Prediction of Clinical Precision Chemotherapy by Patient-Derived 3D Bioprinting Models of Colorectal Cancer and Its Liver Metastases

Article Engineering, Biomedical

3D bioprinting of a gelatin-alginate hydrogel for tissue-engineered hair follicle regeneration

Deni Kang et al.

Summary: A 3D bioprinting technique was used to construct a multi-layer composite scaffold that mimicked the hair follicle microenvironment, leading to successful regeneration of hair follicles in nude mice.

ACTA BIOMATERIALIA (2023)

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Review Engineering, Biomedical

Advances in Gelatin Bioinks to Optimize Bioprinted Cell Functions

Saad Asim et al.

Summary: Gelatin is commonly used in bioprinting because of its cell-adhesive and enzymatically cleavable properties. However, the covalently cross-linked matrix of gelatin is unable to mimic the dynamic microenvironment of the natural extracellular matrix, limiting the functions of bioprinted cells. This review evaluates the progress in developing gelatin bioinks for 3D cell culture and discusses strategies to optimize bioprinted cell functions, including new cross-linking chemistries that emulate the mechanical properties of the extracellular matrix.

ADVANCED HEALTHCARE MATERIALS (2023)

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Article Multidisciplinary Sciences

High cell density and high-resolution 3D bioprinting for fabricating vascularized tissues

Shangting You et al.

Summary: Three-dimensional bioprinting techniques are widely used for fabricating 3D-engineered tissues, but face challenges in maintaining high cell density, cell viability, and fabrication resolution simultaneously. A novel approach using iodixanol in bioink was developed to reduce light scattering and improve fabrication resolution. Tissues with high cell density and fine vascular networks were successfully fabricated, and showed viability and endothelialization after 14 days of culture in a perfusion system.

SCIENCE ADVANCES (2023)

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Review Chemistry, Multidisciplinary

3D Bioprinting of Cell-Laden Hydrogels for Improved Biological Functionality

Sarah M. Hull et al.

Summary: Using gel-phase materials as bioinks offers advantages in providing cell protection and biological signals. Challenges remain in terms of cell compatibility and biological functionality of bioink materials.

ADVANCED MATERIALS (2022)

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Article Oncology

Organoid Sensitivity Correlates with Therapeutic Response in Patients with Pancreatic Cancer

Joseph E. Grossman et al.

Summary: This pilot feasibility trial investigated the use of patient-derived organoids (PDOs) to guide personalized therapy for pancreatic ductal adenocarcinoma (PDAC). The study found that the drug sensitivity of PDOs can predict the clinical outcome of patients and is correlated with treatment responses.

CLINICAL CANCER RESEARCH (2022)

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Review Oncology

Independent Drug Action in Combination Therapy: Implications for Precision Oncology

Deborah Plana et al.

Summary: Combination therapies are more effective in treating cancer than monotherapy, addressing tumor heterogeneity. The model of independent drug action provides multiple opportunities for benefit from at least one drug, and personalized, targeted combination therapy can increase therapeutic benefits.

CANCER DISCOVERY (2022)

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Article Multidisciplinary Sciences

Comprehensive profiling of 1015 patients' exomes reveals genomic-clinical associations in colorectal cancer

Qi Zhao et al.

Summary: Through ultradeep whole-exome sequencing, we identified 46 significantly mutated genes associated with CRC and proposed a subtyping strategy that classifies CRC patients into four genomic subtypes with distinct clinical characteristics. Additionally, we found that mitochondrial DNA copy number is an independent factor for predicting the survival outcome of CRCs.

NATURE COMMUNICATIONS (2022)

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Article Chemistry, Multidisciplinary

Patient-Derived Organoids from Colorectal Cancer with Paired Liver Metastasis Reveal Tumor Heterogeneity and Predict Response to Chemotherapy

Shaobo Mo et al.

Summary: A living biobank with 50 patient-derived organoids (PDOs) derived from colorectal cancer liver metastasis (CRLM) has been successfully constructed. Comprehensive analysis at the multiomics levels confirmed that this organoid platform could capture intra- and interpatient heterogeneity. In vitro chemosensitivity data have revealed the potential clinical application for PDOs to predict chemotherapy response and clinical prognosis for CRLM patients.

ADVANCED SCIENCE (2022)

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Article Gastroenterology & Hepatology

Three-dimensional bioprinted hepatorganoids prolong survival of mice with liver failure

Huayu Yang et al.

Summary: The study focuses on 3D bioprinted hepatorganoids, liver tissue models generated using HepaRG cells, showing comprehensive liver functions in vitro and in vivo. After transplantation, the hepatorganoids improved the survival rate of mice, providing a potential alternative for treating liver failure.

GUT (2021)

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Article Engineering, Biomedical

Biofabrication of endothelial cell, dermal fibroblast, and multilayered keratinocyte layers for skin tissue engineering

Natan R. Barros et al.

Summary: Current skin models are limited in emulating the multifaceted functions of skin tissues. Researchers have developed a 3D skin model with endothelial cell networks, dermal fibroblasts, and multilayered keratinocytes using biomaterial-based approaches and bioengineered techniques, with implications in the biofabrication of skin systems for regenerative medicine and disease modeling.

BIOFABRICATION (2021)

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Article Engineering, Biomedical

Three-dimensional bio-printing of primary human hepatocellular carcinoma for personalized medicine

Feihu Xie et al.

Summary: This study established a modeling system using three-dimensional bioprinting technology for patient-specific drug screening for hepatocellular carcinoma. The models retained features of parental HCCs, including stable biomarker expression and genetic alterations. Additionally, the models were capable of intuitively and quantitatively displaying drug screening results.

BIOMATERIALS (2021)

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Article Oncology

Patient-derived xenograft (PDX) models of colorectal carcinoma (CRC) as a platform for chemosensitivity and biomarker analysis in personalized medicine

Maria Rivera et al.

Summary: This study established, characterized, and tested therapy for colorectal carcinoma-derived PDX, revealing the responsiveness of PDX to various drugs and the molecular mechanisms underlying drug sensitivity. The correlation analysis of predictive factors for cetuximab sensitivity highlighted potential novel therapeutic targets for cancer treatment.

NEOPLASIA (2021)

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Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Article Chemistry, Medicinal

Advanced Strategies for 3D Bioprinting of Tissue and Organ Analogs Using Alginate Hydrogel Bioinks

Qiqi Gao et al.

Summary: Alginate hydrogel as a bioink for 3D bioprinting has advantages of low cost, good biocompatibility, and rapid ionic gelation, but faces limitations such as lack of cell adhesive moieties, erratic biodegradability, and poor printability. Various advanced material formulations and biofabrication strategies have been developed to overcome these drawbacks and enhance the applications of alginate-based bioink in tissue engineering.

MARINE DRUGS (2021)

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Review Medicine, General & Internal

Diagnosis and Treatment of Metastatic Colorectal Cancer: A Review

Leah H. Biller et al.

Summary: Colorectal cancer is the third most common cause of cancer mortality worldwide. For patients diagnosed with metastatic colorectal cancer, approximately 70% to 75% can survive beyond 1 year. Tailoring treatments based on the molecular and pathologic features of the tumor has shown to improve overall survival rates.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

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Editorial Material Gastroenterology & Hepatology

Addressing the variation in hepatic surgery for colorectal liver metastasis

Rachel V. Guest et al.

HEPATOBILIARY SURGERY AND NUTRITION (2021)

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Review Pharmacology & Pharmacy

Bioink: a 3D-bioprinting tool for anticancer drug discovery and cancer management

Arpita P. Tiwari et al.

Summary: Bioinks are crucial for the fabrication of artificial living-tissue constructs using 3D bioprinting technologies, with a significant application in cancer management. The ability to recreate tumor microenvironments using 3D bioprinting is a promising approach for drug development and in vitro cancer modeling.

DRUG DISCOVERY TODAY (2021)

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Editorial Material Gastroenterology & Hepatology

Surgical treatment of colorectal cancer liver metastases: individualized comprehensive treatment makes a difference

Zhiwen Luo et al.

HEPATOBILIARY SURGERY AND NUTRITION (2021)

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Article Biotechnology & Applied Microbiology

A Colorectal Cancer 3D Bioprinting Workflow as a Platform for Disease Modeling and Chemotherapeutic Screening

Yordan Sbirkov et al.

Summary: The research team has developed an affordable, flexible, and highly reproducible 3D bioprinted CRC model, which better mimics tumor morphology, providing a potential for further research and treatment.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2021)

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Review Oncology

Tumor organoids: synergistic applications, current challenges, and future prospects in cancer therapy

Jingjing Qu et al.

Summary: Patient-derived cancer organoids have overcome the limitations of traditional models, closely mimicking the pathophysiological features of natural tumorigenesis and metastasis, enabling personalized treatment and biomarker discovery. Combining cancer organoids with other technologies and treatments has proven effective in overcoming limitations and developing more suitable model systems.

CANCER COMMUNICATIONS (2021)

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Article Oncology

3D Bioprinted cancer models: Revolutionizing personalized cancer therapy

Robin Augustine et al.

Summary: The use of 3D bioprinting technology in generating bioengineered tumor models offers a promising approach for personalized cancer therapy screening, by accurately mimicking the human tumor tissues and microenvironment for high-throughput drug screening.

TRANSLATIONAL ONCOLOGY (2021)

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Review Medicine, General & Internal

Screening and prevention of colorectal cancer

Priyanka Kanth et al.

Summary: Mortality from colorectal cancer can be reduced through screening and early detection; current efforts and tools for screening have been advancing, but overall screening rates in the US are suboptimal.

BMJ-BRITISH MEDICAL JOURNAL (2021)

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Article Cell & Tissue Engineering

Patient-Derived Organoids Predict Chemoradiation Responses of Locally Advanced Rectal Cancer

Ye Yao et al.

CELL STEM CELL (2020)

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Review Engineering, Biomedical

Could 3D models of cancer enhance drug screening?

Virginia Brancato et al.

BIOMATERIALS (2020)

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Article Oncology

Colorectal cancer statistics, 2020

Rebecca L. Siegel et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2020)

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Article Engineering, Biomedical

Cell encapsulation in gelatin bioink impairs 3D bioprinting resolution

Rachel Schwartz et al.

JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS (2020)

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Review Chemistry, Multidisciplinary

Bioprinting: From Tissue and Organ Development to in Vitro Models

Carlos Mota et al.

CHEMICAL REVIEWS (2020)

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Article Oncology

Application of a 3D Bioprinted Hepatocellular Carcinoma Cell Model in Antitumor Drug Research

Lejia Sun et al.

FRONTIERS IN ONCOLOGY (2020)

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Review Oncology

Human-Derived Model Systems in Gynecological Cancer Research

Kadi Lohmussaar et al.

TRENDS IN CANCER (2020)

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Article Engineering, Biomedical

Bioprinting of patient-derivedin vitrointrahepatic cholangiocarcinoma tumor model: establishment, evaluation and anti-cancer drug testing

Shuangshuang Mao et al.

BIOFABRICATION (2020)

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Article Oncology

Capturing colorectal cancer inter-tumor heterogeneity in patient-derived xenograft (PDX) models

Pramudita R. Prasetyanti et al.

INTERNATIONAL JOURNAL OF CANCER (2019)

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Review Engineering, Biomedical

Advancing Frontiers in Bone Bioprinting

Nureddin Ashammakhi et al.

ADVANCED HEALTHCARE MATERIALS (2019)

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Review Oncology

Tumor organoids: From inception to future in cancer research

Liang Yang et al.

CANCER LETTERS (2019)

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Article Multidisciplinary Sciences

3D bioprinting of collagen to rebuild components of the human heart

A. Lee et al.

SCIENCE (2019)

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Review Multidisciplinary Sciences

Cancer modeling meets human organoid technology

David Tuveson et al.

SCIENCE (2019)

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Article Biochemistry & Molecular Biology

Properties of an alginate-gelatin-based bioink and its potential impact on cell migration, proliferation, and differentiation

Liuhanghang Cheng et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2019)

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Review Medicine, General & Internal

Colorectal cancer

Evelien Dekker et al.

LANCET (2019)

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Article Biochemistry & Molecular Biology

A rectal cancer organoid platform to study individual responses to chemoradiation

Karuna Ganesh et al.

NATURE MEDICINE (2019)

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Article Engineering, Biomedical

Bioprinting of 3D breast epithelial spheroids for human cancer models

Swathi Swaminathan et al.

BIOFABRICATION (2019)

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Article Oncology

Clinical Sequencing Defines the Genomic Landscape of Metastatic Colorectal Cancer

Rona Yaeger et al.

CANCER CELL (2018)

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Article Anatomy & Morphology

3D printed tissue engineered model for bone invasion of oral cancer

Thafar Almela et al.

TISSUE & CELL (2018)

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Review Biotechnology & Applied Microbiology

Personalized Cancer Medicine: An Organoid Approach

Hamidreza Aboulkheyr Es et al.

TRENDS IN BIOTECHNOLOGY (2018)

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Article Engineering, Biomedical

Human Tissue Models: Engineering 3D Hydrogels for Personalized In Vitro Human Tissue Models (Adv. Healthcare Mater. 4/2018)

Chya-Yan Liaw et al.

Advanced Healthcare Materials (2018)

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Article Oncology

Parenchymal sparing surgery brings treatment of colorectal liver metastases into the precision medicine era

Serge Evrard et al.

EUROPEAN JOURNAL OF CANCER (2018)

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Review Physics, Applied

Evaluation of bioink printability for bioprinting applications

Zhengyi Zhang et al.

APPLIED PHYSICS REVIEWS (2018)

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Article Biotechnology & Applied Microbiology

Tumor-like lung cancer model based on 3D bioprinting

Xiong Wang et al.

3 BIOTECH (2018)

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Review Oncology

From tumour heterogeneity to advances in precision treatment of colorectal cancer

Cornelis J. A. Punt et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2017)

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Article Cell Biology

Personalized Proteome Profiles of Healthy and Tumor Human Colon Organoids Reveal Both Individual Diversity and Basic Features of Colorectal Cancer

Alba Cristobal et al.

CELL REPORTS (2017)

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Article Biochemistry & Molecular Biology

Combination Cancer Therapy Can Confer Benefit via Patient-to-Patient Variability without Drug Additivity or Synergy

Adam C. Palmer et al.

CELL (2017)

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Review Biochemistry & Molecular Biology

Tumor Organoids as a Pre-clinical Cancer Model for Drug Discovery

Fleur Weeber et al.

CELL CHEMICAL BIOLOGY (2017)

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Review Engineering, Biomedical

3D bioprinting for drug discovery and development in pharmaceutics

Weijie Peng et al.

ACTA BIOMATERIALIA (2017)

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Article Oncology

ESMO consensus guidelines for the management of patients with metastatic colorectal cancer

E. Van Cutsem et al.

ANNALS OF ONCOLOGY (2016)

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Article Engineering, Biomedical

Direct 3D bioprinting of perfusable vascular constructs using a blend bioink

Weitao Jia et al.

BIOMATERIALS (2016)

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Review Biotechnology & Applied Microbiology

3D bioprinting for engineering complex tissues

Christian Mandrycky et al.

BIOTECHNOLOGY ADVANCES (2016)

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Article Cell Biology

Genomic Correlates of Immune-Cell Infiltrates in Colorectal Carcinoma

Marios Giannakis et al.

CELL REPORTS (2016)

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Review Oncology

Managing synchronous liver metastases from colorectal cancer: A multidisciplinary international consensus

Rene Adam et al.

CANCER TREATMENT REVIEWS (2015)

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Article Biochemistry & Molecular Biology

Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients

Marc van de Wetering et al.

CELL (2015)

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Review Biotechnology & Applied Microbiology

Bioprinting for cancer research

Stephanie Knowlton et al.

TRENDS IN BIOTECHNOLOGY (2015)

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Review Biotechnology & Applied Microbiology

3D bioprinting of tissues and organs

Sean V. Murphy et al.

NATURE BIOTECHNOLOGY (2014)

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Review Oncology

Patient-Derived Xenograft Models: An Emerging Platform for Translational Cancer Research

Manuel Hidalgo et al.

CANCER DISCOVERY (2014)

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Article Materials Science, Biomaterials

Bio-ink properties and printability for extrusion printing living cells

Johnson H. Y. Chung et al.

BIOMATERIALS SCIENCE (2013)

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Article Multidisciplinary Sciences

Comprehensive molecular characterization of human colon and rectal cancer

Donna M. Muzny et al.

NATURE (2012)

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Article Biochemistry & Molecular Biology

The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data

Aaron McKenna et al.

GENOME RESEARCH (2010)

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Article Biochemical Research Methods

Fast and accurate short read alignment with Burrows-Wheeler transform

Heng Li et al.

BIOINFORMATICS (2009)

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Article Oncology

Importance of histological tumor response assessment in predicting the outcome in patients with colorectal liver metastases treated with neo-adjuvant chemotherapy followed by liver surgery

L. Rubbia-Brandt et al.

ANNALS OF ONCOLOGY (2007)

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Article Oncology

Survival of patients with advanced colorectal cancer improves with the availability of fluorouracil-leucovorin, irinotecan, and oxaliplatin in the course of treatment

A Grothey et al.

JOURNAL OF CLINICAL ONCOLOGY (2004)

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Article Medicine, General & Internal

Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial

JY Douillard et al.

LANCET (2000)

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Prediction of Clinical Precision Chemotherapy by Patient-Derived 3D Bioprinting Models of Colorectal Cancer and Its Liver Metastases

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