Increasing NPYergic transmission in the hippocampus rescues aging-related deficits of long-term potentiation in the mouse dentate gyrus

Article Pharmacology & Pharmacy

Intranasal Delivery of Galanin 2 and Neuropeptide Y1 Agonists Enhanced Spatial Memory Performance and Neuronal Precursor Cells Proliferation in the Dorsal Hippocampus in Rats

Dasiel O. Borroto-Escuela et al.

Summary: This study assesses the effects of GALR2 and NPYY1R agonists coadministration on sustained memory and hippocampal cell proliferation, suggesting the potential therapeutic benefits for dementia conditions and memory deficits.

FRONTIERS IN PHARMACOLOGY (2022)

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Article Neurosciences

Choosing memory retrieval strategies: A critical role for inhibition in the dentate gyrus

Anne Albrecht et al.

Summary: Remembering food location is crucial for survival. Under stress, rodents and humans shift their strategy from hippocampus-dependent spatial strategies to striatum-mediated stimulus-based strategies. The dorsal dentate gyrus (dDG) in the hippocampus was identified as a crucial hub for mediating stress effects on strategy choices, highlighting its importance in spatial and non-spatial foraging strategies.

NEUROBIOLOGY OF STRESS (2022)

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Article Neurosciences

NPY Released From GABA Neurons of the Dentate Gyrus Specially Reduces Contextual Fear Without Affecting Cued or Trace Fear

Lucas B. Comeras et al.

Summary: Disproportionate and maladapted fear are key features of PTSD, and the hippocampal NPY system, released together with GABA from interneurons, plays a crucial role in modulating fear responses. Co-release of NPY in the dorsal DG affects specific aspects of fear processing, contributing to fear reduction and extinction learning.

FRONTIERS IN SYNAPTIC NEUROSCIENCE (2021)

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Article Biochemistry & Molecular Biology

Inhibitory Neural Network's Impairments at Hippocampal CA1 LTP in an Aged Transgenic Mouse Model of Alzheimer's Disease

Hyeon Jeong Seo et al.

Summary: The study found that impaired neuronal networks in 5xFAD mice are associated with aberrant NRG1-ErbB signaling, leading to hippocampal dysfunction and impaired LTP.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Neurosciences

Rapid Aging in the Perforant Path Projections to the Rodent Dentate Gyrus

Mohammad Amani et al.

Summary: The deterioration of layers II/III of the entorhinal cortex in the early stages of Alzheimer's disease may be due to impaired presynaptic long-term potentiation, reduced endocannabinoid signaling, and decreased TrkB receptor levels. These changes suggest that synaptic plasticity in EC projections related to memory is particularly sensitive to aging, leading to potential pathogenesis later in life.

JOURNAL OF NEUROSCIENCE (2021)

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Article Neurosciences

Reducing glutamic acid decarboxylase in the dorsal dentate gyrus attenuates juvenile stress induced emotional and cognitive deficits

Kuldeep Tripathi et al.

Summary: Regional, temporal and molecular specificity in the regulation of GABAergic signaling in stress-responsive circuitry complicates the use of systemic GABAergic modulators for stress-related psychopathology treatment. Reduction of GAD65 expression in the dorsal dentate gyrus has been shown to provide resilience to juvenile stress-induced emotional and cognitive deficits.

NEUROBIOLOGY OF STRESS (2021)

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Article Neurosciences

Hippocampal β2-GABAA receptors mediate LTP suppression by etomidate and contribute to long-lasting feedback but not feedforward inhibition of pyramidal neurons

Alexander G. Figueroa et al.

Summary: This study found that a specific genetic mutation in mice can resist the inhibitory effects of the general anesthetic etomidate on the formation of new memories. Furthermore, the research suggests that different subunits of GABA(A) receptors play important roles in controlling long-term potentiation and inhibiting neuronal activity. These findings have implications for understanding how anesthetics block memory formation and how inhibitory circuits regulate learning and memory.

JOURNAL OF NEUROPHYSIOLOGY (2021)

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Article Cell Biology

Cholinergic modulation of dentate gyrus processing through dynamic reconfiguration of inhibitory circuits

Mora B. Ogando et al.

Summary: The cholinergic modulation enhances the response of mature granule cells to afferent stimuli through precise reconfiguration of inhibitory circuits. This mechanism allows mature granule cells to escape strong inhibition, creating plasticity and promoting memory formation.

CELL REPORTS (2021)

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Review Biochemistry & Molecular Biology

Sex Differences in the Neuropeptide Y System and Implications for Stress Related Disorders

Roxanna J. Nahvi et al.

BIOMOLECULES (2020)

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Review Clinical Neurology

Current and Future Treatments in Alzheimer Disease: An Update

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JOURNAL OF CENTRAL NERVOUS SYSTEM DISEASE (2020)

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Article Geriatrics & Gerontology

Reduced cognitive performance in aged rats correlates with increased excitation/inhibition ratio in the dentate gyrus in response to lateral entorhinal input

Trinh Tran et al.

NEUROBIOLOGY OF AGING (2019)

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Article Geriatrics & Gerontology

Enhanced postsynaptic inhibitory strength in hippocampal principal cells in high-performing aged rats

Trinh Tran et al.

NEUROBIOLOGY OF AGING (2018)

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Article Multidisciplinary Sciences

HIPP neurons in the dentate gyrus mediate the cholinergic modulation of background context memory salience

Syed Ahsan Raza et al.

NATURE COMMUNICATIONS (2017)

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Article Multidisciplinary Sciences

Distinct Properties of Long-Term Potentiation in the Dentate Gyrus along the Dorsoventral Axis: Influence of Age and Inhibition

An Schreurs et al.

SCIENTIFIC REPORTS (2017)

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Review Neurosciences

Basal Forebrain Cholinergic Circuits and Signaling in Cognition and Cognitive Decline

Elizabeth C. Ballinger et al.

NEURON (2016)

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Article Multidisciplinary Sciences

Rapid erasure of hippocampal memory following inhibition of dentate gyrus granule cells

Noelia Madronal et al.

NATURE COMMUNICATIONS (2016)

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Article Multidisciplinary Sciences

Plasticity of intrinsic excitability in mature granule cells of the dentate gyrus

Jeffrey Lopez-Rojas et al.

SCIENTIFIC REPORTS (2016)

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Article Neurosciences

Etomidate Impairs Long-Term Potentiation In Vitro by Targeting α5-Subunit Containing GABAA Receptors on Nonpyramidal Cells

F. Clifford Rodgers et al.

JOURNAL OF NEUROSCIENCE (2015)

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Review Neurosciences

Neuropeptide Y: An Anti-Aging Player?

Mariana Botelho et al.

TRENDS IN NEUROSCIENCES (2015)

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Article Neurosciences

Rapid Dynamic Changes of Dendritic Inhibition in the Dentate Gyrus by Presynaptic Activity Patterns

Yu-Chao Liu et al.

JOURNAL OF NEUROSCIENCE (2014)

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Article Behavioral Sciences

Amygdala activation and GABAergic gene expression in hippocampal sub- regions at the interplay of stress and spatial learning

Osnat m Hadad-Ophir et al.

FRONTIERS IN BEHAVIORAL NEUROSCIENCE (2014)

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Article Behavioral Sciences

Neuropeptide Y (NPY) prevents depressive-like behavior, spatial memory deficits and oxidative stress following amyloid-β (Aβ1-40) administration in mice

Vanessa V. dos Santos et al.

BEHAVIOURAL BRAIN RESEARCH (2013)

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Hippocampal excitability is increased in aged mice

Youssef Hanna El-Hayek et al.

EXPERIMENTAL NEUROLOGY (2013)

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Hilar interneuron vulnerability distinguishes aged rats with memory impairment

Amy M. Spiegel et al.

JOURNAL OF COMPARATIVE NEUROLOGY (2013)

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Article Multidisciplinary Sciences

Creating a False Memory in the Hippocampus

Steve Ramirez et al.

SCIENCE (2013)

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Reduction of Hippocampal Hyperactivity Improves Cognition in Amnestic Mild Cognitive Impairment

Arnold Bakker et al.

NEURON (2012)

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Information Capacity and Transmission Are Maximized in Balanced Cortical Networks with Neuronal Avalanches

Woodrow L. Shew et al.

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Ultrahigh-resolution microstructural diffusion tensor imaging reveals perforant path degradation in aged humans in vivo

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

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Dissection of Hippocampal Dentate Gyrus from Adult Mouse

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Jove-Journal of Visualized Experiments (2009)

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Estradiol enhances long term potentiation in hippocampal slices from aged ApoE4-TR mice

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HIPPOCAMPUS (2007)

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Review Geriatrics & Gerontology

Hippocampal synaptic loss in early Alzheimer's disease and mild cognitive impairment

Stephen W. Scheff et al.

NEUROBIOLOGY OF AGING (2006)

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Brain-derived neurotrophic factor, phosphorylated cyclic AMP response element binding protein and neuropeptide Y decline as early as middle age in the dentate gyrus and CA1 and CA3 subfields of the hippocampus

B Hattiangady et al.

EXPERIMENTAL NEUROLOGY (2005)

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Article Behavioral Sciences

Aged neuropeptide Y transgenic rats are resistant to acute stress but maintain spatial and non-spatial learning

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Timing and balance of inhibition enhance the effect of long-term potentiation on cell firing

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JOURNAL OF NEUROSCIENCE (2004)

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Reduced synaptic plasticity in the lateral perforant path input to the dentate gyrus of aged C57BL/6 mice

DJ Froc et al.

JOURNAL OF NEUROPHYSIOLOGY (2003)

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Somatostatin depresses long-term potentiation and Ca2+ signaling in mouse dentate gyrus

MV Baratta et al.

JOURNAL OF NEUROPHYSIOLOGY (2002)

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Selective immunolesions of cholinergic neurons in mice: Effects on neuroanatomy, neurochemistry, and behavior

J Berger-Sweeney et al.

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Effects of adult neurogenesis on synaptic plasticity in the rat dentate gyrus

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Spatial learning and long-term potentiation in the dentate gyrus of the hippocampus in animals developmentally exposed to Aroclor 1254

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Increasing NPYergic transmission in the hippocampus rescues aging-related deficits of long-term potentiation in the mouse dentate gyrus

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