期刊
STEM CELL REVIEWS AND REPORTS
卷 -, 期 -, 页码 -出版社
SPRINGER
DOI: 10.1007/s12015-023-10660-9
关键词
COVID-19; CD147; Biomarker; UN SDG3
The study examined plasma sCD147 levels in Covid-19 patients and found that it was significantly associated with disease severity and survival. sCD147 may serve as a valuable biomarker for hospitalized patients with Covid-19 infection.
COVID-19 and infectious diseases have been included in strategic development goals (SDG) of United Nations (UN). The CD147 receptor is one of several receptors for the SARS-CoV-2 spike protein that could mediate Covid-19 viral infection of host cells. It has been recently proposed to regulate viral invasion and dissemination among lymphocytes and progenitor/stem cells. A soluble by-product of CD147 (sCD147) exists in plasma and has been previously identified as a marker of diabetes and platelet activation. We examined plasma sCD147 levels in 161 Covid-19 patients at hospital admission. We demonstrated significantly higher plasma sCD147 levels in Covid-19 patients, which correlated with plasma multiorgan dysfunction biomarkers interleukin-6, creatinine and Troponin I. Importantly, sCD147 admission levels were associated with Covid-19 severity and survival, carrying potential value as a biomarker in hospitalized patients with Covid-19 infection.
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