Sodium alginate/Hydroxyapatite/nanocellulose composites: Synthesis and Potentials for bone tissue engineering

Sodium alginate/hydroxyapatite/Nano cellulose (SA/HA/NC) nanocomposite films that possess good biocom-patibility for bone tissue engineering are prepared by a simple solution casting. HA is one of the most frequently used bioceramic materials to achieve a high biocompatibility. The bionanocomposite films are analysed by XRD, SEM, EDAX and FTIR studies. XRD confirms the existence of fillers in the polymer. FTIR spectrum shows the different functional modes in the bionanocomposite films. The morphology of fillers and bionanocomposite films are obtained through SEM. The inclusion of NC with different concentrations into the biopolymer film improves the tensile strength. As a result, the loading of 5 wt % of NC and 10 wt% of HA in the SA polymer shows high tensile strength when compared to the pure SA, SA filled with 10 wt% of HA and SA loaded with 10 wt% of HA and inclusion of NC (0.5 and 2.5 wt%). The tensile strength (TS) of bionanocomposite film with 10 wt % of HA is increased by 17%. TS of bionanocomposite film with 0.5 and 2.5 wt% of NC is increased by 177 and 277%, whereas TS of bionanocomposite film loaded 5 wt% of NC is increased by 331%. The swelling, biodegradation and biomineralization tests suggest that this bionanocomposite films are hopeful biomaterials for bone tissue engineering.

Automated summary

Sodium alginate/hydroxyapatite/nanocellulose (SA/HA/NC) nanocomposite films were prepared for bone tissue engineering using a simple solution casting method. The structure and properties of the composite films were studied by XRD, SEM, EDAX, and FTIR analysis. The results showed that the inclusion of different concentrations of NC improved the tensile strength of the biopolymer film. These bionanocomposite films have the potential to be used as biomaterials in bone tissue engineering.