期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
卷 19, 期 13, 页码 4311-4326出版社
IVYSPRING INT PUBL
DOI: 10.7150/ijbs.83531
关键词
Glioma; Tumor microenvironment; Tumor evolution; Targeted therapy; Mouse model
This review discusses the paradoxical roles of the tumor microenvironment (TME) in gliomas and provides an overview of recent advances in mouse models for studying the TME. Additionally, it summarizes the recent progress made in TME-targeting therapeutic strategies.
Gliomas develop in unique and complicated environments that nourish tumor cells. The tumor microenvironment (TME) of gliomas comprises heterogeneous cells, including brain-resident cells, immune cells, and vascular cells. Reciprocal interactions among these cells are involved in the evolution of the TME. Moreover, the study of attractive therapeutic strategies that target the TME is transitioning from basic research to the clinic. Mouse models are indispensable tools for dissecting the processes and mechanisms leading to TME evolution. In this review, we overview the paradoxical roles of the TME, as well as the recent progress of mouse models in TME research. Finally, we summarize recent advances in TME-targeting therapeutic strategies.
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