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Article
Biochemistry & Molecular Biology
Song Yang et al.
Summary: O-GlcNAcylation plays a crucial role in cellular nutrient sensing and is involved in various physiological and pathological processes. The study demonstrates the involvement of O-GlcNAcylation in the regulation of phagocytosis. Mechanistic studies reveal that O-GlcNAc transferase interacts with Ezrin to catalyze its O-GlcNAcylation, promoting its localization to the cell cortex and facilitating efficient phagocytosis.
JOURNAL OF GENETICS AND GENOMICS
(2023)
Review
Chemistry, Medicinal
Hui Li Ang et al.
Summary: Epithelial-mesenchymal transition (EMT) is a crucial process in which epithelial cells transform into mesenchymal cells, playing a significant role in tumor progression and resistance to therapy. Various factors, such as signaling pathways, transcriptional regulators, noncoding RNAs, and epigenetic alterations, are involved in the regulation of EMT. However, despite preclinical data, there is a lack of clinical translation in targeting EMT therapeutically. This review discusses the role of these factors in EMT regulation, the contribution of EMT to drug resistance, and potential therapeutic interventions using natural products and nano-formulations as EMT blockers.
MEDICINAL RESEARCH REVIEWS
(2023)
Article
Multidisciplinary Sciences
Qiang Zhu et al.
Summary: Programmed-death ligand 1 (PD-L1) and its receptor programmed cell death 1 (PD-1) play a role in T cell-mediated immune response against tumors. The regulation of cell surface PD-L1 is not well understood, but it is shown in this study that lysosomal degradation of PD-L1 is regulated by O-linked N-acetylglucosamine (O-GlcNAc). Inhibition of O-GlcNAc activates T cell-mediated anti-tumor immunity and combining it with PD-L1 antibody enhances the immune response. A competitive peptide inhibitor of HGS glycosylation decreases PD-L1 expression and enhances T cell-mediated immunity against tumor cells. This study reveals a link between O-GlcNAc and tumor immune evasion, providing strategies for improving PD-L1-mediated immune checkpoint blockade therapy.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Pathology
Benjamin J. Moss et al.
Summary: The pathogenesis of idiopathic pulmonary fibrosis (IPF) involves a complex interplay of various cell types and signaling pathways. Novel bioinformatics tools can help discover disease pathways, cell-specific mechanisms, and cell-cell interactions.
ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE
(2022)
Article
Cardiac & Cardiovascular Systems
Jonathan K. Alder et al.
Summary: This study found an enrichment of variants in telomere-maintenance genes and shorter telomeres among idiopathic pulmonary fibrosis (IPF) lung transplant recipients. However, transplant outcomes of survival and CLAD did not differ based on gene variants or telomere length in these patients. Therefore, the study supports not excluding individuals with telomere-mediated disease from lung transplantation and focusing research efforts on therapies for those with short-telomere mediated disease.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
Article
Biochemistry & Molecular Biology
Charlie Fehl et al.
Summary: The article discusses the important role of O-GlcNAc modification in cellular metabolism, exploring the challenge of identifying key modification sites among thousands of potential global sites and emphasizing the importance of innovative solutions. Additionally, it summarizes critical suggestions and tool strategies from the international O-GlcNAc community to help newcomers drive innovation in the field.
NATURE CHEMICAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Dandan Peng et al.
Summary: TGF-beta plays essential roles in early embryonic development, organogenesis, immune regulation, tissue repair, and adult homeostasis. Its involvement in fibrosis and cancer is complex and context-dependent, showing both inhibitory and promoting effects. Therapeutics targeting TGF-beta signaling hold promise in treating fibrosis and cancer, although the development is hindered by potential systemic cytotoxicity.
Article
Chemistry, Multidisciplinary
Pinou Lv et al.
Summary: This study reveals that O-GlcNAcylation of SynGAP acts as a suppressor of LLPS of the SynGAP/PSD-95 complex. Through the identification of multiple O-GlcNAc modification sites and in vitro and cell-based assays, it is demonstrated that T1306 O-GlcNAc of SynGAP blocks the interaction with PSD-95, inhibiting LLPS. Additionally, O-GlcNAcylation suppresses LLPS in a dominant-negative manner, and O-GlcNAc cycling mediated by OGT and OGA regulates LLPS reversibly.
Review
Cell Biology
Anna Akhmanova et al.
Summary: Microtubules are polarized cytoskeletal filaments that play a crucial role in intracellular transport and cell organization. The formation of microtubule networks is regulated by a variety of proteins, leading to cell type-specific architectures that contribute to diverse cellular functions.
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2022)
Review
Cell Biology
Clare E. Buckley et al.
Summary: Apical-basal polarity is crucial for the form and function of epithelial cells, determining cell adhesion, barrier function, specific cargo secretion, and cytoskeletal organization. Conserved polarity factors play important roles in establishing and maintaining apical-basal polarity, although different mechanisms may be involved in different epithelial tissues.
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2022)
Article
Cell Biology
Fan Yu et al.
Summary: The O-GlcNAcylation of proteins plays a role in regulating ferroptosis by modulating ferritinophagy and mitophagy. Inhibition of O-GlcNAcylation promotes ferritinophagy and enhances mitophagy, resulting in the accumulation of labile iron and increased sensitivity to ferroptosis.
Review
Multidisciplinary Sciences
Rocio Tapia et al.
Summary: Cell migration requires various proteins that interact with the cytoskeleton. Sperm flagella protein-1 (Spef1) is a multifunctional protein that interacts with cytoskeletal structures. It plays important roles in flagellar and ciliary motility, microtubule binding and stability, regulation of cell polarity, and maintenance of actin-based structures during cell migration.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Review
Medicine, General & Internal
Marlies Wijsenbeek et al.
Summary: There are over 200 recognized interstitial lung diseases, which vary in rarity. Most of these diseases are characterized by inflammation or fibrosis in the interstitial space, leading to impaired gas exchange and resulting in symptoms such as breathlessness, decreased exercise tolerance, and reduced quality of life. The prognosis for different interstitial lung diseases varies considerably, with some conditions showing reversibility or stabilization, while others lead to respiratory failure and death. Recent advances in the field have led to the approval of drugs for the treatment of specific interstitial lung diseases, including systemic sclerosis-associated interstitial lung disease, interstitial lung disease-associated pulmonary hypertension, and progressive pulmonary fibrosis.
Review
Biochemistry & Molecular Biology
Xianhui Liu et al.
Summary: O-GlcNAcylation is a nutrient-sensitive protein modification that regulates daily rhythms in biology by modifying circadian clock proteins and downstream effectors. Mistimed feeding disrupts this rhythmic modification and negatively impacts animal biological rhythms and health span.
Review
Cell Biology
Tarik Issad et al.
Summary: O-GlcNAcylation is a crucial protein modification that regulates protein functions and cell signaling, and is associated with numerous physiological and pathological processes.
JOURNAL OF BIOMEDICAL SCIENCE
(2022)
Review
Physiology
John C. Chatham et al.
Summary: The discovery of O-GlcNAcylation in the mid-1980s challenged the conventional notion of glycosylation and its impact on cellular functions. Dysregulation in O-GlcNAc cycling has been implicated in the progression of various diseases.
PHYSIOLOGICAL REVIEWS
(2021)
Review
Chemistry, Multidisciplinary
Junfeng Ma et al.
Summary: Protein O-GlcNAcylation is an important post-translational modification that functions as a nutrient sensor and plays key roles in biochemical processes. Research on this modification has made significant progress in characterizing the components of O-GlcNAc cycling, biochemical properties of enzymes, and potential therapeutic applications. Challenges and solutions for future research in this field are also discussed.
Review
Biochemistry & Molecular Biology
Byeong Eun Lee et al.
Summary: The addition of a sugar tag called O-GlcNAc to proteins found in brain cells plays a critical role in regulating synaptic and neuronal function, with implications for understanding and treating neurodegenerative disease. Aberrant O-GlcNAc levels in the aging brain can fuel cognitive decline, and various neurodegenerative disorders are associated with abnormal O-GlcNAc patterns on disease-associated proteins. Therapeutic alteration of the sugar-tagging process may offer a novel approach for treating these brain disorders.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2021)
Article
Multidisciplinary Sciences
Ievgenia Pastushenko et al.
Summary: This study reveals that mutation of the FAT1 gene promotes tumor initiation, progression, invasiveness, stemness, and metastasis. Loss of function of FAT1 activates a CAMK2-CD44-SRC axis while inactivates EZH2, playing important roles in the expression of YAP1 and ZEB1.
Review
Pharmacology & Pharmacy
Israel Olapeju Bolanle et al.
Summary: Protein O-GlcNAcylation has emerged as a new mechanism in the pathogenesis of cardiovascular diseases, playing a vital role in modulating vascular homeostasis and cardiac function through altering cellular functions of target proteins. Studying this mechanism may provide new therapeutic targets for the development of more effective medicines.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Medicine, Research & Experimental
Wei Jie Huang et al.
Summary: Pulmonary fibrosis, the end stage of various lung diseases, may be triggered by virus infection, but the specific mechanisms are not fully understood. Studying the relationship between pulmonary fibrosis and various viruses, as well as the infection mechanisms, may provide insights into potential anti-fibrotic treatment targets.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Huijie Zhao et al.
Summary: Fibrogranular materials are essential for the ultrastructural fidelity of multicilia, condensing into spherical cores and associating with deuterosomes to promote proper assembly by concentrating specific proteins.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Priyam Banerjee et al.
Summary: Epithelial-to-mesenchymal transition (EMT) is a transcriptionally governed process by which cancer cells establish a front-rear polarity axis that facilitates motility and invasion. The EMT activator ZEB1 influences vesicular trafficking dynamics to execute cell polarity change, impacting cancer cell motility.
NATURE COMMUNICATIONS
(2021)
Review
Biochemistry & Molecular Biology
Victoria A. Ptasinski et al.
Summary: Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease initiated by repeated epithelial injuries, leading to abnormal wound healing responses. Targeting the regenerative capacity of lung epithelium is crucial for developing novel therapies for IPF, which involves coordinated cross-talk among multiple cell types and reestablishment of a normal extracellular matrix environment.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Michael L. Nosella et al.
Summary: The study found that O-GlcNAcylation can reduce the phase separation tendency of the EWS protein, and knockdown of the OGT gene in cells decreases the O-GlcNAcylation of EWS, affecting its accumulation in biomolecular condensates. O-GlcNAcylation may play a general role in regulating biomolecular condensates.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Review
Cell Biology
Terry Lechler et al.
Summary: The orientation of cell divisions plays a crucial role in tissue architecture and cell fate, regulated by intracellular and extracellular signals. Recent studies have shed light on the mechanisms of mitotic spindle positioning in vertebrates, with a focus on how these mechanisms interact with cellular and tissue-wide cues.
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Paolo Spagnolo et al.
Summary: Idiopathic pulmonary fibrosis (IPF) is a chronic progressive disease of unknown cause that is age-related, with current treatments focusing on slowing disease progression and providing a growing portfolio of treatment options.
PHARMACOLOGY & THERAPEUTICS
(2021)
Review
Cell Biology
Feifei Qi et al.
Summary: The centrosome, a membrane-less organelle consisting of centrioles and pericentriolar material, plays crucial roles in cell shaping, division, migration, and is closely linked to various human diseases. Understanding the functions of centrosomes in development and health may provide insights into disease mechanisms and potential therapeutic targets.
JOURNAL OF MOLECULAR CELL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Helen E. Collins et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2020)
Review
Cell Biology
Shailaja Seetharaman et al.
TRENDS IN CELL BIOLOGY
(2020)
Letter
Cell Biology
Fan Yu et al.
Review
Medicine, Research & Experimental
Jeremy Katzen et al.
JOURNAL OF CLINICAL INVESTIGATION
(2020)
Review
Cell Biology
Alex Valenzuela et al.
TRENDS IN CELL BIOLOGY
(2020)
Review
Respiratory System
Vivien Somogyi et al.
EUROPEAN RESPIRATORY REVIEW
(2019)
Review
Cell Biology
Melissa A. Pickett et al.
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 35
(2019)
Letter
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Review
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Dustin T. King et al.
CURRENT OPINION IN CHEMICAL BIOLOGY
(2019)
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Paul M. Levine et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
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Hongik Hwang et al.
PHARMACOLOGICAL RESEARCH
(2018)
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Xiaoyong Yang et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2017)
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NATURE COMMUNICATIONS
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(2017)
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Olof Lagerloef et al.
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Christin S. Kuo et al.
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Gastroenterology & Hepatology
Massimo Pinzani
JOURNAL OF HEPATOLOGY
(2011)
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Michael B. Lazarus et al.
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Sarah E. Siegrist et al.
GENES & DEVELOPMENT
(2007)
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Medicine, Research & Experimental
VJ Thannickal et al.
ANNUAL REVIEW OF MEDICINE
(2004)