Synthesis of 1, 8-dioxodecahydroacridines using core-shell structured Fe3O4@MgO MNP's: a solvent-free protocol

This study presented a solvent-free synthesis of 1,8-dioxodecahydroacridine derivatives by a one-pot condensation reaction between cyclic 1,3-diketone, aldehydes using Fe3O4@MgO core-shell structured nanocatalyst up to 89-98% yield. The study was conducted using both the substrate-ammonium acetate and aniline. The nanocatalyst was synthesized by a simple co-precipitation method and found to be both facile and efficient in facilitating the synthesis of the desired derivatives in a short reaction time (5-18 min). The present methodology offers several advantages, such as low cost, magnetically recoverable and reusable catalyst, solvent-free strategy, easy setup, high yield, and short reaction time, clearly portraying the present reaction's green approach.

Automated summary

This study presents a solvent-free synthesis method for 1,8-dioxodecahydroacridine derivatives using Fe3O4@MgO core-shell structured nanocatalyst, achieving high yields in a short reaction time.