期刊
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
卷 45, 期 3, 页码 544-550出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/21691401.2016.1160918
关键词
Bone morphogenetic protein-2; cranial bone regeneration; critical size defect; mesenchymal stem cell; transfection
资金
- Turkish Academy of Sciences (TUBA)
- Kirikkale University Scientific Research Projects Coordination Unit
Cranial bone repair and regeneration via tissue engineering principles has attracted a great deal of interest from researchers during last decade. Here, within this study, 6mm critical-sized bone defect regeneration via genetically modified mesenchymal stem cells (MSC) were monitored up to 4 months. Cranial bone repair and new bone formations were evaluated by histological staining and real time PCR analysis in five different groups including autograft and bone morphogenetic protein-2 (BMP-2) transfected MSC groups. Results presented here indicate a proper cranial regeneration in autograft groups and a prospering regeneration for hBMP-2 encoding mesenchymal stem cells.
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