4.7 Article

Multi-omics revealed the mechanisms of Codonopsis pilosula aqueous extract in improving UC through blocking abnormal activation of PI3K/Akt signaling pathway

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Gastroenterology & Hepatology

Excessive Apoptosis in Ulcerative Colitis: Crosstalk Between Apoptosis, ROS, ER Stress, and Intestinal Homeostasis

Yue Wan et al.

Summary: Ulcerative colitis is a complex gastrointestinal disease with multifactorial pathogenesis, where intestinal epithelial cells play a crucial role and apoptosis is essential for maintaining intestinal stability. Understanding the role of apoptosis in UC pathogenesis may offer new strategies for clinical treatment and drug development.

INFLAMMATORY BOWEL DISEASES (2022)

Article Chemistry, Medicinal

Anti-inflammatory effect of Rhein on ulcerative colitis via inhibiting PI3K/Akt/mTOR signaling pathway and regulating gut microbiota

Lingling Dong et al.

Summary: The study showed that Rhein had therapeutic effects on ulcerative colitis by inhibiting the production of pro-inflammatory cytokines, alleviating UC-associated symptoms, and modulating the PI3K/Akt/mTOR signaling pathway and gut microbiota.

PHYTOTHERAPY RESEARCH (2022)

Article Pharmacology & Pharmacy

Heat Shock Transcription Factor 2 Promotes Mitophagy of Intestinal Epithelial Cells Through PARL/PINK1/Parkin Pathway in Ulcerative Colitis

Hao Liang et al.

Summary: This study reveals that the overactivation of NLRP3 inflammasome in intestinal epithelial cells (IECs) in ulcerative colitis (UC) can be inhibited by heat shock transcription factor 2 (HSF2) through promoting mitophagy, resulting in the reduction of inflammation.

FRONTIERS IN PHARMACOLOGY (2022)

Article Medicine, Research & Experimental

Crosstalk between miRNA and PI3K/AKT/mTOR signaling pathway in cancer

Maryam Akbarzadeh et al.

Summary: The PI3K/AKT/mTOR signaling pathway plays a crucial role in cancer and has been found to interact with miRNAs, which is important for understanding cancer biology.

LIFE SCIENCES (2021)

Article Biochemistry & Molecular Biology

NOX4 promotes ferroptosis of astrocytes by oxidative stress-induced lipid peroxidation via the impairment of mitochondrial metabolism in Alzheimer?s diseases

Min Woo Park et al.

Summary: The study found elevated levels of NOX4 protein in impaired astrocytes of AD patients and mouse AD models, leading to oxidative stress and ferroptosis. Overexpression of NOX4 resulted in impaired mitochondrial metabolism and oxidative stress, increasing ferroptosis in astrocytes.

REDOX BIOLOGY (2021)

Review Gastroenterology & Hepatology

Mucosal lesions of the upper gastrointestinal tract in patients with ulcerative colitis: A review

Yan Sun et al.

Summary: Ulcerative colitis (UC) can cause mucosal injuries in the esophagus, stomach, and duodenum, with potential complications, yet these upper gastrointestinal symptoms are often overlooked or concealed. There is currently a lack of clear criteria for examination and treatment recommendations for UC-related upper gastrointestinal lesions.

WORLD JOURNAL OF GASTROENTEROLOGY (2021)

Review Gastroenterology & Hepatology

Ulcerative Colitis and Crohn's Disease Have Similar Burden and Goals for Treatment

Catherine Le Berre et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2020)

Review Gastroenterology & Hepatology

Epidemiology and Pathogenesis of Ulcerative Colitis

Lillian Du et al.

GASTROENTEROLOGY CLINICS OF NORTH AMERICA (2020)

Article Biochemistry & Molecular Biology

Extraction, characterization and anti-inflammatory activities of an inulin-type fructan from Codonopsis pilosula

Yan Meng et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

Article Biochemistry & Molecular Biology

Study of the selenizing Codonopsis pilosula polysaccharides protects RAW264.7 cells from hydrogen peroxide-induced injury

Tao Qin et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2019)

Review Gastroenterology & Hepatology

Burden and Cost of Gastrointestinal, Liver, and Pancreatic Diseases in the United States: Update 2018

Anne F. Peery et al.

GASTROENTEROLOGY (2019)

Review Plant Sciences

Traditional uses, phytochemistry, pharmacology and toxicology of Codonopsis: A review

Shi-Man Gao et al.

JOURNAL OF ETHNOPHARMACOLOGY (2018)

Article Chemistry, Medicinal

Chemical constituents of the roots of Codonopsis lanceolata

Young Eun Du et al.

ARCHIVES OF PHARMACAL RESEARCH (2018)

Article Biochemistry & Molecular Biology

Structural characterization of a pectic polysaccharide from Codonopsis pilosula and its immunomodulatory activities in vivo and in vitro

Pei Zhang et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2017)

Review Chemistry, Medicinal

Codonopsis lanceolata: A Review of Its Therapeutic Potentials

Muhammad Jahangir Hossen et al.

PHYTOTHERAPY RESEARCH (2016)

Article Chemistry, Medicinal

Two New Pyrrolidine Alkaloids, Codonopsinol C and Codonopiloside A, Isolated from Codonopsis pilosula

Daigo Wakana et al.

CHEMICAL & PHARMACEUTICAL BULLETIN (2013)

Article Medicine, General & Internal

Ulcerative colitis

Ingrid Ordas et al.

LANCET (2012)

Review Genetics & Heredity

Next-generation transcriptome assembly

Jeffrey A. Martin et al.

NATURE REVIEWS GENETICS (2011)

Article Biochemical Research Methods

Mapping and quantifying mammalian transcriptomes by RNA-Seq

Ali Mortazavi et al.

NATURE METHODS (2008)

Article Biochemistry & Molecular Biology

WEGO: a web tool for plotting GO annotations

Jia Ye et al.

NUCLEIC ACIDS RESEARCH (2006)

Article Biochemistry & Molecular Biology

KEGG: Kyoto Encyclopedia of Genes and Genomes

M Kanehisa et al.

NUCLEIC ACIDS RESEARCH (2000)