期刊
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
卷 45, 期 7, 页码 1255-1271出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/21691401.2016.1246452
关键词
Stemness; MSCs; regenerative medicine; differentiation
资金
- Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran [94/2-1/2]
Recent evidence suggests that mesenchymal stem cells (MSCs) have promising therapeutic potential for a broad range of diseases. Because the percentage of MSCs obtained from tissues is very low for cell therapy applications, ex vivo expansion of MSCs is necessary, but aging, loss of stemness and undesired differentiation of them during in vitro cultivation reduces their effectiveness. For achieving ideal therapeutic potential of MSCs in tissue regenerative purposes, it is necessary to retain their stemness properties in vitro. This review emphasis on the last updates in preserving the self-renewal capability of stem cells through in vitro expansion with different parameters.
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