Strategies for chiral separation: from racemate to enantiomer

Chiral separation has become a crucial topic for effectively utilizing superfluous racemates synthesized by chemical means and satisfying the growing requirements for producing enantiopure chiral compounds. However, the remarkably close physical and chemical properties of enantiomers present significant obstacles, making it necessary to develop novel enantioseparation methods. This review comprehensively summaries the latest developments in the main enantioseparation methods, including preparative-scale chromatography, enantioselective liquid-liquid extraction, crystallization-based methods for chiral separation, deracemization process coupling racemization and crystallization, porous material method and membrane resolution method, focusing on significant cases involving crystallization, deracemization and membranes. Notably, potential trends and future directions are suggested based on the state-of-art coupling strategy, which may greatly reinvigorate the existing individual methods and facilitate the emergence of cross-cutting ideas among researchers from different enantioseparation domains. Research progress and potential trends about six critical chiral resolution methods are summarized. Notable performance improvements based on the state-of-the-art coupling strategies are highlighted.

Automated summary

This review comprehensively summarizes the latest developments in the main enantioseparation methods, focusing on significant cases involving crystallization, deracemization, and membranes. It also highlights potential trends and future directions based on state-of-the-art coupling strategies.