Unveiling a Biomarker Signature of Meningioma: The Need for a Panel of Genomic, Epigenetic, Proteomic, and RNA Biomarkers to Advance Diagnosis and Prognosis

Article Oncology

DNA methylation profiling of meningiomas highlights clinically distinct molecular subgroups

Jyotsna Singh et al.

Summary: The classification and treatment strategy of meningiomas can be significantly improved by DNA methylation profiling, which reveals four distinct molecular subgroups with different clinical characteristics.

JOURNAL OF NEURO-ONCOLOGY (2023)

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Review Cell Biology

Long non-coding RNAs: definitions, functions, challenges and recommendations

John S. S. Mattick et al.

Summary: Genes encoding lncRNAs are abundant in complex organisms and are transcribed by RNA polymerase I, II, and III, as well as processed introns. The classification and annotation of lncRNAs are challenging due to their various functions, isoforms, and interactions with other genes. These lncRNAs evolve rapidly, are cell type-specific, and regulate multiple cellular processes, including gene expression and translation control.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2023)

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Article Oncology

MicroRNA 200a as a histologically independent marker for meningioma recurrence: Results of a four microRNA panel analysis in meningiomas

Steffi Urbschat et al.

Summary: This study investigated the potential function of selected microRNAs as markers of tumor progression in meningiomas. The results showed that microRNA 200a had significantly lower expression in recurrent meningiomas, while microRNA 409 was significantly correlated with tumor volume and had a significant negative correlation with patient age. In addition, the expression patterns of microRNA 34a and microRNA 200a were significantly associated with aberrations of chromosome 1p, and microRNA 409 was associated with aberration of chromosome 14.

CANCER MEDICINE (2023)

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Article Clinical Neurology

Inhibition of YAP/TAZ-driven TEAD activity prevents growth of NF2-null schwannoma and meningioma

Liyam Laraba et al.

Summary: The study reports new roles for the Hippo signalling pathway in NF2-null meningioma and schwannoma, and identifies the cancer stem cell marker ALDH1A1 as a target of Hippo signalling. The novel TEAD inhibitor used in the study effectively blocks the growth of these tumour types, providing potential clinical applications.

BRAIN (2023)

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Review Oncology

Meningioma Grading beyond Histopathology: Relevance of Epigenetic and Genetic Features to Predict Clinical Outcome

Elena Marastoni et al.

Summary: Meningiomas are classified into three main groups based on their genetic features, which can predict their clinical outcomes and recurrence risk more accurately than the current grading system established by WHO. These groups have distinct characteristics and may respond differently to treatments, providing valuable insights for personalized medicine approaches.

CANCERS (2023)

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Article Oncology

Specific gene expression signatures of low grade meningiomas

Erdyni N. N. Tsitsikov et al.

Summary: In this study, gene expression signatures of different subtypes of meningiomas were identified using RNA sequencing. The findings suggest potential signaling pathways involved in tumor development and prognosis.

FRONTIERS IN ONCOLOGY (2023)

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Review Neurosciences

DNA methylation meningioma biomarkers: attributes and limitations

Zhaohui Li et al.

Summary: Meningioma, a common type of brain tumor, is classified into three grades based on histopathology. The gold-standard treatment, surgical resection, faces challenges such as incomplete removal and high recurrence rates. DNA methylation plays a crucial role in meningioma progression. The epigenetic landscape of meningioma can improve tumor classification, identify molecular markers, determine prognosis, guide treatment, and develop new therapeutic strategies.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2023)

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Review Oncology

Diagnostic, therapeutic, and prognostic implications of the 2021 World Health Organization classification of tumors of the central nervous system

Simon Gritsch et al.

Summary: The 2016 revised WHO classification of CNS tumors incorporated molecular features with histologic grading, revolutionizing oncologists' understanding of primary brain and spinal cord tumors. The 2021 revised edition further integrates molecular alterations, updating the pathophysiology understanding of these diseases.

CANCER (2022)

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Review Oncology

The integrated multiomic diagnosis of sporadic meningiomas: a review of its clinical implications

Stephanie M. Robert et al.

Summary: Meningiomas are generally considered benign tumors but can exhibit aggressive behavior and high recurrence rates. Advances in molecular technologies have provided insights into the genomic and epigenomic landscape of meningiomas, leading to potential clinical implications. Clinical trials are currently underway to establish effective medical therapeutic options based on these molecular insights.

JOURNAL OF NEURO-ONCOLOGY (2022)

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Article Multidisciplinary Sciences

Multiple approaches converge on three biological subtypes of meningioma and extract new insights from published studies

James C. Bayley et al.

Summary: One-fifth of meningiomas classified as benign by the WHO histopathological grading system will behave malignantly. By combining RNA sequencing and cytogenetics techniques, researchers have developed a more accurate method for diagnosing these tumors and have identified similar tumor types. Proper classification of meningiomas will enhance our understanding of their biology and improve diagnosis and prognosis.

SCIENCE ADVANCES (2022)

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Review Clinical Neurology

Prognostic impact of genetic alterations and methylation classes in meningioma

Anna S. Berghoff et al.

Summary: Meningioma-relevant mutations and DNA methylation clusters were investigated and found to have correlations with patient survival times. TRAF7, KLF4, and TRAKL mutation genotypes were associated with improved prognosis. DNA methylation clusters showed better prognostic discrimination than individual mutations. Molecular profiling could facilitate more precise prognostic assessment and identification of potential targets for personalized therapy in meningioma patients.

BRAIN PATHOLOGY (2022)

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Article Oncology

Glutamine anaplerosis is required for amino acid biosynthesis in human meningiomas

Omkar B. Ijare et al.

Summary: This study found that alanine and glutamine/glutamate levels are significantly elevated in grade-II meningiomas. Grade-I meningiomas have relatively higher glutamine metabolism providing carbon/nitrogen for the biosynthesis of key nonessential amino acids. The GLS1 inhibitor CB-839 is highly effective in downregulating glutamine metabolic pathways in grade-I meningiomas leading to decreased cellular proliferation.

NEURO-ONCOLOGY (2022)

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Article Oncology

A molecularly integrated grade for meningioma

Joseph Driver et al.

Summary: A molecularly integrated grading scheme for meningiomas was proposed, which significantly improved upon the current WHO grading system in predicting progression-free survival. This framework can be broadly adopted by clinicians using widely available genomic technologies and presents an advance in the care of meningioma patients.

NEURO-ONCOLOGY (2022)

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Article Genetics & Heredity

Meningioma DNA methylation groups identify biological drivers and therapeutic vulnerabilities

Abrar Choudhury et al.

Summary: DNA methylation profiling identified three groups of meningiomas with distinct clinical outcomes, biological drivers, and therapeutic vulnerabilities. Cytostatic cell cycle inhibitors showed efficacy in attenuating meningioma growth.

NATURE GENETICS (2022)

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Article Oncology

Diagnostic potential of extracellular vesicles in meningioma patients

Franz L. Ricklefs et al.

Summary: Elevated levels of EVs in the plasma of meningioma patients could assist in tumor diagnosis and evaluation of treatment response. Analysis of EV-DNA methylation and proteomic profiling revealed genetic and epigenetic tumor alterations, facilitating molecular tumor classification.

NEURO-ONCOLOGY (2022)

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Article Clinical Neurology

Transcriptomic Profiling Revealed Lnc-GOLGA6A-1 as a Novel Prognostic Biomarker of Meningioma Recurrence

Hanus Slavik et al.

Summary: Transcriptomic sequencing revealed specific gene expression signatures of various clinical subtypes of meningioma, with the lnc-GOLGA6A-1 transcript found to be the most reliable predictor of meningioma recurrence.

NEUROSURGERY (2022)

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Article Multidisciplinary Sciences

Machine learning and bioinformatics approaches for classification and clinical detection of bevacizumab responsive glioblastoma subtypes based on miRNA expression

Jian Shi

Summary: By studying the GBM BVZ subtypes, we discovered the differential expression of related miRNAs and mRNAs, clinical characteristics, and functional pathways. Based on the expression of miR-21 and miR-10b, approximately 30% of GBM patients were classified as having the GBM BVZ-responsive subtype, which was associated with significantly shorter survival time. SVM classifiers and miRNA panels were used to classify and detect GBM BVZ subtypes.

SCIENTIFIC REPORTS (2022)

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Article Genetics & Heredity

Single-cell profiling of human dura and meningioma reveals cellular meningeal landscape and insights into meningioma immune response

Anthony Z. Wang et al.

Summary: This study represents the first comprehensive characterization of both non-tumor-associated human dura and primary meningioma samples using single-cell RNA sequencing. The research reveals a complex immune microenvironment in human dura, which is different from that of meningioma, and describes a diverse landscape of non-immune cells. Significant TCR overlap between matched dura and meningioma samples is shown through T cell receptor sequencing, and copy number variant heterogeneity within meningioma samples is reported.

GENOME MEDICINE (2022)

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Review Oncology

PI3K/Akt/mTOR Pathway and Its Role in Cancer Therapeutics: Are We Making Headway?

Yan Peng et al.

Summary: Cancer is a global public health issue that hinders the improvement of life expectancy worldwide. Current therapeutic options are insufficient, necessitating targeted treatments. Understanding the association between the PI3K/AKT/mTOR pathway and tumorigenesis, as well as the development of therapies targeting this pathway, is crucial for clinical decision-making.

FRONTIERS IN ONCOLOGY (2022)

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Article Clinical Neurology

Prostate-Specific Membrane Antigen Expression in Meningioma: A Promising Theranostic Target

Teddi Tubre et al.

Summary: This study found that PSMA is expressed within the endothelial cells of meningiomas and its expression is increased in recurrent and high-grade tumors. This finding may contribute to the development of new treatment strategies for meningiomas.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2022)

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Meeting Abstract Oncology

HIPPO SIGNALING PATHWAY IS STRONGLY INVOLVED IN MENINGIOMA TUMORIGENESIS

G. Mougel et al.

NEURO-ONCOLOGY (2022)

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Article Multidisciplinary Sciences

Movement-related artefacts (MR-ART) dataset of matched motion-corrupted and clean structural MRI brain scans

Adam Narai et al.

Summary: Magnetic Resonance Imaging (MRI) is a valuable tool for studying neural changes, but motion can affect the accuracy of measurements. Researchers are actively developing methods to assess, correct, or prevent motion corruption in MRI. This study presents a unique dataset of structural brain MRI images, including motion-free and motion-affected data from the same participants. The dataset allows direct evaluation of motion artefacts, their impact on data, and testing of correction approaches. It also includes different levels of motion artefacts, expert scoring for clinical image quality, and standard image quality metrics from MRIQC.

SCIENTIFIC DATA (2022)

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Article Oncology

Somatostatin Receptor Theranostics for Refractory Meningiomas

Betty Salgues et al.

Summary: Somatostatin receptor-targeted peptide receptor radionuclide therapy (PRRT) shows potential in the treatment of refractory meningiomas. Our study found that treatment with 177Lu-DOTATATE resulted in a 6-month progression-free survival (PFS-6) rate of 85.7% in patients with refractory meningiomas. Previous studies have shown that PRRT can achieve prolonged PFS-6 in patients with WHO grade I and II meningiomas, except for the most aggressive grade II tumors. Large scale randomized trials are needed to better incorporate PRRT into the clinical practice guidelines for refractory meningioma treatment.

CURRENT ONCOLOGY (2022)

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Review Clinical Neurology

The WHO 2021 Classification of Central Nervous System tumours: a practical update on what neurosurgeons need to know-a minireview

Sverre Helge Torp et al.

Summary: This minireview highlights important changes in the latest edition of WHO classification of CNS tumours that are relevant for practicing neurosurgeons, including standardization of tumour grading and nomenclature, as well as increased incorporation of molecular markers in the classification.

ACTA NEUROCHIRURGICA (2022)

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Article Biochemistry & Molecular Biology

LncRNA-IMAT1 Promotes Invasion of Meningiomas by Suppressing KLF4/hsa-miR22-3p/Snai1 Pathway

Yaodong Ding et al.

Summary: Invasive meningiomas show high expression of IMAT1, a long noncoding RNA, that promotes tumor cell invasion through the KLF4/hsa-miR22-3p/Snai1 pathway. The high expression of IMAT1 is the underlying cause for the loss of tumor suppressive properties of KLF4.

MOLECULES AND CELLS (2022)

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Article Oncology

Associations of meningioma molecular subgroup and tumor recurrence

Mark W. Youngblood et al.

Summary: This study identified distinct clinical outcomes and recurrence rates associated with meningioma molecular subgroups, highlighting the importance of genomic characterization in guiding postoperative management decisions for meningiomas. The different subgroups showed divergent clinical courses, with some aggressive subgroups exhibiting significantly higher recurrence rates compared to others. Recurrence of certain subgroups was associated with specific factors such as male sex, high grade, and elevated Ki-67 levels.

NEURO-ONCOLOGY (2021)

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Article Neurosciences

Endocan serum levels in patients with low- and high-grade meningiomas: does this biomarker have an indicative role?

Mohammad Javad Fattahi et al.

Summary: This study investigated the relationship between endocan serum levels and low- and high-grade meningiomas, revealing that higher grades of meningiomas had higher endocan serum levels. However, further assessment is required to understand the specific role of endocan in the pathogenesis or progression of this type of tumor.

EGYPTIAN JOURNAL OF NEUROLOGY PSYCHIATRY AND NEUROSURGERY (2021)

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Article

Meningioma: not always a benign tumor. A review of advances in the treatment of meningiomas

Ilaria Maggio et al.

CNS oncology (2021)

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Review Oncology

Emerging role of SWI/SNF complex deficiency as a target of immune checkpoint blockade in human cancers

Min Zhou et al.

Summary: Mutations in SWI/SNF subunits are linked to a broad spectrum of human cancers and may impact tumorigenesis and cancer therapeutics. There is a lack of reliable biomarkers to predict clinical response to immune checkpoint blockade (ICB) therapy. Emerging evidence suggests that SWI/SNF components play novel roles in regulating anti-tumor immunity and can be therapeutically targeted by ICB.

ONCOGENESIS (2021)

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Article Oncology

Integrated Molecular-Morphologic Meningioma Classification: A Multicenter Retrospective Analysis, Retrospectively and Prospectively Validated

Sybren L. N. Maas et al.

Summary: Utilizing DNA methylation and copy-number information for risk stratification in meningiomas improves prediction accuracy, with an integrated score showing higher precision, especially in risk separation of WHO grade 1 and grade 2 tumors.

JOURNAL OF CLINICAL ONCOLOGY (2021)

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Letter Neurosciences

Sporadic multiple meningiomas harbor distinct driver mutations

Tareq A. Juratli et al.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2021)

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Article Oncology

Metabolic alterations in meningioma reflect the clinical course

Waseem Masalha et al.

Summary: The study identified associations between alterations in glycine/serine metabolism and lower proliferation as well as more recurrent meningiomas, while changes in choline/tryptophan metabolism were linked to increased proliferation and recurrence. These metabolic alterations may reflect tumor malignancy and support histological classifications in predicting the clinical outcomes of meningioma patients.

BMC CANCER (2021)

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Article Oncology

MPscore: A Novel Predictive and Prognostic Scoring for Progressive Meningioma

Feili Liu et al.

Summary: Subtyping for meningioma is essential for predicting recurrence risk and treatment response. A consensus clustering identified a progressive subtype (subtype 3) with specific genetic and epigenetic features in meningioma. The constructed MPscore showed potential utility in predicting recurrence and stratifying treatment response.

CANCERS (2021)

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Article Nanoscience & Nanotechnology

Urinary MicroRNA-Based Diagnostic Model for Central Nervous System Tumors Using Nanowire Scaffolds

Yotaro Kitano et al.

Summary: There is currently a lack of accurate mass screening methods for early detection of central nervous system tumors. Research suggests that liquid biopsy based on urinary microRNAs may be an effective screening method, with high sensitivity and specificity in differentiating patients from noncancer individuals.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Review Cell Biology

The Role of MicroRNAs in Therapeutic Resistance of Malignant Primary Brain Tumors

Ilgiz Gareev et al.

Summary: Brain tumors, such as glioblastoma, are challenging to treat and have poor outcomes. Research on the role of miRNAs in the pathogenesis of brain tumors and their impact on treatment resistance is crucial for addressing this major clinical challenge.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Oncology

Loss of H3K27me3 in meningiomas

Farshad Nassiri et al.

Summary: The loss of H3K27me3 in meningiomas is associated with worse outcomes, particularly in WHO grade 2 tumors. However, it is not independently associated with recurrence-free survival after controlling for other factors like WHO grade, extent of resection, sex, age, and tumor recurrence status. Further studies with standardized reporting are needed to confirm these findings.

NEURO-ONCOLOGY (2021)

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Article Oncology

Multiple Reaction Monitoring-Based Targeted Assays for the Validation of Protein Biomarkers in Brain Tumors

Saicharan Ghantasala et al.

Summary: Proteomics technologies, including Multiple reaction monitoring, show promise in quantifying proteins in brain cancers, potentially offering alternative strategies with increased accuracy and sensitivity for classifying and grading tumors. Future studies involving a large cohort of samples could lead to a panel of proteins showing ability to accurately detect and quantify peptides with roles in brain malignancies, ultimately making them translatable to clinical settings.

FRONTIERS IN ONCOLOGY (2021)

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Review Clinical Neurology

Biomarkers for differentiating grade II meningiomas from grade I: a systematic review

Agbolahan A. Sofela et al.

Summary: This review evaluates potential clinical biomarkers for grade II meningiomas, focusing on radiological, biochemical, and immunohistochemical markers for diagnosis and prognosis, and how they can distinguish grade II from grade I meningiomas according to the post-2016 WHO classification.

BRITISH JOURNAL OF NEUROSURGERY (2021)

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Review Biochemistry & Molecular Biology

Genomic Biomarkers of Meningioma: A Focused Review

Jacob A. Pawloski et al.

Summary: Meningiomas are a genetically diverse group of tumors with their genetic landscape being a target of investigation, impacting tumor location, recurrence risk, and malignant potential. Targeted therapies based on tumor genomics are being developed, potentially providing personalized chemotherapy in the future.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Meeting Abstract Oncology

Multi-center, single arm phase II study of the dual mTORC1/mTORC2 inhibitor vistusertib for patients with recurrent or progressive grade II-III meningiomas.

Scott Randall Plotkin et al.

JOURNAL OF CLINICAL ONCOLOGY (2021)

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Article Multidisciplinary Sciences

A clinically applicable integrative molecular classification of meningiomas

Farshad Nassiri et al.

Summary: Meningiomas, the most common primary intracranial tumor in adults, often require surgery due to lack of effective medical therapies. This study introduced four consensus molecular groups of meningioma, which accurately predicted clinical outcomes and informed therapeutic options. Single-cell RNA sequencing revealed inter-individual variations in meningioma biology, highlighting the importance of molecular classification in guiding treatment strategies.

NATURE (2021)

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Review Oncology

The 2021 WHO Classification of Tumors of the Central Nervous System: a summary

David N. Louis et al.

Summary: The fifth edition of the WHO Classification of Tumors of the Central Nervous System integrates molecular diagnostics into CNS tumor classification, introduces different approaches to tumor nomenclature and grading, and emphasizes the importance of integrated diagnoses and layered reports.

NEURO-ONCOLOGY (2021)

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Review Immunology

Diverse Effects of Exosomes on COVID-19: A Perspective of Progress From Transmission to Therapeutic Developments

Sangiliyandi Gurunathan et al.

Summary: Exosomes, nano-sized lipid bilayer-enclosed structures, show potential in treating COVID-19 by modulating infection and transmission. Exosomes derived from mesenchymal stem cells have shown promise in reducing cytokine storm, repairing lung injuries, and could be a novel intervention for combating COVID-19.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Oncology

Mouse Models in Meningioma Research: A Systematic Review

Julien Boetto et al.

Summary: Meningiomas are the most common primary central nervous system tumors in adults. Mouse models of cancer play a crucial role in understanding disease mechanisms and testing preclinical drugs. Various mouse models of meningioma have been developed over time, providing useful tools for studying tumorigenesis mechanisms and testing innovative drugs and therapeutic options.

CANCERS (2021)

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Article Neurosciences

Meningioma genomics: a therapeutic challenge for clinicians

Charbel Moussalem et al.

Summary: Meningiomas are common intracranial tumors, with genetic studies showing associations with genes such as NF2 and TRAF7. Ongoing research is focused on finding alternative treatments based on gene therapy.

JOURNAL OF INTEGRATIVE NEUROSCIENCE (2021)

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Article Clinical Neurology

Forkhead box M1 (FOXM1) transcription factor is a key oncogenic driver of aggressive human meningioma progression

H. Kim et al.

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2020)

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Editorial Material Clinical Neurology

YAP1-fusions in pediatric NF2-wildtype meningioma

Philipp Sievers et al.

ACTA NEUROPATHOLOGICA (2020)

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Article Oncology

Phosphoproteomic and Kinomic Signature of Clinically Aggressive Grade I (1.5) Meningiomas Reveals RB1 Signaling as a Novel Mediator and Biomarker

Carolina A. Parada et al.

CLINICAL CANCER RESEARCH (2020)

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Article Biochemical Research Methods

Metabolomic Profile of Aggressive Meningiomas by Using High-Resolution Magic Angle Spinning Nuclear Magnetic Resonance

Laura Bender et al.

JOURNAL OF PROTEOME RESEARCH (2020)

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Article Cell Biology

Critical roles of phosphoinositides and NF2 in Hippo pathway regulation

Audrey W. Hong et al.

GENES & DEVELOPMENT (2020)

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Review Clinical Neurology

Poor prognosis associated with TERT gene alterations in meningioma is independent of the WHO classification: an individual patient data meta-analysis

Christian Mirian et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2020)

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Review Clinical Neurology

Subcutaneous Metastasis of Atypical Meningioma: Case Report and Literature Review

Yikui Liu et al.

WORLD NEUROSURGERY (2020)

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Article Multidisciplinary Sciences

Retrospective Motion Correction in Multishot MRI using Generative Adversarial Network

Muhammad Usman et al.

SCIENTIFIC REPORTS (2020)

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Article Oncology

Differentially Expressed MicroRNAs in Radioresistant and Radiosensitive Atypical Meningioma: A Clinical Study in Chinese Patients

Xiaokang Zhang et al.

FRONTIERS IN ONCOLOGY (2020)

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Letter Clinical Neurology

CDKN2A/Bhomozygous deletion is associated with early recurrence in meningiomas

Philipp Sievers et al.

ACTA NEUROPATHOLOGICA (2020)

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Article Radiology, Nuclear Medicine & Medical Imaging

Theranostics in Nuclear Medicine: Emerging and Re-emerging Integrated Imaging and Therapies in the Era of Precision Oncology

Jose Flavio Gomes Marin et al.

RADIOGRAPHICS (2020)

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Article Medicine, General & Internal

GATA-4, a potential novel therapeutic target for high-grade meningioma, regulates miR-497, a potential novel circulating biomarker for high-grade meningioma

Caterina Negroni et al.

EBIOMEDICINE (2020)

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Review Oncology

Challenges and Opportunities in Clinical Applications of Blood-Based Proteomics in Cancer

Ruchika Bhawal et al.

CANCERS (2020)

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Review Oncology

Multi-Omics Analysis in Initiation and Progression of Meningiomas: From Pathogenesis to Diagnosis

Jiachen Liu et al.

FRONTIERS IN ONCOLOGY (2020)

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Article Oncology

Is DNA Methylation a Ray of Sunshine in Predicting Meningioma Prognosis?

Lu Shen et al.

FRONTIERS IN ONCOLOGY (2020)

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Article Biochemistry & Molecular Biology

Merlin cooperates with neurofibromin and Spred1 to suppress the Ras-Erk pathway

Yan Cui et al.

HUMAN MOLECULAR GENETICS (2020)

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Article

Advances in meningioma genomics, proteomics, and epigenetics: insights into biomarker identification and targeted therapies

Ahmad A. Nazem et al.

Oncotarget (2020)

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Article Clinical Neurology

Identification of Meningioma Patients at High Risk of Tumor Recurrence Using MicroRNA Profiling

Hanus Slavik et al.

NEUROSURGERY (2020)

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Article Oncology

Long Non-Coding RNA MEG3 Modifies Cell-Cycle, Migration, Invasion, and Proliferation Through AKAP12 by Sponging miR-29c in Meningioma Cells

Chenyu Ding et al.

FRONTIERS IN ONCOLOGY (2020)

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Article Clinical Neurology

A Logistic Regression Model for Detecting the Presence of Malignant Progression in Atypical Meningiomas

Qing Zhang et al.

WORLD NEUROSURGERY (2019)

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Article Medicine, Research & Experimental

LINC00702/miR-4652-3p/ZEB1 axis promotes the progression of malignant meningioma through activating Wnt/β-catenin pathway

Tengfei Li et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

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Article Oncology

Proteomic analysis of meningiomas reveals clinically distinct molecular patterns

Michail-Dimitrios Papaioannou et al.

NEURO-ONCOLOGY (2019)

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Review Clinical Neurology

Prediction of High-Grade Histology and Recurrence in Meningiomas Using Routine Preoperative Magnetic Resonance Imaging: A Systematic Review

Dorothee Caecilia Spille et al.

WORLD NEUROSURGERY (2019)

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Article Oncology

DNA methylation profiling to predict recurrence risk in meningioma: development and validation of a nomogram to optimize clinical management

Farshad Nassiri et al.

NEURO-ONCOLOGY (2019)

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Article

Comparative genomic analysis of driver mutations in matched primary and recurrent meningiomas

Joshua Loewenstern et al.

Oncotarget (2019)

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Article Multidisciplinary Sciences

The role of serum and urinary biomarkers in the diagnosis of early diabetic nephropathy in patients with type 2 diabetes

Deyuan Zhang et al.

PEERJ (2019)

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Review Oncology

Apolipoprotein A-I (ApoA-I), Immunity, Inflammation and Cancer

Konstantina Georgila et al.

CANCERS (2019)

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Article Biochemistry & Molecular Biology

Comprehensive analysis of long noncoding RNA (lncRNA)-chromatin interactions reveals lncRNA functions dependent on binding diverse regulatory elements

Guanxiong Zhang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2019)

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Article Multidisciplinary Sciences

Molecular profiling predicts meningioma recurrence and reveals loss of DREAM complex repression in aggressive tumors

Akash J. Patel et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

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Review Oncology

The Role of Merlin/NF2 Loss in Meningioma Biology

Sungho Lee et al.

CANCERS (2019)

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Article Oncology

Circulating Tumor Biomarkers in Meningiomas Reveal a Signature of Equilibrium Between Tumor Growth and Immune Modulation

Erdogan Pekcan Erkan et al.

FRONTIERS IN ONCOLOGY (2019)

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Article Oncology

Nonmalignant and malignant meningioma incidence and survival in the elderly, 20052015, using the Central Brain Tumor Registry of the United States

Rebecca L. Achey et al.

NEURO-ONCOLOGY (2019)

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Article Clinical Neurology

High p-mTOR expression is associated with recurrence and shorter disease-free survival in atypical meningiomas

Valeria Barresi et al.

NEUROPATHOLOGY (2019)

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Article Clinical Neurology

Loss of histone H3K27me3 identifies a subset of meningiomas with increased risk of recurrence

Leah M. Katz et al.

ACTA NEUROPATHOLOGICA (2018)

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Article Medicine, Research & Experimental

Long noncoding RNA LINC00460 targets miR-539/MMP-9 to promote meningioma progression and metastasis

Hongshun Xing et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

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Review Medical Laboratory Technology

Cerebrospinal fluid microRNAs as diagnostic biomarkers in brain tumors

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EBIOMEDICINE (2018)

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RAS Promotes Proliferation and Resistances to Apoptosis in Meningioma

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MOLECULAR NEUROBIOLOGY (2017)

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Receptor tyrosine kinase inhibition by regorafenib/sorafenib inhibits growth and invasion of meningioma cells

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EUROPEAN JOURNAL OF CANCER (2017)

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The Emerging Role of TRAF7 in Tumor Development

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Targeted sequencing of SMO and AKT1 in anterior skull base meningiomas

Matthew R. Strickland et al.

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DNA methylation-based classification and grading system for meningioma: a multicentre, retrospective analysis

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CBTRUS Statistical Report: Primary brain and other central nervous system tumors diagnosed in the United States in 2010-2014

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Therapeutic radiation for childhood cancer drives structural aberrations of NF2 in meningiomas

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NATURE COMMUNICATIONS (2017)

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Genetically engineered mouse models for studying radiation biology

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Evaluating EFEMP1 in Cerebrospinal Fluid and Serum as a Potential Diagnosis Biomarker for Meningiomas

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Pan-cancer analysis of frequent DNA co-methylation patterns reveals consistent epigenetic landscape changes in multiple cancers

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Global epigenetic profiling identifies methylation subgroups associated with recurrence-free survival in meningioma

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ACTA NEUROPATHOLOGICA (2017)

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Visceral and bone metastases of a WHO grade 2 meningioma: A case report and review of the literature

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TERT Promoter Mutations and Risk of Recurrence in Meningioma

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Pathology concordance levels for meningioma classification and grading in NRG Oncology RTOG Trial 0539

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TERT Promoter Mutations and Risk of Recurrence in Meningioma

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The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary

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Expressions of Endocan in Patients with Meningiomas and Gliomas

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A phase II trial of bevacizumab and everolimus as treatment for patients with refractory, progressive intracranial meningioma

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EANO guidelines for the diagnosis and treatment of meningiomas

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Recurrent somatic mutations in POLR2A define a distinct subset of meningiomas

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Oncogenic PI3K mutations are as common as AKT1 and SMO mutations in meningioma

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Review Oncology

Molecular Genetics of Intracranial Meningiomas with Emphasis on Canonical Wnt Signalling

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A serum 6-miRNA panel as a novel non-invasive biomarker for meningioma

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Development of patient-derived xenograft models from a spontaneously immortal low-grade meningioma cell line, KCI-MENG1

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Descriptive epidemiology of World Health Organization grades II and III intracranial meningiomas in the United States

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PDGF activation in PGDS-positive arachnoid cells induces meningioma formation in mice promoting tumor progression in combination with Nf2 and Cdkn2ab loss

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AKT1E17K mutations cluster with meningothelial and transitional meningiomas and can be detected by SFRP1 immunohistochemistry

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Secretory meningiomas are defined by combined KLF4 K409Q and TRAF7 mutations

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The concentration of CYFRA 21-1, NSE and CEA in cerebro-spinal fluid can be useful indicators for diagnosis of meningeal carcinomatosis of lung cancer

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A microRNA expression signature predicts meningioma recurrence

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Distant metastases in meningioma: an underestimated problem

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Genomic sequencing of meningiomas identifies oncogenic SMO and AKT1 mutations

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Genomic Analysis of Non-NF2 Meningiomas Reveals Mutations in TRAF7, KLF4, AKT1, and SMO

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Epigenetic subclassification of meningiomas based on genome-wide DNA methylation analyses

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Possible interaction between ionizing radiation, smoking, and gender in the causation of meningioma

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Proteomic profiling of cerebrospinal fluid identifies prostaglandin D2 synthase as a putative biomarker for pediatric medulloblastoma: A pediatric brain tumor consortium study

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Article Clinical Neurology

Hypermethylation and Transcriptional Downregulation of the TIMP3 Gene is Associated with Allelic Loss on 22q12.3 and Malignancy in Meningiomas

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Hypomethylation of repeated DNA sequences in cancer

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Serial volumetric assessment of the natural history and growth pattern of incidentally discovered meningiomas Clinical article

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Downregulated MicroRNA-200a in Meningiomas Promotes Tumor Growth by Reducing E-Cadherin and Activating the Wnt/β-Catenin Signaling Pathway

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Article Biochemistry & Molecular Biology

NF2/Merlin Is a Novel Negative Regulator of mTOR Complex 1, and Activation of mTORC1 Is Associated with Meningioma and Schwannoma Growth

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Article Clinical Neurology

Natural history of meningioma development in mice reveals: A synergy of Nf2 and p16(Ink4a) mutations

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Merlin is apotent inhibitor of glioma growth

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A typical and anaplastic meningiomas: prognostic implications of clinicopathological features

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An orthotopic skull base model of malignant meningioma

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BRAIN PATHOLOGY (2008)

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Caspase-3 immunohistochemical expression is a marker of apoptosis, increased grade and early recurrence in intracranial meningiomas

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Expression of the hypoxia marker carbonic anhydrase 9 is associated with anaplastic phenotypes in meningiomas

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Establishment of a benign meningioma cell line by hTERT-mediated immortalization

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Different activation of mitogen-activated protein kinase and Akt signaling is associated with aggressive phenotype of human meningiomas

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CLINICAL CANCER RESEARCH (2005)

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Characterization of chromosome 14 abnormalities by interphase in situ hybridization and comparative genomic hybridization in 124 meningiomas

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Predisposing conditions and risk factors for development of symptomatic meningioma in adults

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Neurofibromatosis 2 (NF2) tumor suppressor merlin inhibits phosphatidylinositol 3-kinase through binding to PIKE-L

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

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Intratumoral patterns of clonal evolution in meningiomas as defined by multicolor interphase fluorescence in situ hybridization (FISH) -: Is there a relationship between histopathologically benign and atypical/anaplastic lesions?

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DNA methylation of multiple promoter-associated CpG islands in meningiomas:: relationship with the allelic status at 1p and 22q

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ACTA NEUROPATHOLOGICA (2004)

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Imaging of murine brain tumors using a 1.5 Tesla clinical MRI system

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Intracranial metastasis or meningioma? An uncommon clinical diagnostic dilemma

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Immunohistochemical identification and image analysis quantification of oestrogen and progesterone receptors in canine and feline meningioma

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Nf2 gene inactivation in arachnoidal cells is rate-limiting for meningioma development in the mouse

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Diagnosing dural metastases:: the value of 1H magnetic resonance spectroscopy

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Prostaglandin D synthase (β-trace) in meningeal hemangiopericytoma

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Intracranial injection of human meningioma cells in athymic mice: an orthotopic model for meningioma growth

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JOURNAL OF NEUROSURGERY (2000)

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Unveiling a Biomarker Signature of Meningioma: The Need for a Panel of Genomic, Epigenetic, Proteomic, and RNA Biomarkers to Advance Diagnosis and Prognosis

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