A novel three-component coupling reaction of aryne, C = N derivatives, and acrylonitrile

A literature-unprecedented three-component aryne coupling reaction with pyrroline, imine, dihydroisoquinoline, imidazoline or oxazoline as a nucleophile, and acrylonitrile as a third component, acting as both a proton donor and a nucleophile, has been developed. With imidazoline or oxazoline as the substrate, the initially formed three-component reaction product could react further to provide tetrahydro-1,4-diazepine or tetrahydro-1,4-oxazepine, respectively.

Automated summary

A literature-unprecedented three-component aryne coupling reaction has been developed, utilizing pyrroline, imine, dihydroisoquinoline, imidazoline or oxazoline as nucleophiles and acrylonitrile as a third component, which acts as both a proton donor and a nucleophile.