☆ 4.7 Review

Therapeutic potentials of cannabidiol: Focus on the Nrf2 signaling pathway

BIOMEDICINE & PHARMACOTHERAPY (2023)

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Article Dermatology

Cannabidiol mediates epidermal terminal differentiation and redox homeostasis through aryl hydrocarbon receptor (AhR)-dependent signaling

Young Su Jang et al.

Summary: This study investigated the modulation of epidermal differentiation and scavenging of reactive oxygen species by cannabidiol through the aryl hydrocarbon receptor (AhR) in keratinocytes. The results showed that cannabidiol can activate AhR to increase keratinocyte differentiation and antioxidant activity. This suggests the potential use of cannabidiol in improving skin barrier and reducing oxidative stress.

JOURNAL OF DERMATOLOGICAL SCIENCE (2023)

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Review Biochemistry & Molecular Biology

Phytocannabinoids in the Pharmacotherapy of Psoriasis

Adam Wronski et al.

Summary: Phytocannabinoids are natural compounds found in Cannabis sativa L. They have the ability to affect oxidative stress and inflammation through interaction with G protein-coupled receptors. Due to these properties, they are used in the treatment of various diseases, including autoimmune dermatoses.

MOLECULES (2023)

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Article Neurosciences

THC and CBD: Similarities and differences between siblings

Nephi Stella

NEURON (2023)

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Review Chemistry, Multidisciplinary

Cannabidiol for the Treatment of Brain Disorders: Therapeutic Potential and Routes of Administration

Grace Tsz Yan Yau et al.

Summary: The use of cannabidiol (CBD) for treating brain disorders has gained increasing interest. This review examines the preclinical and clinical evidence on the therapeutic use of CBD in treating various brain disorders, as well as different drug delivery approaches for CBD.

PHARMACEUTICAL RESEARCH (2023)

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Review Pharmacology & Pharmacy

Advances and challenges in therapeutic targeting of NRF2

Albena T. Dinkova-Kostova et al.

Summary: Activation of NRF2 has the potential to address oxidative stress, inflammation, and metabolic imbalances in chronic pathologies. This article discusses the rationale for targeting NRF2, recent advances in drug development of NRF2 modulators, and the challenges in fully harnessing NRF2 as a therapeutic target.

TRENDS IN PHARMACOLOGICAL SCIENCES (2023)

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Review Oncology

Phytocannabinoids in Triple Negative Breast Cancer Treatment: Current Knowledge and Future Insights

Sabrina Bimonte et al.

Summary: Triple negative breast cancer (TNBC) is an aggressive subtype of breast cancer characterized by the absence of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) expression. Current hormonal therapies are ineffective, and chemotherapy is the main treatment option. However, TNBC has a higher risk of metastasis, recurrence, and reduced survival compared to other subtypes. Preliminary studies suggest that cannabinoids derived from Cannabis sativa and synthetic cannabinoids may have potential antitumor effects, but further clinical studies are needed to explore their efficacy and safety in TNBC patients.

ANTICANCER RESEARCH (2023)

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Article Chemistry, Medicinal

Vaping Induced Cannabidiol (CBD) Oxidation Product CBD Quinone Forms Protein Adducts with KEAP1 and Activates KEAP1-Nrf2 Genes

Charlotte A. Love et al.

Summary: CBD vaping products can generate reactive CBD quinone (CBDQ) which forms adducts with protein cysteine residues, altering protein function and inducing cellular stress pathways in the lung. This was demonstrated using click chemistry and an in vitro vaping exposure system. The results suggest that vaping CBD may have negative effects on respiratory health.

CHEMICAL RESEARCH IN TOXICOLOGY (2023)

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Review Clinical Neurology

Medical Cannabis for Chronic Nonmalignant Pain Management

Maha Hameed et al.

Summary: This review article examines the use of medical cannabis for chronic nonmalignant pain management. Recent research shows that medical cannabis can effectively manage symptoms of various conditions including cancer, chronic pain, headaches, migraines, and psychological disorders. The active ingredients THC and CBD in cannabis work through the endocannabinoid system to reduce pain sensation and symptom frequency. Medical cannabis provides convenient and effective pain management for patients with chronic nonmalignant pain.

CURRENT PAIN AND HEADACHE REPORTS (2023)

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Review Medicine, Research & Experimental

The safety and efficacy of low oral doses of cannabidiol: An evaluation of the evidence

Jonathon C. Arnold et al.

Summary: Global interest in CBD is increasing, with clinical trial evidence supporting high doses for treating childhood epilepsies. However, the therapeutic benefits of low-dose CBD products are still being debated. This review evaluated the efficacy and safety of low oral doses of CBD and found that doses of 300 mg or higher showed evidence of reducing anxiety and anti-addiction effects, but the effects on insomnia, neurological disorders, and chronic pain were limited and inconsistent.

CTS-CLINICAL AND TRANSLATIONAL SCIENCE (2023)

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Review Food Science & Technology

Review of the oral toxicity of cannabidiol (CBD)

Jeremy Gingrich et al.

Summary: Information from published literature suggests that CBD consumption can lead to developmental and reproductive toxicity as well as hepatotoxicity in animal models. The toxic effects of CBD on male reproduction have been observed in a wide range of species, from invertebrates to non-human primates. CBD has the potential to inhibit certain enzymes and transporters, resulting in drug-drug interactions and cellular accumulation of xenobiotics. The mechanisms underlying CBD-mediated toxicity are not fully understood, but they may involve disruption of metabolic pathways, receptor binding activity, steroidogenesis, endocannabinoid degradation, and oxidative stress. The toxicological profile of CBD raises safety concerns, especially for long term consumption by the general population.

FOOD AND CHEMICAL TOXICOLOGY (2023)

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Review Biochemistry & Molecular Biology

Effects of Cannabidiol on Innate Immunity: Experimental Evidence and Clinical Relevance

Stefano Martini et al.

Summary: Cannabidiol (CBD), the main non-psychotropic cannabinoid derived from cannabis, has been approved for the treatment of seizures associated with certain syndromes and has shown potential in treating inflammation and immune-related conditions. Preclinical studies have demonstrated CBD's inhibitory effects on cytokine production and tissue infiltration, suggesting its therapeutic role in diseases with inflammatory components. However, clinical studies are needed to validate its efficacy in conditions such as multiple sclerosis, autoimmune diseases, cancer, asthma, and cardiovascular diseases.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

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Review Medicine, General & Internal

Cannabidiol-associated hepatotoxicity: A systematic review and meta-analysis

Lindsay A. A. Lo et al.

Summary: Recent studies have raised concerns over liver safety in relation to cannabidiol use, as liver enzyme elevations and drug-induced liver injury were found to be associated with its use. This systematic review and meta-analysis confirmed the increased probability of liver enzyme elevation and drug-induced liver injury in individuals using cannabidiol compared to placebo controls.

JOURNAL OF INTERNAL MEDICINE (2023)

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Review Biochemistry & Molecular Biology

The Polypharmacological Effects of Cannabidiol

Jorge Castillo-Arellano et al.

Summary: Cannabidiol (CBD) is a major phytocannabinoid found in Cannabis sativa (Linneo, 1753), which does not have intoxicating effects and differs from the psychoactive Δ9-tetrahydrocannabinol (Δ9-THC). However, our understanding of the neuro-molecular mechanisms and complex pharmacology of CBD is still limited. This article provides a comprehensive review of the molecular targets and pharmacological implications of CBD in various animal models and human diseases, highlighting its potential therapeutic effects in epilepsy, pain, neuropsychiatric disorders, Alzheimer's disease, and inflammatory diseases. The compiled knowledge from in vitro and in vivo studies is crucial for a better understanding of the polypharmacological nature of CBD.

MOLECULES (2023)

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Review Chemistry, Medicinal

Nanoformulations as a strategy to overcome the delivery limitations of cannabinoids

T. Srinivasa Reddy et al.

Summary: Medical cannabis has gained significant attention for its potential benefits in managing pain, anxiety, depression, and neurological disorders. The major phytocannabinoids derived from the cannabis plant, THC and CBD, have shown pharmacological and therapeutic properties. In particular, they have been studied for their use in cancer treatment due to their palliative effects and anticancer activities. However, their poor solubility and bioavailability limit their clinical application, thus nanotechnology-based drug delivery strategies are being developed to improve their efficacy.

PHYTOTHERAPY RESEARCH (2023)

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Article Oncology

Cancer statistics, 2023

Rebecca L. Siegel et al.

Summary: The American Cancer Society predicts that there will be 1,958,310 new cancer cases and 609,820 cancer deaths in the United States in 2023. While incidence trends for most cancers are favorable, prostate cancer saw a significant increase of 3% annually from 2014 to 2019. However, the overall cancer death rate continues to decline due to advances in treatment, with a 33% reduction since 1991.

CA-A CANCER JOURNAL FOR CLINICIANS (2023)

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Article Pharmacology & Pharmacy

Cannabidiol Safety Data: A Systematic Mapping Study

Rayetta G. Henderson et al.

Summary: This article presents a systematic map of the safety-related information available for cannabidiol (CBD), aiming to determine a safe intake level for consumer use. The study highlights knowledge gaps and identifies potential areas for further research, such as reproductive and developmental toxicity and immune outcomes.

CANNABIS AND CANNABINOID RESEARCH (2023)

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Review Pharmacology & Pharmacy

A narrative review of molecular mechanism and therapeutic effect of cannabidiol (CBD)

Jiangling Peng et al.

Summary: CBD, an abundant non-psychoactive phytocannabinoid in cannabis extracts, has multiple therapeutic effects and potential applications in human diseases such as neuroprotection, antiepileptic, and anxiolytic properties. This narrative review summarizes the applications of CBD in human diseases from mechanism of action to clinical trials.

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY (2022)

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Review Medicine, General & Internal

Cannabis, cannabidiol and tetrahydrocannabinol in sport: an overview

Michael Kennedy

Summary: The World Anti-Doping Agency now allows the use of cannabidiol (CBD) in elite sport but bans other cannabinoids. The liberalization of cannabis laws and commercial sponsorship of sporting events has sparked interest in its use in sports. This review confirms that CBD and tetrahydrocannabinol (THC) do not enhance performance. CBD has anti-inflammatory and analgesic properties, but its effects in the area of sport have not been thoroughly evaluated. Some CBD formulations may contain THC or other cannabinoids that can lead to a positive drug test.

INTERNAL MEDICINE JOURNAL (2022)

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Review Pharmacology & Pharmacy

Targeting NRF2 and Its Downstream Processes: Opportunities and Challenges

Laura Torrente et al.

Summary: The transcription factor NRF2 plays a crucial role in regulating cytoprotection and metabolism. Its transient activation in healthy tissues prevents cancer initiation, but cancer cells hijack NRF2 to support their proliferation and develop resistance to treatment. Blocking NRF2 activity in tumors is a promising approach to counteract cancer progression and overcome treatment resistance.

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY (2022)

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Review Biochemistry & Molecular Biology

A Concise Overview of Biosensing Technologies for the Detection of Alzheimer's Disease Biomarkers

Marjan Talebi et al.

Summary: This article focuses on the developments, competitions, and trends in Alzheimer's disease biosensing, with an emphasis on the unique properties of nanomaterials. In the past decade, significant advancements have been made, particularly in optical and electrochemical biosensors, for the detection of Alzheimer's disease biomarkers, which aid in the diagnosis and management of the disease.

CURRENT PHARMACEUTICAL BIOTECHNOLOGY (2022)

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Article Immunology

Role of Cannabidiol and Tetrahydrocannabivarin on Paclitaxel-induced neuropathic pain in rodents

Anil Kumar Kalvala et al.

Summary: The purpose of this study was to evaluate the protective effects of phytocannabinoids, synthetic cannabidiol (CBD), and tetrahydrocannabivarin (THCV), both individually and in combination, against Paclitaxel-induced peripheral neuropathy (PIPN) in mice. The combination of CBD and THCV showed a twofold improvement in neurobehavioral symptoms compared to individual treatments. The study identified specific protein targets and mechanisms involved in the therapeutic effects of CBD and THCV. Furthermore, the combination therapy protected neurons in mice by modulating mitochondrial function and through the activation of specific receptors.

INTERNATIONAL IMMUNOPHARMACOLOGY (2022)

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Article Neurosciences

Inflammation and Nitro-oxidative Stress as Drivers of Endocannabinoid System Aberrations in Mood Disorders and Schizophrenia

Gerwyn Morris et al.

Summary: This paper investigates the potential origins and mechanisms of endocannabinoid system (ECS) dysfunction in major neuropsychiatric disorders. It explores the effects of inflammation and oxidative stress on ECS and suggests that cannabidiol and dimethyl fumarate may have therapeutic potential for mental illnesses.

MOLECULAR NEUROBIOLOGY (2022)

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Review Immunology

The Anti-Inflammatory Effects of Cannabidiol on Acne

Nadia Peyravian et al.

Summary: Acne, a common skin condition, can be treated with conventional therapies such as retinoids and antibiotics, but these treatments may have side effects and risks of antibiotic resistance. Therefore, the use of natural plant-derived treatments like CBD as an alternative or adjunct therapy is attractive to patients due to their anti-inflammatory properties and minimal side effects.

JOURNAL OF INFLAMMATION RESEARCH (2022)

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Review Behavioral Sciences

Cannabinoid treatments for anxiety: A systematic review and consideration of the impact of sleep disturbance

Andrea J. Narayan et al.

Summary: Research has found that Cannabidiol (CBD) has anxiolytic effects in healthy and certain clinical populations, but minimal impact on sleep. The dosage and ratio of CBD to THC in combination treatments may moderate these effects. The primary mechanism of action for CBD appears to be modulation of the endocannabinoid system and secondary regulation of neuroendocrine function.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2022)

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Review Behavioral Sciences

Implications of the endocannabinoid system and the therapeutic action of cannabinoids in autism spectrum disorder: A literature review

Rick Wilhiam de Camargo et al.

Summary: Autism spectrum disorder (ASD) is a neurodevelopmental disorder with cognitive, social, behavioral, and sensory impairments. The endocannabinoid system (ECS) is believed to play a role in the pathophysiology of ASD, and the use of cannabis phytocannabinoids, especially cannabidiol (CBD), may have positive effects on symptoms related to ASD.

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2022)

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Review Endocrinology & Metabolism

Examining the role of cannabinoids on osteoporosis: a review

Grace Clouse et al.

Summary: This review examines the role of cannabinoids on osteoporosis, specifically focusing on the endocannabinoid system and its involvement in bone remodeling, as well as the effects of cannabinoids on bone health. Despite many mechanisms still remaining unclear, both preclinical and clinical studies show that the effects of cannabis mediated through the endocannabinoid system may be an effective treatment for osteoporosis.

ARCHIVES OF OSTEOPOROSIS (2022)

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Article Clinical Neurology

A biological classification of Huntington's disease: the Integrated Staging System

Sarah J. Tabrizi et al.

Summary: The current research paradigm for Huntington's disease does not address its pathophysiology nor the biomarker changes that can precede the functional decline by decades. This study introduces a new research framework, the Huntington's Disease Integrated Staging System, to standardise clinical research and enable interventions earlier in the disease course.

LANCET NEUROLOGY (2022)

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Article Medicine, General & Internal

Efficacy and Safety of Dimethyl Fumarate in Patients with Moderate-to-Severe Plaque Psoriasis: DIMESKIN-2, a Multicentre Single-Arm Phase IIIb Study

Giovanni Pellacani et al.

Summary: This multicentre trial evaluated the efficacy and safety of oral dimethyl fumarate (DMF) in patients with moderate-to-severe plaque psoriasis. The results showed that DMF significantly improved disease severity, pruritus and quality of life, with high patient satisfaction.

JOURNAL OF CLINICAL MEDICINE (2022)

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Article Biochemistry & Molecular Biology

Protective effect and mechanism of cannabidiol on myocardial injury in exhaustive exercise training mice

Jun Zhang et al.

Summary: This study demonstrated the protective effect of CBD on myocardial injury in mice subjected to exhaustive exercise training. The mechanism may involve the activation of the Keap1/Nrf2/HO-1 signaling pathway, leading to anti-inflammatory, anti-apoptotic, and antioxidant effects. These findings are important for understanding the mechanism of exercise-induced myocardial injury and developing potential therapeutic interventions.

CHEMICO-BIOLOGICAL INTERACTIONS (2022)

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Article Pharmacology & Pharmacy

Mechanisms underlying paclitaxel-induced neuropathic pain: Channels, inflammation and immune regulations

Yuhao Xu et al.

Summary: Paclitaxel is a widely used chemotherapeutic agent, but its use often leads to severe neuropathic pain that is difficult to manage. The mechanisms underlying paclitaxel-induced neuropathic pain are still unclear, but evidence suggests correlations with ion channels, neuroinflammation, and mitochondrial damage.

EUROPEAN JOURNAL OF PHARMACOLOGY (2022)

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Review Biochemistry & Molecular Biology

Role of Cannabidiol for Improvement of the Quality of Life in Cancer Patients: Potential and Challenges

Ryan Green et al.

Summary: There is a growing interest in using cannabidiol (CBD) to alleviate cancer symptoms, including pain, sleep disruption, and anxiety. However, the mechanisms underlying CBD's anti-cancer activity remain unclear. In vitro studies have shown that CBD has anti-tumor properties, and clinical trials have demonstrated its effectiveness in treating cancer-related pain. Further research is needed to determine the optimal dosage and effective combinations with other drugs.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Immunology

Neuroinflammation represents a common theme amongst genetic and environmental risk factors for Alzheimer and Parkinson diseases

Rachel J. Boyd et al.

Summary: Multifactorial diseases pose a challenge in understanding the interactions between genetic and environmental factors, particularly in neurodegenerative disorders. The focus of research is on how genetic and environmental effects destabilize homeostasis and increase risk, as well as finding effective therapeutic interventions.

JOURNAL OF NEUROINFLAMMATION (2022)

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Review Medicine, General & Internal

Amyotrophic lateral sclerosis

Eva L. Feldman et al.

Summary: Amyotrophic lateral sclerosis, a fatal CNS neurodegenerative disease, lacks optimal management strategies. Improved understanding of clinical presentation, pathophysiology, and diagnostic criteria has not yet translated into direct patient benefit. However, the concept of amyotrophic lateral sclerosis as a complex syndrome is already influencing clinical practice.

LANCET (2022)

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Review Endocrinology & Metabolism

Cannabinoids and terpenes for diabetes mellitus and its complications: from mechanisms to new therapies

Esmaeel Ghasemi-Gojani et al.

Summary: This article discusses the pathogenesis of diabetes, its complications, and the potential use of cannabinoids, terpenes, and flavonoids for its treatment.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2022)

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Review Pharmacology & Pharmacy

Cannabidiol drug interaction considerations for prescribers and pharmacists

Myfanwy Graham et al.

Summary: This article aims to determine the dose range at which clinically relevant cannabidiol drug interactions are likely to occur and provide clinical guidance. Although there are limitations in specific dose-response data and individual pharmacokinetic profiles for individual patients, clinicians should have an understanding of cannabinoid pharmacology and engage in clinical and therapeutic drug monitoring.

EXPERT REVIEW OF CLINICAL PHARMACOLOGY (2022)

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Review Biochemistry & Molecular Biology

Sex Differences in the Neuropsychiatric Effects and Pharmacokinetics of Cannabidiol: A Scoping Review

Justin Matheson et al.

Summary: This scoping review examined the potential role of sex and gender as moderators of the neuropsychiatric effects and pharmacokinetics of CBD, finding that sex may influence the long-term effects and antidepressant-like effects of CBD in preclinical studies. In human studies, there may be sex differences in the pharmacokinetics of CBD, but not in the effects of CBD on trauma recall in patients with PTSD. Consideration of gender in CBD treatment effects was lacking in the identified studies.

BIOMOLECULES (2022)

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Review Pharmacology & Pharmacy

The Effectiveness and Safety of Cannabidiol in Non-seizure-related Indications: A Systematic Review of Published Randomized Clinical Trials

Yuni Tang et al.

Summary: This systematic review investigates the effectiveness and safety of cannabidiol for non-seizure-related health conditions. The findings reveal that while cannabidiol appears to be effective for mental health issues, its effectiveness for other conditions is inconsistent. The study suggests the need for larger, more diverse studies, as well as clearer dosing guidelines and increased regulation of cannabidiol products.

PHARMACEUTICAL MEDICINE (2022)

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Review Pharmacology & Pharmacy

A Systematic Review of Medical Cannabinoids Dosing in Human

David A. Campos et al.

Summary: This systematic review evaluates the clinical use and dosage range of cannabinoids in various medical contexts. The findings suggest that THC, CBD, and THCV can regulate activity in multiple conditions. Further research on cannabinoids is encouraged to develop personalized cannabinoid medication for each patient.

CLINICAL THERAPEUTICS (2022)

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Review Pharmacology & Pharmacy

Molecular Mechanisms Through Which Cannabidiol May Affect Skeletal Muscle Metabolism, Inflammation, Tissue Regeneration, and Anabolism: A Narrative Review

Moniek Schouten et al.

Summary: CBD has the potential to improve muscle recovery as a supplement. However, research on CBD in relation to exercise is still in its early stages and further studies are needed to understand its molecular and functional effects.

CANNABIS AND CANNABINOID RESEARCH (2022)

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Article Pharmacology & Pharmacy

A Randomized, Triple-Blind, Comparator-Controlled Parallel Study Investigating the Pharmacokinetics of Cannabidiol and Tetrahydrocannabinol in a Novel Delivery System, Solutech, in Association with Cannabis Use History

Volker Berl et al.

Summary: This study compared the pharmacokinetic parameters of Solutech and MCT-oil in a healthy population. The results showed that Solutech had higher C-max, faster elimination and absorption rate constants, shorter time to C-max and lag time, and longer half-life for all analytes compared to MCT-oil. Additionally, cannabis use history significantly influenced the pharmacokinetic parameters of CBD, Delta(9)-THC, 11-OH-THC, and THC-COOH. The evaluation results demonstrated that acute consumption of both products was safe and well tolerated.

CANNABIS AND CANNABINOID RESEARCH (2022)

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Review Chemistry, Medicinal

Therapeutic Effects of Resveratrol in Inflammatory Bowel Diseases: Shedding Light on the Role of Cellular and Molecular Pathways

Marjan Talebi et al.

Summary: Inflammatory bowel disease is a debilitating inflammatory disorder of the gastrointestinal tract, consisting of ulcerative colitis and Crohn's disease. Natural products like resveratrol have shown promise in treating inflammatory bowel disease due to their effects on cellular and molecular signaling pathways. Nanotechnological formulations with colon-specific drug delivery systems are being explored to address challenges in resveratrol delivery for therapeutic purposes.

REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY (2022)

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Article Clinical Neurology

Safety and Efficacy of Omaveloxolone in Friedreich Ataxia (MOXIe Study)

David R. Lynch et al.

Summary: Omaveloxolone significantly improved neurological function in patients with FA, showing good safety and tolerability. It represents a potential therapeutic agent for FA.

ANNALS OF NEUROLOGY (2021)

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Review Chemistry, Medicinal

Biological and therapeutic activities of thymoquinone: Focus on the Nrf2 signaling pathway

Marjan Talebi et al.

Summary: Thymoquinone has various pharmacological activities and protective effects on multiple organs and systems, mainly through modulation of the Nrf2 signaling pathway.

PHYTOTHERAPY RESEARCH (2021)

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Article Chemistry, Analytical

Therapeutic application of cannabidiol on UVA and UVB irradiated rat skin. A proteomic study

Sinemyiz Atalay et al.

Summary: The study evaluated the effect of CBD on the metabolism of skin keratinocytes in nude rats exposed to UVA/UVB radiation. The results show that CBD can protect keratinocytes from UV-induced metabolic changes by maintaining proteostasis and reducing inflammation and redox imbalance.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2021)

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Review Biotechnology & Applied Microbiology

Natural products in drug discovery: advances and opportunities

Atanas G. Atanasov et al.

Summary: Natural products and their analogues have historically played a significant role in pharmacotherapy, however, they also present challenges. Recent technological and scientific developments are addressing these challenges and revitalizing interest in natural products as drug leads, particularly for combating antimicrobial resistance.

NATURE REVIEWS DRUG DISCOVERY (2021)

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Article Cell Biology

Antioxidant and Anti-inflammatory Effect of Cannabidiol Contributes to the Decreased Lipid Peroxidation of Keratinocytes of Rat Skin Exposed to UV Radiation

Anna Jastrzab et al.

Summary: The study demonstrated that CBD protects keratinocytes from UVA/UVB radiation by reducing lipid peroxidation products and increasing the levels of endocannabinoids. CBD also enhances the in vivo transcriptional activity of Nrf2 and prevents the expression of proinflammatory factors, ultimately protecting the epidermis against UV damage.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

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Review Chemistry, Medicinal

New insights into the role of the Nrf2 signaling pathway in green tea catechin applications

Marjan Talebi et al.

Summary: Nrf2 plays a crucial role in various diseases, and green tea catechins as a source of phenolic compounds can address a wide range of clinical issues. Green tea catechins, especially EGCG, elucidate the protective role of Nrf2 and its downstream molecules in various disorders, showing significant potential in managing and protecting against different diseases.

PHYTOTHERAPY RESEARCH (2021)

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Review Medicine, Research & Experimental

Curcumin and cardiovascular diseases: Focus on cellular targets and cascades

Ali Mohammad Pourbagher-Shahri et al.

Summary: Curcumin, the main ingredient of turmeric, has been shown to modulate multiple signaling pathways and protect against cardiovascular diseases. However, more research is still needed to discover the exact molecular targets of Curcumin in the treatment of CVDs.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Review Biochemistry & Molecular Biology

Cannabidiol and Other Cannabinoids in Demyelinating Diseases

Carmen Navarrete et al.

Summary: Preclinical evidence suggests that cannabinoids like CBD may have potential in treating demyelinating diseases, but further research is needed. Current studies on the use of CBD and other cannabinoids as future potential treatments are ongoing. Collaboration between researchers, clinicians, and pharmaceutical companies is crucial in bringing novel therapies to patients.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Biochemistry & Molecular Biology

Roles of Nrf2 in Gastric Cancer: Targeting for Therapeutic Strategies

Tahereh Farkhondeh et al.

Summary: Nrf2 plays a complex role in gastric cancer, potentially increasing antioxidant capacity, chemoresistance, and poor clinical prognosis, but also benefiting cancer therapy. Depending on different backgrounds, Nrf2 can act as both an oncogene and a tumor suppressor.

MOLECULES (2021)

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Article Multidisciplinary Sciences

Gene variants and expression changes of SIRT1 and SIRT6 in peripheral blood are associated with Parkinson's disease

Rita Maszlag-Torok et al.

Summary: This study investigated the potential association of SIRT1, -2, and -6 gene polymorphisms with the risk of Parkinson's disease (PD) in the Hungarian population. It found that certain SNPs in SIRT1 and SIRT6 were weakly associated with PD risk, while SNPs in SIRT2 showed no association. Additionally, mRNA levels of SIRT1 were down-regulated, SIRT6 were up-regulated, and SIRT2 remained unchanged in PD patients compared to controls, suggesting a potential role of SIRT1 and SIRT6 in the pathogenesis of PD.

SCIENTIFIC REPORTS (2021)

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Review Oncology

Impact of Metformin on Cancer Biomarkers in Non-Diabetic Cancer Patients: A Systematic Review and Meta-Analysis of Clinical Trials

Tahereh Farkhondeh et al.

Summary: Metformin therapy showed no significant changes in metabolic biomarkers in most clinical trials with breast and endometrial cancer patients, but it was found to decrease Ki-67 levels in patients with endometrial cancer. Due to high heterogeneity and bias in the trials, the effectiveness of metformin for breast and endometrial cancer patients could not be confirmed or rejected based on the current findings.

CURRENT ONCOLOGY (2021)

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Editorial Material Biochemistry & Molecular Biology

Novel role for cannabidiol in circadian clock function

Maurizio Bifulco et al.

ADDICTION BIOLOGY (2020)

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Review Oncology

NRF2 as a regulator of cell metabolism and inflammation in cancer

Feng He et al.

CARCINOGENESIS (2020)

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Editorial Material Psychiatry

Leading the Next CBD Wave-Safety and Efficacy

Yasmin L. Hurd

JAMA PSYCHIATRY (2020)

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Article Biochemistry & Molecular Biology

Beyond repression of Nrf2: An update on Keap1

Aleksandra Kopacz et al.

FREE RADICAL BIOLOGY AND MEDICINE (2020)

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Review Urology & Nephrology

Interstitial cystitis/bladder pain syndrome: The evolving landscape, animal models and future perspectives

Yoshiyuki Akiyama et al.

INTERNATIONAL JOURNAL OF UROLOGY (2020)

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Article Biochemistry & Molecular Biology

Cannabidiol induces antioxidant pathways in keratinocytes by targeting BACH1

Laura Casares et al.

REDOX BIOLOGY (2020)

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Review Biochemistry & Molecular Biology

The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway

Liam Baird et al.

MOLECULAR AND CELLULAR BIOLOGY (2020)

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Review Biochemistry & Molecular Biology

NRF2, a Transcription Factor for Stress Response and Beyond

Feng He et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Cell Biology

Cannabidiol Promotes Endothelial Cell Survival by Heme Oxygenase-1-Mediated Autophagy

Sabine Boeckmann et al.

CELLS (2020)

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Article Clinical Neurology

Epidiolex-induced skin rash

Jaysingh Singh et al.

EPILEPTIC DISORDERS (2020)

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Review Biochemistry & Molecular Biology

A molecular basis for the anti-inflammatory and anti-fibrosis properties of cannabidiol

Falone Sunda et al.

FASEB JOURNAL (2020)

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Article Chemistry, Medicinal

The Essential Medicinal Chemistry of Cannabidiol (CBD)

Kathryn M. Nelson et al.

JOURNAL OF MEDICINAL CHEMISTRY (2020)

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Review Clinical Neurology

Huntington disease: new insights into molecular pathogenesis and therapeutic opportunities

Sarah J. Tabrizi et al.

NATURE REVIEWS NEUROLOGY (2020)

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Review Chemistry, Medicinal

Towards Better Delivery of Cannabidiol (CBD)

Sophie Anne Millar et al.

PHARMACEUTICALS (2020)

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Article Medicine, General & Internal

Safety Considerations in Cannabinoid-Based Medicine

Sven Gottschling et al.

International Journal of General Medicine (2020)

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Review Biochemistry & Molecular Biology

Molecular Targets of Cannabidiol in Experimental Models of Neurological Disease

Serena Silvestro et al.

MOLECULES (2020)

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Review Pharmacology & Pharmacy

Modulating NRF2 in Disease: Timing Is Everything

Matthew Dodson et al.

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 59 (2019)

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Review Endocrinology & Metabolism

Obesity: global epidemiology and pathogenesis

Matthias Blueher

NATURE REVIEWS ENDOCRINOLOGY (2019)

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Article Multidisciplinary Sciences

miRNA expression profiles and molecular networks in resting and LPS-activated BV-2 microglia-Effect of cannabinoids

Ana Juknat et al.

PLOS ONE (2019)

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Editorial Material Medicine, General & Internal

The Search for an Effective Therapy and Pain Relief for Oral Mucositis

Sharon Elad et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2019)

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Review Medicine, Research & Experimental

Cannabidiol: Recent advances and new insights for neuropsychiatric disorders treatment

Marika Premoli et al.

LIFE SCIENCES (2019)

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Review Medicine, General & Internal

Potential Adverse Drug Events and Drug-Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use

Joshua D. Brown et al.

JOURNAL OF CLINICAL MEDICINE (2019)

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Editorial Material Public, Environmental & Occupational Health

Towards a public health approach to psychotic disorders

Kelly K. Anderson

LANCET PUBLIC HEALTH (2019)

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Article Cell Biology

Cannabidiol Regulates the Expression of Keratinocyte Proteins Involved in the Inflammation Process through Transcriptional Regulation

Anna Jastrzab et al.

CELLS (2019)

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Review Biochemistry & Molecular Biology

Broccoli or Sulforaphane: Is It the Source or Dose That Matters?

Yoko Yagishita et al.

MOLECULES (2019)

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Article Multidisciplinary Sciences

Pioglitazone attenuates kidney injury in an experimental model of gentamicin-induced nephrotoxicity in rats

Branislava Medic et al.

SCIENTIFIC REPORTS (2019)

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Editorial Material Dermatology

The growing trend of cannabidiol in skincare products

Nikita Jhawar et al.

CLINICS IN DERMATOLOGY (2019)

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Review Biotechnology & Applied Microbiology

Therapeutic targeting of the NRF2 and KEAP 1 partnership in chronic diseases

Antonio Cuadrado et al.

NATURE REVIEWS DRUG DISCOVERY (2019)

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Article Clinical Neurology

Safety, pharmacodynamics, and potential benefit of omaveloxolone in Friedreich ataxia

David R. Lynch et al.

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2019)

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Review Biochemistry & Molecular Biology

Nrf2-Keap1 signaling in oxidative and reductive stress

Ilaria Bellezza et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2018)

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Article Medicine, General & Internal

Cannabidiol in patients with seizures associated with Lennox-Gastaut syndrome (GWPCARE4): a randomised, double-blind, placebo-controlled phase 3 trial

Elizabeth A. Thiele et al.

LANCET (2018)

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Review Medicine, General & Internal

Multiple Sclerosis

Daniel S. Reich et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

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Review Biochemistry & Molecular Biology

Transcriptional Regulation by Nrf2

Claudia Tonelli et al.

ANTIOXIDANTS & REDOX SIGNALING (2018)

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Letter Medicine, General & Internal

Labeling Accuracy of Cannabidiol Extracts Sold Online

Marcel O. Bonn-Miller et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2017)

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Review Pharmacology & Pharmacy

Cannabidiol: an alternative therapeutic agent for oral mucositis?

L. F. Cuba et al.

JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS (2017)

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Article Medicine, General & Internal

Trial of Cannabidiol for Drug-Resistant Seizures in the Dravet Syndrome

Orrin Devinsky et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

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Review Pharmacology & Pharmacy

Cannabidiol in medical marijuana: Research vistas and potential opportunities

Carola Rong et al.

PHARMACOLOGICAL RESEARCH (2017)

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Review Pharmacology & Pharmacy

Cannabidiol: State of the art and new challenges for therapeutic applications

Simona Pisanti et al.

PHARMACOLOGY & THERAPEUTICS (2017)

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Review Public, Environmental & Occupational Health

Cannabis use, attitudes, and legal status in the US: A review

Hannah Carliner et al.

PREVENTIVE MEDICINE (2017)

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Editorial Material Pharmacology & Pharmacy

Cannabidiol Claims and Misconceptions

Ethan B. Russo

TRENDS IN PHARMACOLOGICAL SCIENCES (2017)

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Review Pharmacology & Pharmacy

Cannabidiol regulation of emotion and emotional memory processing: relevance for treating anxiety-related and substance abuse disorders

Jonathan L. C. Lee et al.

BRITISH JOURNAL OF PHARMACOLOGY (2017)

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Review Biochemistry & Molecular Biology

Nrf2 signaling pathway: Pivotal roles in inflammation

Syed Minhaj Uddin Ahmed et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2017)

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Article Chemistry, Medicinal

Anti-inflammatory and antioxidant effects of a combination of cannabidiol and moringin in LPS-stimulated macrophages

Thangavelu Soundara Rajan et al.

FITOTERAPIA (2016)

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Article Immunology

Pathways and gene networks mediating the regulatory effects of cannabidiol, a nonpsychoactive cannabinoid, in autoimmune T cells

Ewa Kozela et al.

JOURNAL OF NEUROINFLAMMATION (2016)

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Article Clinical Neurology

Cannabidiol in patients with treatment-resistant epilepsy: an open-label interventional trial

Orrin Devinsky et al.

LANCET NEUROLOGY (2016)

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Review Chemistry, Medicinal

The Keap1-Nrf2-ARE Pathway As a Potential Preventive and Therapeutic Target: An Update

Meng-Chen Lu et al.

MEDICINAL RESEARCH REVIEWS (2016)

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Review Psychiatry

Does cannabidiol have a role in the treatment of schizophrenia?

Anand Gururajan et al.

SCHIZOPHRENIA RESEARCH (2016)

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Article Medicine, General & Internal

Urinary Metabolomics Identifies a Molecular Correlate of Interstitial Cystitis/Bladder Pain Syndrome in a Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network Cohort

Kaveri S. Parker et al.

EBIOMEDICINE (2016)

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Review Pharmacology & Pharmacy

Dimethyl fumarate in multiple sclerosis: latest developments, evidence and place in therapy

Ralf A. Linker et al.

THERAPEUTIC ADVANCES IN CHRONIC DISEASE (2016)

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Article Biochemistry & Molecular Biology

Molecular basis of the Keap1-Nrf2 system

Takafumi Suzuki et al.

FREE RADICAL BIOLOGY AND MEDICINE (2015)

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Review Clinical Neurology

Neuroinflammation in Alzheimer's disease

Michael T. Heneka et al.

LANCET NEUROLOGY (2015)

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Article Neurosciences

INTERACTION BETWEEN THE PROTECTIVE EFFECTS OF CANNABIDIOL AND PALMITOYLETHANOLAMIDE IN EXPERIMENTAL MODEL OF MULTIPLE SCLEROSIS IN C57BL/6 MICE

A. Rahimi et al.

NEUROSCIENCE (2015)

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Article Cell Biology

Reactive oxygen species-mediated therapeutic response and resistance in glioblastoma

E. Singer et al.

CELL DEATH & DISEASE (2015)

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Review Clinical Neurology

Cannabidiol as a potential treatment for psychosis

C. D. Schubart et al.

EUROPEAN NEUROPSYCHOPHARMACOLOGY (2014)

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Review Biochemistry & Molecular Biology

Regulation of Nrf2-an update

Suryakant K. Niture et al.

FREE RADICAL BIOLOGY AND MEDICINE (2014)

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Review Biochemistry & Molecular Biology

Macrophage Polarization in Inflammatory Diseases

Yan-Cun Liu et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2014)

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Editorial Material Medicine, General & Internal

Neuroinflammatory Cytokine Signaling and Alzheimer's Disease

W. Sue T. Griffin

NEW ENGLAND JOURNAL OF MEDICINE (2013)

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Article Multidisciplinary Sciences

Microarray and Pathway Analysis Reveal Distinct Mechanisms Underlying Cannabinoid-Mediated Modulation of LPS-Induced Activation of BV-2 Microglial Cells

Ana Juknat et al.

PLOS ONE (2013)

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Article Pharmacology & Pharmacy

Differential transcriptional profiles mediated by exposure to the cannabinoids cannabidiol and Δ9-tetrahydrocannabinol in BV-2 microglial cells

Ana Juknat et al.

BRITISH JOURNAL OF PHARMACOLOGY (2012)

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Review Urology & Nephrology

Intravesical treatments of bladder pain syndrome/interstitial cystitis

Jochen Neuhaus et al.

NATURE REVIEWS UROLOGY (2012)

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Article Pharmacology & Pharmacy

Safety and Side Effects of Cannabidiol, a Cannabis sativa Constituent

Mateus Machado Bergamaschi et al.

CURRENT DRUG SAFETY (2011)

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Article Chemistry, Medicinal

Two new lathyrane type diterpenoids from Euphorbia aellenii

Abdul Majid Ayatollahi et al.

FITOTERAPIA (2010)

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Review Pharmacology & Pharmacy

Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb

Angelo A. Izzo et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2009)

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