Critical evaluation of analytical methodologies for the discrimination of hemp and drug-type cannabis

Article Chemistry, Analytical

Combining microfluidic paper-based platform and metal-organic frameworks in a single device for phenolic content assessment in fruits

H. Martinez-Perez-Cejuela et al.

Summary: A microfluidic paper-based device combined with metal-organic frameworks (MOFs) has been developed for accurate quantification of total phenolic compounds (TPC) in fruit samples. The device, based on the vertical flow approach, shows enhanced performance in determining TPC content. The method utilizes the traditional Folin-Ciocalteu Index and optimizes several analytical parameters for improved colorimetric performance.

MICROCHIMICA ACTA (2023)

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Article Chemistry, Analytical

Developing Prediction Models Using Near-Infrared Spectroscopy to Quantify Cannabinoid Content in Cannabis Sativa

Jonathan Tran et al.

Summary: Cannabis cultivation for therapeutic and recreational purposes is growing, and the main cannabinoids of interest are CBD and THC. Near-infrared spectroscopy coupled with liquid chromatography reference data has achieved rapid and nondestructive determination of cannabinoid levels. However, most literature focuses on predicting decarboxylated cannabinoids, such as THC and CBD, rather than naturally occurring analogues like THCA and CBDA. Accurate prediction of these acidic cannabinoids is important for quality control in the cannabis industry.

SENSORS (2023)

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Article Chemistry, Analytical

Rapid In Situ Detection of THC and CBD in Cannabis sativa L. by 1064 nm Raman Spectroscopy

Stefania Porcu et al.

Summary: In this study, Raman spectroscopy was used to analyze cannabis samples, and the results showed high reproducibility and the ability to immediately distinguish the Raman spectra of different cannabinoids. Additionally, the ratio between specific Raman bands can be used to evaluate the THC content in the samples.

ANALYTICAL CHEMISTRY (2022)

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Article Biochemistry & Molecular Biology

Use of near-infrared spectroscopy for the classification of medicinal cannabis cultivars and the prediction of their cannabinoid and terpene contents

Matan Birenboim et al.

Summary: This article describes the use of Fourier transform near infra-red spectroscopy (FT-NIRS) for the quantitative analysis of cannabinoids and terpenes. By using multivariate classification and regression models, researchers were able to develop prediction models and classification models, showing that there is sufficient information in FT-NIRS to achieve these models.

PHYTOCHEMISTRY (2022)

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Article Chemistry, Analytical

Design of a microfluidic paper-based device for the quantification of phenolic compounds in wine samples

H. Martinez-Perez-Cejuela et al.

Summary: This paper describes the design and development of a microfluidic paper-based device for the quantification of total phenolic compounds in wines. The developed device showed good precision, stability, and no significant interferences from known compounds in wines.

TALANTA (2022)

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Article Medicine, Legal

Validation of the 4-aminophenol color test for the differentiation of marijuana-type and hemp-type cannabis

Kenna Lewis et al.

Summary: The signing of the Agricultural Improvement Act of 2018 significantly impacted the analysis of cannabis plant material submitted to seized-drug laboratories, requiring new protocols to distinguish between marijuana-type and hemp-type cannabis. The validation of the 4-aminophenol (4-AP) color test demonstrated its utility for discriminating between marijuana-type and hemp-type cannabis.

JOURNAL OF FORENSIC SCIENCES (2021)

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Article Chemistry, Analytical

Differentiation between hemp-type and marijuana-type cannabis using the Fast Blue BB colorimetric test

Alexander Acosta et al.

Summary: The Fast Blue BB colorimetric test effectively distinguishes between different cannabinoids in cannabis, particularly THC, demonstrating selectivity for THC while differentiating between hemp and marijuana. The test successfully classified samples with THC levels below 0.3% (hemp) and those with higher THC levels and lower CBD levels (marijuana), but struggled with samples containing slightly above 0.3% THC and high CBD content. Additionally, herbs and spices were accurately distinguished from cannabis samples in the test.

FORENSIC CHEMISTRY (2021)

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Article Spectroscopy

Mid-infrared spectroscopy as process analytical technology tool for estimation of THC and CBD content in Cannabis flowers and extracts

Nikola Geskovski et al.

Summary: The study focuses on the potential of mid-infrared (MIR) spectroscopy as Process Analytical Technology (PAT) for quantifying the main phytocannabinoids (THC and CBD) in Cannabis plants and extracts. Multivariate models were successfully constructed to predict THC and CBD content in samples from different origins.

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY (2021)

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Article Biochemical Research Methods