4.5 Article

Metabolic reprograming and increased inflammation by cadmium exposure following early-life respiratory syncytial virus infection: the involvement of protein S-palmitoylation

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Toxicology

Low-Dose Cadmium Potentiates Metabolic Reprogramming Following Early-Life Respiratory Syncytial Virus Infection

Zachery R. Jarrell et al.

Summary: This study investigated the effects of low-dose cadmium (Cd) exposure following early-life respiratory syncytial virus (RSV) infection on lung metabolism and inflammation. The results showed that low-dose Cd following early-life RSV infection enhanced lung inflammation and caused metabolic disruption. Histopathology data also indicated the occurrence of fibrosis. This study demonstrates the significant impact of cumulative Cd exposure following early-life RSV infection on subsequent inflammation and lung metabolism.

TOXICOLOGICAL SCIENCES (2022)

Article Multidisciplinary Sciences

DARPP32, a target of hyperactive mTORC1 in the retinal pigment epithelium

Jiyang Cai et al.

Summary: mTORC1, an important regulator in cell metabolism and stress response, has been found to play a pathogenic role in age-related macular degeneration (AMD). In this study, a previously unknown signaling protein called DARPP-32, regulated by mTORC1, was identified and found to contribute to the degeneration of retinal pigment epithelium (RPE) in AMD.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

Article Medicine, Research & Experimental

The ZIP8/SIRT1 axis regulates alveolar progenitor cell renewal in aging and idiopathic pulmonary fibrosis

Jiurong Liang et al.

Summary: This study identified a deficiency of the zinc transporter SLC39A8 (ZIP8) in Type 2 alveolar epithelial cells (AEC2s) from both idiopathic pulmonary fibrosis (IPF) lungs and lungs of old mice, which is associated with impaired AEC2 renewal capacity and enhanced lung fibrosis. The regulation of AEC2 progenitor function by ZIP8 is dependent on SIRT1. Replenishment with exogenous zinc and activation of SIRT1 promote self-renewal and differentiation of AEC2s, and therapeutic strategies targeting zinc metabolism and SIRT1 signaling could potentially improve AEC2 progenitor function and mitigate fibrogenesis.

JOURNAL OF CLINICAL INVESTIGATION (2022)

Article Biochemistry & Molecular Biology

MTOR-initiated metabolic switch and degeneration in the retinal pigment epithelium

Young-Mi Go et al.

FASEB JOURNAL (2020)

Article Environmental Sciences

Environmental Cadmium and Mortality from Influenza and Pneumonia in US Adults

Sung Kyun Park et al.

ENVIRONMENTAL HEALTH PERSPECTIVES (2020)

Article Biochemistry & Molecular Biology

Low-dose cadmium disrupts mitochondrial citric acid cycle and lipid metabolism in mouse lung

Xin Hu et al.

FREE RADICAL BIOLOGY AND MEDICINE (2019)

Article Pathology

Environmental Cadmium Enhances Lung Injury by Respiratory Syncytial Virus Infection

Xin Hu et al.

AMERICAN JOURNAL OF PATHOLOGY (2019)

Article Environmental Sciences

Low-dose cadmium potentiates lung inflammatory response to 2009 pandemic H1N1 influenza virus in mice

Joshua D. Chandler et al.

ENVIRONMENT INTERNATIONAL (2019)

Review Immunology

Tryptophan Metabolism in Inflammaging: From Biomarker to Therapeutic Target

Freek J. H. Sorgdrager et al.

FRONTIERS IN IMMUNOLOGY (2019)

Article Biochemistry & Molecular Biology

Selenium supplementation prevents metabolic and transcriptomic responses to cadmium in mouse lung

Xin Hu et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2018)

Article Nutrition & Dietetics

Selenium Supplementation Alters Hepatic Energy and Fatty Acid Metabolism in Mice

Xin Hu et al.

JOURNAL OF NUTRITION (2018)

Article Biochemical Research Methods

Target-Decoy-Based False Discovery Rate Estimation for Large-Scale Metabolite Identification

Xusheng Wang et al.

JOURNAL OF PROTEOME RESEARCH (2018)

Review Biotechnology & Applied Microbiology

Functions and Signaling Pathways of Amino Acids in Intestinal Inflammation

Fang He et al.

BIOMED RESEARCH INTERNATIONAL (2018)

Article Pharmacology & Pharmacy

Cadmium stimulates myofibroblast differentiation and mouse lung fibrosis

Xin Hu et al.

TOXICOLOGY (2017)

Article Chemistry, Analytical

xMSannotator: An R Package for Network-Based Annotation of High-Resolution Metabolomics Data

Karan Uppal et al.

ANALYTICAL CHEMISTRY (2017)

Article Physiology

Metabolic pathways of lung inflammation revealed by high-resolution metabolomics (HRM) of H1N1 influenza virus infection in mice

Joshua D. Chandler et al.

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2016)

Review Chemistry, Medicinal

Computational Metabolomics: A Framework for the Million Metabolome

Karan Uppal et al.

CHEMICAL RESEARCH IN TOXICOLOGY (2016)

Review Oncology

Palmitoylation: a protein S-acylation with implications for breast cancer

Alison M. Anderson et al.

NPJ BREAST CANCER (2016)

Article Physiology

Low-dose oral cadmium increases airway reactivity and lung neuronal gene expression in mice

Joshua D. Chandler et al.

PHYSIOLOGICAL REPORTS (2016)

Article Physiology

Disturbed flow induces systemic changes in metabolites in mouse plasma: a metabolomics study using ApoE-/- mice with partial carotid ligation

Young-Mi Go et al.

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2015)

Article Physiology

Actin cytoskeleton redox proteome oxidation by cadmium

Young-Mi Go et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2013)

Review Pediatrics

Respiratory syncytial virus and asthma: speed-dating or long-term relationship?

Giovanni Piedimonte

CURRENT OPINION IN PEDIATRICS (2013)

Article Biochemical Research Methods

Predicting Network Activity from High Throughput Metabolomics

Shuzhao Li et al.

PLOS COMPUTATIONAL BIOLOGY (2013)

Review Biochemistry & Molecular Biology

mTOR Signaling in Growth Control and Disease

Mathieu Laplante et al.

Article Cell Biology

Autophagy induction by tetrahydrobiopterin deficiency

Sang Su Kwak et al.

AUTOPHAGY (2011)

Review Infectious Diseases

The use of a neonatal mouse model to study respiratory syncytial virus infections

Stephania A. Cormier et al.

EXPERT REVIEW OF ANTI-INFECTIVE THERAPY (2010)

Article Allergy

Respiratory Syncytial Virus Infections in the Adult Asthmatic - Mechanisms of Host Susceptibility and Viral Subversion

Blair D. Westerly et al.

IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA (2010)

Article Toxicology

Interpreting NHANES biomonitoring data, cadmium

Patricia Ruiz et al.

TOXICOLOGY LETTERS (2010)

Article Biochemical Research Methods

apLCMS-adaptive processing of high-resolution LC/MS data

Tianwei Yu et al.

BIOINFORMATICS (2009)

Article Biotechnology & Applied Microbiology

Biological half-life of cadmium in the urine of inhabitants after cessation of cadmium exposure

Yasushi Suwazono et al.

BIOMARKERS (2009)

Article Physiology

The human zinc transporter SLC39A8 (Zip8) is critical in zinc-mediated cytoprotection in lung epithelia

Beth Besecker et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2008)

Article Medicine, General & Internal

Respiratory syncytial virus infection in elderly and high-risk adults

AR Falsey et al.

NEW ENGLAND JOURNAL OF MEDICINE (2005)