期刊
NEW JOURNAL OF CHEMISTRY
卷 47, 期 47, 页码 21654-21660出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d3nj04466a
关键词
-
A colorimetric sensor based on dual-aptamer recognition and nanoparticles was constructed for the precise detection of CTCs, showing high sensitivity and specificity. This sensor has the potential to be used in precise tumor diagnosis.
The precise identification and detection of circulating tumor cells (CTCs) is significant for the early diagnosis and prognostic treatment of cancer. However, it remains a challenge to detect CTCs with high sensitivity and specificity. In this study, a colorimetric sensor for the analysis of CTCs was constructed based on dual-aptamer recognition and core (Fe3O4)-shell (Pt) nanoparticle (Fe3O4@Pt NP) nanozymes coupled with a G-quadruplex as a signal transducer/amplifier. The results show that the linear range of the designed colorimetric sensor is 50-4000 cells and the detection limit is 4 cells. The constructed aptasensor could be extended to identify various CTCs by changing the aptamers, and holds great potential in precise tumor diagnosis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据