Valorization of Deodorizing Distillate Palm Oil Residue for Larvicidal Activity Against Aedes aegypti and Synergistic Effect of Their Free Fatty Acids

Increased consumption of palm oil results in more palm oil by-products. To meet environmental sustainability goals, deodorizing distillate palm oil (DDPO) also calls attention to diversifying its technological or commercial application. Because of this, the present work, to present new economic-scientific alternatives for this by-product, aimed to evaluate the larvicide effect of DDPO as to investigate the synergistic effect of the combination of these free fatty acids (FFA's) present in the composition of DDPO, against larvae of the 3rd instar of Ae. aegypti. The DDPO larvicide assay showed a high mortality rate, with an LC50 of 6.18 mu g.mL(- 1) at 24 h and 8.73 mu g.mL(- 1) at 48 h of treatment. In addition, the results of LC50, among saturated fatty foods and between the combination of free fatty acids (myristic, lauric, stearic, and oleic) with palmitic acid were met positively by second-degree polynomial regression analysis. Finally, the study of molecular docking, corroborated the potential inhibitors of the binding of juvenile hormones. Together, the results suggest that DDPO can be a potential natural larvicide agent, making it an alternative to the excessive use of synthetic insecticides, thus minimizing its impacts on the environment, and promoting new technologies for the use of this palm oil by-product.

Automated summary

This study evaluated the larvicide effect of deodorizing distillate palm oil (DDPO) and investigated the synergistic effect of its free fatty acids (FFAs) against Ae. aegypti larvae. The results showed that DDPO had a high mortality rate and could be a potential natural larvicide agent.