☆ 4.5 Review

Synthetic and biopolymers-based antimicrobial hybrid hydrogels: a focused review

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION (2023)

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Article Biochemistry & Molecular Biology

Incorporation of Saqez essential oil into polyvinyl alcohol/chitosan bilayer hydrogel as a potent wound dressing material

Ali Rezaei et al.

Summary: Currently, research is being conducted in the field of multilayer hydrogels for wound dressing. Additionally, the use of natural essential oils and their derivatives with antibacterial and antioxidant properties has gained attention due to developing bacterial resistance to common antibiotics. In this study, a novel bilayer hydrogel composed of polyvinyl alcohol and chitosan with the incorporation of Saqez essential oil (SEO) was synthesized. The results indicated that the bilayer hydrogel showed gel-type structure, specific compression, and flexibility. Moreover, increasing the concentration of SEO resulted in reduced swelling and water vapor permeability, increased water retention, and enhanced hydrophobicity. The combination of SEO in the bilayer hydrogel demonstrated strong antioxidant properties and increased antimicrobial activity. The bilayer hydrogels were found to be biocompatible, non-toxic, and blood compatible according to in vitro tests. In vivo tests showed that these bilayer hydrogels exhibited good homeostatic efficiency. Overall, these bilayer hydrogels hold great potential as wound dressings.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2023)

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Article Engineering, Biomedical

Silk-based hydrogel incorporated with metal-organic framework nanozymes for enhanced osteochondral regeneration

Zhicheng Cao et al.

Summary: In this study, a multifunctional silk-based hydrogel incorporated with metal-organic framework nanozymes (CuTA@SF) was developed to enhance osteochondral defect (OCD) regeneration. The CuTA@SF hydrogel exhibited enhanced cell proliferation, cell viability, antioxidant and antibacterial properties in vitro. Furthermore, it promoted MSC osteogenesis and deposition of cartilage-specific extracellular matrix (ECM) even under inflammatory conditions. In vivo experiments in a rabbit OCD model showed successful in situ OCD regeneration using CuTA@SF hydrogel. Thus, CuTA@SF hydrogel is a promising biomaterial for OCD regeneration.

BIOACTIVE MATERIALS (2023)

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Article Engineering, Environmental

Conductive hydrogels with hierarchical biofilm inhibition capability accelerate diabetic ulcer healing

Yuxin Zhang et al.

Summary: In this study, advanced hydrogels with stable conductivity and effective antibacterial properties were developed by incorporating antibacterial terbium ions into the hydrogel network. The hydrogel showed tremendous antibacterial effects and biomimetic conductivity, which enabled electrical stimulation (ES) treatment for diabetic ulcers (DUs) and accelerated wound healing.

CHEMICAL ENGINEERING JOURNAL (2023)

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Article Biochemistry & Molecular Biology

Collagen hydrogel with multiple antimicrobial mechanisms as anti-bacterial wound dressing

Xun Wang et al.

Summary: Wound infection by multidrug-resistant bacteria is a serious threat to human life. Chronic wounds, characterized by necrosis, persistent inflammation, and hypoxic tissue, pose significant challenges to anti-infection treatments. Therefore, a multifunctional hydrogel dressing has been developed to address these issues and promote wound healing. The hydrogel incorporates antimicrobial peptides, liposome-encapsulated oxygen carrier, and recombinant collagen, providing multiple antimicrobial mechanisms and improved healing for chronic wounds.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2023)

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Article Biochemistry & Molecular Biology

Photothermal and natural activity-based synergistic antibacterial effects of Ti3C2Tx MXene-loaded chitosan hydrogel against methicillin-resistant Staphylococcus aureus

Yuanhao Dong et al.

Summary: By loading MXene nanomaterial into non-crosslinked chitosan hydrogel, MX-CS hydrogel was developed to effectively treat MRSA infections through the adsorption of MRSA cells and MXene-induced photothermal therapy.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2023)

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Article Engineering, Biomedical

Aloe vera and ofloxacin incorporated chitosan hydrogels show antibacterial activity, stimulate angiogenesis and accelerate wound healing in full thickness rat model

Ahmad Khan et al.

Summary: This study developed wound dressings with good angiogenic and antibacterial activity by incorporating ofloxacin (OX) into chitosan (CS)/aloe vera (AV) based hydrogels. The 0.5 mg OX loaded hydrogel showed sustained drug release and promoted fibroblast cell proliferation. The OX incorporated CS/AV based hydrogels hold promise for future clinical use as wound dressings.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS (2023)

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Article Chemistry, Physical

A polyphenol-modified chitosan hybrid hydrogel with enhanced antimicrobial and antioxidant activities for rapid healing of diabetic wounds

Zejun Xu et al.

Summary: A hydrogel with enhanced antimicrobial and antioxidant properties (CMGFC) was developed to accelerate diabetic wound healing. The CMGFC hydrogel showed high antibacterial efficiency and strong ROS scavenging ability, protecting cells from oxidative stress. In vivo results demonstrated reduced inflammatory responses, enhanced angiogenesis, and improved wound healing with the CMGFC hydrogel.

NANO RESEARCH (2023)

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Article Biochemistry & Molecular Biology

Mxene-Based Supramolecular Composite Hydrogels for Antioxidant and Photothermal Antibacterial Activities

Zakia Riaz et al.

Summary: A new supramolecular antibacterial and antioxidant composite hydrogel made of L-phenylalanine-derivative and Mxene is introduced. The composite hydrogel shows improved mechanical properties and exhibits photothermal broad-spectrum antibacterial activities and excellent antioxidant activity. This chiral supramolecular composite hydrogel based on Mxene has great potential for biomedical applications.

MACROMOLECULAR BIOSCIENCE (2023)

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Article Food Science & Technology

Citric acid crosslinked ternary blended (polyvinyl alcohol, lignin, lemongrass essential oil/nanoemulsions) biopolymeric hydrogel films: structural, functional, antioxidant, antifungal and biodegradable properties

Isha Dudeja et al.

Summary: Rice straw contains three major biopolymers, cellulose, hemicellulose and lignin, which can be converted into high-value materials. In this study, lignin was extracted from rice straw and used to fabricate biopolymer films with the addition of lemongrass essential oil nanoemulsions. The resulting hydrogel films showed good physical, structural and functional properties, with high tensile strength, biodegradability, and antimicrobial and antioxidant activities. These films could be sustainable alternatives to synthetic plastic wraps in food packaging industries.

JOURNAL OF FOOD MEASUREMENT AND CHARACTERIZATION (2023)

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Article Pharmacology & Pharmacy

A Novel Approach for the Treatment of Aerobic Vaginitis: Azithromycin Liposomes-in-Chitosan Hydrogel

Ana Cacic et al.

Summary: This research aimed to prepare and evaluate several types of azithromycin (AZM)-liposomes incorporated into chitosan hydrogel (AZM-liposomal hydrogels) for the treatment of aerobic vaginitis. The AZM-liposomal hydrogels demonstrated sustained drug release, mucoadhesive properties, and inherent antimicrobial activity. Chitosan hydrogel prolonged the release of the liposomal drug and boosted its antibacterial effect. All AZM-liposomal hydrogels were biocompatible and showed suitable mechanical properties for vaginal application, confirming their potential for enhanced local therapy of aerobic vaginitis.

PHARMACEUTICS (2023)

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Article Engineering, Environmental

Injectable, antibacterial, ROS scavenging and pro-angiogenic hydrogel adhesives promote chronic wound healing in diabetes via synergistic release of NMN and Mg2+

Zhen Liang et al.

Summary: Diabetic wound care is a significant clinical problem due to the complex wound microenvironment. This study presents a novel injectable hydrogel for type II diabetic wound healing. The hydrogel exhibits multifunctional properties including antibacterial activity, ROS scavenging, and angiogenesis promotion. The results demonstrate that the hydrogel significantly accelerates diabetic wound healing, providing a feasible strategy for chronic diabetic wound repair.

CHEMICAL ENGINEERING JOURNAL (2023)

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Article Biophysics

3D-printed biosurfactant-chitosan antibacterial coating for the prevention of silicone-based associated infections

Francisco Narciso et al.

Summary: Infections associated with medical device surfaces are a significant concern due to biofilm formation and antibiotic resistance. This study presents a 3D-printed antimicrobial chitosan-biosurfactant hydrogel mesh that can coat silicone-based medical devices to prevent infections. The mesh structure allows for the incorporation of customized bioactive components, and the biosurfactant sophorolipids showed better antibacterial activity compared to surfactin. The resulting coatings demonstrated strong antibacterial and antibiofilm activity against Staphylococcus aureus while still being biocompatible with human dermal fibroblasts.

COLLOIDS AND SURFACES B-BIOINTERFACES (2023)

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Article Materials Science, Characterization & Testing

Preparation and application of poly (hydroxyl ethyl methacrylate) nanocomposite hydrogels containing iron oxide nanoparticles as wound dressing

Azin Paydayesh et al.

Summary: This study reports the preparation and application of pHEMA nanocomposite hydrogels containing iron oxide nanoparticles as wound dressings. The nanocomposite hydrogels exhibited good mechanical properties, suitable water vapor transmission rate and porosity, and higher cell survival rate and antibacterial properties compared to pure pHEMA.

POLYMERS & POLYMER COMPOSITES (2022)

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Article Polymer Science

New Insights of Scaffolds Based on Hydrogels in Tissue Engineering

Denisa-Maria Radulescu et al.

Summary: In recent years, the development and characterization of biomaterials for regenerative medicine and controlled release have posed significant challenges. Hydrogels are considered optimal applications in the biomedical field, particularly in tissue engineering. However, their delicate nature and low mechanical strength limit their use. Therefore, developing stronger and more stable hydrogels with increased biocompatibility is essential. Natural and synthetic polymers both have limitations, but the development of hydrogels based on mixtures of these materials can optimize their properties. Incorporating different nanoparticles can improve stability and yield various biological effects. Essential oils and drug molecules can facilitate desired biological effects and even produce a synergistic effect. The main purpose of this study is to identify the key properties required to develop sustainable polymeric scaffolds for tissue engineering without adverse environmental effects.

POLYMERS (2022)

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Article Engineering, Biomedical

In vivo evaluation of temperature-responsive antimicrobial-loaded PNIPAAm hydrogels for prevention of surgical site infection

John M. Heffernan et al.

Summary: The study evaluated the safety and efficacy of PNDJ hydrogel carriers for antimicrobial delivery in surgical sites, showing good tolerance in various surgical procedures and potential for reducing the incidence of SSIs.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS (2022)

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Review Engineering, Environmental

An Overview on Starch-Based Sustainable Hydrogels: Potential Applications and Aspects

Md. Qamruzzaman et al.

Summary: Hydrogels are a popular area of research due to their water imbibing capacity and potential applications in various fields, while starch-based hydrogels have gained attention for being eco-friendly, readily available, and widely applicable.

JOURNAL OF POLYMERS AND THE ENVIRONMENT (2022)

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Article Polymer Science

Radiation Synthesis of Hydrogels with Silver Nanoparticles for Use as an Antimicrobial Burn Wound Dressing

Rita Singh et al.

Summary: This study reports a method for synthesizing silver nanoparticles and using them in hydrogel for burn wound management. The hydrogel with incorporated silver nanoparticles exhibited good fluid absorption capacity and antimicrobial efficacy, making it suitable for controlling microbial infection and enhancing burn wound healing.

POLYMER SCIENCE SERIES B (2022)

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Article Multidisciplinary Sciences

Assessment of persistent antimicrobial and anti-biofilm activity of p-HEMA hydrogel loaded with rifampicin and cefixime

Ola Tarawneh et al.

Summary: This study aims to improve urological biomaterials to reduce the incidence of Catheter-associated urinary tract infections (CAUTIs). By loading drugs onto the poly-2-hydroxyethyl methacrylate (p-HEMA) material, the formation of mixed biofilms can be reduced, demonstrating good resistance to biofilm attachment and persistent antimicrobial activity, with no significant cytotoxic effects on cells.

SCIENTIFIC REPORTS (2022)

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Review Pharmacology & Pharmacy

Advances in Hydrogel-Based Microfluidic Blood-Brain-Barrier Models in Oncology Research

Ankur Sood et al.

Summary: The complexity of the brain restricts the effectiveness of therapeutic molecules, but advancements in microfluidics have enabled the development of in vitro platforms that mimic the blood-brain barrier. Hydrogel-based models serve as stages for cell growth and nutrient exchange, facilitating research and screening of chemotherapeutic agents for brain malignancies.

PHARMACEUTICS (2022)

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Article Chemistry, Applied

Preparation and properties of O-chitosan quaternary ammonium salt/polyvinyl alcohol/graphene oxide dual self-healing hydrogel

Jilong Cao et al.

Summary: A dual self-healing bacteriostatic hydrogel (O-HACC/PVA/GO) was successfully prepared and characterized in this study. The hydrogel showed high equilibrium swelling rate, compressive strength, and self-healing ability. It also exhibited excellent antibacterial properties and non-toxicity to cells. This research has potential significance in the field of biomedicine.

CARBOHYDRATE POLYMERS (2022)

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Article Polymer Science

Biocompatibility and Antimicrobial Investigation of Agar-Tannic Acid Hydrogel Reinforced with Silk Fibroin and Zinc Manganese Oxide Magnetic Microparticles

Fatemeh Ganjali et al.

Summary: In this study, a three-dimensional cross-linked hydrogel was synthesized using agarose and tannic acid, and silk fibroin and zinc manganese oxide magnetic microparticles were added for biomedical applications. The biocomposite scaffold showed desirable biological capacity, including cell viability, hemolysis, and anti-biofilm activity.

JOURNAL OF INORGANIC AND ORGANOMETALLIC POLYMERS AND MATERIALS (2022)

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Article Engineering, Environmental

PVA/CMC/Attapulgite Clay Composite Hydrogel Membranes for Biomedical Applications: Factors Affecting Hydrogel Membranes Crosslinking and Bio-evaluation Tests

Eman Farid et al.

Summary: In this study, polyvinyl alcohol-carboxymethyl cellulose composite hydrogel membranes were prepared with the addition of citric acid and attapulgite clay. The results showed that these membranes have potential as biomaterials for dermal wound dressings.

JOURNAL OF POLYMERS AND THE ENVIRONMENT (2022)

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Article Chemistry, Multidisciplinary

Tailored Hydrogel Delivering Niobium Carbide Boosts ROS-Scavenging and Antimicrobial Activities for Diabetic Wound Healing

Jing Chen et al.

Summary: In this study, an injectable thermosensitive niobium carbide (Nb2C)-based hydrogel (Nb2C@Gel) was developed to promote diabetic wound healing. The system showed antioxidative and antimicrobial activity, as it efficiently eliminated reactive oxygen species (ROS) and exhibited near-infrared (NIR) photothermal antimicrobial activity. In vivo experiments demonstrated that Nb2C@Gel reduced oxidative damage, eradicated bacterial infection, and accelerated angiogenesis, thus promoting wound healing.

SMALL (2022)

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Article Medicine, Research & Experimental

Polyurethane based hybrid ciprofloxacin-releasing wound dressings designed for skin engineering purpose

Iga Carayon et al.

Summary: In this study, a promising hybrid Cipro-releasing hydrogel wound dressing was developed with biocompatibility and antimicrobial activity, as evidenced by a series of tests. These results are important for designing acceptable solutions in the management of chronic wounds with high potential for infection.

ADVANCES IN MEDICAL SCIENCES (2022)

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Article Chemistry, Applied

Novel chitosan based metal-organic polyhedrons/enzyme hybrid hydrogel with antibacterial activity to promote wound healing

Jie Song et al.

Summary: This study developed a novel chitosan based metal-organic polyhedrons (MOPs)/enzyme hybrid hydrogel with superior antimicrobial properties for wound healing treatment. The hydrogel exhibited excellent bactericidal effect on both gram-negative and gram-positive bacteria, and also showed good cell compatibility. In vivo experiments demonstrated that the hydrogel effectively promoted wound healing. These findings suggest that chitosan based MOPs/enzyme hybrid hydrogel holds great potential for antibacterial therapy in clinical applications.

CARBOHYDRATE POLYMERS (2022)

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Article Biochemistry & Molecular Biology

Formation of biocompatible MgO/cellulose grafted hydrogel for efficient bactericidal and controlled release of doxorubicin

Iram Shahzadi et al.

Summary: In this study, MgO-doped CNC-g-PAA hydrogel was synthesized for antibacterial and anti-cancer activities. The hydrogel showed improved bactericidal tendencies and controlled drug release, making it a prospective carrier for therapeutic applications.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)

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Article Biochemistry & Molecular Biology

Modified gelatin/iron- based metal-organic framework nanocomposite hydrogel as wound dressing: Synthesis, antibacterial activity, and Camellia sinensis release

Sepideh Hezari et al.

Summary: A new kind of nanocomposite hydrogel based on modified gelatin/iron-metal-organic framework was developed as an antibacterial wound dressing. The hydrogel showed enhanced porosity, mechanical strength, and drug loading capability. It also exhibited sustained release of the antibacterial herbal drug Camellia sinensis and effectively inhibited the growth of various bacteria.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)

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Article Polymer Science

Hydroxyapatite Reinforced Polyvinyl Alcohol/Polyvinyl Pyrrolidone Based Hydrogel for Cartilage Replacement

Mallikarjun B. Jalageri et al.

Summary: Polyvinyl alcohol (PVA) and Polyvinyl Pyrrolidone (PVP) hydrogels were blended with one-dimensional hydroxyapatite nanorods (HNr) to synthesize a PVA/PVP/HNr composite hydrogel. The developed hydrogel exhibited improved mechanical strength and bioactivity. It showed satisfactory antimicrobial activity against bacterial species and demonstrated good in vitro biocompatibility, making it a promising alternative for next-generation cartilage substitutes.

GELS (2022)

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Review Polymer Science

Progress in Antibacterial Hydrogel Dressing

Jie Liu et al.

Summary: Antibacterial hydrogel is widely used in biomedical, intelligent textiles, cosmetics, and other fields, especially in medical dressings. It has the characteristics of absorbing wound liquid, controlling drug release, and its preparation method is simple with easily accessible materials.

GELS (2022)

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Article Engineering, Electrical & Electronic

A temperature responsive adhesive hydrogel for fabrication of flexible electronic sensors

Wan Liu et al.

Summary: This study designed a skin-friendly conductive hydrogel with temperature-triggered tunable mechanic, which can reliably adhere to skin and detect electrophysiological signals while being easily removed. The hydrogel also has additional advantages of transparency, breathability, and antimicrobial activity, making it suitable for long-time wear and environmentally friendly and cost-saving.

NPJ FLEXIBLE ELECTRONICS (2022)

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Article Polymer Science

Inherent and Composite Hydrogels as Promising Materials to Limit Antimicrobial Resistance

Rahela Carpa et al.

Summary: Antibiotic resistance has become a global problem, leading to the development of various technologies for controlling healthcare-associated infections. This review discusses the development and application of antimicrobial hydrogels, as well as the need for new carriers for the delivery of CRISPR-Cas9 system.

GELS (2022)

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Article Polymer Science

In Situ Growth of Zeolitic Imidazolate Framework-L in Macroporous PVA/CMC/PEG Composite Hydrogels with Synergistic Antibacterial and Rapid Hemostatic Functions for Wound Dressing

Hang Yang et al.

Summary: In this study, a novel composite hydrogel was prepared using polyvinyl alcohol, carboxymethyl cellulose, and polyethylene glycol. The hydrogel exhibited excellent hemostatic and antibacterial properties, promoting blood clotting and inhibiting the growth of Staphylococcus aureus.

GELS (2022)

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Article Chemistry, Applied

Novel chitosan based metal-organic polyhedrons/enzyme hybrid hydrogel with antibacterial activity to promote wound healing

Jie Song et al.

Summary: This study aims to develop a novel chitosan based metal-organic polyhedrons (MOPs)/enzyme hybrid hydrogel with superior antimicrobial properties for wound healing treatment. The results show that the hydrogel exhibits better bactericidal effect and good cell compatibility, effectively facilitating wound healing. Therefore, the chitosan based MOPs/enzyme hybrid hydrogel holds great promise for antibacterial therapy in clinical applications.

CARBOHYDRATE POLYMERS (2022)

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Article Polymer Science

Versatility of Hydrogels: From Synthetic Strategies, Classification, and Properties to Biomedical Applications

Zubair Ahmad et al.

Summary: This review discusses the importance and applications of hydrogels in the field of biomedicine, including synthetic strategies, characterization, and various application areas. It provides guidance for tracking, designing, and using hydrogels.

GELS (2022)

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Article Engineering, Environmental

An NIR-II light responsive antibacterial gelation for repetitious photothermal/thermodynamic synergistic therapy

Qinzhe Li et al.

Summary: An acidity-responsive near infrared light-triggered injectable hydrogel was designed for non-antibiotic local treatment of drug-resistant bacterial infection. The hydrogel demonstrated strong photothermal property and antibacterial effects, effectively reducing bacterial burden and promoting collagen deposition during treatment.

CHEMICAL ENGINEERING JOURNAL (2021)

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Article Chemistry, Physical

Aluminum nanoparticles, chitosan, acrylic acid and vinyltrimethoxysilane based hybrid hydrogel as a remarkable water super-absorbent and antimicrobial activity

Mehvish Tanveer et al.

Summary: Biodegradable superabsorbent hydrogels derived from chitosan and acrylic acid, cross-linked with vinyltrimethoxysilane, were fabricated and characterized in this study. By incorporating alumina nanoparticles, a series of SAHs with varying swelling ratios were produced. The concentration of nanoparticles had a significant effect on the swelling ratio, with the highest ratio observed in the CAC 0.08 sample containing a higher concentration of Al NPs. The synthesized SAHs exhibited superior antimicrobial and biodegradable properties, making them suitable for soil conditioning in arid areas.

SURFACES AND INTERFACES (2021)

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Article Materials Science, Multidisciplinary

PVA/Poly(hexamethylene guanidine)/Gallic Acid Composite Hydrogel Films and Their Antibacterial Performance

Xu Yang et al.

Summary: A composite hydrogel film based on PVA with excellent antibacterial properties and antioxidant activity was prepared, showing potential for biomedical applications as wound dressings. The presence of gallic acid in the composite films contributes to both the antibacterial and antioxidant effects.

ACS APPLIED POLYMER MATERIALS (2021)

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Article Nanoscience & Nanotechnology

Polydopamine-coated chitosan hydrogel beads for synthesis and immobilization of silver nanoparticles to simultaneously enhance antimicrobial activity and adsorption kinetics

Taoran Wang et al.

Summary: In this study, chitosan-based hydrogel beads immobilized with silver nanoparticles were prepared to enhance antimicrobial and adsorption activity, showing potential for controlling both chemical and biological contaminants in wastewater. The presence of AgNPs improved the adsorption capacity of the beads and exhibited higher antimicrobial activity against Gram-negative bacteria compared to Gram-positive bacteria.

ADVANCED COMPOSITES AND HYBRID MATERIALS (2021)

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Article Materials Science, Biomaterials

A rose bengal/graphene oxide/PVA hybrid hydrogel with enhanced mechanical properties and light-triggered antibacterial activity for wound treatment

Yanan Li et al.

Summary: This study prepared a graphene oxide/rose bengal/polyvinyl alcohol hybrid hydrogel, demonstrating both excellent antibacterial activity and enhanced mechanical properties. The hybrid hydrogel showed outstanding biocompatibility and water-absorbing capacity, accelerating wound healing and preventing bacterial infection simultaneously.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Article Biochemistry & Molecular Biology

Cationic peptide-based salt-responsive antibacterial hydrogel dressings for wound healing

Jingfeng Yuan et al.

Summary: A cationic peptide-based, salt-responsive hydrogel dressing with triple functions of antifouling, bactericidal, and bacterial release was developed, demonstrating high antibacterial activity, biocompatibility, and cell proliferation efficacy.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Article Chemistry, Physical

DNA mediated graphene oxide (GO)-nanosheets dispersed supramolecular GO-DNA hydrogel: An efficient soft-milieu for simplistic synthesis of Ag-NPs@GO-DNA and Gram plus ve/-ve bacteria-based Ag-NPs@GO-DNA-bacteria nano-bio composites

Santanu Majumdar et al.

Summary: The formation of a flexible supramolecular hydrogel structure based on DNA and graphene oxide nanosheets leads to the achievement of nano-bio functionality. This hydrogel is utilized for the synthesis of functional silver nanoparticles and the production of smart bacteria-mediated nano-bio composites. Gram-positive and Gram-negative bacteria are employed to offer stability and catalytic effects on the silver nanoparticles.

JOURNAL OF MOLECULAR LIQUIDS (2021)

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Article Parasitology

Influence of gamma radiation on Amphotericin B incorporated in PVP hydrogel as an alternative treatment for cutaneous leishmaniosis

Maria Jose Alves de Oliveira et al.

Summary: The study focused on analyzing the effects of Cobalt-60 gamma irradiation on crosslinking polymeric hydrogels containing Amphotericin B, in order to develop an alternative treatment method for leishmaniasis. The irradiated Hydg/Amph-B showed similar stability to the standard Amph-B solution and effectively inhibited L. amazonensis promastigotes, demonstrating its potential as a promising alternative therapy.

ACTA TROPICA (2021)

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Article Chemistry, Applied

Hydroxypropyl methylcellulose-copper nanoparticle and its nanocomposite hydrogel films for antibacterial application

Tippabattini Jayaramudu et al.

Summary: This study focuses on the design and fabrication of antibacterial nanocomposite hydrogels for wound dressing applications, with particular emphasis on HCu NPs incorporated HPMC NHFs. The antibacterial activity of the NHFs against S. aureus and E. coli was demonstrated, suggesting their effectiveness for antibacterial applications.

CARBOHYDRATE POLYMERS (2021)

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Article Biochemistry & Molecular Biology

Enhanced anti-cancer activity by localized delivery of curcumin form PVA/CNCs hydrogel membranes: Preparation and in vitro bioevaluation

Yasmein Hussein et al.

Summary: In this study, a curcumin-loaded polyvinyl alcohol/cellulose nanocrystals (PVA/CNCs) membrane was developed as a localized delivery system for breast/liver cancer, exhibiting selective cytotoxicity towards cancer cells and antimicrobial activity against multi-drug-resistant strains. The membranes showed biphasic-release of curcumin and inhibited microbial growth up to 96-99%, making them promising anti-infective biomaterials for breast and liver cancer wound healing.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Article Biochemistry & Molecular Biology

Bioactive Carboxymethyl Starch-Based Hydrogels Decorated with CuO Nanoparticles: Antioxidant and Antimicrobial Properties and Accelerated Wound Healing In Vivo

Zahra Abdollahi et al.

Summary: The study synthesized nanocomposite hydrogels containing CuO nanoparticles for wound healing applications. The hydrogels exhibited antibacterial and antioxidant activities, low cytotoxicity, and good biocompatibility, showing potential for accelerating wound healing. Incorporation of CuO nanoparticles improved the hydrogel's antibacterial properties, antioxidant activity, and swelling capacity.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Materials Science, Composites

Synthesis of novel silver nanocomposite hydrogels based on polyurethane/poly(ethylene glycol) via aqueous extract of oak fruit and their antibacterial and mechanical properties

Sohrab Rahmani et al.

Summary: Novel hydrogels based on polyurethane/polyethylene glycol and their silver nanocomposites were developed using click chemistry and a green method. Introduction of silver nanoparticles significantly enhanced the mechanical properties and antibacterial activity of the hydrogels, particularly against Staphylococcus aureus bacteria. The biocompatibility of these nanocomposites makes them promising candidates for wound dressing applications.

POLYMER COMPOSITES (2021)

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Review Chemistry, Multidisciplinary

Mechanical Properties of DNA Hydrogels: Towards Highly Programmable Biomaterials

Joshua Bush et al.

Summary: DNA hydrogels are programmable biomaterials with controllable mechanical properties and composition, suitable for various biomedical applications. Recent studies show that DNA hydrogels can respond to stimuli such as pH, light, and temperature. Research has also explored the impact of factors like linker flexibility, functionality, and chemical crosslinking on the mechanical properties of DNA hydrogels.

APPLIED SCIENCES-BASEL (2021)

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Article Materials Science, Multidisciplinary

A novel design of wound bandage using heparin-polyvinylpyrrolidone/TiO2 nanocomposite to improved antibacterial treatment and burn wound healing effect: In vitro and in vivo evaluation

Xiuli Li et al.

Materials Express (2021)

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Article Chemistry, Applied

Fabrication of an injectable iron (III) crosslinked alginate-hyaluronic acid hydrogel with shear-thinning and antimicrobial activities

Fangyuan Shuai et al.

Summary: In this study, an ionic-crosslinked alginate-hyaluronic acid hydrogel with shear-thinning property and injectability was successfully developed through simple assembly of alginate-hyaluronic acid mixture and Fe3+ complex. This hydrogel showed potential long-term antibacterial activities against multiple types of bacteria, including gram-negative Escherichia coli and gram-positive Staphylococcus aureus, as well as oral pathogenic bacteria Streptococcus mutans and Porphyromonas gingivalis.

CARBOHYDRATE POLYMERS (2021)

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Article Engineering, Environmental

Dual-crosslinked mussel-inspired smart hydrogels with enhanced antibacterial and angiogenic properties for chronic infected diabetic wound treatment via pH-responsive quick cargo release

Cheng Hu et al.

Summary: The study successfully overcame the challenges in healing chronic diabetic wounds, such as bacterial infections and difficulty in angiogenesis, by using a pH-responsive double-crosslinking hydrogel.

CHEMICAL ENGINEERING JOURNAL (2021)

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Article Engineering, Environmental

Electrospun polyvinylpyrrolidone (PVP) hydrogels containing hydroxycinnamic acid derivatives as potential wound dressings

Marco Contardi et al.

Summary: The study proposes a solution to the rapid dissolution of PVP in water hindering its use in sustained release formulations, by developing PVP-based fiber hydrogels combined with hydroxycinnamic acid derivatives. The hydrogel fiber dressings showed antioxidant release capabilities and protection against oxidative stresses for epithelial cells, indicating promising potential for wound dressings.

CHEMICAL ENGINEERING JOURNAL (2021)

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Article Chemistry, Multidisciplinary

Nanoengineered Peptide-Based Antimicrobial Conductive Supramolecular Biomaterial for Cardiac Tissue Engineering

Priyadarshi Chakraborty et al.

Summary: This di-Fmoc-based hydrogelator containing the RGD fragment exhibits good cell adhesion capacity and achieves semiconductivity by incorporating polyaniline into the hydrogel network, demonstrating excellent antibacterial activity and DNA binding capacity while supporting the growth of functional synchronized monolayers of cardiac cells.

ADVANCED MATERIALS (2021)

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Article Chemistry, Applied

Controlled release of iodine from cross-linked cyclodextrin metal-organic frameworks for prolonged periodontal pocket therapy

Shan Lu et al.

Summary: An effective therapeutic system for periodontitis was developed using COF as a carrier for iodine, with the resulting I2@COF-HEC hydrogel showing extended release of iodine in vitro and similar effects to minocycline ointment in reducing periodontal symptoms in an in vivo rat model of periodontitis. This novel local delivery device of iodine holds promise for broad spectrum antimicrobial use in treating periodontitis.

CARBOHYDRATE POLYMERS (2021)

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Review Biochemistry & Molecular Biology

Recent advances of emerging green chitosan-based biomaterials with potential biomedical applications: A review

Ajahar Khan et al.

Summary: Chitosan, as a natural biopolymer, shows ecological sustainability and flexibility, making it a promising candidate for a wide range of applications. Research has found that nanomaterials based on chitosan and its derivatives play a significant role in biomedical applications, improving stability, promoting drug release, and increasing bioavailability.

CARBOHYDRATE RESEARCH (2021)

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Article Biochemistry & Molecular Biology

Starch based hydrogel NPs loaded by anthocyanins might treat glycogen storage at cardiomyopathy in animal fibrotic model

Nemany A. N. Hanafy

Summary: The encapsulation of anthocyanins in hydrogel nanoparticles can enhance their retention in the heart, improve glycogen content in liver and heart tissues, reduce oxidative stress and fibrosis, and enhance histological cardiac functions after injury.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Article Biochemistry & Molecular Biology

Copper metal-organic framework embedded carboxymethyl chitosan-g-glutathione/polyacrylamide hydrogels for killing bacteria and promoting wound healing

Meng Wang et al.

Summary: HKUST-Hs is a novel hydrogel dressing with dual effects of antibacterial and antioxidant, promoting wound healing through the synergistic effect of slow-released copper ions and CMCs-GSH.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Article Polymer Science

Hybrid antibacterial hydrogels based on PVP and keratin incorporated with lavender extract

Faezeh Tajik et al.

Summary: In this study, hybrid hydrogels were fabricated using a mixture of PVP and keratin with the addition of hydrogen peroxide for crosslinking. The optimal sample had a PVP:keratin ratio of 3:1 and exhibited good antibacterial properties when herbal lavender extract was incorporated. The release profile of the extract demonstrated a diffusion mechanism, and the hydrogels showed potential applications in wound dressing with their effective antibacterial properties against gram-negative and gram-positive bacteria.

JOURNAL OF POLYMER RESEARCH (2021)

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Article Materials Science, Multidisciplinary

Highly Stretchable, Strain-Sensitive, and Antifreezing Macromolecular Microsphere Composite Starch-Based Hydrogel

Shengqu Liu et al.

Summary: This study successfully investigated starch-based hydrogels with high stretchability and conducting capacity, and developed double-network hydrogels with excellent mechanical properties, which can be applied in resistance-type strain sensors.

MACROMOLECULAR MATERIALS AND ENGINEERING (2021)

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Article Chemistry, Medicinal

Preparation of Cross-linked Chitosan Quaternary Ammonium Salt Hydrogel Films Loading Drug of Gentamicin Sulfate for Antibacterial Wound Dressing

Jingjing Zhang et al.

Summary: The study successfully obtained a series of novel CTMCSG hydrogel films with good water stability, thermal stability, drug release capacity, and antibacterial property. The properties of the hydrogel films improved with an increase in the amount of the cross-linking agent, resulting in reduced water vapor permeability.

MARINE DRUGS (2021)

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Article Materials Science, Biomaterials

Improved drug delivery and accelerated diabetic wound healing by chondroitin sulfate grafted alginate-based thermoreversible hydrogels

Syed Ahmed Shah et al.

Summary: This study presents an injectable hydrogel based on chondroitin sulphate and sodium alginate loaded with curcumin for diabetic wound repair. The hydrogel demonstrated good biocompatibility and tissue regeneration ability, with controlled release of curcumin showing promising results in promoting wound healing.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Article Materials Science, Biomaterials

Bio-hybrid hydrogel comprising collagen-capped silver nanoparticles and melatonin for accelerated tissue regeneration in skin defects

Murali Ragothaman et al.

Summary: Hydrogel-based drug delivery system shows promise in treating chronic tissue defects by inhibiting pathogenic infection and accelerating tissue regeneration. A stable bio-hybrid hydrogel system with antimicrobial, antioxidant and anti-inflammatory properties was developed. The bio-hybrid hydrogel exhibited better properties in terms of gelation, surface morphology, rheology and degelation.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Article Materials Science, Characterization & Testing

A facile approach to incorporate silver nanoparticles into solvent-free synthesized PEG-based hydrogels for antibacterial and catalytical applications

Fahimeh Kazeminava et al.

Summary: This study aimed to immobilize silver nanoparticles with catalytic and antibacterial activity inside PEG-based hydrogels through a simple and environmentally friendly design. The resulting nanocomposite hydrogels showed excellent antibacterial activity, catalytic efficiency, dispersion, and production efficiency.

POLYMER TESTING (2021)

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Review Polymer Science

Applications of Biopolymers for Drugs and Probiotics Delivery

Roxana Gheorghita et al.

Summary: Research on the use of biopolymers in pharmaceutical industries has gained attention in recent years, especially as encapsulation materials for controlled drug delivery systems. Challenges and limitations in integrating polymer-derived materials with product delivery optimization exist, but there are also potential benefits in developing new applications.

POLYMERS (2021)

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Article Chemistry, Multidisciplinary

Effect of Tannic Acid and Cellulose Nanocrystals on Antioxidant and Antimicrobial Properties of Gelatin Films

Liliane Samara Ferreira Leite et al.

Summary: By incorporating CNC and nTA into gelatin films, the resulting materials showed improved antioxidant, UV barrier, tensile strength, and water vapor barrier properties. Additionally, the films displayed antimicrobial effects against Staphylococcus aureus and Escherichia coli, suggesting their potential as sustainable and multifunctional materials for food packaging and beyond.

ACS SUSTAINABLE CHEMISTRY & ENGINEERING (2021)

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Article Pharmacology & Pharmacy

Dual Cross-Linked Chitosan/PVA Hydrogels Containing Silver Nanoparticles with Antimicrobial Properties

Dana M. Suflet et al.

Summary: Stable chitosan/PVA-based hydrogels were obtained through a combination of covalent and physical cross-linking methods. The chemical structure and morphology of the hydrogel were analyzed, showing that gel fraction and network morphology were influenced by synthesis conditions. The hydrogels exhibited high swelling rate and low elastic modulus, making them suitable for medical applications; in situ generation of silver nanoparticles under UV irradiation enhanced the antimicrobial activity of chitosan.

PHARMACEUTICS (2021)

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Article Biotechnology & Applied Microbiology

3D Printing of Thermoresponsive Hydrogel Laden with an Antimicrobial Agent towards Wound Healing Applications

Martyna Niziol et al.

Summary: Thermoresponsive hydrogel-based wound dressings with antimicrobial agent were fabricated using 3D printing technology. The ink containing PNIPAAm precursors, ALG, MC and OCT showed accurate printability and drug release profiles. The hydrogel exhibited antimicrobial activity, biocompatibility, and controlled drug release, making it a promising material for wound dressing applications.

BIOENGINEERING-BASEL (2021)

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Review Nanoscience & Nanotechnology

Hybrid Gelatin Hydrogels in Nanomedicine Applications

Bidita Salahuddin et al.

Summary: Gelatin-based hydrogels combined with supporting materials are widely used in nanomedicine, exhibiting unique properties and various applications. Research on the fabrication methods and applications of hydrogels, as well as the characterization of related materials and application challenges, has been conducted.

ACS APPLIED BIO MATERIALS (2021)

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Review Pharmacology & Pharmacy

Hydrogels as potential drug-delivery systems: network design and applications

Hina Shoukat et al.

Summary: Hydrogels have a high water absorption capacity and can swell under physiological conditions, they are responsive to external stimuli (such as pH, temperature), have biodegradable and biocompatible properties, and play an important role in drug delivery.

THERAPEUTIC DELIVERY (2021)

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Article Multidisciplinary Sciences

Carboxymethyl Cellulose-Based Hydrogel: Dielectric Study, Antimicrobial Activity and Biocompatibility

Gamal Turky et al.

Summary: This study investigated the antimicrobial activity, biocompatibility, and electrical conductivity of polypyrrole on conducting hydrogels. The results showed that the addition of polypyrrole improved the conductivity and permittivity of the hydrogels, reduced energy loss, and maintained good compatibility with cells. The prepared hydrogels also demonstrated strong potential for energy storage systems and displayed excellent antimicrobial activity against various pathogens.

ARABIAN JOURNAL FOR SCIENCE AND ENGINEERING (2021)

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Article Immunology

Vancomycin-loaded oxidized hyaluronic acid and adipic acid dihydrazide hydrogel: Bio-compatibility, drug release, antimicrobial and biofilm model

Chun-Hsing Liao et al.

JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION (2020)

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Review Chemistry, Multidisciplinary

Biomedical Applications of DNA-Based Hydrogels

Jasmina Gacanin et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Article Surgery

Efficacy of antimicrobial agents delivered to hernia meshes using an adaptable thermo-responsive hyaluronic acid-based coating

B. Perez-Kohler et al.

HERNIA (2020)

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Article Biochemistry & Molecular Biology

Material properties and cell compatibility of poly(γ-glutamic acid)-keratin hydrogels

Maryam Ijadi Bajestani et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

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Article Biochemistry & Molecular Biology

In situ formation of silver nanoparticles-contained gelatin-PEG-dopamine hydrogels via enzymatic cross-linking reaction for improved antibacterial activities

Thi-Ngoc Pham et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

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Article Nanoscience & Nanotechnology

Hydrogel-Coated Dental Device with Adhesion-Inhibiting and Colony-Suppressing Properties

Liying Peng et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Engineering, Biomedical

Encapsulation of collagen mimetic peptide-tethered vancomycin liposomes in collagen-based scaffolds for infection control in wounds

Raj Kumar Thapa et al.

ACTA BIOMATERIALIA (2020)

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Article Engineering, Biomedical

Self-healing DNA-based injectable hydrogels with reversible covalent linkages for controlled drug delivery

Sayantani Basu et al.

ACTA BIOMATERIALIA (2020)

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Article Chemistry, Physical

Enhanced photocatalytic activity and photothermal effects of cu-doped metal-organic frameworks for rapid treatment of bacteria-infected wounds

Donglin Han et al.

APPLIED CATALYSIS B-ENVIRONMENTAL (2020)

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Article Biochemistry & Molecular Biology

Synthesis of Silver Nanoparticles Using Curcumin-Cyclodextrins Loaded into Bacterial Cellulose-Based Hydrogels for Wound Dressing Applications

Abhishek Gupta et al.

BIOMACROMOLECULES (2020)

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Article Polymer Science

Polyurethane-based hydrogels for controlled drug delivery applications

Musa Kamaci

EUROPEAN POLYMER JOURNAL (2020)

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Article Biochemistry & Molecular Biology

The role of cellulose nanocrystals in biocompatible starch-based clicked nanocomposite hydrogels

Kizkitza Gonzalez et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

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Article Engineering, Environmental

Design of AgNPs -Base Starch/PEG-Poly (Acrylic Acid) Hydrogel for Removal of Mercury (II)

Atefeh Saberi et al.

JOURNAL OF POLYMERS AND THE ENVIRONMENT (2020)

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Article Chemistry, Applied

Cysteine conjugated chitosan based green nanohybrid hydrogel embedded with zinc oxide nanoparticles towards enhanced therapeutic potential of naringenin

Dhanya George et al.

REACTIVE & FUNCTIONAL POLYMERS (2020)

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Article Chemistry, Multidisciplinary

Development of silver nanoparticle-based hydrogel composites for antimicrobial activity

Maulida Zakia et al.

GREEN CHEMISTRY LETTERS AND REVIEWS (2020)

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Article Nanoscience & Nanotechnology

Novel Metal-Organic Framework-Based Photocrosslinked Hydrogel System for Efficient Antibacterial Applications

Kihak Gwon et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Nanoscience & Nanotechnology

Nanoparticle-Loaded Hydrogel for the Light-Activated Release and Photothermal Enhancement of Antimicrobial Peptides

Samuel C. T. Moorcroft et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Materials Science, Biomaterials

Cytotoxicity and Antibacterial Activity of Alginate Hydrogel Containing Nitric Oxide Donor and Silver Nanoparticles for Topical Applications

Alessandro L. Urzedo et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2020)

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Review Polymer Science

Proteins and Peptides as Important Modifiers of the Polymer Scaffolds for Tissue Engineering Applications-A Review

Katarzyna Klimek et al.

POLYMERS (2020)

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Article Chemistry, Multidisciplinary

Three-Dimensional (3D) Printed Silver Nanoparticles/Alginate/Nanocrystalline Cellulose Hydrogels: Study of the Antimicrobial and Cytotoxicity Efficacy

Carlo Bergonzi et al.

NANOMATERIALS (2020)

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Article Nanoscience & Nanotechnology

Encapsulation of Lactobacillus rhamnosus in Hyaluronic Acid-Based Hydrogel for Pathogen-Targeted Delivery to Ameliorate Enteritis

Yao Xiao et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Chemistry, Multidisciplinary

Construction of Chitosan-Based Hydrogel Incorporated with Antimonene Nanosheets for Rapid Capture and Elimination of Bacteria

Yingnan Liu et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Article Microbiology

Topical Antibiotic Elution in a Collagen-Rich Hydrogel Successfully Inhibits Bacterial Growth and Biofilm Formation In Vitro

Jung Gi Min et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2020)

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Article Biophysics

Biomimetic hydrogels based on L-Dopa conjugated gelatin as pH-responsive drug carriers and antimicrobial agents

Thi-Ngoc Pham et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2020)

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Article Biochemistry & Molecular Biology

Lignin-Bimetallic Nanoconjugate Doped pH-Responsive Hydrogels for Laser-Assisted Antimicrobial Photodynamic Therapy

Sanjam Chandna et al.

BIOMACROMOLECULES (2020)

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Article Engineering, Biomedical

Injectable redox and light responsive MnO2 hybrid hydrogel for simultaneous melanoma therapy and multidrug-resistant bacteria-infected wound healing

Shenqiang Wang et al.

BIOMATERIALS (2020)

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Article Biochemistry & Molecular Biology

Anti-staphylococcal hydrogels based on bacterial cellulose and the antimicrobial biopolyester poly

Virginia Rivero-Buceta et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

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Article Biochemistry & Molecular Biology

Bioinspired sodium alginate based thermosensitive hydrogel membranes for accelerated wound healing

Asma Riaz Abbasi et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

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Article Biochemistry & Molecular Biology

Enhanced antimicrobial activity and pH-responsive sustained release of chitosan/poly (vinyl alcohol)/graphene oxide nanofibrous membrane loading with allicin

Yongxu Liu et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

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Article Pharmacology & Pharmacy

Application of arti ficial intelligence in modeling of the doxorubicin release behavior of pH and temperature responsive poly(NIPAAm-co-AAc)-PEG IPN hydrogel

Cihangir Boztepe et al.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2020)

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Article Engineering, Environmental

Carbon dot cross-linked polyvinylpyrrolidone hybrid hydrogel for simultaneous dye adsorption, photodegradation and bacterial elimination from waste water

Suman Nayak et al.

JOURNAL OF HAZARDOUS MATERIALS (2020)

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Article Chemistry, Applied

Hyaluronic acid-based antibacterial hydrogels constructed by a hybrid crosslinking strategy for pacemaker pocket infection prevention

Quanbin Dong et al.

CARBOHYDRATE POLYMERS (2020)

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Article Engineering, Environmental

Rapid bacteria trapping and killing of metal-organic frameworks strengthened photo-responsive hydrogel for rapid tissue repair of bacterial infected wounds

Donglin Han et al.

CHEMICAL ENGINEERING JOURNAL (2020)

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Article Polymer Science

pH-Sensitive Starch-Based Hydrogels: Synthesis and Effect of Molecular Components on Drug Release Behavior

Juan Carlos Quintanilla de Stefano et al.

POLYMERS (2020)

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Review Materials Science, Biomaterials

Functional DNA Based Hydrogels: Development, Properties and Biological Applications

Vinod Morya et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2020)

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Article Biochemistry & Molecular Biology

Novel chitosan/guar gum/PVA hydrogel: Preparation, characterization and antimicrobial activity evaluation

Dure N. Iqbal et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

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Article Biochemistry & Molecular Biology

Catalytic potential of cobalt oxide and agar nanocomposite hydrogel for the chemical reduction of organic pollutants

Ashi Khalil et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

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Review Biochemistry & Molecular Biology

Chitosan and Cellulose-Based Hydrogels for Wound Management

Sibusiso Alven et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Nanoscience & Nanotechnology

Niacin Metal-Organic Framework-Laden Self-Healing Hydrogel for Wound Healing

Youming Deng et al.

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2020)

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Article Materials Science, Biomaterials

Injectable in situ forming thermo-responsive graphene based hydrogels for cancer chemo-photothermal therapy and NIR light-enhanced antibacterial applications

Rita Lima-Sousa et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2020)

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Review Engineering, Biomedical

The role of percolation in hydrogel-based tissue engineering and bioprinting

Franck J. Vernerey et al.

CURRENT OPINION IN BIOMEDICAL ENGINEERING (2020)

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Article Biophysics

Effect of varied hair protein fractions on the gel properties of keratin/chitosan hydrogels for the use in tissue engineering

Ting-Yu Lu et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2020)

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Article Multidisciplinary Sciences

Mussel-Inspired Adhesive Polydopamine-Functionalized Hyaluronic Acid Hydrogel with Potential Bacterial Inhibition

Qi-Hang Yu et al.

GLOBAL CHALLENGES (2020)

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Article Chemistry, Multidisciplinary

Chitosan and pectin core-shell beads encapsulating metformin-clay intercalation compounds for controlled delivery

Ediana Paula Rebitski et al.

NEW JOURNAL OF CHEMISTRY (2020)

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Article Nanoscience & Nanotechnology

Poly(2-Hydroxyethyl Methacrylate) Sponges Doped with Ag Nanoparticles as Antibacterial Agents

Praveen et al.

ACS APPLIED NANO MATERIALS (2020)

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Article Chemistry, Physical

Assembly of pi-functionalized quaternary ammonium compounds with graphene hydrogel for efficient water disinfection

Liang Wang et al.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2019)

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Article Engineering, Biomedical

A PEG-Lysozyme hydrogel harvests multiple functions as a fit-to-shape tissue sealant for internal-use of body

Haoqi Tan et al.

BIOMATERIALS (2019)

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Article Chemistry, Physical

Smart release of antimicrobial ZnO nanoplates from a pH-responsive keratin hydrogel

Maria E. Villanueva et al.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2019)

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Article Polymer Science

Fabrication of an Original Transparent PVA/Gelatin Hydrogel: In Vitro Antimicrobial Activity against Skin Pathogens

Naila Imtiaz et al.

INTERNATIONAL JOURNAL OF POLYMER SCIENCE (2019)

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Article Biophysics

In situ reduction of silver nanoparticles in the lignin based hydrogel for enhanced antibacterial application

Man Li et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2019)

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Article Biochemistry & Molecular Biology

Antibacterial oxidized starch/ZnO nanocomposite hydrogel: Synthesis and evaluation of its swelling behaviours in various pHs and salt solutions

Hassan Namazi et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2019)

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Article Engineering, Biomedical

Dodecenylsuccinic anhydride modified collagen hydrogels loaded with simvastatin as skin wound dressings

Christian E. Olivetti et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2019)

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Article Chemistry, Physical

Tunable keratin hydrogel based on disulfide shuffling strategy for drug delivery and tissue engineering

Yu Cao et al.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2019)

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Article Chemistry, Multidisciplinary

Human hair keratin-based hydrogels as dynamic matrices for facilitating wound healing

So Yeon Kim et al.

JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY (2019)

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Article Food Science & Technology

Hydrogels based on gelatin: Effect of lactic and acetic acids on microstructural modifications, water absorption mechanisms and antibacterial activity

Thaysa Fernandes Moya Moreira et al.

LWT-FOOD SCIENCE AND TECHNOLOGY (2019)

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Review Biochemistry & Molecular Biology

Recent Developments in Antibacterial Therapy: Focus on Stimuli-Responsive Drug-Delivery Systems and Therapeutic Nanoparticles

Roberto Canaparo et al.

MOLECULES (2019)

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Article Polymer Science

Antimicrobial AgNPs composites of gelatin hydrogels crosslinked by ferrocene-containing tetrablock terpolymer

Shengdong Mu et al.

POLYMER (2019)

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Article Microbiology

Curd-Peptide Based Novel Hydrogel Inhibits Biofilm Formation, Quorum Sensing, Swimming Mortility of Multi-Antibiotic Resistant Clinical Isolates and Accelerates Wound Healing Activity

Sounik Manna et al.

FRONTIERS IN MICROBIOLOGY (2019)

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Article Biochemistry & Molecular Biology

Synergic formulation of onion peel quercetin loaded chitosan-cellulose hydrogel with green zinc oxide nanoparticles towards controlled release, biocompatibility, antimicrobial and anticancer activity

Dhanya George et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2019)

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Article Pharmacology & Pharmacy

Uptake and release of Dexamethasone using pH-responsive poly(2-hydroxyethyl methacrylate-co-2-(diisopropylamino) ethyl methacrylate) hydrogels for potential use in ocular drug delivery

Paula A. Faccia et al.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2019)

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Article Chemistry, Multidisciplinary

pH-Switchable Antimicrobial Nanofiber Networks of Hydrogel Eradicate Biofilm and Rescue Stalled Healing in Chronic Wounds

Jianhao Wang et al.

ACS NANO (2019)

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Article Engineering, Environmental

Synthesis of a novel anti-freezing, non-drying antibacterial hydrogel dressing by one-pot method

Kang Wang et al.

CHEMICAL ENGINEERING JOURNAL (2019)

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Article Nanoscience & Nanotechnology

Hydrogel-embedded gold nanorods activated by plasmonic photothermy with potent antimicrobial activity

Carlos Bermudez-Jimenez et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2019)

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Article Chemistry, Applied

Fabricating antimicrobial peptide-immobilized starch sponges for hemorrhage control and antibacterial treatment

Xiao Yang et al.

CARBOHYDRATE POLYMERS (2019)

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Article Biochemistry & Molecular Biology

Mussel-inspired antibacterial polydopamine/chitosan/temperature-responsive hydrogels for rapid hemostasis

Xin Zhang et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2019)

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Article Chemistry, Physical

Carbon dot-DNA-protoporphyrin hybrid hydrogel for sustained photoinduced antimicrobial activity

Sonam Kumari et al.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2019)

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Article Materials Science, Multidisciplinary

UV cross-linked polyvinylpyrrolidone electrospun fibres as antibacterial surfaces

Barbara M. Maciejewska et al.

SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS (2019)

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Article Chemistry, Physical

Surface Modification of Polyester-Fabric with Hydrogels and Silver Nanoparticles: Photochemical Versus Gamma Irradiation Methods

Kathleen A. Montoya-Villegas et al.

MATERIALS (2019)

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Article Chemistry, Applied

Cellulose-based injectable hydrogel composite for pH-responsive and controllable drug delivery

Nusheng Chen et al.

CARBOHYDRATE POLYMERS (2019)

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Article Pharmacology & Pharmacy

Silver nanoparticle impregnated chitosan-PEG hydrogel enhances wound healing in diabetes induced rabbits

Nosheen Masood et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2019)

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Article Materials Science, Multidisciplinary

An Antimicrobial Dental Light Curable Bioadhesive Hydrogel for Treatment of Peri-Implant Diseases

Ehsan Shirzaei Sani et al.

MATTER (2019)

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Article Biotechnology & Applied Microbiology

Novel hydrogels based on collagen and ZnO nanoparticles with antibacterial activity for improved wound dressings

Ionela-Andreea Neacsu et al.

ROMANIAN BIOTECHNOLOGICAL LETTERS (2019)

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Article Nanoscience & Nanotechnology

Hybrid Hydrogel Composed of Carboxymethylcellulose-Silver Nanoparticles-Doxorubicin for Anticancer and Antibacterial Therapies against Melanoma Skin Cancer Cells

Nadia S. V. Capanema et al.

ACS APPLIED NANO MATERIALS (2019)

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Article Chemistry, Multidisciplinary

Investigating the In Vivo Antimicrobial Activity of a Self-Assembling Peptide Hydrogel Using a Galleria mellonella Infection Model

Alice P. McCloskey et al.

ACS OMEGA (2019)

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Article Nanoscience & Nanotechnology

Self-Assembled DNA-THPS Hydrogel as a Topical Antibacterial Agent for Wound Healing

Xingxing Jiang et al.

ACS APPLIED BIO MATERIALS (2019)

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Article Polymer Science

Physicochemical properties and antimicrobial activity of biocompatible carboxymethylcellulose-silver nanoparticle hybrids for wound dressing and epidermal repair

Nadia S. V. Capanema et al.

JOURNAL OF APPLIED POLYMER SCIENCE (2018)

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Article Engineering, Environmental

Development of Anti-bacterial PVA/Starch Based Hydrogel Membrane for Wound Dressing

Awais Hassan et al.

JOURNAL OF POLYMERS AND THE ENVIRONMENT (2018)

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Article Biochemistry & Molecular Biology

Dual-Functional Dextran-PEG Hydrogel as an Antimicrobial Biomedical Material

Lei Wang et al.

MACROMOLECULAR BIOSCIENCE (2018)

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Article Nanoscience & Nanotechnology

Hyaluronic Acid and Polyethylene Glycol Hybrid Hydrogel Encapsulating Nanogel with Hemostasis and Sustainable Antibacterial Property for Wound Healing

Jie Zhu et al.

ACS APPLIED MATERIALS & INTERFACES (2018)

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Article Chemistry, Applied

Mechanically viscoelastic nanoreinforced hybrid hydrogels composed of polyacrylamide, sodium carboxymethylcellulose, graphene oxide, and cellulose nanocrystals

Anuj Kumar et al.

CARBOHYDRATE POLYMERS (2018)

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Review Chemistry, Applied

Chitosan-based hydrogels: From preparation to biomedical applications

Michelly C. G. Pella et al.

CARBOHYDRATE POLYMERS (2018)

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Article Chemistry, Applied

Synthesis and characterization of hyaluronic acid hydrogels crosslinked using a solvent-free process for potential biomedical applications

Eneko Larraneta et al.

CARBOHYDRATE POLYMERS (2018)

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Article Chemistry, Applied

Hydrogels for biomedical applications from glycol chitosan and PEG diglycidyl ether exhibit pro-angiogenic and antibacterial activity

G. Tripodo et al.

CARBOHYDRATE POLYMERS (2018)

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Article Engineering, Environmental

High hydrophilic antifouling membrane modified with capsaicin-mimic moieties via microwave assistance (MWA) for efficient water purification

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Cellulose gum and copper nanoparticles based hydrogel as antimicrobial agents against urinary tract infection (UTI) pathogens

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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2018)

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Review Nanoscience & Nanotechnology

Antimicrobial hydrogels: promising materials for medical application

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Catechol-rich gelatin hydrogels in situ hybridizations with silver nanoparticle for enhanced antibacterial activity

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Review Polymer Science

Cellulose-based hydrogels for personal care products

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Investigation on pH/salt-responsive multifunctional itaconic acid based polymeric biocompatible, antimicrobial and biodegradable hydrogels

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Mild synthesis of a Zn(II) metal organic polymer and its hybrid with activated carbon: Application as antibacterial agent and in water treatment by using sonochemistry: Optimization, kinetic and isotherm study

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pH-Responsive Hybrid Hydrogels as Antibacterial and Drug Delivery Systems

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Engineering Adhesive and Antimicrobial Hyaluronic Acid/Elastin-like Polypeptide Hybrid Hydrogels for Tissue Engineering Applications

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Article Chemistry, Applied

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Article Polymer Science

Novel Bacterial Cellulose-Poly (Acrylic Acid) Hybrid Hydrogels with Controllable Antimicrobial Ability as Dressings for Chronic Wounds

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Smart pH-Responsive Antimicrobial Hydrogel Scaffolds Prepared by Additive Manufacturing

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Review Engineering, Biomedical

Cellulose-based hydrogel materials: chemistry, properties and their prospective applications

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PVA-based hydrogels for tissue engineering: A review

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Synthesis and characterization of silver nanoparticle incorporated gelatin-hydroxypropyl methacrylate hydrogels for wound dressing applications

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PVA-based hydrogels for tissue engineering: A review

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Heparin-mimetic polyurethane hydrogels with anticoagulant, tunable mechanical property and controllable drug releasing behavior

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A transparent wound dressing based on bacterial cellulose whisker and poly(2-hydroxyethyl methacrylate)

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Ultrasmall silver nanoparticles loaded in alginate-hyaluronic acid hybrid hydrogels for treating infected wounds

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Synthesis and characterization of 2-hydroxyethylmethacrylate/2-(3-indol-yl)ethylmethacrylamide-based novel hydrogels as drug carrier with in vitro antibacterial properties

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Fabrication of curcumin-loaded mesoporous silica incorporated polyvinyl pyrrolidone nanofibers for rapid hemostasis and antibacterial treatment

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Article Materials Science, Biomaterials

Ultrasmall silver nanoparticles loaded in alginate-hyaluronic acid hybrid hydrogels for treating infected wounds

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Design of pH-responsive antimicrobial nanocomposite as dual drug delivery system for tumor therapy

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Article Engineering, Biomedical

Minocycline enhances the mesenchymal stromal/stem cell pro-healing phenotype in triple antimicrobial-loaded hydrogels

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Preparation and Supramolecular Recognition of Multivalent Peptide-Polysaccharide Conjugates by Cucurbit[8]uril in Hydrogel Formation

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BIOMACROMOLECULES (2015)

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Biographical-Item Medicine, General & Internal

Alexander Fleming (1881-1955): Discoverer of penicillin

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Hydrogel: Preparation, characterization, and applications: A review

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Article Polymer Science

Addition of antimicrobial properties to hyaluronic acid by grafting of antimicrobial peptide

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EUROPEAN POLYMER JOURNAL (2014)

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Collagen-based hydrogel films as drug-delivery devices with antimicrobial properties

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Increasing Mechanical Strength of Gelatin Hydrogels by Divalent Metal Ion Removal

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The Structure, Functions, and Mechanical Properties of Keratin

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Review Polymer Science

Alginate: Properties and biomedical applications

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Super-tough double-network hydrogels reinforced by covalently compositing with silica-nanoparticles

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Review Biotechnology & Applied Microbiology

Potential applications of natural origin polymer-based systems in soft tissue regeneration

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CRITICAL REVIEWS IN BIOTECHNOLOGY (2010)

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Review Biochemistry & Molecular Biology

Role, Metabolism, Chemical Modifications and Applications of Hyaluronan

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CURRENT MEDICINAL CHEMISTRY (2009)

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Review Chemistry, Multidisciplinary

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