☆ 4.8 Article

Profound N-glycan remodelling accompanies MHC-II immunopeptide presentation

FRONTIERS IN IMMUNOLOGY (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Review Biochemistry & Molecular Biology

Critical considerations in N-glycoproteomics

The Huong Chau et al.

Summary: N-Glycoproteomics, as a system-wide study of glycans asparagine-linked to protein carriers, has the potential to provide deep insights into the complexity and dynamics of the heterogeneous N-glyco-proteome. However, it remains challenging and restricted to specialised laboratories. This article aims to stimulate discussions on method harmonisation, data standardisation, and reporting guidelines to make N-glycoproteomics more reproducible and accessible, and to highlight practical solutions and strategies for enhancing insight into the N-glycoproteome.

CURRENT OPINION IN CHEMICAL BIOLOGY (2023)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Post-translational modifications reshape the antigenic landscape of the MHC I immunopeptidome in tumors

Assaf Kacen et al.

Summary: This study describes an antigen discovery pipeline that analyzes different post-translational modifications (PTMs) of antigens, expands the antigen landscape, and reveals disease-specific modified targets, which have important implications for T cell-mediated therapies in cancer and other fields.

NATURE BIOTECHNOLOGY (2023)

添加到收藏夹

Article Biochemical Research Methods

Comprehensive glycoprofiling of oral tumours associates N-glycosylation with lymph node metastasis and patient survival

Carolina Moretto Carnielli et al.

MOLECULAR & CELLULAR PROTEOMICS (2023)

添加到收藏夹

Review Immunology

Contemplating immunopeptidomes to better predict them

David Gfeller et al.

Summary: The identification of T-cell epitopes is crucial for understanding immune recognition in diseases and for developing personalized vaccines and T-cell therapy. Advances in mass spectrometry technologies have greatly improved our understanding of antigen presentation and MHC ligands. These techniques have allowed researchers to directly identify hundreds of thousands of peptides displayed on MHC molecules and have improved our ability to predict naturally presented MHC ligands and T-cell epitopes.

SEMINARS IN IMMUNOLOGY (2023)

添加到收藏夹

Article Multidisciplinary Sciences

Unraveling the glycosylated immunopeptidome with HLA-Glyco

Georges Bedran et al.

Summary: In this study, a fast computational workflow merging the MSFragger-Glyco search algorithm with a false discovery rate control is introduced for analyzing glycopeptides from mass spectrometry-based immunopeptidome data. The authors analyze eight large-scale publicly available studies and find that glycosylated MHC-associated peptides are predominantly presented by MHC class II. They present a comprehensive resource, HLA-Glyco, which contains over 3,400 human leukocyte antigen (HLA) class II N-glycopeptides from 1,049 distinct protein glycosylation sites. This resource provides valuable insights into glycosylation properties in antigen recognition and immune modulation.

NATURE COMMUNICATIONS (2023)

添加到收藏夹

Article Multidisciplinary Sciences

Glycoproteome remodeling and organelle-specific N -glycosylation accompany neutrophil granulopoiesis

Rebeca Kawahara et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2023)

添加到收藏夹

Article Biochemistry & Molecular Biology

The PRIDE database resources in 2022: a hub for mass spectrometry-based proteomics evidences

Yasset Perez-Riverol et al.

Summary: PRIDE is the largest data repository of mass spectrometry-based proteomics data in the world, with around 500 datasets submitted per month. In addition to continuous improvements in data pipelines and infrastructure, PRIDE has developed the Spectra Archive and MAGE-TAB file format to enhance sample metadata annotation and access to mass spectra.

NUCLEIC ACIDS RESEARCH (2022)

添加到收藏夹

Review Chemistry, Multidisciplinary

Structural aspects of chemical modifications in the MHC-restricted immunopeptidome; Implications for immune recognition

Tatyana Sandalova et al.

Summary: Significant advances in mass-spectroscopy have enabled the investigation of the cellular immunopeptidome, providing essential information about immune responses to pathogens, autoimmunity, and cancer. Protein post-translational modifications play a key role in maintaining cellular homeostasis and increasing proteome diversity, and understanding their importance is crucial for comprehensive understanding of peptide populations and immune responses.

FRONTIERS IN CHEMISTRY (2022)

添加到收藏夹

Review Immunology

Individual HLA heterogeneity and its implications for cellular immune evasion in cancer and beyond

Simona Pagliuca et al.

Summary: The variability of human leukocyte antigen (HLA) is important for immune responses against pathogens and tumors. Genetic alterations affecting this variability can lead to pathological processes and impact the immune system's ability to respond to diseases like cancer. This review provides an overview of the consequences of perturbations in the genomic heterogeneity of HLA complexes on human diseases, with a focus on cancer.

FRONTIERS IN IMMUNOLOGY (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

N-acetyl-β-D-hexosaminidases mediate the generation of paucimannosidic proteins via a putative noncanonical truncation pathway in human neutrophils

Julian Ugonotti et al.

Summary: The study discovered that human neutrophils express immunomodulatory glycoproteins with unusual and highly truncated N-glycans. The researchers found that both Hex alpha and beta subunits may contribute to the formation of paucimannosidic proteins (PMP) via a previously unexplored truncation pathway in neutrophils. This study sheds light on the immune mechanism of neutrophils and is of great importance.

GLYCOBIOLOGY (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

Structural and functional diversity of neutrophil glycosylation in innate immunity and related disorders

Julian Ugonotti et al.

Summary: Granulocytes neutrophils have been found to use specific glycoproteins in their cytosolic granules to fight pathogens, and recent advances in glycoinformatics have shed light on the structural diversity of these glycoproteins. Neutrophils also display unique glycosignatures, such as specific N-glycans and O-glycans, which may play a role in their effector functions. Future research may focus on elucidating the mechanisms behind these glycoprotein modifications and their potential diagnostic and therapeutic applications in innate immune disorders.

MOLECULAR ASPECTS OF MEDICINE (2021)

添加到收藏夹

Article Biochemical Research Methods

Community evaluation of glycoproteomics informatics solutions reveals high-performance search strategies for serum glycopeptide analysis

Rebeca Kawahara et al.

Summary: The study evaluated the performance of glycoproteomics software, identifying high-performance informatics strategies and recommending improvements for search solutions.

NATURE METHODS (2021)

添加到收藏夹

Article Medicine, General & Internal

Serum N-Glycomics Stratifies Bacteremic Patients Infected with Different Pathogens

Sayantani Chatterjee et al.

Summary: Timely detection of bacteremia is crucial to reduce patient mortality, and serum N-glycomics may serve as a novel diagnostic approach. Research shows distinct serum N-glycome profiles of bacteremic patients infected with different bacteria, enabling accurate differentiation from healthy donors.

JOURNAL OF CLINICAL MEDICINE (2021)

添加到收藏夹

Article

Trends in oligomannosylation and α1,2-mannosidase expression in human cancers

Sayantani Chatterjee et al.

Oncotarget (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Site-specific N-glycosylation of integrin α2 mediates collagen-dependent cell survival

Yen-Lin Huang et al.

Summary: ITGA2 is a highly glycosylated transmembrane protein in ovarian cancer tissue and cell lines, with N- and O-glycosylation sites playing a crucial role in collagen and laminin binding. Mutants lacking N-glycosylated ITGA2 show decreased adherence to collagen, potentially due to increased proteasome degradation through poly-ubiquitination.

ISCIENCE (2021)

添加到收藏夹

Article Cell Biology

Mapping the SARS-CoV-2 spike glycoprotein-derived peptidome presented by HLA class II on dendritic cells

Robert Parker et al.

Summary: This study profiles the repertoire of HLA-DR-bound peptides presented by monocyte-derived dendritic cells pulsed with SARS-CoV-2 spike protein. It identifies 209 unique peptide sequences mapping to various sites on the S protein, with substantial trimming of glycan residues observed on the bound peptides. The study also highlights the receptor-binding motif in S1 as a HLA-DR-binding peptide-rich region and identifies potential target peptides in S2 for cross-protective vaccine-elicited responses.

CELL REPORTS (2021)

添加到收藏夹

Article Immunology

IFNγ Modulates the Immunopeptidome of Triple Negative Breast Cancer Cells by Enhancing and Diversifying Antigen Processing and Presentation

Gabriel Goncalves et al.

Summary: Peptide vaccination is a promising strategy to induce T-cell mediated tumor killing. In this study, the effect of IFN gamma on TNBC cells was analyzed, revealing a significant remodeling of the immunopeptidome with increased diversity and abundance of peptides. The results suggest that cytokine stimulation can unveil a wider range of potential HLA-I and HLA-II vaccine targets, which has important implications for personalized cancer vaccination strategies.

FRONTIERS IN IMMUNOLOGY (2021)

添加到收藏夹

Article Biochemical Research Methods

Proteogenomic Analysis Unveils the HLA Class I-Presented Immunopeptidome in Melanoma and EGFR-Mutant Lung Adenocarcinoma

Yue A. Qi et al.

Summary: The study identified potential immunogenic human leukocyte antigen (HLA) class I-presented peptides in melanoma and EGFR-mutant lung adenocarcinoma using large-scale proteogenomic profiling. This discovery could be valuable for developing precision immunotherapies.

MOLECULAR & CELLULAR PROTEOMICS (2021)

添加到收藏夹

Article Immunology

Identification of antigens presented by MHC for vaccines against tuberculosis

Paulo Bettencourt et al.

NPJ VACCINES (2020)

添加到收藏夹

Article Biochemical Research Methods

Improved Prediction of MHC II Antigen Presentation through Integration and Motif Deconvolution of Mass Spectrometry MHC Eluted Ligand Data

Birkir Reynisson et al.

JOURNAL OF PROTEOME RESEARCH (2020)

添加到收藏夹

Article Biochemical Research Methods

Immunopeptidomic Analysis Reveals That Deamidated HLA-bound Peptides Arise Predominantly from Deglycosylated Precursors

Shutao Mei et al.

MOLECULAR & CELLULAR PROTEOMICS (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

NetMHCpan-4.1 and NetMHCIIpan-4.0: improved predictions of MHC antigen presentation by concurrent motif deconvolution and integration of MS MHC eluted ligand data

Birkir Reynisson et al.

NUCLEIC ACIDS RESEARCH (2020)

添加到收藏夹

Article Immunology

Biogenesis of HLA Ligand Presentation in Immune Cells Upon Activation Reveals Changes in Peptide Length Preference

Fabio Marino et al.

FRONTIERS IN IMMUNOLOGY (2020)

添加到收藏夹

Review Urology & Nephrology

Glycosylation in health and disease

Colin Reily et al.

NATURE REVIEWS NEPHROLOGY (2019)

添加到收藏夹

Article Biochemical Research Methods

Mass spectrometry based identification of MHC-bound peptides for immunopeptidomics

Anthony W. Purcell et al.

NATURE PROTOCOLS (2019)

添加到收藏夹

Review Biology

Human protein paucimannosylation: cues from the eukaryotic kingdoms

Harry C. Tjondro et al.

BIOLOGICAL REVIEWS (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

Updates to the Symbol Nomenclature for Glycans guidelines

Sriram Neelamegham et al.

GLYCOBIOLOGY (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

Regulation and functions of integrin α2 in cell adhesion and disease

Valery Adorno-Cruz et al.

GENES & DISEASES (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

Building a PGC-LC-MS N-glycan retention library and elution mapping resource

Jodie L. Abrahams et al.

GLYCOCONJUGATE JOURNAL (2018)

添加到收藏夹

Review Biochemistry & Molecular Biology

Biological roles of glycans

Ajit Varki

GLYCOBIOLOGY (2017)

添加到收藏夹

Article Biochemical Research Methods

Mycobacterium tuberculosis Infection Manipulates the Glycosylation Machinery and the N-Glycoproteome of Human Macrophages and Their Microparticles

Nathan J. Hare et al.

JOURNAL OF PROTEOME RESEARCH (2017)

添加到收藏夹

Article Biochemical Research Methods

Identification and Characterization of Complex Glycosylated Peptides Presented by the MHC Class II Processing Pathway in Melanoma

Stacy A. Malaker et al.

JOURNAL OF PROTEOME RESEARCH (2017)

添加到收藏夹

Article Oncology

LAMP1 expression is associated with poor prognosis in breast cancer

Qingqing Wang et al.

ONCOLOGY LETTERS (2017)

添加到收藏夹

Review Biochemistry & Molecular Biology

Emerging roles of protein mannosylation in inflammation and infection

Ian Loke et al.

MOLECULAR ASPECTS OF MEDICINE (2016)

添加到收藏夹

Editorial Material Biochemistry & Molecular Biology

Symbol Nomenclature for Graphical Representations of Glycans

Ajit Varki et al.

GLYCOBIOLOGY (2015)

添加到收藏夹

Article Immunology

Differential site accessibility mechanistically explains subcellular-specific N-glycosylation determinants

Ling Yen Lee et al.

FRONTIERS IN IMMUNOLOGY (2014)

添加到收藏夹

Article Biochemical Research Methods

Tandem mass spectra of glycan substructures enable the multistage mass spectrometric identification of determinants on oligosaccharides

Arun V. Everest-Dass et al.

RAPID COMMUNICATIONS IN MASS SPECTROMETRY (2013)

添加到收藏夹

Article Biochemistry & Molecular Biology

Site-specific glycoproteomics confirms that protein structure dictates formation of N-glycan type, core fucosylation and branching

Morten Thaysen-Andersen et al.

GLYCOBIOLOGY (2012)

添加到收藏夹

Review Genetics & Heredity

Post-translationally modified T cell epitopes: immune recognition and immunotherapy

Jan Petersen et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2009)

添加到收藏夹

Article Cell Biology

Immunochemical analysis of CD107a (LAMP-1)

EJ Parkinson-Lawrence et al.

CELLULAR IMMUNOLOGY (2005)

添加到收藏夹

Article Biochemical Research Methods

Glycan side chains on naturally presented MHC class II ligands

J Dengjel et al.

JOURNAL OF MASS SPECTROMETRY (2005)

添加到收藏夹

Article Multidisciplinary Sciences

Predominant selection of T cells specific for the glycosylated collagen type II epitope (263-270) in humanized transgenic mice and in rheumatoid arthritis

J Bäcklund et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.