicine LOD/TPZ@Lips-LA, which combines lactate oxidase (LOD) and prodrug tirapazamine (TPZ) loaded liposomes anchored on lactobacillus (LA) surface for chemotherapy-synergized antitumor immunity. The nanomedicine induces tumor cell apoptosis through in situ ROS generation and TPZ activation based on LA metabolism, resulting in strong immunogenic cell death (ICD). By regulating biomarker expression, it promotes anti-tumorigenic M1 polarization of innate tumor-associated macrophages and infiltration of adaptive cytotoxic CD8+ T cells, synergistically enhancing the tumor inhibition effects.

NANO TODAY (2022)

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Review Biotechnology & Applied Microbiology

Targeting cancer metabolism in the era of precision oncology

Zachary E. Stine et al.

Summary: In the past century, there have been significant advancements in targeting cancer metabolism, but progress in the past decade has been limited. Some metabolism-based drugs for cancer have been successfully developed and are in clinical trials. However, consideration of the metabolism of non-cancer cells is crucial for successful treatment of cancer.

NATURE REVIEWS DRUG DISCOVERY (2022)

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Article Chemistry, Multidisciplinary

Recent advances in upconversion nanoparticle-based nanocomposites for gas therapy

Nailin Yang et al.

Summary: Gas therapy using upconversion nanoparticles (UCNPs) for controlled gas release has shown great promise in various medical applications, such as cancer therapy and bacterial therapy. The unique upconversion luminescence (UCL) ability of UCNPs enables the conversion of long wavelength light to ultraviolet/visible (UV/Vis) light for precise gas release. Further research and development in this area are needed to explore the full potential of UCNP-based nanocomposites in gas therapy.

CHEMICAL SCIENCE (2022)

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Article Medicine, Research & Experimental

Mitochondrion-targeted supramolecular nano-boat simultaneously inhibiting dual energy metabolism for tumor selective and synergistic chemo-radiotherapy

Jie Gao et al.

Summary: The mitochondrion-targeted supramolecular nano-boat constructed by self-assembled peptides can inhibit the dual energy metabolism of cancer cells, selectively kill cancer cells, and enhance radio-sensitization.

THERANOSTICS (2022)

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Review Engineering, Biomedical

Hydrogen Sulfide: An Emerging Precision Strategy for Gas Therapy

He Ding et al.

Summary: Advances in nanotechnology have led to the rapid development of therapeutic nanomaterials for gas therapy, particularly with H2S-responsive properties. The interdisciplinary study of H2S is a scientific hotspot exploring its chemical properties, biological mechanisms, and therapeutic effects, showcasing potential for treating diseases in biological systems.

ADVANCED HEALTHCARE MATERIALS (2022)

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Article Engineering, Biomedical

Dendritic Polyglycerol-Conjugated Gold Nanostars for Metabolism Inhibition and Targeted Photothermal Therapy in Breast Cancer Stem Cells

Yuanwei Pan et al.

Summary: In this study, a method for efficient eradication of CSCs was developed by conjugating HK2 inhibitor, mitochondrial targeting molecule, and CSCs targeting agent onto a nanoplatform. The nanocomposite particles showed good biocompatibility and enhanced therapeutic efficacy by inhibiting metabolism and inducing cellular apoptosis. The treatment successfully suppressed CSC self-renewal and tumor growth, achieving eradication of CSCs.

ADVANCED HEALTHCARE MATERIALS (2022)

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Article Chemistry, Multidisciplinary

Nano-enabled Tumor Systematic Energy Exhaustion via Zinc (II) Interference Mediated Glycolysis Inhibition and Specific GLUT1 Depletion

Sixuan Wu et al.

Summary: A novel paradigm of starvation therapy is proposed to synergize Zn2+ interference-mediated glycolysis inhibition and Zn2+-activating GLUT1 tumor specific depletion. This therapeutic platform enables ion interference-inductive starvation strategy for effective tumor therapy, showing remarkable tumor growth suppression without systemic toxicity in vivo.

ADVANCED SCIENCE (2022)

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Article Chemistry, Multidisciplinary

A Valve-Closing Starvation Strategy for Amplification of Tumor-Specific Chemotherapy

Xianglong Li et al.

Summary: By closing the valve of glucose transported into tumor cells, the novel valve-closing starvation strategy effectively reduces glucose levels in tumor cells, induces tumor cell starvation, and enhances the cytotoxicity of chemotherapy.

ADVANCED SCIENCE (2022)

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Article Chemistry, Multidisciplinary

Targeting Cancer Metabolism Plasticity with JX06 Nanoparticles via Inhibiting PDK1 Combined with Metformin for Endometrial Cancer Patients with Diabetes

Xiao Yang et al.

Summary: This study found that diabetes is closely related to endometrial cancer and there is currently no effective treatment for patients with both conditions. Through experiments, a new drug (JX06-NPs) that disrupts cancer metabolism was discovered to significantly inhibit the growth of endometrial cancer cells, with better results when combined with metformin. This study provides a new adjuvant therapy for patients with diabetes and endometrial cancer.

ADVANCED SCIENCE (2022)

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Article Pharmacology & Pharmacy

Co-delivery of photosensitizer and diclofenac through sequentially responsive bilirubin nanocarriers for combating hypoxic tumors

Yang Zhou et al.

Summary: By utilizing a modified nanocarrier, this study proposes a sequentially responsive platform to enhance photodynamic therapy and overcome hypoxia resistance, leading to improved anti-tumor outcomes.

ACTA PHARMACEUTICA SINICA B (2022)

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Article Nanoscience & Nanotechnology

Dual Closed-Loop of Catalyzed Lactate Depletion and Immune Response to Potentiate Photothermal Immunotherapy

Xiao Zheng et al.

Summary: In this study, a dual closed-loop strategy was developed using a rational material design to enhance the efficacy of cancer immunotherapy by catalyzing lactate depletion and immune response. This strategy effectively inhibited tumor growth, providing a promising treatment modality for cancer immunotherapy.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Article Chemistry, Multidisciplinary

A Metabolic Multistage Glutathione Depletion Used for Tumor-Specific Chemodynamic Therapy

Ying Huang et al.

Summary: In this study, a multistage chemodynamic therapy (CDT) specific to tumor cells is proposed, which can efficiently deplete the high glutathione (GSH) content in tumor cells. By consuming reserved GSH and inhibiting GSH synthesis in cancer cells, the CDT achieves potent GSH exhaustion. The glycolysis inhibitor used in this study not only increases the sensitivity of tumor cells to CDT, but also stimulates a protective mode in normal cells. This tumor-specific CDT utilizes the responsiveness of the glycolysis inhibitor and nanocarrier to the tumor microenvironment.

ACS NANO (2022)

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Article Engineering, Biomedical

Tumor metabolism destruction via metformin-based glycolysis inhibition and glucose oxidase-mediated glucose deprivation for enhanced cancer therapy

Xiangyu Meng et al.

Summary: An intelligent nanomedicine based on glucose deprivation and glycolysis inhibition was created for enhanced cancer synergistic treatment. The nanomedicine effectively blocks glycolysis and depletes glucose, leading to cancer cell apoptosis and growth suppression.

ACTA BIOMATERIALIA (2022)

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Article Engineering, Biomedical

Metabolic reprogramming by dual-targeting biomimetic nanoparticles for enhanced tumor chemo-immunotherapy

Shuya Zang et al.

Summary: The study presents a biomimetic nanocarrier for targeted blockade of metabolic support between cancer cells and cancer-associated fibroblasts (CAFs). The nanocarrier effectively increases chemosensitivity of cancer cells, inhibits tumor growth, and reduces lactate production in the tumor microenvironment, leading to enhanced immune response and tumor suppression.

ACTA BIOMATERIALIA (2022)

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Article Chemistry, Multidisciplinary

Targeted Drug/Gene/Photodynamic Therapy via a Stimuli-Responsive Dendritic-Polymer-Based Nanococktail for Treatment of EGFR-TKI-Resistant Non-Small-Cell Lung Cancer

Jinxing Huang et al.

Summary: This study proposes a nanococktail therapeutic strategy for treating EGFR-TKI resistant NSCLC by targeted co-delivery of drugs and genes, along with photodynamic therapy. The results show that this nanococktail therapy effectively releases drugs and genes at the tumor site, demonstrating potent antitumor efficacy.

ADVANCED MATERIALS (2022)

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Article Engineering, Biomedical

OGA activated glycopeptide-based nano-activator to activate PKM2 tetramerization for switching catabolic pathways and sensitizing chemotherapy resistance

Da-Yong Hou et al.

Summary: In this study, a glycopeptide-based PKM2 nanoactivator was developed to activate PKM2 from dimers to tetramers, leading to the inhibition of tumor cell metabolism and proliferation. The nanoactivator formed nanofibrillar structures in vivo and accumulated at the tumor sites, enhancing the sensitivity to chemotherapy drugs.

BIOMATERIALS (2022)

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Article Engineering, Biomedical

A Sub-6 nm MnFe2O4-dichloroacetic acid nanocomposite modulates tumor metabolism and catabolism for reversing tumor immunosuppressive microenvironment and boosting immunotherapy

Zan Dai et al.

Summary: In this study, a sub-6 nm MnFe2O4-DCA nanoparticle was developed to modulate tumor glucose metabolism and ATP catabolism, improving the tumor immunosuppressive microenvironment and enhancing cancer immunotherapy efficacy.

BIOMATERIALS (2022)

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Article Engineering, Environmental

Zinc-enriched nanosystem for dual glycolysis regulation and photothermal therapy to synergistically inhibit primary melanoma and lung metastasis

Zhaoxu Meng et al.

Summary: In this study, a zinc-enriched nanosystem was developed for the treatment of melanoma. The nanosystem demonstrated high photothermal conversion efficacy and was able to regulate glycolysis and provide photothermal therapy. Upon laser irradiation, the nanosystem generated heat energy and released glycolysis regulators, resulting in the inhibition of lactate dehydrogenase and hexokinase II and down-regulation of glycolysis. Additionally, the nanosystem showed potent antitumor efficacy by down-regulating the expression of Akt, p-Akt, HIF-1 alpha, inducing cell cycle arrest, and inhibiting distant metastasis. Overall, this study provides a novel perspective for tumor metabolism and phototherapy to achieve complete tumor regression.

CHEMICAL ENGINEERING JOURNAL (2022)

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Review Chemistry, Inorganic & Nuclear

Biodegradable two-dimensional nanomaterials for cancer theranostics

Nengyi Ni et al.

Summary: Two-dimensional nanomaterials have great potential in cancer applications, but their potential long-term toxicity is a major obstacle. Biodegradable 2D nanomaterials with good in vivo metabolism and biological safety are an upcoming key breakthrough in cancer nanotheranostics research.

COORDINATION CHEMISTRY REVIEWS (2022)

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Article Chemistry, Physical

Dual inhibition of glycolysis and oxidative phosphorylation by aptamer-based artificial enzyme for synergistic cancer therapy

Xiao Fang et al.

Summary: In this study, an aptamer-based artificial enzyme was developed to simultaneously inhibit glycolysis and oxidative phosphorylation (OXPHOS) in cancer cells. The artificial enzyme, called AptCCN, can capture intracellular arginine and catalyze its oxidation to nitric oxide (NO) under red light irradiation. In vitro and in vivo experiments demonstrated that this strategy effectively blocked energy supply and induced apoptosis in cancer cells.

NANO RESEARCH (2022)

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Article Chemistry, Multidisciplinary

Anti-alcoholism drug disulfiram for targeting glioma energy metabolism using BBB-penetrating delivery of fixed-dose combination

Pengfei Zhao et al.

Summary: The interplay between tumor metabolism and the immune microenvironment plays a crucial role in glioma progression. In this study, the researchers discovered that the drugs disulfiram (DSF) and shikonin (SHK) can inhibit the ATP supply pathway and glycolysis in glioma cells, leading to a reduction in ATP generation. By developing a nanoparticle system, they were able to efficiently deliver a fixed-dose combination of DSF and SHK to the glioma cells, resulting in prolonged survival in glioma mice by modulating energy metabolism and the immune microenvironment.

NANO TODAY (2022)

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Article Multidisciplinary Sciences

A hydrogen sulphide-responsive and depleting nanoplatform for cancer photodynamic therapy

Yuqi Zhang et al.

Summary: The authors report the design of a H2S-responsive and -depleting nanoplatform that can be used for H2S imaging and cancer therapy, which shows great potential in studying the vital impacts of H2S in related diseases.

NATURE COMMUNICATIONS (2022)

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Article Multidisciplinary Sciences

In vivo three-dimensional multispectral photoacoustic imaging of dual enzyme-driven cyclic cascade reaction for tumor catalytic therapy

Shan Lei et al.

Summary: The study demonstrates the use of three-dimensional multispectral photoacoustic molecular imaging to monitor cascade catalytic therapy in vivo, and shows its potential application in tumor treatment.

NATURE COMMUNICATIONS (2022)

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Article Multidisciplinary Sciences

Combining PEGylated mito-atovaquone with MCT and Krebs cycle redox inhibitors as a potential strategy to abrogate tumor cell proliferation

Gang Cheng et al.

Summary: Glycolytic and mitochondrial oxidative metabolism are two major energy sources in tumors. Developing highly potent, nontoxic, and tumor-selective oxidative phosphorylation inhibitors may help advance therapeutic targeting of mitochondrial drugs in cancer. The newly developed PEGylated mitochondria-targeted ATO (Mito-(PEG)n-ATO) shows significant antiproliferative effects and synergistic effects when combined with other inhibitors in tumor cells.

SCIENTIFIC REPORTS (2022)

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Article Biotechnology & Applied Microbiology

Regulating Acidosis and Relieving Hypoxia by Platelet Membrane-Coated Nanoparticle for Enhancing Tumor Chemotherapy

Xingyu Luo et al.

Summary: This study developed a new strategy for tumor chemotherapy by regulating acidosis and relieving hypoxia using Hb-LOX-DOX-ZIF8@platelet membrane nanoparticles. These nanoparticles exhibited active tumor-targeting ability and good biocompatibility, and the lactate oxidase could efficiently deplete intratumoral lactate and amplify oxidative stress.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2022)

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Article Nanoscience & Nanotechnology

Designing Lactate Dehydrogenase-Mimicking SnSe Nanosheets To Reprogram Tumor-Associated Macrophages for Potentiation of Photothermal Immunotherapy

Jiabao Ling et al.

Summary: This study proposes a feasible therapeutic strategy for depleting lactate and reconstructing an immunosuppressive tumor microenvironment using Se-containing nanosheets, which can restore the potent tumor-killing activity of macrophages, thereby amplifying the effects of TAM-based antitumor immunotherapy.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Article Nanoscience & Nanotechnology

Nanodrugs Incorporating LDHA siRNA Inhibit M2-like Polarization of TAMs and Amplify Autophagy to Assist Oxaliplatin Chemotherapy against Colorectal Cancer

Lijun Hu et al.

Summary: A polymer nanocomplex was prepared to deliver siRNA to silence the LDHA gene and inhibit lactic acid secretion and M2-like polarization of TAMs, while enhancing OXA-induced autophagy and inducing autophagic death. The combination treatment of OXA and nanocomplex showed a significantly increased chemotherapeutic effect on CC.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Article Chemistry, Multidisciplinary

Efficient Immunotherapy of Drug-Free Layered Double Hydroxide Nanoparticles via Neutralizing Excess Acid and Blocking Tumor Cell Autophagy

Lingxiao Zhang et al.

Summary: This study demonstrates that weakly alkaline layered double hydroxide nanoparticles (LDH NPs) can remodel the suppressive tumor immune microenvironment (TIME) and enhance antitumor immune responses, showing promising potential for solid tumor immunotherapy.

ACS NANO (2022)

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Article Chemistry, Multidisciplinary

A Nanounit Strategy Disrupts Energy Metabolism and Alleviates Immunosuppression for Cancer Therapy

Yang Luo et al.

Summary: Aberrant energy metabolism in tumors not only promotes cell proliferation but also inhibits antitumor immunity. A novel metabolic nanoregulator was developed to cut off energy supply and improve immune suppression, enabling synergistic tumor starvation-immunotherapy.

NANO LETTERS (2022)

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Article Chemistry, Multidisciplinary

Lactate-driving Pt nanoflower with positive chemotaxis for deep intratumoral penetration

Zhentao Zhang et al.

Summary: This study developed a lactate oxidase (LOX)-powered Pt Nanoflowers (Pt NFs) that can penetrate deep into the tumor in response to lactate-driven positive chemotaxis. The LOX-powered Pt NFs have self-oxygenation properties and can alleviate hypoxia through cascading catalysis. Furthermore, the X-ray radiation deposited in Pt NFs improves the effectiveness of low-dose radiotherapy.

NANO TODAY (2022)

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Article Multidisciplinary Sciences

Engineered biomimetic nanoparticles achieve targeted delivery and efficient metabolism-based synergistic therapy against glioblastoma

Guihong Lu et al.

Summary: The use of cancer cell-membrane encapsulated nanoparticles for targeted therapy in lactate-high cancer cells shows promising results in reducing tumorigenesis in glioblastoma.

NATURE COMMUNICATIONS (2022)

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Review Immunology

Tumor Microenvironment: Lactic Acid Promotes Tumor Development

Yuting Gao et al.

Summary: Lactic acid plays an important role in tumor development and its accumulation is detrimental to health. It acts as an immunomodulatory chemical and affects immune cell functions. Inhibiting lactate metabolism to enhance anticancer immune responses may alter lactate levels in the tumor microenvironment. Targeting lactate synthesis and sources has emerged as a potential therapeutic option for cancer treatment.

JOURNAL OF IMMUNOLOGY RESEARCH (2022)

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Review Oncology

A novel strategy to fuel cancer immunotherapy: targeting glucose metabolism to remodel the tumor microenvironment

Xu Liu et al.

Summary: The promising results of immunotherapy in tumors have led to a change in the current treatment strategy for cancer. However, the limited effectiveness in a minority of patients is attributed to immune suppression in the tumor microenvironment. Recent evidence has shown that abnormal glucose metabolism plays a crucial role in tumor immune escape and can be targeted in combination with immunotherapy. By understanding the functions of glucose metabolism in tumor cells, immune cells, and the tumor microenvironment, strategies can be developed to improve tumor therapy by targeting glucose metabolism.

FRONTIERS IN ONCOLOGY (2022)

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Article Oncology

Glutor, a Glucose Transporter Inhibitor, Exerts Antineoplastic Action on Tumor Cells of Thymic Origin: Implication of Modulated Metabolism, Survival, Oxidative Stress, Mitochondrial Membrane Potential, pH Homeostasis, and Chemosensitivity

Mithlesh Kumar Temre et al.

Summary: The GLUT inhibitor glutor not only inhibits glucose uptake, but also modulates tumor growth and survival pathways, demonstrating its potential as an effective anticancer agent.

FRONTIERS IN ONCOLOGY (2022)

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Article Oncology

Retro-inversion follicle-stimulating hormone peptide-modified nanoparticles for delivery of PDK2 shRNA against chemoresistant ovarian cancer by switching glycolysis to oxidative phosphorylation

Meng Zhang et al.

Summary: The expression of PDK2 is found to be higher in chemoresistant ovarian cancer tissues and cell lines, and is associated with shorter progression-free survival. Inhibition of PDK2 suppresses proliferation and migration, and promotes apoptosis of both cisplatin-sensitive and cisplatin-resistant ovarian cancer cells. PDK2 knockdown also increases cisplatin sensitivity and switches metabolism from glycolysis to oxidative phosphorylation.

CANCER NANOTECHNOLOGY (2022)

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Article Biochemistry & Molecular Biology

Structural aspects of the glucose and monocarboxylate transporters involved in the Warburg effect

Xin Jiang et al.

Summary: The Warburg effect refers to the phenomenon in which cancer cells shift their glucose metabolism from aerobic respiration to lactic fermentation even in the presence of oxygen. Elevated expression levels of human glucose transporters (GLUTs) and human monocarboxylate transporters (MCTs) are observed to maintain metabolic homeostasis and prevent lactate accumulation. Inhibition of GLUTs and/or MCTs shows potential as therapeutic strategies for cancer treatment. Recent advances in the structural characterization of GLUTs and MCTs provide a comprehensive understanding of their transport and inhibition mechanisms, contributing to the development of anticancer therapies.

IUBMB LIFE (2022)

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Article Chemistry, Multidisciplinary

Biodegradable Ferrous Sulfide-Based Nanocomposites for Tumor Theranostics through Specific Intratumoral Acidosis-Induced Metabolic Symbiosis Disruption

Jingjing Wang et al.

Summary: The study introduces a tumor therapy strategy that disrupts intratumoral metabolic symbiosis by inducing acidosis for tumor elimination, using carbonic anhydrase inhibitor-modified ferrous sulfide nanoparticles. The nanoparticles also have dual-mode imaging capabilities.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)

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Article Materials Science, Multidisciplinary

Robust photothermal self-healing superhydrophobic coating based on carbon nanosphere/carbon nanotube composite

Yiqi Ma et al.

Summary: In this study, a photothermal superhydrophobic surface was fabricated using carbon nanospheres/carbon nanotubes (CNSs/CNTs) composite, and its self-healing effect under solar irradiation was demonstrated. The coating exhibited excellent superhydrophobic properties with a water contact angle of 160.7 degrees and sliding angle of 4.0 degrees, and could convert light energy into heat energy efficiently. The self-healing mechanism of the coating was found to involve the migration of hydrophobic long chains under thermodynamic drive.

MATERIALS & DESIGN (2022)

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Article Chemistry, Multidisciplinary

An acid degradable, lactate oxidizing nanoparticle formulation for non-small cell lung cancer virotherapy

S-Ja Tseng et al.

Summary: Resistance to approved targeted therapies in non-small cell lung cancer (NSCLC) is a challenge, and oncolytic virotherapy has potential but faces systemic administration and viral delivery issues. This study designs an acid-degradable nanoparticle that releases virus using lactate secreted by tumors, offering a potential avenue for NSCLC treatment.

NANO TODAY (2022)

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Review Oncology

Molecular Engines, Therapeutic Targets, and Challenges in Pediatric Brain Tumors: A Special Emphasis on Hydrogen Sulfide and RNA-Based Nano-Delivery

Sherif Ashraf Fahmy et al.

Summary: Pediatric brain tumors are a significant challenge in the field of oncology. The molecular sub-types of pediatric brain tumors and their oncogenic pathways are not fully understood. This review discusses novel therapeutic targets for different sub-types of pediatric brain tumors and highlights the potential role of hydrogen sulfide (H2S) in these tumors. The review also emphasizes the need for better brain-delivery strategies to improve therapeutic results for brain tumor patients.

CANCERS (2022)

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Review Oncology

Targeting Glucose Metabolism Enzymes in Cancer Treatment: Current and Emerging Strategies

Yi Zhang et al.

Summary: Reprogramming glucose metabolism is an important strategy for targeted cancer treatment. Although advanced and effective drugs have been developed, there are still challenges in translating them into clinical applications due to limitations such as short half-life, poor solubility, and multiple side effects. Combining glucose metabolism modulators with conventional anticancer drugs may be a future direction for cancer treatment.

CANCERS (2022)

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Review Pharmacology & Pharmacy

Recent Strategies to Address Hypoxic Tumor Environments in Photodynamic Therapy

Yuyin Du et al.

Summary: Photodynamic therapy (PDT) is a promising cancer treatment method due to its noninvasiveness and low toxicity. However, the effectiveness of PDT is significantly reduced in hypoxic tumor environments. Researchers are exploring strategies such as oxygen transport, oxygen generation, reducing oxygen consumption, and regulating tumor microenvironments to overcome tumor hypoxia and enhance PDT.

PHARMACEUTICS (2022)

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Review Cell Biology

Lactate drives cellular DNA repair capacity: Role of lactate and related short-chain fatty acids in cervical cancer chemoresistance and viral infection

Wojciech M. Ciszewski et al.

Summary: The presence of high levels of L-lactate in the cancer microenvironment has a characteristic feature, which can affect cancer cells through its receptoric and epigenetic modes of action and may be associated with drug resistance. Increased DNA repair capacity and enhanced drug efflux are important mechanisms for ineffective radiotherapy and drug-based therapies.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

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Article Medicine, Research & Experimental

PKM2 Is Overexpressed in Glioma Tissues, and Its Inhibition Highly Increases Late Apoptosis in U87MG Cells With Low-density Specificity

Jae Hyeon Park et al.

Summary: This study found that PKM2 is overexpressed in gliomas and may be an important trigger factor for glioma tumorigenesis. Inhibition of PKM2 has a significant inhibitory effect on glioma cells, and co-treatment with two PKM2 inhibitors may enhance the inhibitory effects.

IN VIVO (2022)

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Article Materials Science, Biomaterials

A deep tumor penetration nanoplatform for glycolysis inhibition and antimetastasis of breast cancer

Jie Zhou et al.

Summary: This study reports a new approach to increase tumor penetration using nanomedicines. By releasing specific substances, it reduces lactic acid accumulation in tumors and prevents tumor metastasis by decreasing extracellular matrix production. The results demonstrate that indirectly reducing extracellular matrix production enhances tumor penetration and inhibits deep tumor glycolysis.

JOURNAL OF MATERIALS CHEMISTRY B (2022)

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Article Pharmacology & Pharmacy

H2S-Responsive Small-Molecule Nanocarriers for Drug Delivery to Colorectal Tumors

Kaiqi Long et al.

Summary: This study develops a H2S-responsive nanocarrier based on self-assembly, which can be used for controlled drug release in cancer therapy. The results show that the nanocarrier exhibits efficient H2S-responsive drug release in colon cancer cells and effectively inhibits tumor growth in animal models.

ADVANCED THERAPEUTICS (2022)

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Review Nanoscience & Nanotechnology

Bionanoparticles in cancer imaging, diagnosis, and treatment

Yan Li et al.

Summary: Biological nanoparticles have unique properties for applications in cancer imaging, diagnosis, and treatment, potentially outperforming synthetic inorganic nanoparticles. By genetically or chemically modifying or redesigning these nanoparticles, they can gain new functions like tumor-seeking or tumor-destructive capabilities, enhancing their usefulness in cancer theranostics.

VIEW (2022)

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Review Nanoscience & Nanotechnology

Novel gas-based nanomedicines for cancer therapy

Xianxian Yao et al.

Summary: Gas therapy is an emerging cancer treatment method that utilizes nanotechnology for precise and targeted treatment. Combining gas therapy with other treatment methods can enhance the efficacy of cancer therapy. Understanding the mechanism of how gas enhances other therapies is crucial for designing effective cancer treatment strategies.

VIEW (2022)

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Review Nanoscience & Nanotechnology

Emerging biocompatible nanoplatforms for the potential application in diagnosis and therapy of deep tumors

Wenna Guo et al.

Summary: The development of nanotechnology has brought new hope in the diagnosis and treatment of cancer through nanoplatforms. This review summarizes the latest research progress on the diagnosis and therapy of deep tumors based on biocompatible nanoplatforms, discussing the application prospects and challenges in this field.

VIEW (2022)

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Review Multidisciplinary Sciences

Advances in nanomaterials for treatment of hypoxic tumor

Mei-Zhen Zou et al.

Summary: The hypoxic tumor microenvironment poses challenges for tumor therapy, leading researchers to focus on developing functional nanomaterials to treat hypoxic tumors. These nanomaterials are categorized into those that elevate oxygen levels in tumors and those with diminished oxygen dependence for hypoxic tumor therapy, with discussions on their biocompatibility and therapeutic efficacy.

NATIONAL SCIENCE REVIEW (2021)

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Review Chemistry, Multidisciplinary

Lactate detection sensors for food, clinical and biological applications: a review

Gurdeep Rattu et al.

Summary: L-lactate plays a major role in various industries and medical fields, prompting the development of high-throughput nanobiosensors for real-time detection. These sensors are essential for overcoming current challenges and improving efficiency in different sectors.

ENVIRONMENTAL CHEMISTRY LETTERS (2021)

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Article Nanoscience & Nanotechnology

Silencing of Pyruvate Kinase M2 via a Metal-Organic Framework Based Theranostic Gene Nanomedicine for Triple-Negative Breast Cancer Therapy

Siming Huang et al.

Summary: TNBC is typically associated with poor prognosis due to its only partial response to chemotherapy and lack of clinically established targeted therapies coupled with an aggressive disease course. In this study, a novel nanomedicine was developed to target PKM2 enzyme in TNBC cells, inhibiting tumor glycolysis and achieving anticancer effects.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Nanoscience & Nanotechnology

pH-Regulating Nanoplatform for the Double Channel Chase of Tumor Cells by the Synergistic Cascade between Chlorine Treatment and Methionine-Depletion Starvation Therapy

Yuping Jiang et al.

Summary: The study developed ClO2-loaded nanoparticles for cascade chlorine treatment and methionine-depletion starvation therapy targeting mitochondria and regulating intracellular pH, which effectively inhibited tumor growth and induced cell apoptosis.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Chemistry, Multidisciplinary

A Self-Driven Bioreactor Based on Bacterium-Metal-Organic Framework Biohybrids for Boosting Chemotherapy via Lactate Catabolism

Jia-Wei Wang et al.

Summary: In this study, a self-driven bioreactor called SO@MDH was constructed to sensitize chemotherapy through active targeting, lactate degradation, rapid drug release, and inhibition of multidrug resistance. The research demonstrated high tumor specificity and promising therapeutic prospects, indicating the potential of SO@MDH in cancer therapy.

ACS NANO (2021)

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Article Chemistry, Multidisciplinary

Metal-Phenolic Network-Enabled Lactic Acid Consumption Reverses Immunosuppressive Tumor Microenvironment for Sonodynamic Therapy

Zhan Zhang et al.

Summary: The constructed nanocomplex can remodel the immunosuppressive tumor microenvironment and achieve effective inhibition of tumors through sonodynamic therapy, while alleviating tumor hypoxia and acidic environment.

ACS NANO (2021)

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Review Pharmacology & Pharmacy

Recent developments of human monocarboxylate transporter (hMCT) inhibitors as anticancer agents

Puhua Wu et al.

Summary: MCTs play a crucial role in lactate/proton efflux and may serve as a new target for anticancer therapies. While X-ray co-crystal structures of human MCTs with inhibitors are unavailable, homology models have aided in the design of new MCT inhibitors. Future directions include studying the structures and functions of MCT inhibitors and discovering more small-molecule inhibitors.

DRUG DISCOVERY TODAY (2021)

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Review Chemistry, Multidisciplinary

Recent Strategies to Develop Innovative Photosensitizers for Enhanced Photodynamic Therapy

Thanh Chung Pham et al.

Summary: This review presents a robust strategy for designing photosensitizers for different species, highlighting the importance of organic PSs in photodynamic therapy. While previous studies have focused on nanomaterials and traditional PSs, this review sets out to report recent innovative strategies for developing organic photosensitizers for enhanced PDT, providing detailed examples to offer intuitive and specific insights to readers.

CHEMICAL REVIEWS (2021)

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Article Chemistry, Medicinal

Novel strategies to improve tumour therapy by targeting the proteins MCT1, MCT4 and LAT1

Yang Wang et al.

Summary: This article summarizes the recent progress in therapeutic strategies targeting MCT1, MCT4, and LAT1 in tumors, including protein structures, relationships with cancer, drug targeting, and delivery strategies. The dual targeted strategy is proposed to enhance the effect on tumor proliferation.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)

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Article Chemistry, Multidisciplinary

Uncovering the Metabolic Origin of Aspartate for Tumor Growth Using an Integrated Molecular Deactivator

Ruixue Duan et al.

Summary: The study designed a molecular deactivator based on upconversion nanoprobes to investigate the link between glucose and aspartate, revealing that cellular synthesis of aspartate for tumor growth is dependent on glucose. The research demonstrates the potential of molecularly engineered upconversion nanoprobes in discovering hidden metabolic pathways and enhancing the effectiveness of conventional antitumor drugs.

NANO LETTERS (2021)

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Review Chemistry, Multidisciplinary

Reactive Oxygen Species-Regulating Strategies Based on Nanomaterials for Disease Treatment

Chenyang Zhang et al.

Summary: ROS play a vital role in physiological and pathological processes, and research on regulating ROS for disease treatments has gained wide attention. Advances in nanotechnology have led to the development of numerous nanomaterials with the ability to regulate ROS, aiming to find new and effective ROS-related nanotherapeutic modalities. Despite significant progress in ROS-based nanomedicines, there is a need to address fundamental principles for designing ROS-associated nanomedicines to minimize gaps in biomedical applications. This review summarizes current progress in ROS-associated nanomedicines in disease treatments and presents key principles for their design. Future perspectives in the development of ROS-associated nanomedicines are also discussed.

ADVANCED SCIENCE (2021)

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Article Chemistry, Multidisciplinary

Regulating Glucose Metabolism with Prodrug Nanoparticles for Promoting Photoimmunotherapy of Pancreatic Cancer

Fang Sun et al.

Summary: The study presents a novel strategy to enhance photoimmunotherapy of pancreatic cancer by provoking T cells activation and overcoming adaptive immune resistance.

ADVANCED SCIENCE (2021)

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Article Chemistry, Multidisciplinary

An Acidity-Unlocked Magnetic Nanoplatform Enables Self-Boosting ROS Generation through Upregulation of Lactate for Imaging-Guided Highly Specific Chemodynamic Therapy

Linan Shi et al.

Summary: A novel nanoplatform was developed in this study, which can achieve high-efficient tumor-specific catalytic anticancer treatment in acidic tumor microenvironments through a cyclic amplification strategy, leading to enhanced Fenton-like reaction. Ultimately, this smart nanoplatform enables self-boosting generation of reactive oxygen species (ROS), inducing strong intracellular oxidative stress, and resulting in substantial anticancer outcomes in vivo.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

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Article Engineering, Biomedical

Polymer-conjugated glucosamine complexed with boric acid shows tumor-selective accumulation and simultaneous inhibition of glycolysis

Waliul Islam et al.

Summary: The study synthesized a water-soluble synthetic-polymer, SMA conjugated glucosamine complex that formed a stable compound with boric acid, showing significant anti-cancer activity against tumor cells.

BIOMATERIALS (2021)

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Article Electrochemistry

Design of an enzyme-mimicking NiO@Au nanocomposite for the sensitive electrochemical detection of lactic acid in human serum and urine

Govindhan Maduraiveeran et al.

Summary: The study introduces a novel enzyme-free gold modified flower-structured nickel oxide nanocomposite synthesized through an electrochemical strategy. This material exhibits highly porous structured NiO flowers providing extensive surface area to mimic enzymatic activity and enhanced electron transfer process at the electrode surface for sensitive detection of lactic acid.

ELECTROCHIMICA ACTA (2021)

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Review Pathology

The role of glycometabolic plasticity in cancer

Yuyang Peng et al.

Summary: Glycometabolic plasticity, characterized by the ability of cancer cells to modulate glycometabolism in response to different stimuli, plays a key role in cancer progression, metastasis, and treatment resistance. Understanding the molecular mechanisms of glycometabolic plasticity in cancer is crucial for cancer research and treatment.

PATHOLOGY RESEARCH AND PRACTICE (2021)

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Article Chemistry, Multidisciplinary

Engineering a Hydrogen-Sulfide-Based Nanomodulator to Normalize Hyperactive Photothermal Immunogenicity for Combination Cancer Therapy

Jie Li et al.

Summary: The gas-modulated photothermal immunogenicity strategy, which integrates a polysulfide-based hydrogen sulfide donor with a conjugated polymer, shows great potential in inhibiting tumor growth and limiting inflammation.

ADVANCED MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Zwitterion-Based Hydrogen Sulfide Nanomotors Induce Multiple Acidosis in Tumor Cells by Destroying Tumor Metabolic Symbiosis

Mimi Wan et al.

Summary: The destruction of tumor metabolism symbiosis is an attractive cancer treatment method that targets tumor cells with little harm to normal cells. The proposed zero-waste zwitterion-based hydrogen sulfide (H2S)-driven nanomotor shows promising potential in inducing acidosis of tumor cells and inhibiting tumor growth through a synergistic effect in the tumor microenvironment. This nanomotor may offer a competitive candidate for active drug delivery systems in cancer treatment due to its good biosafety and limited variety of available nanomotors for tumor microenvironment movement.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

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Article Engineering, Biomedical

Enhanced response to PD-L1 silencing by modulation of TME via balancing glucose metabolism and robust co-delivery of siRNA/Resveratrol with dual-responsive polyplexes

Li Jia et al.

Summary: Balancing glucose metabolic pathways of glycolysis and mitochondrial OXPHOS can modulate the immunosuppressive tumor microenvironment and promote immune cell infiltration and anti-tumor effects. Downregulating glycolysis while upregulating mitochondrial OXPHOS in tumor cells leads to reduced lactate production, enhanced immune cell activity, and superior anti-tumor effects in combination with PD-L1 silencing.

BIOMATERIALS (2021)

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Article Biotechnology & Applied Microbiology

Nanofactory for metabolic and chemodynamic therapy: pro-tumor lactate trapping and anti-tumor ROS transition

Ruiqing He et al.

Summary: The study introduces a lactate treatment plant that converts pro-tumor lactate into anti-tumor ROS, showing potential for synergistic tumor therapy.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Review Biotechnology & Applied Microbiology

Fenton/Fenton-like metal-based nanomaterials combine with oxidase for synergistic tumor therapy

Wei Cao et al.

Summary: The metal-oxidase cascade catalytic system combines the advantages of chemodynamic therapy and starvation therapy, while also activating the immune response, showing a significant anti-tumor effect.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Article Chemistry, Multidisciplinary

Dual-Depletion of Intratumoral Lactate and ATP with Radicals Generation for Cascade Metabolic-Chemodynamic Therapy

Feng Tian et al.

Summary: A multifunctional nanoagent designed for cascade metabolic-chemodynamic therapy efficiently depletes lactate and ATP in the tumor microenvironment, generating hydroxyl radicals for therapy. The nanoagent efficiently accumulates in tumors, showing evidence of anti-angiogenesis and anti-metastasis effects.

ADVANCED SCIENCE (2021)

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Article Chemistry, Multidisciplinary

Tumor-Targeted Disruption of Lactate Transport with Reactivity-Reversible Nanocatalysts to Amplify Oxidative Damage

Xuan Wang et al.

Summary: Nanocatalytic tumor therapy utilizes Prussian blue-based nanomaterials and the hyperglycolysis characteristics of tumors to create vulnerabilities for in situ nanocatalytic therapies. This strategy can inhibit tumor growth and reduce cancer stemness and lung metastasis.

SMALL (2021)

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Article Engineering, Biomedical

An Ultra-Stable, Oxygen-Supply Nanoprobe Emitting in Near-Infrared-II Window to Guide and Enhance Radiotherapy by Promoting Anti-Tumor Immunity

Meng Wang et al.

Summary: A new type of nanozyme has been developed for tumor-targeted radiotherapy, which is constructed as in vivo nanoprobes guided by NIR-II imaging. These nanoprobes exhibit high stability in vivo and continuous oxygen generation to relieve tumor hypoxia, enhancing the efficacy of radiotherapy.

ADVANCED HEALTHCARE MATERIALS (2021)

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Article Pharmacology & Pharmacy

Self-propelled nanomotor reconstructs tumor microenvironment through synergistic hypoxia alleviation and glycolysis inhibition for promoted anti-metastasis

Wenqi Yu et al.

Summary: The study introduces a novel cascade enzyme-powered nanomotor that provides sufficient oxygen and inhibits aerobic glycolysis in deep tumors, effectively alleviating hypoxia and inhibiting tumor metastasis. The nanomotor autonomously moves towards deep tumors, facilitating efficient gene knockdown to inhibit tumor metabolism and metastasis.

ACTA PHARMACEUTICA SINICA B (2021)

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Article Chemistry, Multidisciplinary

Smart Tumor-Cell-Derived Microparticles Provide On-Demand Photosensitizer Synthesis and Hypoxia Relief for Photodynamic Therapy

Liping Zuo et al.

Summary: The study encapsulated HAL and 3BP in microparticles collected from X-ray-irradiated tumor cells, allowing for specific targeting and recognition of tumor cells. This led to efficient accumulation of PpIX and increased oxygen supply, resulting in improved PDT outcomes by disrupting mitochondria with sufficient ROS.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

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Article Engineering, Biomedical

NIR-II fluorescence imaging guided tumor-specific NIR-II photothermal therapy enhanced by starvation mediated thermal sensitization strategy

Yeneng Dai et al.

Summary: The study proposed a tumor-specific enhanced NIR-II PTT strategy through starvation-mediated thermal sensitization, using a semiconducting polymer and glycolysis inhibitor 2DG encapsulated into folate modified liposomes. By targeting and triggering NIR-II photothermal effect, spatial-temporal release of 2DG was achieved and enhanced the tumor thermal sensitivity towards PTT.

BIOMATERIALS (2021)

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Article Engineering, Environmental

Multimode CaCO3/pneumolysin antigen delivery systems for inducing efficient cellular immunity for anti-tumor immunotherapy

Jie Lu et al.

Summary: This study successfully induced cellular immunity for tumor vaccines by combining the multi-functional vaccine adjuvant pneumolysin (PLY) and carrier calcium carbonate (CaCO3) nanoparticles to construct multimode antigen delivery systems CaCO3/PLY. The minimalist tumor vaccine OVA/CaCO3/PLY exhibited significant anti-tumor efficacy in both preventive and therapeutic aspects, highlighting the promising platform offered by the multimode antigen delivery system CaCO3/PLY.

CHEMICAL ENGINEERING JOURNAL (2021)

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Article Chemistry, Multidisciplinary

Redox-responsive nanoassembly restrained myeloid-derived suppressor cells recruitment through autophagy-involved lactate dehydrogenase A silencing for enhanced cancer immunochemotherapy

Chunyu Xia et al.

Summary: Myeloid-derived suppressor cells (MDSCs) play a crucial role in supporting tumor survival and suppressing anti-tumor immunity by being recruited through tumor-derived cytokines. A redox-responsive nanoassembly strategy is developed to inhibit MDSC recruitment and enhance tumor immunogenicity, leading to powerful anti-tumor effects.

JOURNAL OF CONTROLLED RELEASE (2021)

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Article Chemistry, Multidisciplinary

GSH-Responsive Nanoprodrug to Inhibit Glycolysis and Alleviate Immunosuppression for Cancer Therapy

Xiaohan Liu et al.

Summary: The study synthesized a nanoprodrug that can inhibit glycolysis of cancer cells and alleviate the immunosuppressive microenvironment by releasing two drugs, which increased intracellular oxidative stress and induced immunogenic cell death of cancer cells. This strategy opens up new possibilities for exploring dimeric prodrugs for synergistic cancer therapy.

NANO LETTERS (2021)

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Article Chemistry, Multidisciplinary

Sugar-originated carbon nanodots selectively damage the tumor and enhance the sensitivity of chemotherapy

Yi Wang et al.

Summary: This study developed sugar-originated carbon nanodots that can block tumor energy metabolism, inhibit tumor growth, enhance sensitivity to chemotherapy, with favorable biosafety and edibility. The advanced therapeutic carbon nanodots pave the way for future clinical applications.

NANO TODAY (2021)

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Article Chemistry, Multidisciplinary

The Sustainability of Energy Conversion Inhibition for Tumor Ferroptosis Therapy and Chemotherapy

Wei Jiang et al.

Summary: Intelligent nanoparticles can effectively restrict tumor cells energy metabolism and growth, providing a promising approach to conquer malignant tumors. The components of nanoparticles can function in the tumor tissue microenvironment, inhibiting tumor cell proliferation through multiple pathways.

SMALL (2021)

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Article Chemistry, Multidisciplinary

Activatable Biomineralized Nanoplatform Remodels the Intracellular Environment of Multidrug-Resistant Tumors for Enhanced Ferroptosis/Apoptosis Therapy

Xuan Wang et al.

Summary: An ACP-based nanoplatform is developed for targeted combinational ferroptosis/apoptosis therapy against drug resistant tumor cells by blocking MCT4-mediated efflux of lactic acid. The nanoplatform can remodel the tumor intracellular environment, enhancing the efficacy of combinational ferroptosis/chemotherapy and prolonging the survival of tumor-bearing mice. This study provides new avenues for the treatment of multidrug-resistant tumors.

SMALL (2021)

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Article Multidisciplinary Sciences

Peroxisome inspired hybrid enzyme nanogels for chemodynamic and photodynamic therapy

Xing Qin et al.

Summary: This study demonstrates a peroxisome-inspired approach for tumor therapy by incorporating lactate oxidase and catalase into nanoparticles. This method effectively inhibits tumor growth by regulating intracellular ROS levels.

NATURE COMMUNICATIONS (2021)

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Article Engineering, Biomedical

Lactate Consumption via Cascaded Enzymes Combined VEGF siRNA for Synergistic Anti-Proliferation and Anti-Angiogenesis Therapy of Tumors

Yan Tang et al.

Summary: This study introduces a novel codelivery strategy that combines cascaded enzymes and gene therapy to suppress tumor proliferation and angiogenesis effectively, demonstrating promising antitumor and antimetastatic properties in vitro and in vivo.

ADVANCED HEALTHCARE MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Advanced Cancer Starvation Therapy by Simultaneous Deprivation of Lactate and Glucose Using a MOF Nanoplatform

Jiantao Yu et al.

Summary: Recent research has shown that lactate is a major energy source for cells, prompting the development of a new strategy for cancer starvation therapy involving dual deprivation of lactate and glucose. Nanoplatforms are used to co-deliver CHC and GOx in order to achieve this, resulting in enhanced anti-tumor effects both in vitro and in vivo.

ADVANCED SCIENCE (2021)

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Review Nanoscience & Nanotechnology

Mesoporous organosilica nanoparticles: Degradation strategies and application in tumor therapy

Lei Guan et al.

Summary: Biodegradation is a crucial issue for silica-based mesoporous nanoparticles in tumor therapy. A hybridization strategy has been developed to improve the biodegradability by synthesizing mesoporous organosilica nanoparticles (MONs). MONs show great potential as multifunctional therapeutic nanoplatforms in tumor therapy.

VIEW (2021)

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Review Nanoscience & Nanotechnology

Extracellular vesicle-coated nanoparticles

Parinaz Fathi et al.

Summary: Synthetic nanoparticles have been used for theranostic applications in targeting imaging and therapy of diseased tissues. Coating nanoparticles with membrane-derived extracellular vesicles (EVs) offers a promising approach for expanding nanoparticle targeting and enhancing immune evasion properties for increased circulation time. Applications of EV coating on nanoparticles are mainly focused on cancer treatment.

VIEW (2021)

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Review Nanoscience & Nanotechnology

Smart materials for drug delivery and cancer therapy

Yao Yang et al.

Summary: Smart materials play a crucial role in drug delivery, with endogenous/exogenous responsive materials possessing properties such as controlled drug release and enhanced diagnostic accuracy. Significant research advancements have been made in the development of smart materials responsive to various triggers.

VIEW (2021)

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Review Nanoscience & Nanotechnology

Teaching new tricks to old dogs: A review of drug repositioning of disulfiram for cancer nanomedicine

Pengfei Zhao et al.

Summary: The increasing incidence and mortality of malignant tumors have led to the development of diversified innovative therapies. Repositioning old drugs that are already on the market or in clinical trials for tumor treatment is a more cost-effective and efficient approach compared to developing new therapeutic molecules. Old approved drugs like aspirin, artemisinin derivatives, metformin, and disulfiram have shown broad tumor-suppressive effects, and utilizing DSF repositioning strategy through nanotechnology can be beneficial for cancer targeting delivery and therapy.

VIEW (2021)

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Review Nanoscience & Nanotechnology

Nanomaterial-mediated platinum drug-based combinatorial cancer therapy

Zhiqin Deng et al.

Summary: Platinum-based drugs play a crucial role in cancer chemotherapy but are limited by side effects and drug resistance. The application of nanotechnology offers opportunities to overcome these limitations, with nanoparticles co-loading platinum drugs and other anticancer agents enhancing synergistic efficacy and pharmacokinetic properties, favoring cancer treatment.

VIEW (2021)

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Review Nanoscience & Nanotechnology

Hybrid nano- and microgels doped with photoacoustic contrast agents for cancer theranostics

Yu Xiao et al.

Summary: Photoacoustic imaging (PAI) is an emerging noninvasive bioimaging modality for cancer theranostics, where hybrid nano- and microgels serve as protective carriers for PAI contrast agents due to their biocompatibility and high loading capacity. The development of photoacoustic active nano- and microgels has opened up new opportunities for innovative cancer theranostic agents. The chemical nature of gels, PAI contrast agents, and hybrid matrices, as well as their applications in multimodal cancer theranostics, are discussed.

VIEW (2021)

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Article Chemistry, Multidisciplinary

Nanoengineering of a newly designed chlorin e6 derivative for amplified photodynamic therapy via regulating lactate metabolism

Xiaohan Qin et al.

Summary: A new chlorin e6 derivative TCe6 was designed and coupled with amphiphilic TPGS to enhance its therapeutic efficacy. The TCe6/CHC nanoparticles were constructed to address the insufficient oxygen in PDT, showing excellent performance in tumor growth inhibition. This work provides a versatile strategy for advanced photodynamic nanoplatform design.

NANOSCALE (2021)

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Article Nanoscience & Nanotechnology

Self-Assembled Hybrid Nanogel as a Multifunctional Theranostic Probe for Enzyme-Regulated Ultrasound Imaging and Tumor Therapy

Qing Wu et al.

Summary: Multifunctional theranostic nanoprobes integrated with stimuli-responsive imaging and therapeutic capabilities have the potential to enhance early cancer diagnosis and treatment efficacy.

ACS APPLIED BIO MATERIALS (2021)

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Review Nanoscience & Nanotechnology

Nanomaterials for cascade promoted catalytic cancer therapy

Zongrui Tong et al.

Summary: Catalytic therapy using special substances at tumor sites is a promising approach to achieve tumor-specific treatment or enhance the efficacy of other treatments. Utilizing nanomaterials and cascade strategies can significantly improve the effectiveness of catalytic therapy, presenting important implications for cancer treatment.

VIEW (2021)

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Article Chemistry, Multidisciplinary

Tumor chemical suffocation therapy by dual respiratory inhibitions

Yingying Xu et al.

Summary: The study proposes a novel therapeutic strategy of tumor suffocation by concurrently suppressing glycolysis and mitochondrial oxidative phosphorylation through the co-deliveries of EDTA and rotenone into a glutathione-overexpressed tumor microenvironment. EDTA blocks glycolytic pathway by chelating magnesium ion to inhibit glycolytic enzymes, while rotenone inhibits mitochondrial OXPHOS. This work provides a new approach to treating tumors by inhibiting glucose metabolism, especially by de-functioning glycolytic enzymes.

CHEMICAL SCIENCE (2021)

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Review Biochemistry & Molecular Biology

NAD+ metabolism, stemness, the immune response, and cancer

Lola E. Navas et al.

Summary: NAD(+) plays important roles in redox metabolism, aging, longevity, immune system, and DNA repair. Dysregulation of NAD(+) levels is associated with metabolic diseases and aging-related diseases. NAMPT is the key enzyme recovering NAD from nicotinamide. The roles of NAD(+) and NAMPT in cancer metabolism, immune system, stemness, aging, and cancer are significant.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Review Immunology

Lactate modulation of immune responses in inflammatory versus tumour microenvironments

Michelangelo Certo et al.

Summary: The microenvironments of cancerous tissues and tissues affected by chronic inflammatory diseases exhibit different immune states but similar metabolic states. Understanding the metabolic signature allows for therapeutic intervention to reset metabolite availability and correct dysregulated immune states.

NATURE REVIEWS IMMUNOLOGY (2021)

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Review Endocrinology & Metabolism

Monocarboxylate transporters in cancer

Valery L. Payen et al.

MOLECULAR METABOLISM (2020)

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Review Oncology

The dichotomous role of the glycolytic metabolism pathway in cancer metastasis: Interplay with the complex tumor microenvironment and novel therapeutic strategies

Btissame El Hassouni et al.

SEMINARS IN CANCER BIOLOGY (2020)

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Review Chemistry, Multidisciplinary

Recent Advances in Nanostrategies Capable of Overcoming Biological Barriers for Tumor Management

Da Huo et al.

ADVANCED MATERIALS (2020)

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Article Oncology

Benserazide is a novel inhibitor targeting PKM2 for melanoma treatment

Youyou Zhou et al.

INTERNATIONAL JOURNAL OF CANCER (2020)

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Article Cell Biology

PKM2 suppresses osteogenesis and facilitates adipogenesis by regulating β-catenin signaling and mitochondrial fusion and fission

Jiachao Guo et al.

AGING-US (2020)

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Article Chemistry, Multidisciplinary

Two-Dimensional Tin Selenide (SnSe) Nanosheets Capable of Mimicking Key Dehydrogenases in Cellular Metabolism

Meng Gao et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

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Article Engineering, Biomedical

The novel platinum(IV) prodrug with self-assembly property and structure transformable character against triple-negative breast cancer

Conglian Yang et al.

BIOMATERIALS (2020)

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Review Engineering, Biomedical

Improving cancer therapy through the nanomaterials-assisted alleviation of hypoxia

Abhishek Sahu et al.

BIOMATERIALS (2020)

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Article Multidisciplinary Sciences

Metabolic heterogeneity confers differences in melanoma metastatic potential

Alpaslan Tasdogan et al.

NATURE (2020)

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Article Oncology

Improving cancer immunotherapy using nanomedicines: progress, opportunities and challenges

John D. Martin et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2020)

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Article Neurosciences

Selenium nanoparticles reduce glucose metabolism and promote apoptosis of glioma cells through reactive oxygen species-dependent manner

Binchu Xu et al.

NEUROREPORT (2020)

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Review Oncology

Metabolic Plasticity in Chemotherapy Resistance

Maria Andrea Desbats et al.

FRONTIERS IN ONCOLOGY (2020)

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Article Nanoscience & Nanotechnology

Self-Assembled Multiple-Enzyme Composites for Enhanced Synergistic Cancer Starving-Catalytic Therapy

Huihui Wang et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Nanoscience & Nanotechnology

Smart Biomimetic Nanocomposites Mediate Mitochondrial Outcome through Aerobic Glycolysis Reprogramming: A Promising Treatment for Lymphoma

Qiangqiang Zhao et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Chemistry, Multidisciplinary

Carbon Nitride Hollow Theranostic Nanoregulators Executing Laser-Activatable Water Splitting for Enhanced Ultrasound/Fluorescence Imaging and Cooperative Phototherapy

Xing Zhang et al.

ACS NANO (2020)

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Article Chemistry, Multidisciplinary

Nanoenabled Disruption of Multiple Barriers in Antigen Cross-Presentation of Dendritic Cells via Calcium Interference for Enhanced Chemo-Immunotherapy

Jingyi An et al.

ACS NANO (2020)

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Article Chemistry, Multidisciplinary

Tumor-Specific Chemotherapy by Nanomedicine-Enabled Differential Stress Sensitization

Bowen Yang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

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Review Biochemistry & Molecular Biology

Targeting Strategies for Tissue-Specific Drug Delivery

Zongmin Zhao et al.

CELL (2020)

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Article Chemistry, Multidisciplinary

Augmenting Tumor-Starvation Therapy by Cancer Cell Autophagy Inhibition

Bowen Yang et al.

ADVANCED SCIENCE (2020)

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Article Engineering, Biomedical

Jet-Lagged Nanoparticles Enhanced Immunotherapy Efficiency through Synergistic Reconstruction of Tumor Microenvironment and Normalized Tumor Vasculature

Zhijie Jiang et al.

ADVANCED HEALTHCARE MATERIALS (2020)

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Review Microbiology

The Controversial Role of Human Gut Lachnospiraceae

Mirco Vacca et al.

MICROORGANISMS (2020)

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Article Nanoscience & Nanotechnology

Dual-Modal Therapeutic Role of the Lactate Oxidase-Embedded Hierarchical Porous Zeolitic Imidazolate Framework as a Nanocatalyst for Effective Tumor Suppression

Xi Zhou et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Chemistry, Multidisciplinary

Metabolic Modulation of the Tumor Microenvironment Leads to Multiple Checkpoint Inhibition and Immune Cell Infiltration

David Kolb et al.

ACS NANO (2020)

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Article Chemistry, Multidisciplinary

3-Bromopyruvate-Conjugated Nanoplatform-Induced Pro-Death Autophagy for Enhanced Photodynamic Therapy against Hypoxic Tumor

Yongyan Deng et al.

ACS NANO (2020)

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Article Chemistry, Multidisciplinary

Inhibition of Tumor Progression through the Coupling of Bacterial Respiration with Tumor Metabolism

Qi-Wen Chen et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

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Article Chemistry, Multidisciplinary

Openwork@Dendritic Mesoporous Silica Nanoparticles for Lactate Depletion and Tumor Microenvironment Regulation

Jie Tang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

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Review Biochemistry & Molecular Biology

Hydrogen sulfide and its donors: Novel antitumor and antimetastatic therapies for triple-negative breast cancer

Haonan Li et al.

REDOX BIOLOGY (2020)

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Review Cell Biology

Role of Proton-Coupled Monocarboxylate Transporters in Cancer: From Metabolic Crosstalk to Therapeutic Potential

Xiangyu Sun et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

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Article Chemistry, Multidisciplinary

Engineering of Cascade-Responsive Nanoplatform to Inhibit Lactate Efflux for Enhanced Tumor Chemo-Immunotherapy

Ke Li et al.

ACS NANO (2020)

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Article Chemistry, Physical

Rod-shape inorganic biomimetic mutual-reinforcing MnO2-Au nanozymes for catalysis-enhanced hypoxic tumor therapy

Lifang Yang et al.

NANO RESEARCH (2020)

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Article Biochemistry & Molecular Biology

The tumor microenvironment

Nicole M. Anderson et al.

CURRENT BIOLOGY (2020)

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Article Biochemistry & Molecular Biology

The self-assembled α-lactalbumin-oleic acid complex inhibits ATP supply from both glycolysis and the TCA cycle in HepG2 cells and HepG2-bearing nude mice

Bing Fang et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

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Article Nanoscience & Nanotechnology

Click-Nucleic-Acid-Containing Codelivery System Inducing Collapse of Cellular Homeostasis for Tumor Therapy through Bidirectional Regulation of Autophagy and Glycolysis

Qin Guo et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Review Chemistry, Multidisciplinary

Nanomaterials to relieve tumor hypoxia for enhanced photodynamic therapy

Cheng Zhang et al.

NANO TODAY (2020)

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Review Chemistry, Multidisciplinary

Recent progress of chemodynamic therapy-induced combination cancer therapy

Xianwen Wang et al.

NANO TODAY (2020)

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Article Nanoscience & Nanotechnology

Multifunctional Nanoparticles Boost Cancer Immunotherapy Based on Modulating the Immunosuppressive Tumor Microenvironment

Ji Li et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Multidisciplinary Sciences

Redox-responsive nanoplatform for codelivery of miR-519c and gemcitabine for pancreatic cancer therapy

Xiaofei Xin et al.

SCIENCE ADVANCES (2020)

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Article Biotechnology & Applied Microbiology

Enhanced antitumor effects of follicle-stimulating hormone receptor-mediated hexokinase-2 depletion on ovarian cancer mediated by a shift in glucose metabolism

Meng Zhang et al.

JOURNAL OF NANOBIOTECHNOLOGY (2020)

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Article Materials Science, Biomaterials

A multifunctional oxygen-producing MnO2-based nanoplatform for tumor microenvironment-activated imaging and combination therapy in vitro

Chunlei Yang et al.

JOURNAL OF MATERIALS CHEMISTRY B (2020)

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Review Oncology

Lactate in the Tumor Microenvironment: An Essential Molecule in Cancer Progression and Treatment

Ricardo Perez-Tomas et al.

CANCERS (2020)

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Article Materials Science, Biomaterials

Biodegradable pH-responsive amorphous calcium carbonate nanoparticles as immunoadjuvants for multimodal imaging and enhanced photoimmunotherapy

Meng Wang et al.

JOURNAL OF MATERIALS CHEMISTRY B (2020)

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Review Endocrinology & Metabolism

Lactate: the ugly duckling of energy metabolism

Joshua D. Rabinowitz et al.

NATURE METABOLISM (2020)

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Article Chemistry, Multidisciplinary

A MSN-based tumor-targeted nanoplatform to interfere with lactate metabolism to induce tumor cell acidosis for tumor suppression and anti-metastasis

Zhao-Xia Chen et al.

NANOSCALE (2020)

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Review Chemistry, Multidisciplinary

Photothermal therapy and photoacoustic imaging via nanotheranostics in fighting cancer

Yijing Liu et al.

CHEMICAL SOCIETY REVIEWS (2019)

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Review Biochemistry & Molecular Biology

Lactate: A Metabolic Driver in the Tumour Landscape

Luigi Ippolito et al.

TRENDS IN BIOCHEMICAL SCIENCES (2019)

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Article Oncology

Clinical significance of metabolism-related biomarkers in non-Hodgkin lymphoma-MCT1 as potential target in diffuse large B cell lymphoma

Julieta Afonso et al.

CELLULAR ONCOLOGY (2019)

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Review Oncology

The role and mechanisms of action of microRNAs in cancer drug resistance

Wengong Si et al.

CLINICAL EPIGENETICS (2019)

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Article Chemistry, Multidisciplinary

Biodegradable Nanoparticles of Polyacrylic Acid-Stabilized Amorphous CaCO3 for Tunable pH-Responsive Drug Delivery and Enhanced Tumor Inhibition

Chengyuan Xu et al.

ADVANCED FUNCTIONAL MATERIALS (2019)

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Article Chemistry, Multidisciplinary

Reprogramming Tumor Immune Microenvironment (TIME) and Metabolism via Biomimetic Targeting Codelivery of Shikonin/JQ1

Hairui Wang et al.

NANO LETTERS (2019)

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Article Chemistry, Multidisciplinary

Nanoenabled Modulation of Acidic Tumor Microenvironment Reverses Anergy of Infiltrating T Cells and Potentiates Anti-PD-1 Therapy

Yu-Xue Zhang et al.

NANO LETTERS (2019)

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Article Biotechnology & Applied Microbiology

Bovine serum albumin-templated nanoplatform for magnetic resonance imaging-guided chemodynamic therapy

Wei Tang et al.

JOURNAL OF NANOBIOTECHNOLOGY (2019)

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Review Oncology

The Tumor Metabolic Microenvironment: Lessons from Lactate

Juan C. Garcia-Canaveras et al.

CANCER RESEARCH (2019)

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Article Biochemistry & Molecular Biology

Phase-shifted pentafluorobutane nanoparticles for ultrasound imaging and ultrasound-mediated hypoxia modulation

Wei-Jian Chen et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2019)

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Article Biochemistry & Molecular Biology

Meta-omics analysis of elite athletes identifies a performance-enhancing microbe that functions via lactate metabolism

Jonathan Scheiman et al.

NATURE MEDICINE (2019)

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Article Biophysics

The NIR inspired nano-CuSMn(II) composites for lactate and glycolysis attenuation

Xiu-Lin Fang et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2019)

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Article Chemistry, Multidisciplinary

Catalytically Selective Chemotherapy from Tumor-Metabolic Generated Lactic Acid

Zhimin Tian et al.

SMALL (2019)

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Review Oncology

The Flick of a Switch: Conferring Survival Advantage to Breast Cancer Stem Cells Through Metabolic Plasticity

Hayley R. Walsh et al.

FRONTIERS IN ONCOLOGY (2019)

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Article Chemistry, Multidisciplinary

Intra/Extracellular Lactic Acid Exhaustion for Synergistic Metabolic Therapy and Immunotherapy of Tumors

Fan Gao et al.

ADVANCED MATERIALS (2019)

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Article Chemistry, Multidisciplinary

Self-Supply of O2 and H2O2 by a Nanocatalytic Medicine to Enhance Combined Chemo/Chemodynamic Therapy

Shutao Gao et al.

ADVANCED SCIENCE (2019)

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Article Oncology

Dimethylaminomicheliolide (DMAMCL) Suppresses the Proliferation of Glioblastoma Cells via Targeting Pyruvate Kinase 2 (PKM2) and Rewiring Aerobic Glycolysis

Jianshuang Guo et al.

FRONTIERS IN ONCOLOGY (2019)

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Review Oncology

Lactate in the Regulation of Tumor Microenvironment and Therapeutic Approaches

Karen G. de la Cruz-Lopez et al.

FRONTIERS IN ONCOLOGY (2019)

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Article Oncology

Nanoliposomal formulation encapsulating celecoxib and genistein inhibiting COX-2 pathway and Glut-1 receptors to prevent prostate cancer cell proliferation

Jingyan Tian et al.

CANCER LETTERS (2019)

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Article Biophysics

A new drug carrier with oxygen generation function for modulating tumor hypoxia microenvironment in cancer chemotherapy

Zhe Zhang et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2019)

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Article Engineering, Biomedical

Multivalency-assisted membrane-penetrating siRNA delivery sensitizes photothermal ablation via inhibition of tumor glycolysis metabolism

Juanjuan Dang et al.

BIOMATERIALS (2019)

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Article Nanoscience & Nanotechnology

In situ sprayed bioresponsive immunotherapeutic gel for post-surgical cancer treatment

Qian Chen et al.

NATURE NANOTECHNOLOGY (2019)

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Article Chemistry, Multidisciplinary

Extracellular pH modulating injectable gel for enhancing immune checkpoint inhibitor therapy

Hyung-seung Jin et al.

JOURNAL OF CONTROLLED RELEASE (2019)

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Article Chemistry, Multidisciplinary

Glucose Oxidase-Instructed Multimodal Synergistic Cancer Therapy

Lian-Hua Fu et al.

ADVANCED MATERIALS (2019)

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Article Multidisciplinary Sciences

A Novel Lactate Dehydrogenase Inhibitor, 1-(Phenylseleno)-4-(Trifluoromethyl) Benzene, Suppresses Tumor Growth through Apoptotic Cell Death

Eun-Yeong kim et al.

SCIENTIFIC REPORTS (2019)

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Review Chemistry, Multidisciplinary

Nanozyme: new horizons for responsive biomedical applications

Dawei Jiang et al.

CHEMICAL SOCIETY REVIEWS (2019)

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Review Toxicology

Potential applications and human biosafety of nanomaterials used in nanomedicine

Hong Su et al.

JOURNAL OF APPLIED TOXICOLOGY (2018)

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Article Nanoscience & Nanotechnology

MnO2 Motor: A Prospective Cancer-Starving Therapy Promoter

Yao-Hui Zhang et al.

ACS APPLIED MATERIALS & INTERFACES (2018)

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Article Chemistry, Multidisciplinary

Normalizing Tumor Microenvironment Based on Photosynthetic Abiotic/Biotic Nanoparticles

Diwei Zheng et al.

ACS NANO (2018)

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Article Chemistry, Multidisciplinary

Engineering of a Nanosized Biocatalyst for Combined Tumor Starvation and Low-Temperature Photothermal Therapy

Jun Zhou et al.

ACS NANO (2018)

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Article Chemistry, Multidisciplinary

Engineering Multifunctional RNAi Nanomedicine To Concurrently Target Cancer Hallmarks for Combinatorial Therapy

Yanlan Liu et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2018)

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Article Engineering, Biomedical

Biomimetic O2-Evolving metal-organic framework nanoplatform for highly efficient photodynamic therapy against hypoxic tumor

Shutao Gao et al.

BIOMATERIALS (2018)

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Review Cell Biology

The Science and Translation of Lactate Shuttle Theory

George A. Brooks

CELL METABOLISM (2018)

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Review Chemistry, Multidisciplinary

Catalytic chemistry of glucose oxidase in cancer diagnosis and treatment

Lian-Hua Fu et al.

CHEMICAL SOCIETY REVIEWS (2018)

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Article Multidisciplinary Sciences

Interruption of lactate uptake by inhibiting mitochondrial pyruvate transport unravels direct antitumor and radiosensitizing effects

Cyril Corbet et al.

NATURE COMMUNICATIONS (2018)

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Article Oncology

Targeting glucose transport and the NAD pathway in tumor cells with STF-31: a re-evaluation

Dominik Kraus et al.

CELLULAR ONCOLOGY (2018)

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Review Oncology

Metabolic Symbiosis and immunomodulation: How Tumor Cell-Derived Lactate May Disturb innate and Adaptive immune Responses

Alexandre Morrot et al.

FRONTIERS IN ONCOLOGY (2018)

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Article Chemistry, Multidisciplinary

Interfering with Lactate-Fueled Respiration for Enhanced Photodynamic Tumor Therapy by a Porphyrinic MOF Nanoplatform

Zhao-Xia Chen et al.

ADVANCED FUNCTIONAL MATERIALS (2018)

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Article Engineering, Biomedical

Hypoxic tumor therapy by hemoglobin-mediated drug delivery and reversal of hypoxia-induced chemoresistance

Jie Yang et al.

BIOMATERIALS (2018)

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Article Cell Biology

Increased Lactate Secretion by Cancer Cells Sustains Non-cell-autonomous Adaptive Resistance to MET and EGFR Targeted Therapies

Maria Apicella et al.

CELL METABOLISM (2018)

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Article Oncology

Preclinical Efficacy of the Novel Monocarboxylate Transporter 1 Inhibitor BAY-8002 and Associated Markers of Resistance

Maria Quanz et al.

MOLECULAR CANCER THERAPEUTICS (2018)

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Article Chemistry, Multidisciplinary

Targeting Tumor Microenvironment by Bioreduction-Activated Nanoparticles for Light-Triggered Virotherapy

S. -Ja Tseng et al.

ACS NANO (2018)

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Article Cell Biology

SOX2 as a novel contributor of oxidative metabolism in melanoma cells

Elena Andreucci et al.

CELL COMMUNICATION AND SIGNALING (2018)

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Review Chemistry, Multidisciplinary

Theranostic nanosystems for targeted cancer therapy

Homan Kang et al.

NANO TODAY (2018)

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Article Chemistry, Multidisciplinary

Perfluorocarbon Nanoparticles Mediated Platelet Blocking Disrupt Vascular Barriers to Improve the Efficacy of Oxygen-Sensitive Antitumor Drugs

Zaigang Zhou et al.

SMALL (2018)

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Review Oncology

Nutrient scavenging in cancer

Brendan T. Finicle et al.

NATURE REVIEWS CANCER (2018)

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Review Oncology

Cancer metabolism: a therapeutic perspective

Ubaldo E. Martinez-Outschoorn et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2017)

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Article Multidisciplinary Sciences

Glucose feeds the TCA cycle via circulating lactate

Sheng Hui et al.

NATURE (2017)

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Review Nutrition & Dietetics

Review of the mechanisms of probiotic actions in the prevention of colorectal cancer

Sandra A. dos Reis et al.

NUTRITION RESEARCH (2017)

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Editorial Material Oncology

Metabolic symbiosis in cancer and its therapeutic implication

Mark R. Lipstein et al.

SEMINARS IN ONCOLOGY (2017)

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Review Oncology

Cancer nanomedicine: progress, challenges and opportunities

Jinjun Shi et al.

NATURE REVIEWS CANCER (2017)

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Article Biochemistry & Molecular Biology

Lactate Metabolism in Human Lung Tumors

Brandon Faubert et al.

CELL (2017)

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Review Biochemistry & Molecular Biology

Linking metabolic reprogramming to therapy resistance in cancer

Andrea Morandi et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2017)

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Article Microbiology

Unexpected complexity in the lactate racemization system of lactic acid bacteria

Benoit Desguin et al.

FEMS MICROBIOLOGY REVIEWS (2017)

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Review Multidisciplinary Sciences

Natural products to prevent drug resistance in cancer chemotherapy: a review

Renyikun Yuan et al.

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES (2017)

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Article Nanoscience & Nanotechnology

Mussel-Inspired Hyaluronic Acid Derivative Nanostructures for Improved Tumor Targeting and Penetration

Song Yi Lee et al.

ACS APPLIED MATERIALS & INTERFACES (2017)

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Article Genetics & Heredity

Stimulation of lactate receptor (HCAR1) affects cellular DNA repair capacity

Waldemar Wagner et al.

DNA REPAIR (2017)

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Article Chemistry, Multidisciplinary

Overcoming the Heat Endurance of Tumor Cells by Interfering with the Anaerobic Glycolysis Metabolism for Improved Photothermal Therapy

Wei-Hai Chen et al.

ACS NANO (2017)

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Article Chemistry, Multidisciplinary

Hemoglobin-Based Nanoarchitectonic Assemblies as Oxygen Carriers

Yi Jia et al.

ADVANCED MATERIALS (2016)

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Review Clinical Neurology

The Regulation and Function of Lactate Dehydrogenase A: Therapeutic Potential in Brain Tumor

Cara J. Valvona et al.

BRAIN PATHOLOGY (2016)

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Article Oncology

Neutralization of Tumor Acidity Improves Antitumor Responses to Immunotherapy

Shari Pilon-Thomas et al.

CANCER RESEARCH (2016)

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Article Chemistry, Medicinal

Recent Update on Human Lactate Dehydrogenase Enzyme 5 (hLDH5) Inhibitors: A Promising Approach for Cancer Chemotherapy

Reshma Rani et al.

JOURNAL OF MEDICINAL CHEMISTRY (2016)

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Review Biotechnology & Applied Microbiology

Gasotransmitters in cancer: from pathophysiology to experimental therapy

Csaba Szabo

NATURE REVIEWS DRUG DISCOVERY (2016)

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Article Biochemistry & Molecular Biology

miR-4458 suppresses glycolysis and lactate production by directly targeting hexokinase2 in colon cancer cells

Yaguang Qin et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2016)

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Review Biochemistry & Molecular Biology

Mechanism of antineoplastic activity of lonidamine

Kavindra Nath et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2016)

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Review Oncology

Tumor microenvironment and cancer therapy resistance

Yu Sun

CANCER LETTERS (2016)

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Article Biochemistry & Molecular Biology

Metabolic Heterogeneity in Human Lung Tumors

Christopher T. Hensley et al.

CELL (2016)

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Article Chemistry, Multidisciplinary

An Implantable Depot That Can Generate Oxygen in Situ for Overcoming Hypoxia-Induced Resistance to Anticancer Drugs in Chemotherapy

Chieh-Cheng Huang et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2016)

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Review Endocrinology & Metabolism

Facilitative glucose transporters: Implications for cancer detection, prognosis and treatment

Carly C. Barron et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2016)

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Article Chemistry, Multidisciplinary

Monodispersed calcium carbonate nanoparticles modulate local pH and inhibit tumor growth in vivo

Avik Som et al.

NANOSCALE (2016)

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Review Microbiology

Extracellular electron transfer mechanisms between microorganisms and minerals

Liang Shi et al.

NATURE REVIEWS MICROBIOLOGY (2016)

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Article Materials Science, Biomaterials

Polymer nanoparticle delivery of dichloroacetate and DACH-Pt to enhance antitumor efficacy and lower systemic toxicity

Qiang Yang et al.

BIOMATERIALS SCIENCE (2016)

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Review Oncology

Reprogramming glucose metabolism in cancer: can it be exploited for cancer therapy?

Nissim Hay

NATURE REVIEWS CANCER (2016)

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Article Biotechnology & Applied Microbiology

Utilization of D-Lactate as an Energy Source Supports the Growth of Gluconobacter oxydans

Binbin Sheng et al.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2015)

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Article Cell Biology

L- and D-lactate enhance DNA repair and modulate the resistance of cervical carcinoma cells to anticancer drugs via histone deacetylase inhibition and hydroxycarboxylic acid receptor 1 activation

Waldemar Wagner et al.

CELL COMMUNICATION AND SIGNALING (2015)

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Article Pathology

Expression of lactate/H+ symporters MCT1 and MCT4 and their chaperone CD147 predicts tumor progression in clear cell renal cell carcinoma: immunohistochemicat and The Cancer Genome Atlas data analyses

Younghye Kim et al.

HUMAN PATHOLOGY (2015)

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Article Biophysics

Glycolytic inhibitors 2-deoxyglucose and 3-bromopyruvate synergize with photodynamic therapy respectively to inhibit cell migration

Xiaolan Feng et al.

JOURNAL OF BIOENERGETICS AND BIOMEMBRANES (2015)

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Review Chemistry, Multidisciplinary

Nanomedicine in cancer therapy: Challenges, opportunities, and clinical applications

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Knocking down disease: a progress report on siRNA therapeutics

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Perfluorocarbon nanoparticles enhance reactive oxygen levels and tumour growth inhibition in photodynamic therapy

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NATURE COMMUNICATIONS (2015)

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PKM2 promotes glucose metabolism and cell growth in gliomas through a mechanism involving a let-7a/c-Myc/hnRNPA1 feedback loop

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ONCOTARGET (2015)

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Glycolytic inhibitors 2-deoxyglucose and 3-bromopyruvate synergize with photodynamic therapy respectively to inhibit cell migration

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JOURNAL OF BIOENERGETICS AND BIOMEMBRANES (2015)

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Multifunctional Albumin-MnO2 Nanoparticles Modulate Solid Tumor Microenvironment by Attenuating Hypoxia, Acidosis, Vascular Endothelial Growth Factor and Enhance Radiation Response

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ACS NANO (2014)

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Flavin Redox Bifurcation as a Mechanism for Controlling the Direction of Electron Flow during Extracellular Electron Transfer

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ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2014)

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Utilizing hydrogen sulfide as a novel anti-cancer agent by targeting cancer glycolysis and pH imbalance

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BRITISH JOURNAL OF PHARMACOLOGY (2014)

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Functional Nanomaterials for Phototherapies of Cancer

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CHEMICAL REVIEWS (2014)

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Oleanolic Acid Induces Metabolic Adaptation in Cancer Cells by Activating the AMP-Activated Protein Kinase Pathway

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Non-viral vectors for gene-based therapy

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Immune evasion mediated by tumor-derived lactate dehydrogenase induction of NKG2D ligands on myeloid cells in glioblastoma patients

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

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Targeting lactate metabolism for cancer therapeutics

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JOURNAL OF CLINICAL INVESTIGATION (2013)

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Review Biochemistry & Molecular Biology

Tumor glycolysis as a target for cancer therapy: progress and prospects

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MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors

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Metabolic targets for cancer therapy

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NATURE REVIEWS DRUG DISCOVERY (2013)

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Monocarboxylate transporters (MCTs) in gliomas: expression and exploitation as therapeutic targets

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NEURO-ONCOLOGY (2013)

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Review Biochemistry & Molecular Biology

Hydrogen sulfide chemical biology: Pathophysiological roles and detection

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NITRIC OXIDE-BIOLOGY AND CHEMISTRY (2013)

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M2 pyruvate kinase provides a mechanism for nutrient sensing and regulation of cell proliferation

Hugh P. Morgan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

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pH sensing and regulation in cancer

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FRONTIERS IN PHYSIOLOGY (2013)

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Beyond oxidative stress: an immunologist's guide to reactive oxygen species

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Galloflavin, a new lactate dehydrogenase inhibitor, induces the death of human breast cancer cells with different glycolytic attitude by affecting distinct signaling pathways

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EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2012)

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Review Biophysics

Role of monocarboxylate transporters in human cancers: state of the art

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JOURNAL OF BIOENERGETICS AND BIOMEMBRANES (2012)

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Pyruvate kinase M2-specific siRNA induces apoptosis and tumor regression

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A Small-Molecule Inhibitor of Glucose Transporter 1 Downregulates Glycolysis, Induces Cell-Cycle Arrest, and Inhibits Cancer Cell Growth In Vitro and In Vivo

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MOLECULAR CANCER THERAPEUTICS (2012)

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Hydrogen sulphide and angiogenesis: mechanisms and applications

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BRITISH JOURNAL OF PHARMACOLOGY (2011)

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Drug Resistance and Cellular Adaptation to Tumor Acidic pH Microenvironment

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MOLECULAR PHARMACEUTICS (2011)

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Cancer immunotherapy comes of age

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Targeting cancer metabolism: a therapeutic window opens

Matthew G. Vander Heiden

NATURE REVIEWS DRUG DISCOVERY (2011)

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GENOMIC INSTABILITY IN CANCER Strategies to improve radiotherapy with targeted drugs

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NATURE REVIEWS CANCER (2011)

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Dysregulated pH: a perfect storm for cancer progression

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NATURE REVIEWS CANCER (2011)

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Markedly reduced toxicity of a hydrogen sulphide-releasing derivative of naproxen (ATB-346)

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BRITISH JOURNAL OF PHARMACOLOGY (2010)

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Photothermal Response of Human and Murine Cancer Cells to Multiwalled Carbon Nanotubes after Laser Irradiation

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CANCER RESEARCH (2010)

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Review Cell Biology

HIF-1: upstream and downstream of cancer metabolism

Gregg L. Semenza

CURRENT OPINION IN GENETICS & DEVELOPMENT (2010)

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Expression of Monocarboxylate Transporters 1, 2, and 4 in Human Tumours and Their Association with CD147 and CD44

Celine Pinheiro et al.

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Delivering nanomedicine to solid tumors

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Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

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Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

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Cancer cell metabolism: Warburg and beyond

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Article Cardiac & Cardiovascular Systems

Characterization of a novel, water-soluble hydrogen sulfide - Releasing molecule (GYY4137): New insights into the biology of hydrogen sulfide

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CIRCULATION (2008)

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A novel inhibitor of glucose uptake sensitizes cells to FAS-induced cell death

Tabitha E. Wood et al.

MOLECULAR CANCER THERAPEUTICS (2008)

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Methyl jasmonate binds to and detaches mitochondria-bound hexokinase

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ONCOGENE (2008)

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Review Biotechnology & Applied Microbiology

RNAi-mediated knockdown of target genes: a promising strategy for pancreatic cancer research

Hong Chang

CANCER GENE THERAPY (2007)

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Review Biochemistry & Molecular Biology

Glycolysis inhibition for anticancer treatment

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ONCOGENE (2006)

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Review Multidisciplinary Sciences

Hypoxia signalling in cancer and approaches to enforce tumour regression

Jacques Pouyssegur et al.

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The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1α-dependent mechanism

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JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

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Autophagy in health and disease: A double-edged sword

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SCIENCE (2004)

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Article Pharmacology & Pharmacy

Tumor acidity, ion trapping and chemotherapeutics I.: Acid pH affects the distribution of chemotherapeutic agents in vitro

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BIOCHEMICAL PHARMACOLOGY (2003)

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Review Oncology

Hypoxia - A key regulatory factor in tumour growth

AL Harris

NATURE REVIEWS CANCER (2002)

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Review Oncology

Cancer gene therapy: Fringe or cutting edge?

F McCormick

NATURE REVIEWS CANCER (2001)

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Free radical scavenging and antioxidant effects of lactate ion: an in vitro study

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Resistance mechanisms associated with altered intracellular distribution of anticancer agents

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PHARMACOLOGY & THERAPEUTICS (2000)

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