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Advancing cell surface modification in mammalian cells with synthetic molecules

CHEMICAL SCIENCE (2023)

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Article Biochemistry & Molecular Biology

Effects of Various Cell Surface Engineering Reactions on the Biological Behavior of Mammalian Cells

Fengying Cai et al.

Summary: Cell surface engineering technologies modify the cell surface to regulate cell function and behavior. This study investigates the effects of different surface engineering reactions on the behavior of HUVECs and human skin fibroblasts. The results show that these reactions have varying effects on cell viability, growth, proliferation, cell cycle, adhesion, and migration.

MACROMOLECULAR BIOSCIENCE (2023)

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Article Nanoscience & Nanotechnology

Targeting the activity of T cells by membrane surface redox regulation for cancer theranostics

Changrong Shi et al.

Summary: This study designs T-cell-targeting fusogenic liposomes to regulate and quantify the activity of T cells by exploiting their surface redox status. The T-cell-targeting fusogenic liposomes neutralize reactive oxygen species to protect T cells and allow magnetic resonance imaging quantification of T cell activity. In multiple mouse models, the T-cell-targeting fusogenic liposomes efficiently inhibit tumors and predict radiotherapy outcomes. This study provides insights into measuring the in situ activity of T cells and may contribute to cancer treatment.

NATURE NANOTECHNOLOGY (2023)

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Article Engineering, Biomedical

ZipperCells Exhibit Enhanced Accumulation and Retention at the Site of Myocardial Infarction

Natalie E. Jasiewicz et al.

Summary: A novel system of in situ crosslinking mesenchymal stem cells (MSCs) for the formation of a living depot at the infarct site is reported, addressing the issues of cellular accumulation and retention.

ADVANCED HEALTHCARE MATERIALS (2023)

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Article Biochemistry & Molecular Biology

NTA-Cholesterol Analogue for the Nongenetic Liquid-Ordered Phase-Specific Functionalization of Lipid Membranes with Proteins

Yanjun Zheng et al.

Summary: The nongenetic modification of cell membranes with proteins is a straightforward method in cellular engineering. A cholesterol analogue called CHIM-NTA has been developed for specific membrane immobilization of polyhistidine-tagged proteins, particularly in the liquid-ordered (Lo) domains. It can integrate into phase-separated giant unilamellar vesicles (GUVs) and live cell membranes, enabling the nongenetic modification of cell surfaces with proteins.

ACS CHEMICAL BIOLOGY (2023)

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Review Chemistry, Multidisciplinary

Materials for Cell Surface Engineering

Kolade Adebowale et al.

Summary: Cell therapies have shown promise in treating previously incurable diseases, and the engineering of cell surfaces with various materials has emerged as a valuable tool to enhance their therapeutic performance. This review summarizes recent advances in decorating cell surfaces with nanoparticles, microparticles, and polymeric coatings, and highlights the benefits of surface modifications in protecting carrier cells, enhancing cell trafficking, and delivering therapeutic agents. While these technologies are still in the proof-of-concept stage, their promising efficacy from preclinical studies provides a strong foundation for future clinical translation, revolutionizing the field of cell therapies.

ADVANCED MATERIALS (2023)

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Article Biochemistry & Molecular Biology

Deoxyribonucleic Acid-Based Polyvalent Ligand-Receptor Binding for Engineering the Cell Surface with Nanoparticles

Brandon Davis et al.

Summary: This study developed a DNA-based synthetic ligand-receptor pair to tether nanoparticles onto the cell surface, which holds great potential for applications such as targeted nanoparticle delivery and enhanced cell therapy.

BIOMACROMOLECULES (2023)

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Article Chemistry, Multidisciplinary

Sequential Control of Cellular Interactions Using Dynamic DNA Displacement

Yu Cheng et al.

Summary: Intercellular interactions are important in biological processes and their dysregulation leads to disease progression. Mimicking multicellular behaviors in vitro is technically challenging due to dynamic interactions. In this study, DNA was used as a lock and key to regulate intercellular interactions and improve antitumor therapy efficacy.

NANO LETTERS (2023)

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Article Multidisciplinary Sciences

Orientation-controlled membrane anchoring of bioorthogonal catalysts on live cells via liposome fusion-based transport

Yuanyuan Chen et al.

Summary: The sensitivity of artificial metal catalysts presents an obstacle to conducting diverse bioorthogonal reactions in living systems. In this study, we propose a strategy called membrane-anchored catalysts with precise spatial control via liposome fusion-based transport (MAC-LiFT) to address this issue. By loading bioorthogonal catalytic complexes onto the membrane leaflets, we found that the inner face of the cytoplasmic membrane can effectively protect the complexes from deactivation, significantly reducing the amount of catalyst needed for intracellular catalysis. The MAC-LiFT approach enables the establishment of catalyst-protective systems using exclusively exogenous agents in a wide range of mammalian cells, facilitating the convenient and broader use of diverse bioorthogonal reactions in live cellular systems.

SCIENCE ADVANCES (2023)

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Article Chemistry, Multidisciplinary

Sensitizing Tumors to Immune Checkpoint Blockage via STING Agonists Delivered by Tumor-Penetrating Neutrophil Cytopharmaceuticals

Meixi Hao et al.

Summary: Researchers have developed a novel neutrophil cytopharmaceutical (NEs@STING-Mal-NP) that enhances the tumor penetration of STING agonists, which activate immune cells and enhance the tumoricidal ability of T cells for the treatment of triple-negative breast cancer (TNBC).

ACS NANO (2023)

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Article Chemistry, Multidisciplinary

Membrane-Fusion-Mediated Multiplex Engineering of Tumor Cell Surface Glycans for Enhanced NK Cell Therapy

Chunxiong Zheng et al.

Summary: A core-shell membrane-fusogenic liposome (MFL) was designed to reverse the immunosuppressive effects of tumor cell surface glycans and enhance tumor elimination through the presentation of NK-activating glycans. This was achieved by fusing the MFL with tumor cell membranes, delivering sialyltransferase-inhibitor-loaded cores into the cytoplasm to downregulate immunosuppressive sialic acid, and anchoring NK-activating-glycan-modified shells onto the tumor surface. The reprogrammed tumor surface resulted in NK activation and improved tumor susceptibility to NK-cell-mediated recognition and lysis.

ADVANCED MATERIALS (2023)

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Review Pharmacology & Pharmacy

Bioempowerment of Therapeutic Living Cells by Single-Cell Surface Engineering

Seoin Yang et al.

Summary: Living cells have the unique ability to perform complex biochemical reactions with precision and efficiency, making them attractive for therapeutic applications. Recent progress has been made in the development of engineered therapeutic cells by chemically modifying cell surfaces at the single-cell level, allowing individual cells to possess designed therapeutic functions in a compatible manner. This review highlights the latest advances in therapeutic living cells using single-cell surface engineering, including potential applications in blood transfusion, drug delivery, cancer therapy, probiotic therapy, and tissue engineering and regenerative medicine. The review also briefly discusses strategies for functionalizing cell surfaces with biomolecules and materials, as well as the future direction of constructing active cell-in-shell nanobiohybrid systems for single-cell surface engineering.

ADVANCED THERAPEUTICS (2023)

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Article Chemistry, Physical

In situ PEGylation of CAR T cells alleviates cytokine release syndrome and neurotoxicity

Ningqiang Gong et al.

Summary: In situ PEGylation of CAR T cells provides a materials-based strategy for safer cellular immunotherapy by blocking cell-to-cell interactions and decreasing toxic cytokine secretion. It also allows for controlled tumor killing and immune response stimulation, mitigating cytokine release syndrome and reducing neurotoxicity.

NATURE MATERIALS (2023)

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Article Biochemistry & Molecular Biology

Maximizing the performance of protein-based fluorescent biosensors

Fu Chai et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2023)

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Article Engineering, Biomedical

Maleimide as the PEG end-group promotes macrophage-targeted drug delivery of PEGylated nanoparticles in vivo by enhancing interaction with circulating erythrocytes

Xin Wang et al.

Summary: Radiotherapy enhances antitumor immune responses but also promotes infiltration of peripheral macrophages into tumors, which hinders the therapeutic effects. Finding a strategy to prevent macrophage infiltration can improve the efficacy of radiotherapy.

BIOMATERIALS (2023)

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Article Engineering, Biomedical

Liposome-anchored mesenchymal stem cells for radiation pneumonia/ fibrosis treatment

Hailin Zhou et al.

Summary: Antioxidant liposome (Lipo-OPC) is designed to anchor onto the surface of mesenchymal stem cells (MSCs) membrane via click chemical reaction (MSC-Lipo-OPC). MSC-Lipo-OPC can efficiently accumulate in X-ray irradiated lung sites, promote the change of innate immunocytes, and prevent the formation of radioactive pulmonary fibrosis.

BIOMATERIALS (2023)

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Article Nanoscience & Nanotechnology

Synthetic DNA for Cell Surface Engineering: Experimental Comparison between Click Conjugation and Lipid Insertion in Terms of Cell Viability, Engineering Efficiency, and Displaying Stability

Xuelin Wang et al.

Summary: This study systematically evaluated and compared click conjugation and lipid insertion methods for engineering the cell surface with synthetic DNA. Results showed that lipid insertion is more efficient in displaying DNA on the cell surface, while physically inserted DNA has a shorter half-life. These findings can serve as a guideline for choosing an appropriate method for engineering the cell surface with synthetic DNA or other biomolecules.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Article Nanoscience & Nanotechnology

Glycopolymer Engineering of the Cell Surface Changes the Single Cell Migratory Direction and Inhibits the Collective Migration of Cancer Cells

Lijuan Zhu et al.

Summary: Cancer cell migration is a crucial step in cancer metastasis. Cell surface engineering can modify cell interactions with the microenvironment and has been shown to affect cell migration. This study demonstrates that modifying the surface of melanoma cells can alter their migration direction and velocity, and suppress the collective migration of unmodified cells.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Article Chemistry, Multidisciplinary

A Biomimetic Approach for Spatially Controlled Cell Membrane Engineering Using Fusogenic Spherical Nucleic Acid

Minjie Lin et al.

Summary: By utilizing liposome fusion-based transport, functional DNA can be applied to both external and internal cell surfaces, expanding the applications of cell engineering. This approach allows for efficient and spatially controlled engineering of cell membranes, enabling the construction of anisotropic membrane structures.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

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Review Chemistry, Multidisciplinary

Metal-free bioorthogonal click chemistry in cancer theranostics

Dan Wu et al.

Summary: Bioorthogonal chemistry is a powerful tool for site-specific drug activation in living systems, offering high selectivity and efficiency. Metal-free bioorthogonal click reactions are more biocompatible compared to metal-catalyzed reactions. This review highlights the recent progress and advantages of metal-free bioorthogonal click chemistry in cancer theranostics.

CHEMICAL SOCIETY REVIEWS (2022)

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Review Chemistry, Physical

Benzoxaboroles: New emerging and versatile scaffold with a plethora of pharmacological activities

Bharti Dhawan et al.

Summary: Benzoxaboroles are versatile boron heterocyclic compounds with a wide range of pharmacological activities, making them suitable for treating various diseases. Some benzoxaborole-based lead candidates have shown promising clinical trial results and have been approved for specific disease treatments, paving the way for a new area in medicinal chemistry.

JOURNAL OF MOLECULAR STRUCTURE (2022)

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Article Chemistry, Multidisciplinary

DNA Engineered Lymphocyte-Based Homologous Targeting Artificial Antigen-Presenting Cells for Personalized Cancer Immunotherapy

Lele Sun et al.

Summary: This study successfully constructed lymphocyte-based homologous targeting aAPCs (LC-aAPCs) that mimic the characteristics of natural antigen-presenting cells through lipid-DNA-mediated noninvasive live cell surface engineering. These LC-aAPCs can optimize T cell activation and effectively inhibit tumor growth.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)

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Article Biochemistry & Molecular Biology

Cell-type-specific labeling and profiling of glycans in living mice

Xinqi Fan et al.

Summary: The development of genetically encoded metabolic glycan labeling (GeMGL) provides a cell-type-specific strategy for glycan analysis in multicellular systems. This method involves the use of an unnatural sugar and an engineered enzyme, allowing specific labeling of glycans in cells expressing a mutant enzyme. GeMGL has been successfully demonstrated in cell cocultures and mouse xenograft tumors, and further application in specific glycan imaging and glycoproteomics is expected.

NATURE CHEMICAL BIOLOGY (2022)

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Article Biotechnology & Applied Microbiology

Dual-binding nanoparticles improve the killing effect of T cells on solid tumor

Zhenyu Luo et al.

Summary: A dual-binding magnetic nanoparticle platform was developed to enhance the efficacy of adoptive cell therapy (ACT) for solid tumors and reduce toxic side effects.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

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Article Chemistry, Analytical

Screening T-Cell Activity via a Photodetachable DNA-Copolymer Nanocage and Its Therapeutic Application

Yanyun Fang et al.

Summary: In this study, a photo detachable DNA-copolymer nanocage was designed to screen the activities of T cells for the success of T-cell therapy. The DNA-copolymer nanocage on the cell membrane encapsulated a single T cell and the secretion of cytokine interferon-gamma (IFN-gamma) was monitored to indicate individual T-cell activity. The selected active T cells showed improved capabilities for downstream cell activation and cancer cell killing.

ANALYTICAL CHEMISTRY (2022)

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Article Chemistry, Analytical

Cell-Membrane-Anchored Upconversion Nanoprobe for Near-Infrared Light Triggered Cell-Cell Interactions

Yujing Kong et al.

Summary: Controllable cell assembly and disassembly using reversible near-infrared light-induced interactions have significant implications. In this study, a NIR-controlled system based on S-cyclodextrin modified upconversion nanoparticles was developed for reversible manipulation of cell assembly, realized by host-guest interactions between arylazopyrazole and S-CD under NIR irradiation.

ANALYTICAL CHEMISTRY (2022)

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Article Chemistry, Multidisciplinary

Engineering living cells with cucurbit[7]uril-based supramolecular polymer chemistry: from cell surface engineering to manipulation of subcellular organelles

Fang Huang et al.

Summary: Supramolecular polymer chemistry, integrating noncovalent interactions with polymeric structures, is utilized for living cell engineering, including cell surface engineering and subcellular organelle manipulation, providing a new strategy for living cell engineering.

CHEMICAL SCIENCE (2022)

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Article Biochemistry & Molecular Biology

Fluorescence-Based and Fluorescent Label-Free Characterization of Polymer Nanoparticle Decorated T Cells

Tanja Thomsen et al.

Summary: Cells are considered attractive carriers for nanoparticulate cargo, allowing enhanced control over drug-loaded polymers. Monitoring surface modification or internalization of nanoparticles by cells using fluorescence-based techniques poses risks and drawbacks. Covalently tethered fluorescent dyes provide a robust approach for monitoring cell surface conjugation reactions and analyzing nanoparticle-decorated cells, while optical diffraction tomography is suggested as an alternative technique for characterization without the need for fluorescent labels.

BIOMACROMOLECULES (2021)

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Article Chemistry, Multidisciplinary

Glycoengineering of NK Cells with Glycan Ligands of CD22 and Selectins for B-Cell Lymphoma Therapy

Senlian Hong et al.

Summary: By modifying natural killer cells with glycan ligands targeting CD22, as well as selectins to promote trafficking to bone marrow, it is possible to achieve targeted killing of B lymphoma cells and improve cell trafficking to cancer cell locations, resulting in efficient suppression of lymphoma in vivo.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

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Article Chemistry, Multidisciplinary

Covalent Cell Surface Conjugation of Nanoparticles by a Combination of Metabolic Labeling and Click Chemistry

Alexander Lamoot et al.

Summary: Conjugation of nanoparticles to living cells can be achieved through either covalent or non-covalent reactions, with covalent conjugation resulting in a permanent bound state. Challenges with non-covalent conjugation include dynamic equilibrium between bound and unbound states. Researchers have developed a 2-step click conjugation sequence to address the need for efficient covalent cell surface conjugation, resulting in highly specific binding with low non-specific background.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

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Article Chemistry, Multidisciplinary

Surface-Anchored Nanogel Coating Endows Stem Cells with Stress Resistance and Reparative Potency via Turning Down the Cytokine-Receptor Binding Pathways

Ling Zhang et al.

Summary: The research introduces a novel approach involving single-cell coating of surface-anchored nanogel to enhance the anti-apoptosis capacity of stem cells in the infarcted heart environment. This method shows significant improvements in cell survival, engraftment, cardiac function, and infarct size, indicating the immense potential for producing robust therapeutic stem cells in cell-based therapy.

ADVANCED SCIENCE (2021)

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Article Chemistry, Multidisciplinary

Partial Coated Stem Cells with Bioinspired Silica as New Generation of Cellular Hybrid Materials

Marta M. Maciel et al.

Summary: By partially coating human adipose-derived mesenchymal stem cells (hASCs) with a hard silica layer, cell survival in suspension conditions is enhanced, leading to a more adherent phenotype. This new protocol not only improves cell handling and application, but also provides a new generation of hybrid materials with functionalization of the silica backpack for various applications in tissue engineering, biosensing, drug delivery, and targeted cell-based therapies.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Article Chemistry, Analytical

Self-Assembled Nanorods of Phenylboronic Acid Functionalized Pyrene for In Situ Two-Photon Imaging of Cell Surface Sialic Acids and Photodynamic Therapy

Ting Li et al.

Summary: A Py-PBA nanorod was synthesized for efficient imaging of SA on living cells with unique two-photon fluorescence properties, making it a promising candidate for photodynamic therapy. This nanoplatform provides a new approach for simple and selective analysis of SA in living cells and image-guided therapy.

ANALYTICAL CHEMISTRY (2021)

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Article Chemistry, Multidisciplinary

Cell Surface Engineering Using DNAzymes: Metal Ion Mediated Control of Cell-Cell Interactions

Ruo-Can Qian et al.

Summary: The strategy based on DNAzymes allows for controllable cell-cell interactions triggered by metal ions, effectively manipulating cell behaviors such as cell-cell conjunctions and disaggregation. This method has been successfully applied to control assembly and disassembly between two cell spheroids.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

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Article Biochemistry & Molecular Biology

A Gadolinium DO3A Amide m-Phenyl Boronic Acid MRI Probe for Targeted Imaging of Sialated Solid Tumors

Christu Rajan et al.

Summary: A new probe, Gd-DO3A-Am-PBA, was developed for tumor imaging, showing active targeting to sialic acid (SA) moieties. The probe demonstrated enhanced tumor accumulation and retention, as well as faster renal clearance, reducing toxicity risks. This study opens up new avenues for drug delivery and tumor diagnosis through imaging.

BIOMEDICINES (2021)

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Article Biochemistry & Molecular Biology

Towards Enhanced MRI Performance of Tumor-Specific Dimeric Phenylboronic Contrast Agents

Jonathan Martinelli et al.

Summary: It is known that phenylboronic acid can target tumor tissues by binding to sialic acid, a substrate overexpressed by cancer cells, and has been explored in the design of diagnostic probes for MRI and PET. Furthermore, the use of multimeric Gd-III complexes can enhance MRI contrast by increasing local concentration of paramagnetic ions, as demonstrated in the synthesis of dimeric analogues.

MOLECULES (2021)

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Review Engineering, Biomedical

A Decade of Advances in Single-Cell Nanocoating for Mammalian Cells

Hojae Lee et al.

Summary: Significant progress has been made in the past decade in the single-cell nanocoating of mammalian cells, with various materials and strategies being utilized to ensure cell sustainability and explore potential applications. A potential future direction is the creation of a cytospace system composed of interacting cellular hybrids.

ADVANCED HEALTHCARE MATERIALS (2021)

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Article Nanoscience & Nanotechnology

Hitchhiking Nanoparticles: Mesenchymal Stem Cell-Mediated Delivery of Theranostic Nanoparticles

Dominyka Dapkute et al.

Summary: A complex composed of photoluminescent quantum dots and a photosensitizer chlorin e6 was constructed to obtain multifunctional nanoparticles for cancer diagnostic and therapeutic purposes. In vitro and in vivo studies demonstrated the potential of the complex-loaded MSCs in transporting theranostic nanoparticles and inducing cancer cell death, leading to increased survival of tumor-bearing mice and slowed down tumor progression and metastases.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Chemistry, Multidisciplinary

Supramolecular Macrophage-Liposome Marriage for Cell-Hitchhiking Delivery and Immunotherapy of Acute Pneumonia and Melanoma

Cheng Gao et al.

Summary: A cell-friendly, host-guest chemistry mediated macrophage-liposome conjugate (M-L) has been developed for stable cell-hitchhiking drug delivery targeting inflamed tissues or cancer tissues. This strategy shows potential clinical applications as it does not affect the migratory and invasive behaviors of macrophages and enhances the therapeutic effects of drugs on diseases.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Polymer-Assisted Metallization of Mammalian Cells

Wenshuo Wang et al.

Summary: Developing biotemplating techniques to convert microorganisms and cultured mammalian cells into metallic biocomposites is important for biosensors, electronics, and energy applications. A new method called polymer-assisted cell metallization (PACM) has been proposed to transform mammalian cells into metallic biocomposites while preserving their structures. This new biotemplating method is versatile and compatible with different cell types and metals, allowing for the production of a wide variety of metallic biocomposites with controlled structures and properties.

ADVANCED MATERIALS (2021)

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Article Biochemistry & Molecular Biology

Covalent and Noncovalent Conjugation of Degradable Polymer Nanoparticles to T Lymphocytes

Tanja Thomsen et al.

Summary: Using cells as carriers for polymer nanomedicines can help improve control over biodistribution. Different strategies exist for immobilizing nanoparticles on cell surfaces, with this study exploring multiple approaches for PLA nanoparticle immobilization on T lymphocyte cell lines. The impact of surface modification on cell viability and functional properties is important for improving cell-based nanoparticle delivery systems.

BIOMACROMOLECULES (2021)

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Article Chemistry, Multidisciplinary

Hydrophobic Interactions between DNA Duplexes and Synthetic and Biological Membranes

Sioned F. Jones et al.

Summary: Equipping DNA with hydrophobic anchors enables targeted interaction with lipid bilayers for various applications. Through experiments and molecular dynamics simulations, the study reveals the complex structure and energetics of hydrophobically tagged DNA within lipid membranes. Fundamental insight gained on DNA-bilayer interactions will guide the rational design of membrane-targeting nanostructures.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

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Article Chemistry, Multidisciplinary

Polyvalent spherical aptamer engineered macrophages: X-ray-actuated phenotypic transformation for tumor immunotherapy

Yuanyuan Chen et al.

Summary: The research developed an X-ray-induced phenotypic transformation strategy through macrophage engineering for safe and efficient tumor immunotherapy. The engineered macrophages demonstrated high tumor recognition and X-ray-induced polarization effects, significantly inhibiting tumor growth in mice even with a reduced radiation dose compared to natural macrophages. The X-PT strategy opens a new avenue for clinical immune cell-based therapy.

CHEMICAL SCIENCE (2021)

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Review Chemistry, Multidisciplinary

Cell surface-localized imaging and sensing

Hao-Ran Jia et al.

Summary: Studying the molecular basis of cell surface and related biological activities is a cutting-edge field, where advanced cell imaging techniques allow us to understand how cell surface is structured and responds to signals. Researchers are now focusing on artificially manipulating the cell surface properties, developing more maneuverable labeling strategies for imaging, sensing, and biomedical applications. The future challenges and opportunities in visualizing cell surface structures and monitoring the microenvironment are discussed, highlighting the importance of cell surface-based studies.

CHEMICAL SOCIETY REVIEWS (2021)

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Article Chemistry, Multidisciplinary

Covalent cell surface recruitment of chemotherapeutic polymers enhances selectivity and activity

Ruben M. F. Tomas et al.

Summary: The covalent recruitment strategy using metabolic oligosaccharide engineering to label targeted cells with azido glycans, followed by capturing chemotherapeutic polymers, results in up to 10-fold reduction in EC50 and widening of the therapeutic window. Cell death is induced not only by membrane leakage but also by apoptosis due to internalization of the conjugated chemotherapeutic by glycan recycling.

CHEMICAL SCIENCE (2021)

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Review Nanoscience & Nanotechnology

Chemical Cell Surface Modification and Analysis of Nanoparticle-Modified Living Cells

Tanja Thomsen et al.

Summary: Cells show promise as carriers for enhancing the delivery of nanomedicines, but careful selection of chemical strategies is necessary for loading and understanding the impact of cell-surface modification chemistries. This article reviews contemporary strategies for cell surface immobilization of nanoparticle cargo and discusses techniques used for characterizing nanoparticle-modified cells.

ACS APPLIED BIO MATERIALS (2021)

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Article Materials Science, Biomaterials

A vaccine for photodynamic immunogenic cell death: tumor cell caged by cellular disulfide-thiol exchange for immunotherapy

Ya Wen et al.

Summary: The study proposes an in vitro method for inducing ICD to overcome the impact of the immunosuppressive microenvironment on anticancer immunity. By generating a hot whole tumor cell vaccine and subcutaneously vaccinating it in normal tissue, the study effectively promotes T-cell responses and protects mice from tumor initiation.

BIOMATERIALS SCIENCE (2021)

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Article Chemistry, Multidisciplinary

A Universal Platform for High-Efficiency Engineering Living Cells: Integration of Cell Capture, Intracellular Delivery of Biomolecules, and Cell Harvesting Functions

Yangcui Qu et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Article Chemistry, Multidisciplinary

In Vivo Monocyte/Macrophage-Hitchhiked Intratumoral Accumulation of Nanomedicines for Enhanced Tumor Therapy

Liyan Zheng et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

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Article Chemistry, Multidisciplinary

Cell Engineering with Functional Poly(oxanorbornene) Block Copolymers

Derek C. Church et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

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Article Chemistry, Multidisciplinary

Equipping Natural Killer Cells with Specific Targeting and Checkpoint Blocking Aptamers for Enhanced Adoptive Immunotherapy in Solid Tumors

Da Zhang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

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Article Chemistry, Multidisciplinary

DNA-Edited Ligand Positioning on Red Blood Cells to Enable Optimized T Cell Activation for Adoptive Immunotherapy

Lele Sun et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

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Article Chemistry, Multidisciplinary

In Situ Synthesis of an Aptamer-Based Polyvalent Antibody Mimic on the Cell Surface for Enhanced Interactions between Immune and Cancer Cells

Peng Shi et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

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Article Biochemistry & Molecular Biology

Thiol-Disulfide Exchange Reaction Promoted Highly Efficient Cellular Uptake of Pyridyl Disulfide Appended Nonionic Polymers

Raju Bej et al.

CHEMBIOCHEM (2020)

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Article Materials Science, Biomaterials

Tris(2-carboxyethyl)phosphine-Mediated Nanometric Extracellular Matrix-Coating Method of Mesenchymal Stem Cells

IlKyoo Koh et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2020)

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Review Chemistry, Multidisciplinary

Responsive boron biomaterials and their biomedical applications

Weizhi Chen et al.

SCIENCE CHINA-CHEMISTRY (2020)

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Article Chemistry, Multidisciplinary

2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells

Nan Ma et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

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Article Materials Science, Biomaterials

Transglutaminase-Catalyzed Encapsulation of Individual Mammalian Cells with Biocompatible and Cytoprotective Gelatin Nanoshells

Jimin Sun et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2020)

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Article Chemistry, Multidisciplinary

Classifying Cell Types with DNA-Encoded Ligand-Receptor Interactions on the Cell Membrane

Luhao Zhang et al.

NANO LETTERS (2020)

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Cellular backpacks for macrophage immunotherapy

C. Wyatt Shields et al.

SCIENCE ADVANCES (2020)

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Surface-anchored framework for generating RhD-epitope stealth red blood cells

Yueqi Zhao et al.

SCIENCE ADVANCES (2020)

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Article Chemistry, Physical

Metabolic labeling and targeted modulation of dendritic cells

Hua Wang et al.

NATURE MATERIALS (2020)

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Article Chemistry, Multidisciplinary

Anchoring Supramolecular Polymers to Human Red Blood Cells by Combining Dynamic Covalent and Non-Covalent Chemistries

Giulia Morgese et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

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Article Biochemistry & Molecular Biology

Synthesis and Characterization of Silk Ionomers for Layer-by-Layer Electrostatic Deposition on Individual Mammalian Cells

Onur Hasturk et al.

BIOMACROMOLECULES (2020)

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Article Engineering, Biomedical

Promotion of cell membrane fusion by cell-cell attachment through cell surface modification with functional peptide-PEG-lipids

Akifumi Yoshihara et al.

BIOMATERIALS (2020)

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Article Materials Science, Multidisciplinary

Bioorthogonal supramolecular cell-conjugation for targeted hitchhiking drug delivery

Cheng Gao et al.

MATERIALS TODAY (2020)

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Article Polymer Science

100th Anniversary of Macromolecular Science Viewpoint: Re-Engineering Cellular Interfaces with Synthetic Macromolecules Using Metabolic Glycan Labeling

Ruben M. F. Tomas et al.

ACS MACRO LETTERS (2020)

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Review Polymer Science

Engineering the Mammalian Cell Surface with Synthetic Polymers: Strategies and Applications

Maria C. Arno

MACROMOLECULAR RAPID COMMUNICATIONS (2020)

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Article Cell Biology

Combination of metabolic intervention and T cell therapy enhances solid tumor immunotherapy

Meixi Hao et al.

SCIENCE TRANSLATIONAL MEDICINE (2020)

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Intercellular delivery of bioorthogonal chemical receptors for enhanced tumor targeting and penetration

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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2019)

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Bottom-up Nanoencapsulation from Single Cells to Tunable and Scalable Cellular Spheroids for Hair Follicle Regeneration

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Layer-by-layer cell coating technique using extracellular matrix facilitates rapid fabrication and function of pancreatic β-cell spheroids

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Engineered erythrocytes covalently linked to antigenic peptides can protect against autoimmune disease

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Nanoencapsulation of individual mammalian cells with cytoprotective polymer shell

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Construction of three-dimensional vascularized functional human liver tissue using a layer-by-layer cell coating technique

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Cell-Surface Engineering by a Conjugation-and-Release Approach Based on the Formation and Cleavage of Oxime Linkages upon Mild Electrochemical Oxidation and Reduction

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Engineered red blood cells as carriers for systemic delivery of a wide array of functional probes

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

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On-Cell Surface Cross-Linking of Polymer Molecules by Horseradish Peroxidase Anchored to Cell Membrane for Individual Cell Encapsulation in Hydrogel Sheath

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Labeling Primary Amine Groups in Peptides and Proteins with N-Hydroxysuccinimidyl Ester Modified Fe3O4@SiO2 Nanoparticles Containing Cleavable Disulfide-Bond Linkers

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Multicellular aggregation of maltol-modified cells triggered by Fe3+ ions

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Development of amphiphilic, enzymatically-degradable PEG-peptide conjugate as cell crosslinker for spheroid formation

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Glycoproteomics enabled by tagging sialic acid- or galactose-terminated glycans

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Dual-Responsive Surfaces Modified with Phenylboronic Acid-Containing Polymer Brush To Reversibly Capture and Release Cancer Cells

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Effectiveness of Nanometer-Sized Extracellular Matrix Layer-by-Layer Assembled Films for a Cell Membrane Coating Protecting Cells from Physical Stress

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Modifying cellular properties using artificial aptamer-lipid receptors

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Synapse-directed delivery of immunomodulators using T-cell-conjugated nanoparticles

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Engineering Cell Surfaces via Liposome Fusion

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Investigation of Layer-by-Layer Assembly of Polyelectrolytes on Fully Functional Human Red Blood Cells in Suspension for Attenuated Immune Response

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Synthetic Chemoselective Rewiring of Cell Surfaces: Generation of Three-Dimensional Tissue Structures

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Cell Surface Engineering with Polyelectrolyte Multilayer Thin Films

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Red blood cell membrane grafting of multi-functional hyperbranched polyglycerols

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Therapeutic cell engineering with surface-conjugated synthetic nanoparticles

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Enhanced insulin secretion of physically crosslinked pancreatic β-cells by using a poly(ethylene glycol) derivative with oleyl groups

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ACTA BIOMATERIALIA (2009)

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Chemical Engineering of Mesenchymal Stem Cells to Induce a Cell Rolling Response

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Dendrimer hydrazides as multivalent transient inter-cellular linkers

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Site-specific protein modification on living cells catalyzed by Sortase

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Transient inter-cellular polymeric linker

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Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

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Transglutaminase-catalyzed site-specific conjugation of small-molecule probes to proteins in vitro and on the surface of living cells

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Rapid localized cell trapping on biodegradable polymers using cell surface derivatization and microfluidic networking

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Metabolic installation of thiols into sialic acid modulates adhesion and stem cell biology

SG Sampathkumar et al.

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Rapid protein anchoring into the membranes of mammalian cells using oleyl chain and poly(ethylene glycol) derivatives

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Specific labeling of cell surface proteins with chemically diverse compounds

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The relationship among pKa,pH, and binding constants in the interactions between boronic acids and diols -: it is not as simple as it appears

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TETRAHEDRON (2004)

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A general method for the covalent labeling of fusion proteins with small molecules in vivo

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NATURE BIOTECHNOLOGY (2003)

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Chemical modification of mammalian cell surfaces

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CHEMICAL SOCIETY REVIEWS (2003)

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Biophysical consequences of linker chemistry and polymer size on stealth erythrocytes: size does matter

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BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2002)

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Cell surface engineering by a modified Staudinger reaction

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Reversible cell aggregation induced by specific ligand-receptor coupling

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