期刊
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
卷 45, 期 8, 页码 1597-1604出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/21691401.2016.1267012
关键词
Artemether; lumefantrine; microcomplex; inclusion complex
The objective of the present work was to engineer and characterize stable citric acid cross-linked microcomplex of the inclusion complexes of artemether with -cyclodextrin and Kollidon VA 64((R)) with lumefantrine to release the drugs in controlled manner for effective combinational drug treatment in malaria. The microcomplex had a hydrodynamic diameter of 1047 +/- 147nm with surface charge of -19.7 +/- 0.5mV. The microcomplex showed high encapsulation efficiencies 85.6 +/- 1.78% for artemether and 91.16 +/- 2.21% for lumefantrine due to the lipophilic nature of drugs. In-vitro and in-vivo drug release studies showed the controlled release of artemether and lumefantrine for a period of 24h.
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