The CYBA Gene*49A>G Polymorphism (rs7195830) Is Associated with Hypertension in Patients with Coronary Artery Disease

Purpose. Single nucleotide polymorphisms of the CYBA gene maymodify the risk of coronary artery disease (CAD). The aim of the present study was to investigate whether the *49A>G (rs7195830) polymorphism is associated with CAD. Materials and Methods. CYBA gene *49A>G polymorphism was determined in 481 subjects: 242 patients with premature CAD and 239 age and sex matched controls using the fluorescently labeled allele-specific oligonucleotidesmethod. Results. The frequency of the *49G allele carrier state was significantly higher in patients than in controls (84.8% versus 76.6%, resp., P = 0.020), as well as the frequency of the *49G allele (62.2% versus 54.0%, P = 0.009). Both factors were associated with CAD in the analyzed population (OR = 1.70, 95% CI: 1.04-2.76 for GG+AG versus AA and OR = 1.40, 95% CI: 1.08-1.83 for *49G versus *49A). Carrier state of the *49G allele was a stronger and independent risk factor for CAD among women (OR = 4.35, 95% CI: 1.50-13.20, P = 0.002), as well as the *49G allele (OR = 2.25, 95% CI: 1.34-3.77, P = 0.001). The *49G allele carrier state was also associated with left ventricular hypertrophy in patients with coronary artery disease (P = 0.015). Conclusion. The CYBA gene *49A>G polymorphism modifies the risk of coronary artery disease.