In silico designing of an epitope-based peptide vaccine cocktail against Nipah virus: an Indian population-based epidemiological study

Nipah virus, a zoonotic virus from the family Paramyxoviridae has led to significant loss of lives till date with the most recent outbreak in India reported in Kerala. The virus has a considerably high mortality rate along with lack of characteristic symptoms which results in the delay of the virus detection. No specific vaccine is available for the virus although monoclonal antibody treatment has been seen to be effective along with favipiravir. The high mortality and complications caused by the virus underscores the necessity to develop alternative modes of vaccination. One such method has been designed in this study using peptide cocktail consisting of the immunologically important epitopes for use as vaccine. The human leucocytic antigens that are used for the study were analyzed for their presence in various ethnic Indian populations. This study may serve as a new avenue for development of more efficient peptide cocktail vaccines in recent future based on the population genetics and ethnicity.

Automated summary

Nipah virus, a dangerous virus with high mortality and lack of characteristic symptoms, has caused significant loss of lives. This study proposes a new method using peptide cocktail as a vaccine, which may lead to the development of more effective vaccines in the future based on population genetics and ethnicity.