期刊
ASIAN JOURNAL OF ORGANIC CHEMISTRY
卷 5, 期 11, 页码 1345-1352出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ajoc.201600321
关键词
benzofurans; copper; mechanistic studies; natural products; tandem reactions
资金
- Fundamental Research Funds for the Central Universities [20720160047]
- NSFC [21273187, 21133004]
An asymmetric dinuclear copper(I) complex, Cu-2(I)(pip)(2) (pip=(2-picolyliminomethyl)pyrrole anion), was used to catalyze the tandem coupling/cyclization reaction of o-iodophenols and terminal alkynes, which led to the formation of valuable 2-arylbenzofurans in good yields. DFT calculations showed that the two proximate copper atoms play cooperative roles throughout the catalytic cycle. Using this catalytic protocol, bioactive natural products stemofuran A and moracin M were concisely synthesized.
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