☆ 4.8 Article

IGF2BP2 Drives Cell Cycle Progression in Triple-Negative Breast Cancer by Recruiting EIF4A1 to Promote the m6A-Modified CDK6 Translation Initiation Process

ADVANCED SCIENCE (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Biochemistry & Molecular Biology

eIF4A1-dependent mRNAs employ purine-rich 5'UTR sequences to activate localised eIF4A1-unwinding through eIF4A1-multimerisation to facilitate translation

Tobias Schmidt et al.

Summary: This study shows that single-stranded RNA sequence motifs can activate eIF4A1, leading to structural rearrangement and translation of highly structured oncogene mRNAs. These eIF4A1-dependent mRNAs contain AG-rich motifs within their 5'UTR, which specifically activate eIF4A1 unwinding and make them sensitive to eIF4A1-inhibition.

NUCLEIC ACIDS RESEARCH (2023)

添加到收藏夹

Article Oncology

Novel Association of IGF2BP2 Gene Variants With Altered Risk of Breast Cancer and as Potential Molecular Biomarker of Triple Negative Breast Cancer

Wassim Y. Almawi et al.

Summary: This study investigated the association of IGF2BP2 rs4402960 and rs1470579 variants with breast cancer (BC) and triple negative BC (TNBC). The results showed a significant positive association between rs440960 and BC, and a significant negative association between rs1470579 and TNBC. These findings suggest the potential diagnostic/prognostic role of rs4402960 and rs1470579 in BC and its complications.

CLINICAL BREAST CANCER (2023)

添加到收藏夹

Review Pathology

Pathogenesis of Triple-Negative Breast Cancer

Fatemeh Derakhshan et al.

Summary: This article introduces the heterogeneity of triple-negative breast cancer (TNBC) and discusses its histologic, molecular classifications, and genomic alterations. The article also explores the role of the tumor microenvironment in TNBC and its potential impact on therapeutic response. Understanding the biology of each TNBC subtype is essential for delivering personalized medicine to patients.

ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE (2022)

添加到收藏夹

Review Oncology

Dynamic regulation and functions of mRNA m6A modification

Shanshan Wang et al.

Summary: N-6-Methyladenosine (m6A) is the most abundant internal modification associated with eukaryotic mRNAs, and it plays a dynamic regulatory role in gene expression by affecting various steps of mRNA metabolism. This review discusses the general role of m6A, focusing on the three major types of enzymes that determine the level of m6A modification and the regulatory mechanism by which m6A influences RNA metabolism. Understanding the role of m6A in physiological and pathophysiological processes, especially in tumorigenesis, is of great importance.

CANCER CELL INTERNATIONAL (2022)

添加到收藏夹

Article Oncology

RNA N6-methyladenosine reader IGF2BP2 promotes lymphatic metastasis and epithelial-mesenchymal transition of head and neck squamous carcinoma cells via stabilizing slug mRNA in an m6A-dependent manner

Dan Yu et al.

Summary: This study reveals the oncogenic role and potential mechanism of IGF2BP2 in HNSCC, demonstrating that IGF2BP2 affects lymphatic metastasis and EMT process through the regulation of m6A modification. This suggests that IGF2BP2 may serve as a therapeutic target and prognostic biomarker for HNSCC patients with metastasis.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

m6A modification: recent advances, anticancer targeted drug discovery and beyond

Li-Juan Deng et al.

Summary: Abnormal N6-methyladenosine (m6A) modification is closely related to cancer development, and finding targeted anticancer drugs is important. Traditional herbs and computer-synthesized compounds are reasonable sources for these drugs. Artificial intelligence has advantages in discovering m6A-targeting anticancer drugs.

MOLECULAR CANCER (2022)

添加到收藏夹

Review Oncology

Treatment landscape of triple-negative breast cancer - expanded options, evolving needs

Giampaolo Bianchini et al.

Summary: Recent advances in omics technologies have improved our understanding of the heterogeneity and microenvironment of triple-negative breast cancers (TNBCs), supporting a view of this breast cancer subtype as an ecosystem that encompasses both intrinsic and extrinsic features of cancer cells. The authors of this Review describe the current and upcoming therapeutic landscape of TNBC and discuss how an integrated view of the TNBC ecosystem can provide improved opportunities for tailoring treatment.

NATURE REVIEWS CLINICAL ONCOLOGY (2022)

添加到收藏夹

Article Oncology

INK4 Tumor Suppressor Proteins Mediate Resistance to CDK4/6 Kinase Inhibitors

Qing Li et al.

Summary: This study identifies CDK4/6 kinase activation as a common mechanism in oncogenic signaling-induced proliferation and develops a new strategy for inhibiting CDK4/6 kinases to overcome resistance.

CANCER DISCOVERY (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

YTHDF3 Facilitates eIF2AK2 and eIF3A Recruitment on mRNAs to Regulate Translational Processes in Oxaliplatin-Resistant Colorectal Cancer

Yang Zhao et al.

Summary: In this study, we identified the high expression of YTHDF3 in oxaliplatin-resistant CRC tissues and cells. YTHDF3 was found to recognize and facilitate the translation of significantly m6A-methylated RNAs associated with tumor resistance through its coordination with eIF2AK2.

ACS CHEMICAL BIOLOGY (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

CircEZH2/miR-133b/IGF2BP2 aggravates colorectal cancer progression via enhancing the stability of m(6)A-modified CREB1 mRNA

Bing Yao et al.

Summary: This study identified a novel circular RNA called circEZH2 in colorectal cancer tissues, which is closely related to the clinical characteristics and prognosis of colorectal cancer patients. circEZH2 promotes the proliferation and migration of colorectal cancer cells, and regulates the expression of IGF2BP2 by interacting with m(6)A reader IGF2BP2 and acting as a sponge for miR-133b. Additionally, circEZH2/IGF2BP2 enhances the stability of CREB1 mRNA, thereby aggravating colorectal cancer progression.

MOLECULAR CANCER (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

The role of Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs) as m6A readers in cancer

Chao-Yue Sun et al.

Summary: RNA can undergo various chemical modifications, with m(6)A being the most abundant internal modification in eukaryotes. The m(6)A modification plays a crucial role in regulating mRNA processing and is implicated in tumorigenesis. IGF2BPs are unique RNA-binding proteins that stabilize mRNA targets through m(6)A modification and have important implications in cancer progression.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2022)

添加到收藏夹

Review Cell Biology

The roles ofhnRNP A2/B1inRNAbiology and disease

Yu Liu et al.

Summary: The RNA-binding protein hnRNPA2/B1 plays crucial roles in recognizing and binding specific RNA substrates and DNA motifs, regulating the transcription, splicing, and translation of various RNA molecules, in addition to being involved in telomere maintenance, DNA repair, and the development of tumors and neurodegenerative diseases.

WILEY INTERDISCIPLINARY REVIEWS-RNA (2021)

添加到收藏夹

Article Oncology

Differential Regulation of Cancer Progression by CDK4/6 Plays a Central Role in DNA Replication and Repair Pathways

Meiou Dai et al.

Summary: The study demonstrates distinct and novel functions of CDK4 and CDK6 in regulating tumor formation and metastatic colonization in various solid tumors. Transcriptomic analysis reveals these kinases to regulate cancer progression through different mechanisms, with CDK4 affecting prometastatic inflammatory signaling and CDK6 controlling DNA replication and repair processes. Inhibition of CDK6 but not CDK4 results in defective DNA repair and increased DNA damage, suggesting potential targeted therapy for deadly tumors.

CANCER RESEARCH (2021)

添加到收藏夹

Review Pharmacology & Pharmacy

Inhibiting CDK4/6 in Breast Cancer with Palbociclib, Ribociclib, and Abemaciclib: Similarities and Differences

C. Louwrens Braal et al.

Summary: CDK 4/6 inhibitors are a new class of drugs that interrupt proliferation of malignant cells by inhibiting progression through the cell cycle. This article reviews the clinical pharmacokinetic and pharmacodynamic profiles of these inhibitors and discusses important future directions for their clinical applicability.

DRUGS (2021)

添加到收藏夹

Editorial Material Oncology

CDK4/6 inhibition in early-stage breast cancer: how far is it from becoming standard of care?

Binghe Xu et al.

LANCET ONCOLOGY (2021)

添加到收藏夹

Review Oncology

The role of IGF2BP2, an m6A reader gene, in human metabolic diseases and cancers

Jinyan Wang et al.

Summary: IGF2BP2 is an RNA-binding protein that regulates cellular metabolism and cancer development by post-transcriptional regulation. It is also an independent prognostic factor for multiple cancer types.

CANCER CELL INTERNATIONAL (2021)

添加到收藏夹

Review Oncology

Epigenetic Alterations in Triple-Negative Breast Cancer-The Critical Role of Extracellular Matrix

Vasiliki Zolota et al.

Summary: Current data suggest that epigenetic alterations play a key role in the initiation and subclonal evolution of breast cancer, especially in the aggressive molecular subgroup of triple-negative breast cancer. The extracellular matrix undergoes significant structural alterations during cancer progression, which are closely linked with epigenetic modifiers. Targeting tumor microenvironment and epigenetic pathways may provide potential therapeutic strategies, particularly in triple-negative breast cancer where standard chemotherapy is limited.

CANCERS (2021)

添加到收藏夹

Article Oncology

Efficacy and mechanism of the combination of PARP and CDK4/6 inhibitors in the treatment of triple-negative breast cancer

Xiuzhi Zhu et al.

Summary: The combination of PARPi olaparib and CDK4/6i palbociclib shows synergistic effects against BRCA(mut)/TNBC, especially in cells resistant to olaparib, by inhibiting HR repair, increasing DNA damage, and suppressing tumor growth.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

添加到收藏夹

Review Oncology

Main N6-Methyladenosine Readers: YTH Family Proteins in Cancers

Xin-Yuan Dai et al.

Summary: N6-methyladenosine (m6A) is the most abundant internal modification in eukaryotic RNAs, installed by writers and erased by erasers, recognized by readers. YTH family proteins, as the first identified m6A reader proteins, play essential roles in cancer tumorigenesis through regulating RNA metabolism.

FRONTIERS IN ONCOLOGY (2021)

添加到收藏夹

Article Oncology

IGF2BP2 promotes the progression of colorectal cancer through a YAP-dependent mechanism

Jie Cui et al.

Summary: IGF2BP2 activates ErbB2 expression by recognizing the m6A modification of YAP, thus promoting proliferation and invasion of CRC cells while inhibiting apoptosis.

CANCER SCIENCE (2021)

添加到收藏夹

Review Oncology

The biological function of IGF2BPs and their role in tumorigenesis

Qiu-Ying Du et al.

Summary: IGF2BPs are a highly conservative RNA-binding family that regulate RNA processing and metabolism, participating in various cellular functions and pathophysiologies. They play crucial roles in cancer development and progression, while also functioning in embryo development, neurogenesis, and other processes. Understanding the role of IGF2BPs in tumor progression provides new insights into cancer pathophysiology.

INVESTIGATIONAL NEW DRUGS (2021)

添加到收藏夹

Article Oncology

m6A modification of lncRNA PCAT6 promotes bone metastasis in prostate cancer through IGF2BP2-mediated IGF1R mRNA stabilization

Chuandong Lang et al.

Summary: This study uncovers a novel molecular mechanism involving the m(6)A-induced PCAT6/IGF2BP2/IGF1R axis in promoting PCa bone metastasis and tumor growth, suggesting that PCAT6 may serve as a promising prognostic marker and therapeutic target for bone-metastatic PCa.

CLINICAL AND TRANSLATIONAL MEDICINE (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

The role of m6A modification in the biological functions and diseases

Xiulin Jiang et al.

Summary: This paper highlights the importance of m6A RNA modification in eukaryotic RNA, including the roles of m6A methyltransferases, demethylases, and binding proteins. It emphasizes the crucial role of m6A RNA modification in the development of human cancers and discusses its impact on the physiological and pathological progressions of hematopoietic, central nervous, and reproductive systems.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

IGF2BP2 regulates DANCR by serving as an N6-methyladenosine reader

Xiaoge Hu et al.

CELL DEATH AND DIFFERENTIATION (2020)

添加到收藏夹

Review Oncology

Mechanisms of Sensitivity and Resistance to CDK4/6 Inhibition

Monica Alvarez-Fernandez et al.

CANCER CELL (2020)

添加到收藏夹

Review Oncology

m6A Modification in Coding and Non-coding RNAs: Roles and Therapeutic Implications in Cancer

Huilin Huang et al.

CANCER CELL (2020)

添加到收藏夹

Review Oncology

The role of CDK6 in cancer

Sofie Nebenfuehr et al.

INTERNATIONAL JOURNAL OF CANCER (2020)

添加到收藏夹

Review Oncology

Triple-negative breast cancer molecular subtyping and treatment progress

Li Yin et al.

BREAST CANCER RESEARCH (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

METTL3 facilitates tumor progression via an m6A-IGF2BP2-dependent mechanism in colorectal carcinoma

Ting Li et al.

MOLECULAR CANCER (2019)

添加到收藏夹

Review Cell Biology

Reading, writing and erasing mRNA methylation

Sara Zaccara et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

添加到收藏夹

Article Multidisciplinary Sciences

m6A in mRNA coding regions promotes translation via the RNA helicase-containing YTHDC2

Yuanhui Mao et al.

NATURE COMMUNICATIONS (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

Functions of N6-methyladenosine and its role in cancer

Liuer He et al.

MOLECULAR CANCER (2019)

添加到收藏夹

Review Cell Biology

Reading, writing and erasing mRNA methylation

Sara Zaccara et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

添加到收藏夹

Article Cell Biology

Recognition of RNA N6- methyladenosine by IGF2BP proteins enhances mRNA stability and translation

Huilin Huang et al.

NATURE CELL BIOLOGY (2018)

添加到收藏夹

Article Multidisciplinary Sciences

mRNA circularization by METTL3-eIF3h enhances translation and promotes oncogenesis

Junho Choe et al.

NATURE (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

Acquired CDK6 amplification promotes breast cancer resistance to CDK4/6 inhibitors and loss of ER signaling and dependence

C. Yang et al.

ONCOGENE (2017)

添加到收藏夹

Review Oncology

Cyclin-dependent kinase 4/6 inhibitors in breast cancer: palbociclib, ribociclib, and abemaciclib

Dorota Kwapisz

BREAST CANCER RESEARCH AND TREATMENT (2017)

添加到收藏夹

Review Cell Biology

IMPs: an RNA-binding protein family that provides a link between stem cell maintenance in normal development and cancer

Nils Degrauwe et al.

GENES & DEVELOPMENT (2016)

添加到收藏夹

Article Biochemistry & Molecular Biology

Nuclear m6A Reader YTHDC1 Regulates mRNA Splicing

Wen Xiao et al.

MOLECULAR CELL (2016)

添加到收藏夹

Article Biochemistry & Molecular Biology

Translational dysregulation in cancer: eIF4A isoforms and sequence determinants of eIF4A dependence

Farheen Raza et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2015)

添加到收藏夹

Article Medicine, Research & Experimental

Correlation between IGF2BP2 gene polymorphism and the risk of breast cancer in Chinese Han women

Guihong Liu et al.

BIOMEDICINE & PHARMACOTHERAPY (2015)

添加到收藏夹

Article Biochemistry & Molecular Biology

HNRNPA2B1 Is a Mediator of m6A-Dependent Nuclear RNA Processing Events

Claudio R. Alarcon et al.

CELL (2015)

添加到收藏夹

Article Biochemistry & Molecular Biology

N6-methyladenosine Modulates Messenger RNA Translation Efficiency

Xiao Wang et al.

CELL (2015)

添加到收藏夹

Article Immunology

Autoimmune Response to IGF2 mRNA-Binding Protein 2 (IMP2/p62) in Breast Cancer

W. Liu et al.

SCANDINAVIAN JOURNAL OF IMMUNOLOGY (2015)

添加到收藏夹

Article Cell Biology

The malignant phenotype in breast cancer is driven by eIF4A1-mediated changes in the translational landscape

A. Modelska et al.

CELL DEATH & DISEASE (2015)

添加到收藏夹

Review Cell Biology

The mechanism of eukaryotic translation initiation and principles of its regulation

Richard J. Jackson et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.