期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 24, 期 21, 页码 -出版社
MDPI
DOI: 10.3390/ijms242115850
关键词
PCV; phylogeny; serology; Cap; prevalence
This study investigated the prevalence of Porcine circoviruses (PCVs) and characterized their genetic and serological features. The data showed that PCV2d and PCV3a are widely distributed in Southwest China, while PCV4 has sporadic circulation. Serological investigations revealed high antibody positivity for PCV2, followed by PCV4 and PCV3. The findings contribute to the understanding of PCV epidemiology and provide new insights for antiviral interventions.
Porcine circoviruses (PCVs) are notorious for triggering severe diseases in pigs and causing serious economic losses to the swine industry. In the present study, we undertook a comprehensive approach for the investigation of PCV prevalence, including the phylogenetic analysis of obtained PCV sequences, the determination of major circulating genotypes and serological screening based on different recombinant Cap proteins with specific immunoreactivity. Epidemiological surveillance data indicate that PCV2d and PCV3a are widely distributed in Southwest China, while PCV4 has only sporadic circulation. Meanwhile, serological investigations showed high PCV2 antibody positivity in collected serum samples (>50%), followed by PCV4 (nearly 50%) and PCV3 (30-35%). The analysis supports different circulation patterns of PCV2, PCV3 and PCV4 and illustrates the PCV2/PCV3 genetic evolution characteristics on a nationwide basis. Taken together, our findings add up to the current understanding of PCV epidemiology and provide new tools and insight for PCV antiviral intervention.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据