Visible-light-induced iron-catalyzed S-N cross-coupling of thiols with dioxazolones

An efficient visible-light induced iron-catalyzed S-N coupling of thiols with dioxazolones under mild conditions has been developed. The reaction proceeds under ligand- and photosensitizer-free conditions, and has features of satisfactory yields, broad functional group tolerance, and an easy operation procedure. Preliminary mechanistic investigations showed that these reactions were conducted via a radical pathway. The visible-light-promoted iron-catalyzed S-N cross coupling of thiols with dioxazolones is described. This reaction occurred via an exogenous-photosensitizer-free process and showed wide substrate scope under mild reaction conditions.

Automated summary

An efficient visible-light-induced iron-catalyzed S-N coupling of thiols with dioxazolones under mild conditions has been developed. The reaction occurs without the need for ligands and photosensitizers, showing satisfactory yields, broad functional group tolerance, and an easy operation procedure. Preliminary mechanistic investigations suggest that the reactions proceed via a radical pathway.