期刊
NATURE REVIEWS GENETICS
卷 -, 期 -, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/s41576-023-00662-1
关键词
-
Non-coding RNAs (ncRNAs) are a group of transcripts that are not translated into proteins. They play important roles in regulating biological functions and are implicated in disease. In this review, the authors summarize the roles of miRNAs, lncRNAs, and circRNAs in cancer and other major human diseases, and discuss their potential as biomarkers and therapeutic targets.
Non-coding RNAs (ncRNAs) are a heterogeneous group of transcripts that, by definition, are not translated into proteins. Since their discovery, ncRNAs have emerged as important regulators of multiple biological functions across a range of cell types and tissues, and their dysregulation has been implicated in disease. Notably, much research has focused on the link between microRNAs (miRNAs) and human cancers, although other ncRNAs, such as long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs), are also emerging as relevant contributors to human disease. In this Review, we summarize our current understanding of the roles of miRNAs, lncRNAs and circRNAs in cancer and other major human diseases, notably cardiovascular, neurological and infectious diseases. Further, we discuss the potential use of ncRNAs as biomarkers of disease and as therapeutic targets. In this Review, the authors describe our current knowledge of the role of microRNAs, long non-coding RNAs and circular RNAs in disease, with a focus on cardiovascular, neurological, infectious diseases and cancer. Further, they discuss the potential use of non-coding RNAs as disease biomarkers and as therapeutic targets.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据