期刊
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
卷 45, 期 7, 页码 1356-1362出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/21691401.2016.1236805
关键词
Crocetin; polyamidoamine; polypropyleneimine; alkylation; solubility enhancement
资金
- Mashhad University of Medical Sciences, Mashhad, Iran [920848]
Poor water solubility of hydrophobic drugs is one of the major problems in pharmaceutical sciences. Herein, in order to address the poor solubility of crocetin, the 30% of primary amines of PAMAM G4 and PPI G4 were alkylated and evaluated as drug delivery vectors. According to the results, this modification could improve the drug delivery efficiency in term of drug solubility, release pattern and cytotoxicity; however, the encapsulation yield was decreased. Accordingly, it can be concluded that the designed alkylated dendrimers are able to improve the drug delivery efficiency, may be through improving the solubility and cellular uptake of crocetin.
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