☆ 4.6 Article

The value of regular follow-up of oral leukoplakia for early detection of malignant transformation

ORAL DISEASES (2023)

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Summary: This meta-analysis aimed to assess the rate of malignant transformation (MT) of oral leukoplakia (OL) and to study potential risk factors for the MT of OL into oral squamous cell carcinoma (OSCC). The pooled proportion of OL MT for the total population described in the selected studies was 7.20%. Nonhomogeneous type lesions, higher grades of dysplasia, the location of the lesion (tongue and multifocal), and female sex had significant effects on the MT of OL. Patients with significant MT risk factors should be subjected to regular follow-up and observation.

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