Single crystal formation in core-shell capsules

This work extends the scope of microfluidic-based crystallization methods by introducing solid microcapsules. Hundreds of perfectly similar microcapsules were generated per second, allowing a fast screening of crystallization conditions. XRD analyses were performed directly on encapsulated single crystals demonstrating the potential of this process for the characterization of compounds, including screening polymorphism. We introduce a new approach to the generation of single crystals by inducing slow nucleation within core-shell solid microcapsules.

Automated summary

This work extends the application scope of microfluidic-based crystallization methods by introducing solid microcapsules, and demonstrates the potential of this method for compound characterization.