The impact of donor-specific anti-HLA antibody levels on primary poor graft function and graft rejection in rituximab desensitized haploidentical stem cell transplantation

Article Hematology

Successful desensitization of high level donor-specific anti-HLA antibody in patients with hematological diseases receiving haploidentical allografts

Xiaoli Zheng et al.

Summary: The combination of rituximab, high-dose IVIG, and PE proved to be effective in desensitizing haploidentical allograft recipients with high levels of DSA, leading to successful hematopoietic recovery and overall good survival outcomes.

ANNALS OF HEMATOLOGY (2022)

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Article Hematology

Haematopoietic stem-cell transplantation in China in the era of targeted therapies: current advances, challenges, and future directions

Ying-Jun Chang et al.

Lancet Haematology (2022)

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Article Biophysics

Hematopoietic cell transplantation and cellular therapy survey of the EBMT: monitoring of activities and trends over 30 years

Jakob R. Passweg et al.

Summary: The number of Hematopoietic Cell Transplantations in Europe and collaborating countries has been on the rise, with a total of 48,512 HCT reported in 43,581 patients during 2019. The main indications were myeloid malignancies, lymphoid malignancies, and nonmalignant disorders. CAR-T cellular therapies also showed significant growth from 2017 to 2019. Over the past 30 years, there has been a substantial increase in the number of centers and countries performing HCT procedures, with more than 800,000 transplants reported overall.

BONE MARROW TRANSPLANTATION (2021)

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Article Immunology

Management of Donor-Specific Antibodies in Haploidentical Transplant: Multicenter Experience From the Madrid Group of Hematopoietic Transplant

Rebeca Bailen et al.

Summary: This study reports the experience of using desensitization treatments for patients with DSAs undergoing haplo-HSCT. The results show that utilizing desensitization strategies guided by DSAs intensity kinetics can effectively decrease DSA intensity and improve engraftment rates.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Oncology

The consensus from The Chinese Society of Hematology on indications, conditioning regimens and donor selection for allogeneic hematopoietic stem cell transplantation: 2021 update

Xiao-hui Zhang et al.

Summary: The recent updated consensus recommendations from The Chinese Society of Hematology on allogeneic hematopoietic stem cell transplantation (allo-HSCT) include a new donor selection algorithm, encouraging salvage treatment with novel immunotherapies, and reflecting additional evidence for specific patient groups in transplantation application.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2021)

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Article Hematology

Standardizing Definitions of Hematopoietic Recovery, Graft Rejection, Graft Failure, Poor Graft Function, and Donor Chimerism in Allogeneic Hematopoietic Cell Transplantation: A Report on Behalf of the American Society for Transplantation and Cellular Therapy

Mohamed A. Kharfan-Dabaja et al.

Summary: Allogeneic hematopoietic cell transplantation (allo-HCT) has made significant advances in recent years, broadening its indications and improving outcomes. Despite achieving consensus on certain definitions, challenges remain, such as the lack of agreement on delayed engraftment.

TRANSPLANTATION AND CELLULAR THERAPY (2021)

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Article Medical Laboratory Technology