Stimuli-responsive release of active anionophore from RGD-peptide-linked proanionophore

Integrin-mediated cellular delivery was attempted to optimize practical applications of hydrophobic ionophores. The potent ionophore preferentially transports H+/Cl- across the lipid bilayers following a symport mechanism. The RGD-peptide-appended tag was stimulated by glutathione to generate the active ionophore, prompting the transport of Cl- under the cellular environment. Integrin-mediated cellular delivery was attempted to optimize practical applications of hydrophobic ionophores.

Automated summary

This study attempted to optimize practical applications of hydrophobic ionophores through integrin-mediated cellular delivery, facilitating the transport of Cl- in the cellular environment.