Linalool attenuates lipid accumulation and oxidative stress in metabolic dysfunction-associated steatotic liver disease via Sirt1/Akt/PPRA-α/AMPK and Nrf-2/HO-1 signaling pathways

Article Biochemistry & Molecular Biology

Biochanin A attenuates obesity cardiomyopathy in rats by inhibiting oxidative stress and inflammation through the Nrf-2 pathway

A. Jansy Isabella Rani et al.

Summary: This study found that biochanin A (BCA) may attenuate obesity and its associated cardiomyopathy by suppressing oxidative stress and inflammation through activation of the Nrf-2 pathway and inhibition of NF-kappa B activation.

ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY (2023)

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Article Multidisciplinary Sciences

De novo lipogenesis fuels adipocyte autophagosome and lysosome membrane dynamics

Leslie A. Rowland et al.

Summary: Fatty acid synthesis from carbohydrates by adipocytes has little contribution to fat storage. This study reveals that de novo lipogenesis (DNL) is critical for autophagy, as it provides fatty acids necessary for autophagosome and lysosome maturation and fusion. Deficiency of Fasn impairs autophagy and decreases certain membrane phosphoinositides needed for fusion. The dependence of autophagy on DNL cannot be fully compensated by exogenous fatty acids.

NATURE COMMUNICATIONS (2023)

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Article Gastroenterology & Hepatology

Progression to cirrhosis is similar among all ages in nonalcoholic fatty liver disease, but liver-related events increase with age

Matthew J. Miller et al.

Summary: This retrospective study characterized genetic and metabolic risk factors for NAFLD and their impact on disease progression across age groups. The study found that while older adults had a higher baseline prevalence of cirrhosis, the rate of NAFLD progression to cirrhosis was similar in young and older adults. Older patients were more likely to experience liver-related events.

HEPATOLOGY COMMUNICATIONS (2023)

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Article Integrative & Complementary Medicine

Phytoformulation with hydroxycitric acid and capsaicin protects against high-fat-diet-induced obesity cardiomyopathy by reducing cardiac lipid deposition and ameliorating inflammation and apoptosis in the heart

V. V. Sathibabu Uddandrao et al.

Journal of Traditional and Complementary Medicine (2023)

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Article Chemistry, Medicinal

Linalool Mitigated High-Fat Diet-Induced Non-alcoholic Fatty Liver Disease by Regulating the Intestinal-Hepatic Axis via TGF-β/NF-kB/TLR4/ZO-1 Pathway

Tamilmani Periyasamy et al.

Summary: Linalool may prevent high-fat diet-induced non-alcoholic fatty liver disease by regulating the intestinal-hepatic axis, alleviating insulin resistance, and anomalies in lipid homeostasis.

REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY (2023)

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Article Cardiac & Cardiovascular Systems

Polyherbal Formulation Ameliorates Diabetic Cardiomyopathy Through Attenuation of Cardiac Inflammation and Oxidative Stress Via NF-κB/Nrf-2/HO-1 Pathway in Diabetic Rats

V. V. Sathibabu Uddandrao et al.

Summary: This study demonstrated that the polyherbal formulation (PHF) successfully attenuated inflammation and oxidative stress in diabetic cardiomyopathy rats by regulating the NF-kappa B/Nrf-2/HO-1 pathway. The results suggest that PHF may be a potential therapeutic agent for DCM.

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2022)

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Article

Zingiberene attenuates high fat diet–induced non-alcoholic fatty liver disease through suppression of lipogenesis and oxidative stress in rats

R. Sivaraj et al.

Comparative Clinical Pathology (2022)

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Article Nutrition & Dietetics

Distinct AMPK-Mediated FAS/HSL Pathway Is Implicated in the Alleviating Effect of Nuciferine on Obesity and Hepatic Steatosis in HFD-Fed Mice

Hanyuan Xu et al.

Summary: The main component in lotus leaf called Nuciferine (Nuci) has been found to prevent obesity induced by high fat diet. It reduces lipid accumulation in liver/hepatocytes and adipocytes/eWAT by regulating AMPK-mediated FAS/HSL pathway. Nuci supplementation also improves glycolipid metabolism, enhances energy expenditure and attenuates hepatic steatosis.

NUTRIENTS (2022)

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Article Multidisciplinary Sciences

Hibiscus sabdariffa extract improves hepatic steatosis, partially through IRS-1/Akt and Nrf2 signaling pathways in rats fed a high fat diet

Janjira Prasomthong et al.

Summary: Roselle extract exhibits protective effects on NAFLD rat models by reducing hepatic lipid accumulation, inflammation, and oxidative stress, while improving antioxidant properties and insulin signal proteins.

SCIENTIFIC REPORTS (2022)

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Review Gastroenterology & Hepatology

Nuclear factor erythroid 2-related factor 2-mediated signaling and metabolic associated fatty liver disease

Vidyasagar Naik Bukke et al.

Summary: Oxidative stress is a key driver in the development and progression of various diseases, including MAFLD. NRF2, a master regulator of redox homeostasis, plays a crucial role in every step of MAFLD development. NRF2 activators regulate lipid metabolism and oxidative stress, alleviating fatty liver disease by inducing the expression of cytoprotective genes.

WORLD JOURNAL OF GASTROENTEROLOGY (2022)

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Article Cardiac & Cardiovascular Systems

Polyherbal Formulation Ameliorates Diabetic Cardiomyopathy Through Attenuation of Cardiac Inflammation and Oxidative Stress Via NF-?B/Nrf-2/HO-1 Pathway in Diabetic Rats

V. V. Sathibabu Uddandrao et al.

Summary: The study demonstrates that the polyherbal formulation successfully alleviates inflammation and oxidative stress in DCM rats by regulating the NF-κB/Nrf-2/HO-1 pathway and protecting against cardiac damage. Therefore, PHF may be a prospective therapeutic agent for DCM.

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2022)

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Review Biochemistry & Molecular Biology

The Interplay between Insulin Resistance, Inflammation, Oxidative Stress, Base Excision Repair and Metabolic Syndrome in Nonalcoholic Fatty Liver Disease

Sylwia Ziolkowska et al.

Summary: NAFLD is a common chronic liver disorder which is often associated with type 2 diabetes and obesity. Metabolic syndrome is a key factor in the development of NAFLD, as it includes a range of conditions such as abdominal obesity, elevated blood triacylglycerol level, reduced high-density lipoprotein cholesterol level, increased blood pressure, and high fasting glucose.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Biology

Cardioprotective Effect of Linalool against Isoproterenol-Induced Myocardial Infarction

Maged E. Mohamed et al.

Summary: Linalool was found to limit the infarcted area size, reduce cardiac enzymes, enhance cardiac antioxidant activities, decrease inflammatory mediators and apoptotic markers, and increase the levels of the anti-apoptotic protein Bcl2. Therefore, Linalool may act as an effective cardioprotective agent in the MI model by improving oxidative conditions via the Nrf2/HO-1 pathway and abolishing apoptotic and inflammatory responses.

LIFE-BASEL (2021)

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Review Biochemistry & Molecular Biology

Recent updates on bioactive properties of linalool

Qi An et al.

Summary: Linalool, a natural product found in essential oils, exhibits various bioactivities such as anticancer, antimicrobial, neuroprotective effects, and protective effects on the liver, kidney, and lung. Due to its low toxicity and protective properties, it has the potential to be used as an adjuvant with anticancer drugs or antibiotics.

FOOD & FUNCTION (2021)

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Review Gastroenterology & Hepatology

What Are the Current Pharmacological Therapies for Nonalcoholic Fatty Liver Disease?

Deepu David et al.

Summary: The most effective drugs currently available for treating NAFLD are pioglitazone and vitamin E, but there is no drug specifically approved for this condition. Many drugs approved for other components of metabolic syndrome have potential for NAFLD treatment, suggesting potential underutilization of available drugs.

JOURNAL OF CLINICAL AND EXPERIMENTAL HEPATOLOGY (2021)

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Article Biochemistry & Molecular Biology