期刊
MAGNETIC RESONANCE IN MEDICINE
卷 -, 期 -, 页码 -出版社
WILEY
DOI: 10.1002/mrm.29912
关键词
dynamic; lung function; oxygenation; oxygen-enhanced MRI; repeatability; susceptibility contrast
This study aims to address the challenges of dynamic lung oxygen-enhanced MRI (OE-MRI) at 3 T, including confounding signals and poor signal-to-noise ratio. The study utilizes independent component analysis (ICA) to automatically extract the oxygen-induced signal change and improve the accuracy and sensitivity of lung OE-MRI. The results demonstrate that the developed pipeline shows sensitivity to the signal enhancements of lung tissue and oxygenated blood.
Purpose: Dynamic lung oxygen-enhanced MRI (OE-MRI) is challenging due to the presence of confounding signals and poor signal-to-noise ratio, particularly at 3 T. We have created a robust pipeline utilizing independent component analysis (ICA) to automatically extract the oxygen-induced signal change from confounding factors to improve the accuracy and sensitivity of lung OE-MRI.Methods: Dynamic OE-MRI was performed on healthy participants using a dual-echo multi-slice spoiled gradient echo sequence at 3 T and cyclical gas delivery. ICA was applied to each echo within a thoracic mask. The ICA component relating to the oxygen-enhancement signal was automatically identified using correlation analysis. The oxygen-enhancement component was reconstructed, and the percentage signal enhancement (PSE) was calculated. The lung PSE of current smokers was compared with nonsmokers; scan-rescan repeatability, ICA pipeline repeatability, and reproducibility between two vendors were assessed.Results: ICA successfully extracted a consistent oxygen-enhancement component for all participants. Lung tissue and oxygenated blood displayed the opposite oxygen-induced signal enhancements. A significant difference in PSE was observed between the lungs of current smokers and nonsmokers. The scan-rescan repeatability and the ICA pipeline repeatability were good.Conclusion: The developed pipeline demonstrated sensitivity to the signal enhancements of the lung tissue and oxygenated blood at 3 T. The difference in lung PSE between current smokers and nonsmokers indicates a likely sensitivity to lung function alterations that may be seen in mild pathology, supporting future use of our methods in patient studies.
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