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Article
Cell Biology
Jinke Huang et al.
Summary: This study investigates the correlation between Helicobacter pylori (H. pylori) immunoglobulin G (IgG) seropositivity and plasma homocysteine (Hcy) levels. Based on data from the National Health and Nutrition Examination Survey (NHANES) cycle 1999-2000, it is found that H. pylori IgG seropositivity is prevalent in the population, with higher prevalence in older individuals, Mexican Americans, lower education, and lower household income. Overall, there is no significant association between H. pylori IgG seropositivity and Hcy levels, but a negative correlation is observed in Mexican Americans.
MEDIATORS OF INFLAMMATION
(2023)
Article
Chemistry, Multidisciplinary
X. Y. Lin et al.
Summary: A near-infrared fluorescent probe LS-NO has been developed for the real-time detection of nitric oxide in inflammatory bowel disease. The probe utilizes oligoglycol morpholine-functionalized thiophene as electron donors and diaminobenzene as a weak electron acceptor and NO trapping group. It can detect exogenous and endogenous NO in living cell lysosomes with high sensitivity and specificity. The analysis of electron transfer in model molecules DAD-NO and DAD-TZ under density functional theory reveals the transformation from diaminobenzene as a weak electron acceptor to triazolo-benzo-(1,2,5-thiadiazole) as a strong electron acceptor, making LS-NO an effective off-on near-infrared NO fluorescent probe.
FRONTIERS IN CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Adelie Gothland et al.
Summary: Reprogrammed metabolism, redox equilibrium, and ROS production play important roles in cancer development and are particularly influential in HHV-8 related diseases such as Kaposi sarcoma and primary effusion lymphoma. Primaquine diphosphate has been found to induce apoptosis in HHV-8 infected PEL cell lines through ROS production, indicating that targeting the redox balance could be a potential approach for treating HHV-8 related diseases. This review focuses on the role of ROS in cancer development and provides evidence for the importance of redox pathways in HHV-8 pathologies.
Review
Chemistry, Multidisciplinary
Rahul Kaushik et al.
Summary: Biothiols, such as cysteine, homocysteine, and glutathione, are important compounds with a free thiol group. They play a crucial role in metabolic processes when present in optimal concentrations. Researchers have developed various probes, including NIR organic probes, for the detection and quantification of biothiols, which have been widely used in in vivo and in vitro imaging. This review summarizes the NIR probes for biothiols, discusses their sensing mechanism and potential applications, and classifies them based on the fluorophore used, providing information on their photophysical and sensing properties.
Article
Biochemistry & Molecular Biology
Qi Cao et al.
Summary: Recent studies have shown that pyroptosis has an influence on tumor development, but the relationship between pyroptosis and tumors varies for different tissues and cells. Pyroptosis has potential as a promising target for cancer therapy and can be used as a therapeutic approach for treating tumors.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Review
Cardiac & Cardiovascular Systems
Elizabeth Murphy et al.
Summary: Cardiomyocytes have a high density of mitochondria, which play a crucial role in energy production and cellular functions. The regulation of mitochondrial calcium and reactive oxygen species is important in the development of cardiovascular disease.
CARDIOVASCULAR RESEARCH
(2023)
Article
Materials Science, Textiles
Zixiong Peng et al.
Article
Biochemistry & Molecular Biology
Jignesh D. Pandya et al.
Summary: Traumatic Brain Injury (TBI) is a heterogeneous disorder caused by external physical assaults that damages the brain. Mitochondrial dysfunction plays a pivotal role in long-term injury progression through cellular excitotoxicity. This study provides an in-depth evaluation of mitochondrial endpoints with respect to redox and calcium homeostasis, and cell death responses following penetrating TBI (PTBI).
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Review
Chemistry, Multidisciplinary
Yi Chen et al.
Summary: The etiology of inflammatory bowel disease (IBD) is complex and involves an excessive immune response leading to the release of reactive oxygen species (ROS) and chronic inflammation. Targeting excess ROS for inflammatory suppression has been recognized as a feasible strategy for treating IBD. Additionally, overexpression of ROS can trigger drug release from novel drug delivery systems to alleviate IBD symptoms.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Biochemistry & Molecular Biology
Weizhong Ding et al.
Summary: A new near-infrared thioxanthene-hemicyanine dye (Cy-DNBS) has been developed for simultaneous fluorescence and photoacoustic imaging of biothiols. Upon treatment with biothiols, Cy-DNBS exhibits strong near-infrared absorption and a subsequent turn-on photoacoustic signal. Additionally, the fluorescence intensity of Cy-DNBS increases instantly. The dye has been successfully used for imaging endogenous and exogenous biothiols in cells and mice, as well as tracking biothiols upregulation in the liver of mice triggered by S-adenosyl methionine. Cy-DNBS shows great potential for studying biothiols-related physiological and pathological processes.
Article
Chemistry, Analytical
Yongquan Wu et al.
Summary: This study designed and synthesized a near-infrared (NIR) xanthene derivative IFU-1 as a frequency up-conversion luminescence (FUCL) probe for detecting biothiols. The probe IFU-1 exhibited high selectivity for biothiols and enhanced FUCL signals in response to them. Additionally, it had extremely low detection limits for different biothiols, which were about 10 times lower than the detection limits of traditional excitation methods.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Spectroscopy
Boxin Zhou et al.
Summary: Cysteine plays an important role in the human body, and abnormal concentration can lead to various diseases. Detecting cysteine in vivo with high selectivity and sensitivity is therefore significant. In this study, a small organic fluorescent probe ZHJ-X was designed and synthesized based on cyanobiphenyl, which specifically recognized cysteine. The probe ZHJ-X demonstrated specific selectivity, high sensitivity, short response time, good anti-interference ability, and a low detection limit of 3.8 x 10-6 M. It was successfully applied for visualizing cysteine in living cells and holds potential for cell imaging and detection.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Spectroscopy
Pai Liu et al.
Summary: The level of hydrogen sulfide (H2S) in the human body is associated with various diseases. Therefore, the detection of H2S level in biological systems is important and has attracted attention from researchers. This study thoroughly investigated the mechanisms of a highly efficient fluorescent probe based on the Fluorescence Resonance Energy Transfer (FRET), providing insights for designing new probes applicable in biological systems.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Chemistry, Organic
Yong Zhang et al.
Summary: In this study, a novel and highly effective probe for biothiols detection was developed by integrating a four-ring quinoxaline fluorophore and a maleimide receptor into one molecule for the first time. The fluorescence of the quinoxaline fluorophore was quenched by the maleimide group through the photoinduced electron transfer (PET) mechanism. The PET process was then blocked and the fluorescence restored after the Michael addition of the biothiols to the maleimide. The probe demonstrated high selectivity towards biothiols over other amino acids, and it exhibited a good linearity range and low detection limit to Cys, Hcy, and GSH. Furthermore, the probe could be used for monitoring biothiols in living cells and zebrafish. (c) 2023 Elsevier Ltd. All rights reserved.
Review
Nutrition & Dietetics
Jordan Swiderski et al.
Summary: The shift to Western style and sedentary lifestyles in modern dietary regimens is believed to contribute to the global burden of cardiovascular diseases. Natural products, such as taurine and black pepper, have gained attention for their non-toxic beneficial health effects. This review examines whether the combination of taurine and black pepper extract is an effective natural treatment for reducing cardiovascular disease risk factors and combating related diseases.
Article
Biochemistry & Molecular Biology
Eleni A. Kisty et al.
Summary: The mitochondrion is a crucial component in cellular energy production and oxidoregulation. This study identified redox-sensitive cysteines on mitochondrial proteins through the use of mitochondrial enrichment and redox proteomics techniques. The results revealed both known and unknown cysteines on diverse mitochondrial proteins that are responsive to endogenous and exogenous reactive oxygen species.
Article
Biochemistry & Molecular Biology
Ricardo Pires das Neves et al.
Summary: This study reveals the importance of thiol groups from cysteines in cellular response to ROS and their role in signaling. Different subcellular compartments have different amounts of these thiol groups, with the nucleolus having the highest concentration. These findings provide insights into the differential sensitivity of cells to ROS.
Article
Chemistry, Analytical
Wei Du et al.
Summary: In this study, a coumarin derivative, SWJT-14, was synthesized as a fluorescence probe to effectively distinguish Cys, Hcy, and GSH in aqueous solutions. The probe showed a lower detection limit for Cys, Hcy, and GSH compared to biothiols in cells. It reacted with biothiols to generate different products with distinct conjugated structures, and fluorescence and UV-Vis spectra were used for differentiation. The detection mechanism was confirmed by MS. SWJT-14 was successfully utilized in cellular experiments for the detection of both endogenous and exogenous biothiols.
Article
Nanoscience & Nanotechnology
Le Qu et al.
Summary: This study demonstrates the first use of π-conjugated radicals for scavenging reactive oxygen species (ROS). 1,2,4-benzotriazinyl monoradical VER and its carboxyl counterpart VAR exhibit different stability and dispersibility when self-assembled with DSPE-PEG1000. VER NPs are stable with good water dispersibility, while VAR NPs are unstable and prone to aggregation. The results also show that VER NPs effectively scavenge excessive ROS in model cells, whereas VAR NPs do not show the same effect.
ACS APPLIED NANO MATERIALS
(2023)
Article
Chemistry, Applied
Ge Ding et al.
Summary: Due to the crucial role of biothiols in physiological processes, it is of great scientific significance to develop a convenient and efficient sensing method for biothiols detection. In this study, a novel fluorescent probe DEMCA-NBSC based on coumarin fragment was successfully designed and developed. It exhibited rapid response, high selectivity, low toxicity, and outstanding sensitivity for biothiols, making it an effective tool for real-time detection of biothiols in both vivo and vitro.
Article
Chemistry, Applied
Lin Si et al.
Summary: A fluorescent copper(I) iodide-based coordination polymer was synthesized and utilized for the detection of biothiols and antimicrobial study, highlighting its potential application in optical field.
Article
Chemistry, Applied
Guo-Biao Zhu et al.
Summary: The synthesis of quinoline-malononitrile (QM)-based fluorescent probes with and without iodine substitution surrounding its phenolic ring was studied. It was found that iodine substitution compromised the aggregation-induced emission of QM but enhanced the sensitivity for biothiols including L-cystine (L-Cys) detection in weakly acidic to neutral aqueous solutions by reducing the pKa of the QM fluorogen. The probe also enabled the visualization of fluctuating L-Cys levels in cells.
Article
Chemistry, Analytical
Ruke Wang et al.
Summary: An enhanced nanozyme was synthesized by functionalizing natural microperoxidase-11 (MP-11) on a hybrid graphene oxide-gold (GO-Au) material. The designed nanozyme showed enhanced catalysis activity and achieved robust and efficient colorimetric detection of cysteine based on specific binding reaction. These enhanced properties of the nanozyme demonstrate promising applications and provide a great opportunity for developing efficient sensing systems.
ANALYTICA CHIMICA ACTA
(2023)
Article
Spectroscopy
Rong Tang et al.
Summary: The homeostasis of biothiols is crucial for organisms' health. A fluorescent probe (7HIN-D) based on a chalcone fluorophore 7HIN was developed for intracellular biothiols detection. The probe exhibited turn-on AIE fluorescence upon the nucleophilic substitution reaction between biothiols and DNBS unit, with good sensitivity and selectivity. It successfully detected endogenous biothiols in living cells due to its excellent performance, biocompatibility, and low cytotoxicity.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Chemistry, Organic
Zhou Siyi et al.
Summary: Biothiols, such as cysteine, homocysteine, and glutathione, play important roles in physiological and pathological processes. A fluorescent probe was designed and synthesized for the selective imaging of biothiols in living cells and mice. The probe showed high selectivity and low detection limits, and could also achieve the selective imaging of normal hepatocytes and hepatocarcinoma cells.
CHINESE JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Volha Mezhnina et al.
Summary: This article discusses the role of the circadian clock and mitochondrial rhythms in maintaining ROS homeostasis. The circadian clock regulates mitochondrial functions, including nutrient flux, oxidation, antioxidant defense, and mitochondrial dynamics. Understanding the molecular mechanisms of circadian control of mitochondrial functions is essential in preventing metabolic diseases and delaying aging.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Chemistry, Physical
Guijie Zhao et al.
Summary: This study investigates the excited state intramolecular proton transfer process (ESIPT) of Compound 1 under different solvent conditions using density functional and time-dependent density functional methods. The results show that the photophysical properties of Compound 1 are influenced by the solvent environment.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Nanoscience & Nanotechnology
Yaqun Ma et al.
Summary: In this research, a fluorescent probe with multiple binding sites was synthesized to detect biothiols in tumor cells with strong NIR II luminescence. The probe showed good stability and biocompatibility with little luminescence quenching in aqueous phase. When combined with bevacizumab and Capmatinib, the probe exhibited stronger targeted imaging in head and neck squamous cell carcinoma.
Article
Chemistry, Multidisciplinary
Huimin Jiang et al.
Summary: This study developed a multisite-binding fluorescent probe for simultaneous sensing of mitochondrial Cys, GSH, and Hcy. The probe exhibited rapid fluorescence turn-on, good water-solubility, and high selectivity.
CHINESE CHEMICAL LETTERS
(2022)
Article
Chemistry, Physical
Yu-ling Liu et al.
Summary: A small molecule probe has been designed recently for the simultaneous detection of Human Serum Albumin (HSA) and Sulfite via distinct fluorescent signals, providing a significant opportunity for understanding the synergistic action between sulfite and HSA in disease.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Biochemistry & Molecular Biology
Francisca Villavicencio-Tejo et al.
Summary: Alzheimer's disease is characterized by memory and cognitive impairment, with the accumulation of amyloid beta-peptide and the presence of pathological forms of tau protein. Activation of the Nrf2 pathway has been found to protect against mitochondrial injury induced by pathological tau protein.
Article
Nanoscience & Nanotechnology
Ranadip Goswami et al.
Summary: Metal-organic frameworks (MOFs) combine renewable energy generation and environmental remediation to devise smarter materials. The robust and non-interpenetrated cationic MOF shows remarkable performance in efficient electrochemical oxygen evolution reaction (OER) and ultrasensitive monitoring of biohazards.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Applied
Xiang-Gen Chen et al.
Summary: In this paper, a novel fluorescent probe was developed for the selective detection of biothiols in biological systems. The probe has been successfully applied to sense biothiols in living cells.
Article
Chemistry, Analytical
Huiling Hou et al.
Summary: Research has shown that metabolic imbalances of biothiols are closely linked to various diseases. In this study, the synthesized probe CDS-NBD displayed significant fluorescence enhancement, good sensitivity and selectivity towards Cys/Hcy and GSH, and the ability to distinguish between different fluorescent signals. This research contributes to the quantitative evaluation and discrimination of biothiols in complex biological environments.
Article
Chemistry, Analytical
Lingliang Long et al.
Summary: A novel fluorescent probe and a portable fluorescence detection device have been developed to simultaneously discriminate Cys, CysGly, Hcy, and GSH in different fluorescence channels. This provides a quick and inexpensive method for on-site quantitative discrimination of these biothiols in biological fluids.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Analytical
Yuan-Qiang Hao et al.
Summary: A dual-emission fluorescent probe (RED-NBD) was developed for discriminative detection of Cys/Hcy and GSH. This probe can differentiate between Cys/Hcy and GSH by displaying distinct fluorescence colors under a single-wavelength excitation. It also has the potential for visualizing Cys/Hcy and GSH in cells.
CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Lingliang Long et al.
Summary: The newly developed fluorescent probe can differentiate cysteine, cysteinylglycine, homocysteine, and glutathione in biological fluids simultaneously. Combined with a portable fluorescence detection device, it can accurately quantify the fluorescence intensities in biological fluids, providing a quick and inexpensive method for screening and diagnosing diseases related to biothiols.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Engineering, Biomedical
Boyi Niu et al.
Summary: Glutathione (GSH) plays a crucial role in cellular antioxidative system, particularly in cancer cells, where a high level of GSH is essential for scavenging ROS and detoxifying xenobiotics. Depletion of GSH has been shown to enhance the efficacy of various therapies such as ROS-based therapy, ferroptosis, and chemotherapy. This review comprehensively discusses the importance of GSH depletion in cancer therapy and various strategies employed to achieve it.
Review
Chemistry, Inorganic & Nuclear
Yuning Liu et al.
Summary: RSS and RSeS play important roles in maintaining physiological balance, and their imbalance is closely related to human diseases. Using fluorescent probes for quantitative analysis may promote the development of personalized diagnosis and treatment.
COORDINATION CHEMISTRY REVIEWS
(2021)
Article
Chemistry, Physical
Yong-jin Peng et al.
Summary: Copper nanoclusters have significant price advantages compared to gold and silver, making them promising materials for photoluminescence analysis, biological imaging, and catalysis. Understanding the electronic structures and optical properties of these nanoclusters can help in designing new structures with desired properties.
CHEMICAL PHYSICS LETTERS
(2021)
Review
Chemistry, Organic
Jiko Raut et al.
Summary: Thiol-containing amino acids and peptides play crucial roles in physiological processes, with Cysteine and Homocysteine linked to various health disorders and Glutathione performing vital biological functions in combating oxidative stress. The development of highly sensitive and selective chemosensors for the detection of biothiols is of considerable importance, with researchers exploring novel approaches and applications in different biological samples.
MINI-REVIEWS IN ORGANIC CHEMISTRY
(2021)
Article
Optics
Guijie Zhao et al.
Summary: This study investigates the excited-state intramolecular proton transfer (ESIPT) reaction mechanism of a novel chromophore BTS using density functional theory (DFT) and time-dependent density functional theory (TD-DFT) methods. The research shows that the intramolecular hydrogen bonding is enhanced under the excited state, providing driving force for the ESIPT process.
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PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2005)
