4.5 Article

SARS-CoV-2 Causes Brain Damage: Therapeutic Intervention with AZD8797

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Cell & Tissue Engineering

Fractalkine enhances oligodendrocyte regeneration and remyelination in a demyelination mouse model

Monique M. A. de Almeida et al.

Summary: Demyelinating disorders of the CNS can be improved by introducing fractalkine into the damaged murine brain, which promotes the formation of new oligodendrocytes, enhances remyelination, and reduces activation of microglia/macrophages. This pro-regenerative effect is achieved through increased OPC proliferation, OPC differentiation, and modulation of microglia biology. These findings highlight the potential of fractalkine as a therapeutic target for demyelinating disorders.

STEM CELL REPORTS (2023)

Article Cell Biology

Influence of SARS-CoV-2 on Adult Human Neurogenesis

Tomasz Stepien et al.

Summary: Infection with SARS-CoV-2 leads to neurological and psychiatric symptoms due to inflammation and hypoxia in key brain regions. The mechanisms behind these symptoms are largely unknown. A study comparing COVID-19 patients with a control group found a decrease in neuronal progenitor cells and newborn neurons in the infected group. The COVID-19 patients also showed increased microglial activation. The inflammatory response caused by COVID-19 negatively affects adult neurogenesis through increased cytokine concentration.
Article Medicine, Research & Experimental

Nesfatin-1 ameliorates oxidative brain damage and memory impairment in rats induced with a single acute epileptic seizure

Sevil Arabaci Tamer et al.

Summary: This study found that Nesfatin-1 has neuroprotective effects and can alleviate oxidative damage and memory dysfunction caused by epilepsy. It acts by inhibiting reactive nitrogen species and increasing antioxidant capacity.

LIFE SCIENCES (2022)

Review Immunology

The Role of Cytokines and Chemokines in Severe Acute Respiratory Syndrome Coronavirus 2 Infections

Ren-Jun Hsu et al.

Summary: This review focuses on the cytokine storm in COVID-19, discussing its pathological features and potential immunotherapeutic approaches. Using cytokines as diagnostic markers and proactively managing the cytokine storm can improve disease outcomes and prognosis.

FRONTIERS IN IMMUNOLOGY (2022)

Article Medicine, General & Internal

Comprehensive Clinical Characterisation of Brain Fog in Adults Reporting Long COVID Symptoms

Glenn Jennings et al.

Summary: Self-reported brain fog in long COVID is a symptom cluster characterized by fatigue, dizziness, myalgia, word-finding difficulties, and memory impairment, and is associated with adverse psychological and psychomotor outcomes.

JOURNAL OF CLINICAL MEDICINE (2022)

Article Multidisciplinary Sciences

Development, analysis, and preclinical evaluation of inactivated vaccine candidate for prevention of Covid-19 disease

Engin Alp Onen et al.

Summary: This study reports the development of an inactivated SARS-CoV-2 vaccine candidate and demonstrates its efficacy and safety in preclinical studies, supporting further clinical evaluation. Findings indicate potential for this vaccine candidate in preventing SARS-CoV-2 infection.

ALL LIFE (2022)

Article Endocrinology & Metabolism

Glutathione, polyamine, and lysophosphatidylcholine synthesis pathways are associated with circulating pro-inflammatory cytokines

Ming Liu et al.

Summary: This study investigated the association between pro-inflammatory cytokines and metabolites/metabolic pathways using a metabolomics approach under homeostatic conditions. The results showed that glutathione, polyamine, and lysophosphatidylcholine synthesis pathways were positively associated with circulating pro-inflammatory cytokine levels.

METABOLOMICS (2022)

Review Biochemistry & Molecular Biology

Interactions of SARS-CoV-2 with the Blood-Brain Barrier

Michelle A. Erickson et al.

Summary: This review discusses the mechanisms by which SARS-CoV-2 interactions with the blood-brain barrier (BBB) may lead to neurological dysfunction associated with COVID-19. It considers peripheral diseases such as hypoxia and systemic inflammatory response syndrome, as well as CNS infection and viral entry into the brain. Additionally, it explores the contribution of risk factors for severe COVID-19 to BBB dysfunction.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Editorial Material Psychiatry

How COVID-19 Affects the Brain

Maura Boldrini et al.

JAMA PSYCHIATRY (2021)

Review Clinical Neurology

SARS-CoV-2 and the brain: A review of the current knowledge on neuropathology in COVID-19

Aniello Maiese et al.

Summary: SARS-CoV-2 can affect the central nervous system, leading to neurological manifestations, which are likely due to systemic inflammation and coagulopathy caused by COVID-19. Further studies are needed to confirm this hypothesis and identify other possible alterations in neural tissue.

BRAIN PATHOLOGY (2021)

Article Rheumatology

Interleukin-1 and interleukin-6 inhibition compared with standard management in patients with COVID-19 and hyperinflammation: a cohort study

Giulio Cavalli et al.

Summary: IL-1 inhibition was associated with reduced mortality in patients with COVID-19 and hyperinflammation, while IL-6 inhibition showed effectiveness in patients with high C-reactive protein concentrations. Both IL-1 and IL-6 inhibition were effective in patients with low lactate dehydrogenase concentrations.

LANCET RHEUMATOLOGY (2021)

Article Neurosciences

Neuropathological analysis of the brains of fifty-two patients with COVID-19

Teresa Wierzba-Bobrowicz et al.

Summary: This study reported neuropathological changes in brains of patients infected with CoV-2 coronavirus, showing vascular lesions and inflammatory process characteristic of the infection. Damage of vessel walls and morphological feature of the damage to the blood-brain barrier were observed, along with lymphocytic and microglial infiltrates.

FOLIA NEUROPATHOLOGICA (2021)

Article Biochemistry & Molecular Biology

An inflammatory cytokine signature predicts COVID-19 severity and survival

Diane Marie Del Valle et al.

NATURE MEDICINE (2020)

Article Rheumatology

Anakinra for severe forms of COVID-19: a cohort study

Thomas Huet et al.

LANCET RHEUMATOLOGY (2020)

Article Clinical Neurology

The cognitive consequences of the COVID-19 epidemic: collateral damage?

Karen Ritchie et al.

BRAIN COMMUNICATIONS (2020)

Article Biochemistry & Molecular Biology

AZD8797 is an allosteric non-competitive modulator of the human CX3CR1 receptor

Linda Cederblad et al.

BIOCHEMICAL JOURNAL (2016)

Editorial Material Neurosciences

The CA3 region of the hippocampus: how is it? What is it for? How does it do it?

Enrico Cherubini et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2015)

Article Multidisciplinary Sciences

Pharmacological inhibition of the chemokine receptor CX3CR1 attenuates disease in a chronic-relapsing rat model for multiple sclerosis

Anna Ridderstad Wollberg et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Neurosciences

CX3CL1 is up-regulated in the rat hippocampus during memory-associated synaptic plasticity

Graham K. Sheridan et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2014)

Article Biochemical Research Methods

Object recognition test in mice

Marianne Leger et al.

NATURE PROTOCOLS (2013)

Article Biochemistry & Molecular Biology

Antidepressants recruit new neurons to improve stress response regulation

A. Surget et al.

MOLECULAR PSYCHIATRY (2011)