Ugi-type Multicomponent Reaction of Nitrile Imines, Isocyanides, and Isocyanates: Effective Synthesis of 1,2,4-Triazinedione Derivatives

We have developed a Ugi-type multicomponent reaction, in which a nitrile imine, an isocyanide, and an isocyanate reacted to give the corresponding 1,2,4-triazinedione derivatives in good-to-high yields. This reaction is one of the few examples of isocyanide-based multicomponent reactions using an isocyanate in place of a carboxylic acid. A wide range of nitrile imines, isocyanides, and isocyanates were found to be applicable to the reaction.