☆ 4.7 Review

Revolutionizing medicine with toll-like receptors: A path to strengthening cellular immunity

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2023)

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Article Infectious Diseases

TLR7 agonist RO7020531 versus placebo in healthy volunteers and patients with chronic hepatitis B virus infection: a randomised, observer-blind, placebo-controlled, phase 1trial

Man-Fung Yuen et al.

Summary: The safety and tolerability of RO7020531 were assessed in healthy volunteers and patients with chronic hepatitis B virus (HBV) infection. The results showed that RO7020531 demonstrated acceptable safety and tolerability in both healthy volunteers and patients. Therefore, RO7020531 has the potential to be developed for the treatment of chronic HBV infection.

LANCET INFECTIOUS DISEASES (2023)

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Article Chemistry, Multidisciplinary

Indocyanine green-/TLR7 agonist-constructed thermosensitive liposome for low-temperature PTT induced synergistic immunotherapy of colorectal cancer

Xiang Sun et al.

Summary: A cascade synergistic nanosystem, R837/ICG@Lip, was developed to overcome the obstacles of low immunogenicity, immunosuppressive tumor microenvironment, and poor drug permeability in colorectal cancer (CRC). The nanosystem demonstrated NIR-triggered drug release, photothermal conversion efficiency, and phototoxicity against CT26 colorectal cancer cells. In vivo results showed effective accumulation of the nanosystem in tumors and lymph nodes, triggering immunogenic cell death and promoting adaptive antitumor T-cell responses. Combining with an IDO inhibitor further enhanced the antitumor immune response.

CHINESE CHEMICAL LETTERS (2023)

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Review Immunology

Future perspectives of emerging novel drug targets and immunotherapies to control drug addiction

Jonaid Ahmad Malik et al.

Summary: Substance Use Disorder (SUD) is a rapidly intensifying global mental illness that is difficult to treat due to limited options. Understanding the complexity of addiction disorders and utilizing cutting-edge technologies and immunotherapeutic methods such as vaccines and antibodies hold promise in controlling this disorder. Vaccines have been successful in eliminating and controlling various diseases, and antibody therapy has shown potential in treating serious diseases like cancer.

INTERNATIONAL IMMUNOPHARMACOLOGY (2023)

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Article Gastroenterology & Hepatology

Safety and efficacy of the oral TLR8 agonist selgantolimod in individuals with chronic hepatitis B under viral suppression

Edward J. Gane et al.

Summary: Selgantolimod treatment showed positive effects on hepatitis B surface antigen, but only a few patients achieved the primary efficacy endpoint. The common adverse events during treatment included nausea, upper respiratory tract infection, and vomiting. Overall, this treatment approach showed potential in a small proportion of patients.

JOURNAL OF HEPATOLOGY (2023)

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Article Chemistry, Multidisciplinary

Spleen-selective co-delivery of mRNA and TLR4 agonist-loaded LNPs for synergistic immunostimulation and Th1 immune responses

Longze Pan et al.

Summary: This study designed a spleen-selective mRNA vaccine that delivered unmodified mRNA and Toll-like Receptor (TLR) agonists to the spleen after systemic administration, resulting in a sufficient and persistent antitumor cellular immune response with potent tumor immunotherapeutic efficacy.

JOURNAL OF CONTROLLED RELEASE (2023)

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Article Multidisciplinary Sciences

T cell-independent eradication of experimental glioma by intravenous TLR7/8-agonist-loaded nanoparticles

Verena Turco et al.

Summary: Glioblastoma, the most aggressive brain tumor type, can be treated by reprogramming myeloid cells using CDNP-R848 nanoparticles. CDNP-R848 induces tumor regression by targeting blood-borne macrophages independently of adaptive immunity.

NATURE COMMUNICATIONS (2023)

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Article Immunology

Human toll-like receptor 8 (TLR8) in NK cells: Implication for cancer immunotherapy

Irene Veneziani et al.

Summary: Toll-like receptors (TLRs) are described as homo- or heterodimeric proteins mainly in antigen presenting cells like dendritic cells (DCs), but recent studies have discovered their expression and role also in natural killer (NK) cells. The activation and function of TLRs can be modulated directly or indirectly by TLR agonists. The interplay between DCs and NK cells, mediated by cell-to-cell contact and soluble factors, promotes DC maturation and NK cell activation. Based on this concept, TLR-based immunotherapy targeting the NK-DC axis has been proposed to modulate the tumor microenvironment, improve DC antigen presentation, and enhance NK cell cytotoxicity against tumor cells.

IMMUNOLOGY LETTERS (2023)

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Article Oncology

Rewiring innate and adaptive immunity with TLR9 agonist to treat osteosarcoma

Caterina Cascini et al.

Summary: Osteosarcoma (OS) is the most common primary bone tumor in children and adolescent. In this study, it was found that intralesional administration of a TLR9 agonist can effectively inhibit tumor growth and also have therapeutic effects on untreated contralateral lesions. The findings suggest that TLR9 agonist can act as an in situ anti-tumor vaccine, activating innate and adaptive immune responses to suppress tumor growth.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2023)

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Article Medicine, Research & Experimental

TLR8 agonist Motolimod-induced inflammatory death for treatment of acute myeloid leukemia

Wei Yang et al.

Summary: The clinical treatment of AML is often toxic and limited in efficacy, therefore, novel therapeutic strategies are urgently needed. Small-molecule inhibitors, such as the TLR8 agonist Motolimod (MTL), show high specificity and low off-target toxicity, and have strong potential in tumor therapy. In this study, MTL demonstrated significant anti-AML activity in vitro and in vivo, with minimal effects on normal lymphocytes.

BIOMEDICINE & PHARMACOTHERAPY (2023)

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Article Multidisciplinary Sciences

Complementarity-determining region clustering may cause CAR-T cell dysfunction

Tina Saren et al.

Summary: Chimeric antigen receptor (CAR)-T cell therapy is an important advancement in cancer treatment. However, designing an optimal CAR is challenging due to the presence of complementarity-determining regions (CDRs), which can cause CAR clustering and result in antigen-independent tonic signalling and subsequent CAR-T cell dysfunction.

NATURE COMMUNICATIONS (2023)

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Article Oncology

A Chemically Defined TLR3 Agonist with Anticancer Activity

Julie Le Naour et al.

Summary: A novel TLR3 agonist TL-532 was shown to have favorable pharmacokinetic, pharmacodynamic, mechanistic, and toxicological properties. It stimulated the production of multiple chemokines and interleukins, resulting in anticancer immune responses. TL-532 demonstrated efficacy in reducing bladder cancer growth and restoring the response to immunogenic chemotherapy in immunodeficient mice.

ONCOIMMUNOLOGY (2023)

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Review Oncology

Chimeric antigen receptor T cells therapy in solid tumors

Fatimah Rababah et al.

Summary: CAR-T therapy is an ACT therapy that uses CAR to enable T cells to recognize tumor antigens in a HLA-independent manner and destroy tumors. However, there are limitations such as antigen escape and the diversity of the tumor microenvironment, but these can be improved by introducing multiplexing CAR-T cells and local administration.

CLINICAL & TRANSLATIONAL ONCOLOGY (2023)

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Review Immunology

Toll-Like Receptor Signaling and Its Role in Cell-Mediated Immunity

Tianhao Duan et al.

Summary: This article provides a detailed overview of the innate immune system's defense mechanisms against pathogens, with a focus on the role of Toll-like receptors (TLRs) in immune responses. TLRs not only link innate immunity to adaptive immunity, but also directly regulate the function of T cells. In addition, the article discusses the critical role of TLR signaling in host defense against infectious diseases, autoimmune diseases, and cancer.

FRONTIERS IN IMMUNOLOGY (2022)

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Review Immunology

Fiction and Facts about BCG Imparting Trained Immunity against COVID-19

Gurpreet Kaur et al.

Summary: The BCG vaccine, used against Mycobacterium tuberculosis, is known to induce non-specific heterologous immunity and may have a role in protecting against COVID-19. However, the effectiveness of vaccines against COVID-19 remains uncertain.

VACCINES (2022)

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Article Biochemistry & Molecular Biology

Targeting dendritic cells with TLR-2 ligand-coated nanoparticles loaded with Mycobacterium tuberculosis epitope induce antituberculosis immunity

Deepjyoti Kumar Das et al.

Summary: Novel vaccination strategies are crucial for controlling tuberculosis, but drug-resistant strains of Mycobacterium tuberculosis are a major obstacle. A new vaccine formulation was developed, which effectively triggered an immune response to control tuberculosis infection.

JOURNAL OF BIOLOGICAL CHEMISTRY (2022)

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Review Pharmacology & Pharmacy

Entolimod as a radiation countermeasure for acute radiation

Vijay K. Singh et al.

Summary: Entolimod has been shown effective in protecting against and mitigating acute radiation syndrome in rodents and nonhuman primates. It reduces radiation-induced apoptosis and accelerates tissue regeneration. Clinical evaluation of its pharmacokinetics, toxicity, and biomarkers, as well as FDA approval for investigational new drug, fast-track, and orphan drug statuses, have paved the way for its progression in pre-emergency use authorization.

DRUG DISCOVERY TODAY (2021)

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Review Immunology

TLR10: Insights, controversies and potential utility as a therapeutic target

Si-Biao Su et al.

Summary: TLR10 is a poorly understood member of the Toll-like receptor family, with the ability to induce proinflammatory cytokine production and inhibit proinflammatory responses. Mutations and polymorphisms in the TLR10 gene can alter the balance between anti-inflammatory and pro-inflammatory responses.

SCANDINAVIAN JOURNAL OF IMMUNOLOGY (2021)

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Editorial Material Biochemistry & Molecular Biology

Messenger RNA vaccines against SARS-CoV-2

Eric J. Topol

CELL (2021)

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Review Immunology

Toll-like receptor-2/7-mediated T cell activation: An innate potential to augment CD8+ T cell cytokine production

Julian J. Freen-van Heeren

Summary: CD8(+) T cells play a critical role in immune response by producing effector molecules to kill target cells. In addition to TCR triggering, T cells can also be activated by pathogen-derived molecules through Toll-like receptors (TLRs), enhancing their effector function.

SCANDINAVIAN JOURNAL OF IMMUNOLOGY (2021)

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Review Biochemistry & Molecular Biology

The Role of Toll-like Receptors (TLRs) Mediated Inflammation in Pancreatic Cancer Pathophysiology

Arturo Orlacchio et al.

Summary: Pancreatic cancer is a lethal form of cancer characterized by its aggressiveness and metastatic potential. Toll-like receptors play a pivotal role in inflammation and immune response, and can be potential targets for cancer therapy. Studies have shown that TLRs play an important role in the progression of pancreatic cancer.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Pharmacology & Pharmacy

TLR Agonists as Vaccine Adjuvants Targeting Cancer and Infectious Diseases

Marina Luchner et al.

Summary: Modern vaccines have shifted towards subunit components, requiring adjuvants to enhance immunogenicity. Toll-like receptor agonists show promise as adjuvants by linking innate and adaptive immune responses and providing danger signals for effective immune responses.

PHARMACEUTICS (2021)

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Letter Cell Biology

SARS-CoV-2 spike protein interacts with and activates TLR41

Yingchi Zhao et al.

CELL RESEARCH (2021)

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Review Oncology

T-cell intrinsic Toll-like receptor signaling: implications for cancer immunotherapy and CAR T-cells

Yasmin Nouri et al.

Summary: TLRs expressed within T-cells serve as important costimulatory and regulatory molecules that enhance T-cell function and memory, while incorporating TLR signaling domains into CAR T-cells allows for the specific exploitation of T-cell intrinsic TLR function, presenting a new opportunity for cancer immunotherapies.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

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Article Immunology

TLR2 senses the SARS-CoV-2 envelope protein to produce inflammatory cytokines

Min Zheng et al.

Summary: The study revealed that the envelope protein of SARS-CoV-2 is sensed by TLR2, leading to the production of inflammatory cytokines, and the severity of the disease is associated with the expression of TLR2 and MYD88. The findings demonstrate the critical role of TLR2 signaling in promoting proinflammatory cytokine production during coronavirus infection, providing new insights for therapeutic strategies against the ongoing COVID-19 pandemic.

NATURE IMMUNOLOGY (2021)

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Article Chemistry, Medicinal

Design, Synthesis, and Structure-Activity Relationship of N-Aryl-N′-(thiophen-2-yl)thiourea Derivatives as Novel and Specific Human TLR1/2 Agonists for Potential Cancer Immunotherapy

Zhipeng Chen et al.

Summary: Through chemical optimization, a highly efficient and specific human TLR2 agonist was identified, which can promote cytokine release through the MyD88 and NF-kappa B pathways, while activating immune cells to affect the apoptosis of cancer cells.

JOURNAL OF MEDICINAL CHEMISTRY (2021)

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Article Immunology

Cumulative Signaling Through NOD-2 and TLR-4 Eliminates the Mycobacterium Tuberculosis Concealed Inside the Mesenchymal Stem Cells

Mohammad Aqdas et al.

Summary: The study observed that MSC stimulated through TLR-4 and NOD-2 (N2.T4) activated MSC and augmented the secretion of pro-inflammatory cytokines, co-localized Mtb in the lysosomes, induced autophagy, enhanced NF-kappa B activity via p38 MAPK signaling pathway, and significantly reduced the intracellular survival of Mtb in the MSC. Overall, the results suggest that triggering through N2.T4 may be a future method of immunotherapy to eliminate the Mtb concealed inside the MSC.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2021)

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Article Gastroenterology & Hepatology

HBV vaccination with Fendrix is effective and safe in pre-dialysis CKD population

Fabrizio Fabrizi et al.

CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY (2020)

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Article Cell Biology

Induction of autophagy through CLEC4E in combination with TLR4: an innovative strategy to restrict the survival of Mycobacterium tuberculosis

Susanta Pahari et al.

AUTOPHAGY (2020)

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Review Immunology

Dynamic Post-Transcriptional Events Governing CD8(+) T Cell Homeostasis and Effector Function

Fiamma Salerno et al.

TRENDS IN IMMUNOLOGY (2020)

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Review Chemistry, Medicinal

Agonist and antagonist ligands of toll-like receptors 7 and 8: Ingenious tools for therapeutic purposes

Cindy Patinote et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)

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Review Neurosciences

Inflammatory Role of TLR-MyD88 Signaling in Multiple Sclerosis

Chao Zheng et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2020)

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Article Immunology

IDENTIFICATION OF A NOVEL TLR5 AGONIST DERIVED FROM THE P97 PROTEIN OF MYCOPLASMA HYOPNEUMONIAE

Laurie Gauthier et al.

IMMUNOBIOLOGY (2020)

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Article

First-in-human study of anticancer immunotherapy drug candidate mobilan: safety, pharmacokinetics and pharmacodynamics in prostate cancer patients

Natalia V. Eremina et al.

Oncotarget (2020)

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Article Cell Biology

mTORC1 Signaling Controls TLR2-Mediated T-Cell Activation by Inducing TIRAP Expression

Takayuki Imanishi et al.

CELL REPORTS (2020)

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Article Oncology

Constitutively active MyD88/CD40 costimulation enhances expansion and efficacy of chimeric antigen receptor T cells targeting hematological malignancies

Matthew R. Collinson-Pautz et al.

LEUKEMIA (2019)

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Article Public, Environmental & Occupational Health

Postlicensure Safety Surveillance of Recombinant Zoster Vaccine (Shingrix) — United States, October 2017–June 2018

Elisabeth M. Hesse et al.

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT (2019)

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Review Immunology

Understanding the immunology of Shingrix, a recombinant glycoprotein E adjuvanted herpes zoster vaccine

Thomas C. Heineman et al.

CURRENT OPINION IN IMMUNOLOGY (2019)

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Article Immunology

TLR2 Stimulation Increases Cellular Metabolism in CD8+ T Cells and Thereby Enhances CD8+ T Cell Activation, Function, and Antiviral Activity

Ejuan Zhang et al.

JOURNAL OF IMMUNOLOGY (2019)

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Review Immunology

The Role of TLRs in Anti-cancer Immunity and Tumor Rejection

Zuzanna Urban-Wojciuk et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Article Immunology

Costimulation through TLR2 Drives Polyfunctional CD8+ T Cell Responses

Fiamma Salerno et al.

JOURNAL OF IMMUNOLOGY (2019)

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Article Oncology

Intratumoral G100, a TLR4 Agonist, Induces Antitumor Immune Responses and Tumor Regression in Patients with Merkel Cell Carcinoma

Shailender Bhatia et al.

CLINICAL CANCER RESEARCH (2019)

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Article Immunology

Toll-Like Receptor 7 Enhances Rabies Virus-Induced Humoral Immunity by Facilitating the Formation of Germinal Centers

Zhaochen Luo et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Article Oncology

Toll-like receptor 2 costimulation potentiates the antitumor efficacy of CAR T Cells

Y. Lai et al.

LEUKEMIA (2018)

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Article Biochemistry & Molecular Biology

Mobilan: a recombinant adenovirus carrying Toll-like receptor 5 self-activating cassette for cancer immunotherapy

V Mett et al.

ONCOGENE (2018)

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Review Immunology

Toll-like receptors in immunity and inflammatory diseases: Past, present, and future

Kumar Vijay

INTERNATIONAL IMMUNOPHARMACOLOGY (2018)

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Article Oncology

A novel generation 1928zT2 CAR T cells induce remission in extramedullary relapse of acute lymphoblastic leukemia

Jianyu Weng et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2018)

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Article Immunology

Safety of a two-dose investigational hepatitis B vaccine, HBsAg-1018, using a toll-like receptor 9 agonist adjuvant in adults

Randall Hyer et al.

VACCINE (2018)

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Article Immunology

TLR-3 Stimulation Skews M2 Macrophages to M1 Through IFN-αβ Signaling and Restricts Tumor Progression

Aurobind Vidyarthi et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Review Oncology

Anti-PD-1 and Anti-CTLA-4 Therapies in Cancer: Mechanisms of Action, efficacy, and Limitations

Judith A. Seidel et al.

FRONTIERS IN ONCOLOGY (2018)

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Article Immunology

Humoral and cell-mediated immune responses to H5N1 plant-made virus-like particle vaccine are differentially impacted by alum and GLA-SE adjuvants in a Phase 2 clinical trial

Stephane Pillet et al.

NPJ VACCINES (2018)

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Article Oncology

SD-101 in Combination with Pembrolizumab in Advanced Melanoma: Results of a Phase Ib, Multicenter Study

Antoni Ribas et al.

CANCER DISCOVERY (2018)

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Review Oncology

Adoptive transfer of tumor-infiltrating lymphocytes in melanoma: a viable treatment option

Maartje W. Rohaan et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2018)

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Article Oncology

A randomized trial of TLR-2 agonist CADI-05 targeting desmocollin-3 for advanced non-small-cell lung cancer

C. P. Belani et al.

ANNALS OF ONCOLOGY (2017)

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Review Clinical Neurology

Brain MRI atrophy quantification in MS From methods to clinical application

Maria A. Rocca et al.

NEUROLOGY (2017)

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Article Neurosciences

Toll-like Receptor 4 Mediates Morphine-Induced Neuroinflammation and Tolerance via Soluble Tumor Necrosis Factor Signaling

Lori N. Eidson et al.

NEUROPSYCHOPHARMACOLOGY (2017)

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Review Immunology

The immunogenicity and safety of GSK's recombinant hepatitis B vaccine in adults: a systematic review of 30 years of experience

Caroline Van Den Ende et al.

EXPERT REVIEW OF VACCINES (2017)

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Article Immunology

Adoptive transfer of murine T cells expressing a chimeric-PD1-Dap10 receptor as an immunotherapy for lymphoma

Adam Lynch et al.

IMMUNOLOGY (2017)

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Review Oncology

Stimulating Innate Immunity to Enhance Radiation Therapy-Induced Tumor Control

Jason R. Baird et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2017)

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Article Biotechnology & Applied Microbiology

Regulated Expansion and Survival of Chimeric Antigen Receptor-Modified T Cells Using Small Molecule-Dependent Inducible MyD88/CD40

Aaron E. Foster et al.

MOLECULAR THERAPY (2017)

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Article Multidisciplinary Sciences

Distinct PKC-mediated posttranscriptional events set cytokine production kinetics in CD8+ T cells

Fiamma Salerno et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

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Article Multidisciplinary Sciences

T cell costimulatory receptor CD28 is a primary target for PD-1-mediated inhibition

Enfu Hui et al.

SCIENCE (2017)

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Article Biotechnology & Applied Microbiology

Reactogenicity of Cervarix and Gardasil human papillomavirus (HPV) vaccines in a randomized single blind trial in healthy UK adolescent females

Tao Haskins-Coulter et al.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2017)

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Meeting Abstract Oncology

Immune response, safety, and survival impact from CMB305 in NY-ESO-1+recurrent soft tissue sarcomas (STS)

Neeta Somaiah et al.

JOURNAL OF CLINICAL ONCOLOGY (2017)

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Article Immunology

Toll like Receptor 2 engagement on CD4+ T cells promotes TH9 differentiation and function

Ahmad Faisal Karim et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2017)

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Article Oncology

Chimeric PD-1:28 Receptor Upgrades Low-Avidity T cells and Restores Effector Function of Tumor-Infiltrating Lymphocytes for Adoptive Cell Therapy

Ramona Schlenker et al.

CANCER RESEARCH (2017)

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Review Immunology

The Role of Toll-Like Receptors in Autoimmune Diseases through Failure of the Self-Recognition Mechanism

Mark Farrugia et al.

INTERNATIONAL JOURNAL OF INFLAMMATION (2017)

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Article Oncology

A Chimeric Switch-Receptor Targeting PD1 Augments the Efficacy of Second-Generation CAR T Cells in Advanced Solid Tumors

Xiaojun Liu et al.

CANCER RESEARCH (2016)

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Article Immunology

TLR-Mediated Innate Production of IFN-γ by CD8+ T Cells Is Independent of Glycolysis

Fiamma Salerno et al.

JOURNAL OF IMMUNOLOGY (2016)

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Review Oncology

Driving CAR T-cells forward

Hollie J. Jackson et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2016)

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Review Pharmacology & Pharmacy

Toll-like receptors mediating vascular malfunction: Lessons from receptor subtypes

Yu Wang et al.

PHARMACOLOGY & THERAPEUTICS (2016)

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Review Biology

Innate recognition of microbial-derived signals in immunity and inflammation

Yue Zhang et al.

SCIENCE CHINA-LIFE SCIENCES (2016)

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Review Gastroenterology & Hepatology

Toll-like receptors in pathophysiology of liver diseases

Safak Kiziltas

WORLD JOURNAL OF HEPATOLOGY (2016)

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Review Medicine, General & Internal

Treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Systematic Review for a National Institutes of Health Pathways to Prevention Workshop

M. E. Beth Smith et al.

ANNALS OF INTERNAL MEDICINE (2015)

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Article Oncology

The TLR-2/TLR-6 agonist macrophage-activating lipopeptide-2 augments human NK cell cytotoxicity when PGE2 production by monocytes is inhibited by a COX-2 blocker

Christina Mueller et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2015)

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Review Immunology

The role of natural killer cells in pathogenesis of autoimmune diseases

Katarzyna Popko et al.

CENTRAL EUROPEAN JOURNAL OF IMMUNOLOGY (2015)

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Article Oncology

Impact of a New Fusion Receptor on PD-1-Mediated Immunosuppression in Adoptive T Cell Therapy

Sebastian Kobold et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2015)

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Article Oncology

Impact of a New Fusion Receptor on PD-1-Mediated Immunosuppression in Adoptive T Cell Therapy

Sebastian Kobold et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2015)

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Article Oncology

Resiquimod as an Immunologic Adjuvant for NY-ESO-1 Protein Vaccination in Patients with High-Risk Melanoma

Rachel Lubong Sabado et al.

CANCER IMMUNOLOGY RESEARCH (2015)

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Article Oncology

Self-adjuvanted mRNA vaccination in advanced prostate cancer patients: a first-in-man phase I/IIa study

Hubert Kuebler et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2015)

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Review Immunology

Vaccine adjuvant uses of poly-IC and derivatives

Karen Ao Martins et al.

EXPERT REVIEW OF VACCINES (2015)

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Article Immunology

Triggering Through Toll-like Receptor 2 Limits Chronically Stimulated T-helper Type 1 Cells From Undergoing Exhaustion

Sathi Babu Chodisetti et al.

JOURNAL OF INFECTIOUS DISEASES (2015)

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Review Biochemistry & Molecular Biology

The Role of the Transcriptional Regulation of Stromal Cells in Chronic Inflammation

Alvaro Valin et al.

BIOMOLECULES (2015)

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Meeting Abstract Oncology

A phase I study of the toll-like receptor 5 (TLR5) agonist, entolimod in patients (pts) with advanced cancers.

Hatoon Bakhribah et al.

JOURNAL OF CLINICAL ONCOLOGY (2015)

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Article Immunology

Role of Toll-Like Receptor 13 in Innate Immune Recognition of Group B Streptococci

Giacomo Signorino et al.

INFECTION AND IMMUNITY (2014)

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Article Immunology

Latency-Associated Protein Acr1 Impairs Dendritic Cell Maturation and Functionality: A Possible Mechanism of Immune Evasion by Mycobacterium tuberculosis

Kaneez F. Siddiqui et al.

JOURNAL OF INFECTIOUS DISEASES (2014)

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Review Immunology

Clinical evaluation of CpG oligonucleotides as adjuvants for vaccines targeting infectious diseases and cancer

Julia Scheiermann et al.

VACCINE (2014)

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Review Immunology

Toll-like receptor signaling pathways

Takumi Kawasaki et al.

FRONTIERS IN IMMUNOLOGY (2014)

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Review Immunology

Assembly and localization of Toll-like receptor signalling complexes

Nicholas J. Gay et al.

NATURE REVIEWS IMMUNOLOGY (2014)

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Review Immunology

Toll-Like Receptors' Pathway Disturbances are Associated with Increased Susceptibility to Infections in Humans

Josias Brito Frazao et al.

ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS (2013)

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Article Gastroenterology & Hepatology

Loss of immunity-supported senescence enhances susceptibility to hepatocellular carcinogenesis and progression in Toll-like receptor 2-deficient mice

Heng Lin et al.

HEPATOLOGY (2013)

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Article Immunology

Recognition of Profilin by Toll-like Receptor 12 Is Critical for Host Resistance to Toxoplasma gondii

A. Alicia Koblansky et al.

IMMUNITY (2013)

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Article Immunology

Cooperation of TLR12 and TLR11 in the IRF8-Dependent IL-12 Response to Toxoplasma gondii Profilin

Megan Raetz et al.

JOURNAL OF IMMUNOLOGY (2013)

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Article Immunology

Human T Cells Engineered To Express a Programmed Death 1/28 Costimulatory Retargeting Molecule Display Enhanced Antitumor Activity

Chen Ankri et al.

JOURNAL OF IMMUNOLOGY (2013)

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Review Cell Biology

TLR agonists: our best frenemy in cancer immunotherapy

Sabina Kaczanowska et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2013)

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Article Multidisciplinary Sciences

The Ultra-Potent and Selective TLR8 Agonist VTX-294 Activates Human Newborn and Adult Leukocytes

David J. Dowling et al.

PLOS ONE (2013)

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Article Gastroenterology & Hepatology

Controversial role of toll-like receptors in acute pancreatitis

Juan Vaz et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2013)

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Article Pharmacology & Pharmacy

Enhanced Dendritic Cell-Mediated Antigen-Specific CD4+ T Cell Responses: IFN-Gamma Aids TLR Stimulation

Kuo-Ching Sheng et al.

JOURNAL OF DRUG DELIVERY (2013)

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Review Biochemistry & Molecular Biology

Signaling Organelles of the Innate Immune System

Jonathan C. Kagan

CELL (2012)

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Review Immunology

The Effects of TLR Activation on T-Cell Development and Differentiation

Bo Jin et al.

CLINICAL & DEVELOPMENTAL IMMUNOLOGY (2012)

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Article Oncology

Topical TLR7 Agonist Imiquimod Can Induce Immune-Mediated Rejection of Skin Metastases in Patients with Breast Cancer

Sylvia Adams et al.

CLINICAL CANCER RESEARCH (2012)

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Article Oncology

Phase I Trial of Overlapping Long Peptides from a Tumor Self-Antigen and Poly-ICLC Shows Rapid Induction of Integrated Immune Response in Ovarian Cancer Patients

Paul Sabbatini et al.

CLINICAL CANCER RESEARCH (2012)

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Article Immunology

A specific role for TLR1 in protective TH17 immunity during mucosal infection

R. William DePaolo et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2012)

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Article Multidisciplinary Sciences

A Double-Blind, Placebo-Controlled, Randomized, Clinical Trial of the TLR-3 Agonist Rintatolimod in Severe Cases of Chronic Fatigue Syndrome

David R. Strayer et al.

PLOS ONE (2012)

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Article Biochemistry & Molecular Biology

TLR Signaling Is Required for Salmonella typhimurium Virulence

Nicholas Arpaia et al.

CELL (2011)

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Review Immunology

Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity

Taro Kawai et al.

IMMUNITY (2011)

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Review Immunology

Use of defined TLR ligands as adjuvants within human vaccines

Malcolm S. Duthie et al.

IMMUNOLOGICAL REVIEWS (2011)

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Article Immunology

Nucleic acid-stimulated antigen-presenting cells trigger T cells to induce disease in a rat transfer model of inflammatory arthritis

Markus H. Hoffmann et al.

JOURNAL OF AUTOIMMUNITY (2011)

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Review Cell Biology

Co-ordination of Incoming and Outgoing Traffic in Antigen-Presenting Cells by Pattern Recognition Receptors and T Cells

Priyanka Nair et al.

TRAFFIC (2011)

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Article Hematology

When Toll-like receptor and T-cell receptor signals collide: a mechanism for enhanced CD8 T-cell effector function

Degui Geng et al.

BLOOD (2010)

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Review Biochemistry & Molecular Biology

HMGB1, a potent proinflammatory cytokine in sepsis

Wenchang Huang et al.

CYTOKINE (2010)

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Review Biochemistry & Molecular Biology

Toll-like receptor signaling in cell proliferation and survival

Xinyan Li et al.

CYTOKINE (2010)

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Article Hematology

A critical role for direct TLR2-MyD88 signaling in CD8 T-cell clonal expansion and memory formation following vaccinia viral infection

Michael Quigley et al.

BLOOD (2009)

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Review Gastroenterology & Hepatology

Toll-like receptors as targets in chronic liver diseases

A. Mencin et al.

GUT (2009)

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Article Immunology

The contribution of direct TLR signaling to T cell responses

Adeeb H. Rahman et al.

IMMUNOLOGIC RESEARCH (2009)

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Article Immunology

Ampligen: A potential toll-like 3 receptor adjuvant for immunotherapy of cancer

B. Jasani et al.

VACCINE (2009)

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Review Immunology

Toll-like receptor signalling on Tregs: to suppress or not to suppress?

Wendy W. C. van Maren et al.

IMMUNOLOGY (2008)

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Review Oncology

Innate Immunity in Sepsis Pathogenesis and Its Modulation: New Immunomodulatory Targets Revealed

V. Kumar et al.

JOURNAL OF CHEMOTHERAPY (2008)

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Article Immunology

The agonists of TLR4 and 9 are sufficient to activate memory B cells to differentiate into plasma cells in vitro but not in vivo

Katharina Richard et al.

JOURNAL OF IMMUNOLOGY (2008)

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Article Immunology

The myeloid differentiation factor 88 (MyD88) is required for CD4+ T cell effector function in a murine model of inflammatory bowel disease

Masayuki Fukata et al.

JOURNAL OF IMMUNOLOGY (2008)

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Review Rheumatology

High-mobility group box protein 1 (HMGB1): an alarmin mediating the pathogenesis of rheumatic disease

David S. Pisetsky et al.

ARTHRITIS RESEARCH & THERAPY (2008)

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Review Immunology

Toll-like receptors and immune regulation:: their direct and indirect modulation on regulatory CD4+ CD25+ T cells

Guangwei Liu et al.

IMMUNOLOGY (2007)

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Review Immunology

GlaxoSmithKline Adjuvant systems in vaccines: concepts, achievements and perspectives

Nathalie Garcon et al.

EXPERT REVIEW OF VACCINES (2007)

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Article Immunology

Cutting edge: A common polymorphism impairs cell surface trafficking and functional responses of TLR1 but protects against leprosy

Christopher M. Johnson et al.

JOURNAL OF IMMUNOLOGY (2007)

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Article Immunology

Cutting edge: TLR2 directly triggers Th1 effector functions

Takayuki Imanishi et al.

JOURNAL OF IMMUNOLOGY (2007)

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Article Pathology

The toll-like receptor adaptor proteins MyD88 and Mal/TIRAP contribute to the inflammatory and destructive processes in a human model of rheumatoid arthritis

Sandra M. Sacre et al.

AMERICAN JOURNAL OF PATHOLOGY (2007)

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Review Immunology

Expression and function of Toll-like receptors in T lymphocytes

Dieter Kabelitz

CURRENT OPINION IN IMMUNOLOGY (2007)

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Article Immunology

The adaptor molecule MyD88 activates PI-3 kinase signaling in CD4+ T cells and enables CpG oligodeoxynucleotide-mediated costimulation

Andrew E. Gelman et al.

IMMUNITY (2006)

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Article Immunology

Pollinex® Quattro:: a novel and well-tolerated, ultra short-course allergy vaccine

Piyush Patel et al.

EXPERT REVIEW OF VACCINES (2006)

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Article Multidisciplinary Sciences

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

E Bettelli et al.

NATURE (2006)

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Article Multidisciplinary Sciences

Toll-like receptor 2 signaling modulates the functions of CD4+CD25+ regulatory T cells

HY Liu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

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Review Biochemistry & Molecular Biology

TLR signaling

T Kawai et al.

CELL DEATH AND DIFFERENTIATION (2006)

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Article Immunology

Human CD4+CD25high regulatory T cells modulate myeloid but not plasmacytoid dendritic cells activation

Roch Houot et al.

JOURNAL OF IMMUNOLOGY (2006)

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Article Immunology

Cutting edge: Diminished T cell TLR expression and function modulates the immune response in human filarial infection

Subash Babu et al.

JOURNAL OF IMMUNOLOGY (2006)

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Article Multidisciplinary Sciences

Activation of anti-hepatitis C virus responses via Toll-like receptor 7

J Lee et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

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Article Medicine, Research & Experimental

Toll-like receptor 2 controls expansion and function of regulatory T cells

RPM Sutmuller et al.

JOURNAL OF CLINICAL INVESTIGATION (2006)

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Article Multidisciplinary Sciences

Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response

G Oganesyan et al.

NATURE (2006)

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Article Immunology

Erythromycin differentially inhibits lipopolysaccharide- or poly(I:C)-induced but not peptidoglycan-induced activation of human monocyte-derived dendritic cells

M Yasutomi et al.

JOURNAL OF IMMUNOLOGY (2005)

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Article Immunology

Human CD4+ T cells express TLR5 and its ligand flagellin enhances the suppressive capacity and expression of FOXP3 in CD4+CD25+ T regulatory cells

NK Crellin et al.

JOURNAL OF IMMUNOLOGY (2005)

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Article Biochemistry & Molecular Biology

TLR3 and TLR7 are targeted to the same intracellular compartments by distinct regulatory elements

T Nishiya et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

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Article Immunology

Nucleic acids of mammalian origin can act as endogenous ligands for toll-like receptors and may promote systemic lupus erythematosus

FJ Barrat et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2005)

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Review Microbiology

From the Th1/Th2 paradigm towards a toll-like receptor/T-helper bias

MG Netea et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2005)

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Article Immunology

CPG 7909 adjuvant improves hepatitis B virus vaccine seroprotection in anti retroviral-treated HIV-infected adults

CL Cooper et al.

AIDS (2005)

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Article Multidisciplinary Sciences

Toll-like, receptor 8-mediated reversal of CD4+ regulatory T cell function

GY Peng et al.

SCIENCE (2005)

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Article Immunology

Direct stimulation of human T cells via TLR5 and TLR7/8:: Flagellin and R-848 up-regulate proliferation and IFN-γ production by memory CD4+ T cells

G Caron et al.

JOURNAL OF IMMUNOLOGY (2005)

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Article Immunology

TLR2 agonist ameliorates established allergic airway inflammation by promoting Th1 response and not via regulatory T cells

M Patel et al.

JOURNAL OF IMMUNOLOGY (2005)

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Article Oncology

Defining the antigen-specific T-Cell response to vaccination and poly(I:C)/TLR3 signaling -: Evidence of enhanced primary and memory CD8 T-Cell responses and antitumor immunity

ML Salem et al.

JOURNAL OF IMMUNOTHERAPY (2005)

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Article Immunology

Upon TLR9 signaling, CD5+ B cells control the IL-12-dependent Th1-priming capacity of neonatal DCs

CM Sun et al.

IMMUNITY (2005)

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Article Multidisciplinary Sciences

Foxp3+ CD25- CD4 T cells constitute a reservoir of committed regulatory cells that regain CD25 expression upon homeostatic expansion

S Zelenay et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

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Article Neurosciences

The physiological regulation of toll-like receptor expression and function in humans

GI Lancaster et al.

JOURNAL OF PHYSIOLOGY-LONDON (2005)

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Article Immunology

CD4+CD25+ regulatory T cells control innate immune reactivity after injury

TJ Murphy et al.

JOURNAL OF IMMUNOLOGY (2005)

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Article Multidisciplinary Sciences

TLR2 is expressed on activated T cells as a costimulatory receptor

M Komai-Koma et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

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Review Immunology

Toll-like receptor control of the adaptive immune responses

A Iwasaki et al.

NATURE IMMUNOLOGY (2004)

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Article Genetics & Heredity

A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis

AB Begovich et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2004)

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Article Immunology

TLRs govern neutrophil activity in aspergillosis

S Bellocchio et al.

JOURNAL OF IMMUNOLOGY (2004)

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Article Immunology

Toll-dependent control mechanisms of CD4 T cell activation

C Pasare et al.

IMMUNITY (2004)

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Article Immunology

FcγRIIa is expressed on natural IFN-α-producing cells (plasmacytoid dendritic cells) and is required for the IFN-α production induced by apoptotic cells combined with lupus IgG

U Båve et al.

JOURNAL OF IMMUNOLOGY (2003)

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Article Immunology

Differential induction of interleukin-10 and interleukin-12 in dendritic cells by microbial Toll-like receptor activators and skewing of T-cell cytokine profiles

H Qi et al.

INFECTION AND IMMUNITY (2003)

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Article Immunology

IKKε and TBK1 are essential components of the IRF3 signaling pathway

KA Fitzgerald et al.

NATURE IMMUNOLOGY (2003)

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Review Immunology

Regulatory T cells under scrutiny

JF Bach

NATURE REVIEWS IMMUNOLOGY (2003)

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Article Immunology

Regulatory T cells selectively express toll-like receptors and are activated by lipopolysaccharide

I Caramalho et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2003)

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Article Multidisciplinary Sciences

Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells

C Pasare et al.

SCIENCE (2003)

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Article Multidisciplinary Sciences

Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4

M Yamamoto et al.

NATURE (2002)

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Article Multidisciplinary Sciences

Toll-like receptor 4-dependent activation of dendritic cells by β-defensin 2

A Biragyn et al.

SCIENCE (2002)

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