4.4 Article

Growth differentiation factor-15 stimulates the synthesis of corticotropin-releasing factor in hypothalamic 4B cells

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

Growth differentiation factor-15 modulates adrenocorticotropic hormone synthesis in murine AtT-20 corticotroph cells

Kazunori Kageyama et al.

Summary: This study investigated the regulatory effects of dexamethasone on Gdf15 expression in murine corticotroph cells and found that GDF15 modulates ACTH synthesis by suppressing Pomc expression, contributing to pituitary stress response and homeostasis.

PEPTIDES (2022)

Article Biochemistry & Molecular Biology

GDF15 as a central mediator for integrated stress response and a promising therapeutic molecule for metabolic disorders and NASH

Kook Hwan Kim et al.

Summary: This review highlights the mechanism of GDF15 expression in response to organelle stress, particularly mitochondrial stress, and its association with pathophysiological conditions or diseases. It emphasizes the dual systemic effects of GDF15 in response to mitochondrial stress, serving as a potential mitokine.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2021)

Review Cell Biology

The Role of GDF15 as a Myomitokine

Kornelia Johann et al.

Summary: Growth differentiation factor 15 (GDF15) is a cytokine that affects systemic energy metabolism and its expression and secretion in various organs and tissues are induced in different physiological and pathophysiological states, often associated with mitochondrial stress. GDF15 is considered as a myokine and cardiokine, and activation of the GDF15-GFRAL pathway may lead to increased sympathetic outflow and activation of the HPA stress axis.
Review Oncology

GDF15/GFRAL Pathway as a Metabolic Signature for Cachexia in Patients with Cancer

Darakhshan Sohail Ahmed et al.

Summary: This article critically reviews the mechanisms involving GDF15 in cancer cachexia, emphasizing the importance of identifying biomarkers and discussing therapeutic interventions to improve outcomes for cancer patients.

JOURNAL OF CANCER (2021)

Article Endocrinology & Metabolism

GDF15 Is Elevated in Conditions of Glucocorticoid Deficiency and Is Modulated by Glucocorticoid Replacement

Audrey Melvin et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2020)

Review Endocrinology & Metabolism

GDF15: A Hormone Conveying Somatic Distress to the Brain

Samuel M. Lockhart et al.

ENDOCRINE REVIEWS (2020)

Article Physiology

The GDF15-GFRAL Pathway in Health and Metabolic Disease: Friend or Foe?

Samuel N. Breit et al.

Annual Review of Physiology (2020)

Article Biochemistry & Molecular Biology

Mitochondrial stress and GDF15 in the pathophysiology of sepsis

Yasunori Fujita et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2020)

Review Endocrinology & Metabolism

Insights Into Mechanisms of GDF15 and Receptor GFRAL: Therapeutic Targets

Luc Rochette et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2020)

Article Biochemistry & Molecular Biology

GDF15 Is an Inflammation-Induced Central Mediator of Tissue Tolerance

Harding H. Luan et al.

Review Endocrinology & Metabolism

Uniting GDF15 and GFRAL: Therapeutic Opportunities in Obesity and Beyond

Shannon E. Mullican et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2018)

Article Multidisciplinary Sciences

TGF-β contamination of purified recombinant GDF15

Oddrun Elise Olsen et al.

PLOS ONE (2017)

Review Endocrinology & Metabolism

Diabetes mellitus related biomarker: The predictive role of growth-differentiation factor-15

Alexander E. Berezin

DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS (2016)

Review Endocrinology & Metabolism

GDF-15 as a Target and Biomarker for Diabetes and Cardiovascular Diseases: A Translational Prospective

Ramu Adela et al.

JOURNAL OF DIABETES RESEARCH (2015)

Article Biochemistry & Molecular Biology

Stimulation of corticotropin-releasing factor gene expression by FosB in rat hypothalamic 4B cells

Kazunori Kageyama et al.

PEPTIDES (2014)

Article Endocrinology & Metabolism

Cytokines Induce NF-kappa B, Nurr1 and Corticotropin-Releasing Factor Gene Transcription in Hypothalamic 4B Cells

Kazunori Kageyama et al.

NEUROIMMUNOMODULATION (2010)

Article Endocrinology & Metabolism

Involvement of regulatory elements on corticotropin-releasing factor gene promoter in hypothalamic 4B cells

K. Kageyama et al.

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION (2008)