CD147 Plasma Levels in Hospitalised Patients with Covid-19 Pneumonia Predict Illness Severity and In-Hospital Mortality

Article Biochemistry & Molecular Biology

CD147 contributes to SARS-CoV-2-induced pulmonary fibrosis

Jiao Wu et al.

Summary: This study systematically analyzed lung pathogenesis in SARS-CoV-2-infected humanized CD147 transgenic mice and identified CD147 as a crucial regulator for fibroblast activation induced by SARS-CoV-2. The study demonstrated that CD147 plays a significant role in SARS-CoV-2-triggered progressive pulmonary fibrosis and identified it as a potential therapeutic target for treating post-COVID-19 pulmonary fibrosis.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)

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Article Peripheral Vascular Disease

Circulating Von Willebrand factor and high molecular weight multimers as markers of endothelial injury predict COVID-19 in-hospital mortality

Aurelien Philippe et al.

Summary: This study examined the correlation between endothelial dysfunction and in-hospital mortality in COVID-19 patients. Results showed that levels of various endothelial biomarkers were elevated in critically ill patients, particularly Von Willebrand factor antigen (VWF:Ag) and high molecular weight multimers (HMWM). VWF:Ag was identified as the best predictor for in-hospital mortality among all endothelial biomarkers measured.

ANGIOGENESIS (2021)

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Review Peripheral Vascular Disease

COVID-19 is a systemic vascular hemopathy: insight for mechanistic and clinical aspects

David M. Smadja et al.

Summary: COVID-19 caused by SARS-CoV-2 is a systemic disease associated with vascular inflammation and endothelial injury, which can lead to ARDS and hypercoagulation. Besides pro-inflammatory cytokines, endothelial dysfunction can also cause hypercoagulation, thrombosis and pathological angiogenesis.

ANGIOGENESIS (2021)

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Article Biochemistry & Molecular Biology

CD147 antibody specifically and effectively inhibits infection and cytokine storm of SARS-CoV-2 and its variants delta, alpha, beta, and gamma

Jiejie Geng et al.

Summary: SARS-CoV-2 mutations increase viral transmissibility and immune escape, requiring in-depth investigation on COVID-19 pathogenesis for strategy development. CD147 is identified as a universal receptor for SARS-CoV-2 and its variants, and Meplazeumab effectively inhibits viral entry and inflammation.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Article Biochemistry & Molecular Biology