期刊
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
卷 305, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.saa.2023.123501
关键词
Iron oxide nanoparticle; Dipicolinic acid; Lanthanide complex; Photoluminscence assay; Photoluminescence quenching
类别
Researchers have reported a strategy for sensitive detection of dipicolinic acid (DPA) assisted by magnetic separation. By using poly(acrylic acid)-coated iron oxide nanoparticles as a magnetic carrier, only a necessary amount of Tb3+ ions are delivered to DPA in a sample solution, allowing for accurate photoluminescence measurement of the Tb3+-DPA complex with minimal background noise.
Dipicolinic acid (DPA) is a chelate capable of binding to a variety of lanthanide ions to make them luminescent in the visible range. Based on this property and also assisted by magnetic separation, we report a strategy for the sensitive detection of DPA. Poly(acrylic acid)-coated iron oxide nanoparticles (IONPs) serve as a magnetic carrier to deliver only a necessary amount of Tb3+ ions to DPA in a sample solution. This enables photoluminescence measurement of the Tb3+-DPA complex with minimal background noise. The obtained detection limit, which is as low as 0.236 nM, is more than two orders of magnitude lower than that of the assay not assisted by magnetic separation. Not only does this method possess a potential for diagnosing anthrax, given that DPA is a major constituent of Bacillus anthracis spores, but it is also useful for detecting aqueous Cu2+ ions through the luminescence quenching effect. High sensitivity with a detection limit of 54 nM [Cu2+] is demonstrated using the Eu3+-DPA complex.
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