☆ 4.4 Article

Reprogramming a Doxycycline-Inducible Gene Switch System for Bacteria-Mediated Cancer Therapy

MOLECULAR IMAGING AND BIOLOGY (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Editorial Material Multidisciplinary Sciences

Bioengineering of bacteria for cancer immunotherapy

Dinh-Huy Nguyen et al.

Summary: This article provides a brief overview of the approaches and strategies used in bacteria-based cancer immunotherapy (BCiT). It also discusses research in the field of synthetic biology, which aims to regulate bacterial growth and gene expression for immunotherapeutic purposes. Finally, the current clinical status and limitations of BCiT are examined.

NATURE COMMUNICATIONS (2023)

添加到收藏夹

Article Chemistry, Analytical

Genetic Programming by Nitric Oxide-Sensing Gene Switch System in Tumor-Targeting Bacteria

Yeshan Qin et al.

Summary: Recent progress in synthetic biology allows bacteria to respond to specific disease signals for diagnosis and/or therapy. This study presents a NO-sensing gene switch system that triggers tumor-specific gene expression in an attenuated strain of S. Typhimurium. The genetic circuit senses NO through NorR, leading to the expression of FimE DNA recombinase and the unidirectional inversion of a promoter region (fimS), inducing target gene expression. In vitro experiments show that target gene expression in bacteria transformed with this switch system is triggered by the chemical source of NO, DETA/NO. In vivo results demonstrate that the gene expression is tumor-targeted and specific to NO generated by iNOS after S. Typhimurium colonization.

BIOSENSORS-BASEL (2023)

添加到收藏夹

Review Pharmacology & Pharmacy

Bacteria and bacterial derivatives as delivery carriers for immunotherapy

Sae-Ryung Kang et al.

Summary: There is a growing interest in the role of microorganisms in human health and disease, with evidence suggesting that biotherapies using engineered bacteria and their derivatives can address specific disease mechanisms. The complex interactions between microorganisms and metabolic/immunologic pathways are fundamental to many diseases with unmet medical needs, and targeting these interactions may improve patient treatment.

ADVANCED DRUG DELIVERY REVIEWS (2022)

添加到收藏夹

Article Radiology, Nuclear Medicine & Medical Imaging

Optimized Doxycycline-Inducible Gene Expression System for Genetic Programming of Tumor-Targeting Bacteria

Dinh-Huy Nguyen et al.

Summary: The newly developed Doxy-inducible gene expression system in pJH18 plasmid showed improved expression balance of bidirectional tet promoters compared to the previous system. Expression levels were significantly higher, and plasmid stability was increased in Salmonella transformed with pJH18, showing potential for future clinical applications.

MOLECULAR IMAGING AND BIOLOGY (2022)

添加到收藏夹

Article Engineering, Biomedical

Enhancing the tropism of bacteria via genetically programmed biosensors

Tiffany Chien et al.

Summary: The tropism of engineered bacteria in vivo can be enhanced by genetic circuits, linked by AND-gate logic, that couple bacterial sensing and growth. Engineered bacteria for therapeutic applications would benefit from control mechanisms that confine the growth of the bacteria within specific tissues or regions in the body. Multiplexing of genetic circuits may enhance the localization of bacteria to specified niches, providing increased specificity for therapeutic applications.

NATURE BIOMEDICAL ENGINEERING (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

Regulation of RNA stability at the 3′ end

Mallory Frederick et al.

Summary: RNA homeostasis is regulated by various cellular pathways, with different 3' end modifications affecting RNA stability and maturation. Uridylation plays a crucial role in mRNA decay and is also a key regulator of various RNA species such as miRNAs and tRNAs, with dual regulatory functions. Additionally, low levels of untemplated guanine and cytidine residues have been observed as part of more complex tailing patterns.

BIOLOGICAL CHEMISTRY (2021)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Engineering precision nanoparticles for drug delivery

Michael J. Mitchell et al.

Summary: The development of nanoparticles has shown promising clinical applications, overcoming the limitations of therapeutic interventions and biological barriers. Precision therapies have enhanced treatment efficacy through personalized interventions. Advancements in nanoparticle design aim to optimize drug delivery, improving efficacy in general applications and enabling tailored designs for precision applications.

NATURE REVIEWS DRUG DISCOVERY (2021)

添加到收藏夹

Review Nanoscience & Nanotechnology

Bacteria-Mediated Synergistic Cancer Therapy: Small Microbiome Has a Big Hope

Xinyu Lou et al.

Summary: Bacteria-mediated bio-therapy has shown promising antitumor effects and can be combined with traditional anticancer therapies for improved efficacy. While there are opportunities for development in this field, there are also challenges that need to be addressed.

NANO-MICRO LETTERS (2021)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Engineering living therapeutics with synthetic biology

Andres Cubillos-Ruiz et al.

Summary: Cell-based therapeutics designed with synthetic biology is an emerging strategy in medicine, utilizing genetically engineered cells for precise therapeutic control and potential treatment of various diseases. Compared to traditional therapies, synthetic biology approaches offer greater flexibility, specificity, and predictability in combating human diseases.

NATURE REVIEWS DRUG DISCOVERY (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Bacterial-induced pH shifts link individual cell physiology to macroscale collective behavior

Veeramuthu Dharanishanthi et al.

Summary: Bacteria can adjust their motility by collectively modifying environmental pH, which interacts with the carbon repression pathway. This regulation affects bacterial movement by lowering pH, rather than acting directly through glucose molecules. Changes in environmental pH by neighboring bacterial species can override glucose-dependent repression and induce collective behaviors in bacteria.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

添加到收藏夹

Article Microbiology

Salmonella enterica Serovar Typhimurium SPI-1 and SPI-2 Shape the Global Transcriptional Landscape in a Human Intestinal Organoid Model System

Anna-Lisa E. Lawrence et al.

Summary: The human intestinal organoid (HIO) model provides a more accurate platform to study host transcriptional responses to foodborne pathogens like Salmonella enterica Typhimurium. Infection with S. Typhimurium strongly stimulates proinflammatory gene expression and downregulates genes associated with cell cycle and DNA repair, leading to reduced cellular proliferation. The findings highlight the importance of Salmonella pathogenicity island-1 (SPI-1) and SPI-2-encoded type 3 secretion systems in modulating early host responses during enteric infection.

MBIO (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Small molecules in targeted cancer therapy: advances, challenges, and future perspectives

Lei Zhong et al.

Summary: Targeted therapeutic drugs have become mainstream cancer treatments due to their advantages in efficacy and safety, but still face challenges such as low response rate and drug resistance. A comprehensive review was conducted on small-molecule targeted anti-cancer drugs to promote their development, discussing current challenges and providing insights and perspectives for future research and development.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

添加到收藏夹

Review Oncology

Tweak to Treat: Reprograming Bacteria for Cancer Treatment

Brendan Fu-Long Sieow et al.

Summary: Recent advances in cancer biology, microbiology, and bioengineering have led to the development of engineered live biotherapeutics for targeted cancer therapy. Engineered bacteria, including tumor-targeting and probiotics, can deliver anticancer agents to the tumor microenvironment. Combination therapies involving engineered bacteria and traditional anticancer treatments show promise in addressing intratumor heterogeneity. Exciting prospects lie ahead for the clinical translation of engineered bacteria in cancer prevention and treatment.

TRENDS IN CANCER (2021)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Fusion tags to enhance heterologous protein expression

Mi-Ran Ki et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2020)

添加到收藏夹

Editorial Material Cell Biology

Confounding factors from inducible systems for spatiotemporal gene expression regulation

Rob C. I. Wuest et al.

JOURNAL OF CELL BIOLOGY (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Immunotherapy with engineered bacteria by targeting the STING pathway for anti-tumor immunity

Daniel S. Leventhal et al.

NATURE COMMUNICATIONS (2020)

添加到收藏夹

Article Biochemical Research Methods

RecV recombinase system for in vivo targeted optogenomic modifications of single cells or cell populations

Shenqin Yao et al.

NATURE METHODS (2020)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Radiopharmaceutical therapy in cancer: clinical advances and challenges

George Sgouros et al.

NATURE REVIEWS DRUG DISCOVERY (2020)

添加到收藏夹

Review Microbiology

Microbiota and Cancer: The Emerging Beneficial Role of Bifidobacteria in Cancer Immunotherapy

Giulia Longhi et al.

FRONTIERS IN MICROBIOLOGY (2020)

添加到收藏夹

Article Microbiology

The Site-Specific Recombination System of theEscherichia coliBacteriophage φ24B

Mohammed Radhi Mohaisen et al.

FRONTIERS IN MICROBIOLOGY (2020)

添加到收藏夹

Review Urology & Nephrology

William B. Coley His Hypothesis, His Toxin, and the Birth of Immunotherapy

Kevin R. Loughlin

UROLOGIC CLINICS OF NORTH AMERICA (2020)

添加到收藏夹

Article Medicine, Research & Experimental

Imaging of tumor colonization by Escherichia coli using 18F-FDS PET

Sae-Ryung Kang et al.

THERANOSTICS (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Programmable bacteria induce durable tumor regression and systemic antitumor immunity

Sreyan Chowdhury et al.

NATURE MEDICINE (2019)

添加到收藏夹

Review Medicine, General & Internal

Antibody-drug conjugates for cancer

Cindy H. Chau et al.

LANCET (2019)

添加到收藏夹

Article Multidisciplinary Sciences

Oxidative stress drives the selection of quorum sensing mutants in the Staphylococcus aureus population

Shilpa Elizabeth George et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

Antitumoral effects of attenuated Listeria monocytogenes in a genetically engineered mouse model of melanoma

Marianna Vitiello et al.

ONCOGENE (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

Bacteria-Driven Hypoxia Targeting for Combined Biotherapy and Photothermal Therapy

Wenfei Chen et al.

ACS NANO (2018)

添加到收藏夹

Review Engineering, Biomedical

Synthetic gene circuits for the detection, elimination and prevention of disease

Ferdinand Sedlmayer et al.

NATURE BIOMEDICAL ENGINEERING (2018)

添加到收藏夹

Review Biology

RNA polyadenylation and its consequences in prokaryotes

Eliane Hajnsdorf et al.

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2018)

添加到收藏夹

Review Oncology

Tumour-targeting bacteria engineered to fight cancer

Shibin Zhou et al.

NATURE REVIEWS CANCER (2018)

添加到收藏夹

Article Cell Biology

Two-step enhanced cancer immunotherapy with engineered Salmonella typhimurium secreting heterologous flagellin

Jin Hai Zheng et al.

SCIENCE TRANSLATIONAL MEDICINE (2017)

添加到收藏夹

Article Biochemical Research Methods

Riboswitch-Based Reversible Dual Color Sensor

Svetlana V. Harbaugh et al.

ACS SYNTHETIC BIOLOGY (2017)

添加到收藏夹

Review Microbiology

Salmonella SPI-2 Type III Secretion System Effectors: Molecular Mechanisms And Physiological Consequences

Elliott Jennings et al.

CELL HOST & MICROBE (2017)

添加到收藏夹

Article Microbiology

Salmonella enterica Remodels the Host Cell Endosomal System for Efficient Intravacuolar Nutrition

Viktoria Liss et al.

CELL HOST & MICROBE (2017)

添加到收藏夹

Review Biochemistry & Molecular Biology

Overview of Fusion Tags for Recombinant Proteins

E. N. Kosobokova et al.

BIOCHEMISTRY-MOSCOW (2016)

添加到收藏夹

Review Biochemical Research Methods

Principles of genetic circuit design

Jennifer A. N. Brophy et al.

NATURE METHODS (2014)

添加到收藏夹

Article Biochemical Research Methods

Permanent genetic memory with >1-byte capacity

Lei Yang et al.

NATURE METHODS (2014)

添加到收藏夹

Article Cell Biology

Intratumoral injection of Clostridium novyi-NT spores induces antitumor responses

Nicholas J. Roberts et al.

SCIENCE TRANSLATIONAL MEDICINE (2014)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Engineering of Bacteria for the Visualization of Targeted Delivery of a Cytolytic Anticancer Agent

Sheng-Nan Jiang et al.

MOLECULAR THERAPY (2013)

添加到收藏夹

Article Multidisciplinary Sciences

Rewritable digital data storage in live cells via engineered control of recombination directionality

Jerome Bonnet et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

添加到收藏夹

Review Multidisciplinary Sciences

Synthetic Biology Moving into the Clinic

Warren C. Ruder et al.

SCIENCE (2011)

添加到收藏夹

Article Oncology

Genetically Engineered Salmonella typhimurium as an Imageable Therapeutic Probe for Cancer

Vu H. Nguyen et al.

CANCER RESEARCH (2010)

添加到收藏夹

Review Cell Biology

Designing customized cell signalling circuits

Wendell A. Lim

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)

添加到收藏夹

Article Biochemistry & Molecular Biology

DNA sequence heterogeneity in Fim tyrosine-integrase recombinase-binding elements and functional motif asymmetries determine the directionality of the fim genetic switch in Escherichia coli K-12

Matthew P. McCusker et al.

MOLECULAR MICROBIOLOGY (2008)

添加到收藏夹

Article Medicine, Research & Experimental

Doxycycline influences microcirculation patterns in B16 melanoma

Baocun Sun et al.

EXPERIMENTAL BIOLOGY AND MEDICINE (2007)

添加到收藏夹

Article Biotechnology & Applied Microbiology

A tightly regulated inducible expression system utilizing the fim inversion recombination switch

TS Ham et al.

BIOTECHNOLOGY AND BIOENGINEERING (2006)

添加到收藏夹

Article Cell Biology

The lac operator-repressor system is functional in the mouse

CA Cronin et al.

GENES & DEVELOPMENT (2001)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.