期刊
BIOMATERIALS SCIENCE
卷 4, 期 4, 页码 605-609出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5bm00467e
关键词
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资金
- intramural programs of KIST
- Global Innovative Research Center program of the National Research Foundation of Korea [2012K1A1A2A01055811]
- Intramural Research Program (Global RNAi Carrier Initiative) of KIST
- National Research Foundation of Korea (NRF) grant - Korea government (MSIP) [2014-R1A2A2A04002526]
- Pioneer Research Center Program through NRF - Ministry of Science, ICT & Future Planning [2014M3C1A3054141]
- Intramural Research Program (Convergence Technology Program) of KIST
Photodynamic therapy (PDT) is a cytotoxic treatment using singlet oxygen produced by photosensitizers. Approved porphyrinoid PDT still suffers from a lack of robust production methods and low water solubility. Methylene blue (MB) is a good candidate for the PDT drug, because the dye is an effective photosensitizer, can be easily synthesized, and is already being used in other clinical fields. However, its poor cell/tissue penetration and low stability against the reducible biological conditions should be addressed by using a proper delivery vehicle. Here, we employed a DNA tetrahedron, a self-assembled nanostructure as the carrier for intracellular delivery of MB by taking advantage of the DNA binding property of the photosensitizer and demonstrated photo-induced cytotoxicity by the MB delivered by the DNA nanocarrier. We also evaluated the PDT potency of the MB-loaded DNA nanoconstruct in vivo tumor model to suppress tumor growth.
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