☆ 4.6 Review

Molecular aspects of optic nerve autophagy in glaucoma

MOLECULAR ASPECTS OF MEDICINE (2023)

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Summary: Macroautophagy and microautophagy are highly conserved cellular processes in eukaryotes that involve the degradation of cellular material in lysosomes. These processes are regulated by autophagy-related proteins and other molecules, with some shared components between the pathways. Recent advancements in technology have allowed for a better understanding of the functions of individual autophagy gene products and their implications in human disorders. Additionally, genome data has shed light on the evolution of autophagy genes and their origins in prokaryotes.

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Garcinol protects SH-SY5Y cells against MPP plus -induced cell death by activating DJ-1/SIRT1 and PGC-1α mediated antioxidant pathway in sequential stimulation of p-AMPK mediated autophagy

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